Cdk9 - cyclin-dependent kinase 9 (CDC2-related kinase) Gene

Mus musculus

Also known as PITALRE

Gene ID: 107951 | Gene type: protein coding

About Cdk9

Chromosome 2: 32,595,796-32,603,088 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 208 orthologues, 25 paralogues and is associated with 15 phenotypes. Ubiquitous expression in ovary adult (RPKM 28.4), thymus adult (RPKM 26.4) and 28 other tissues.

Summary

Enables several functions, including RNA polymerase II CTD heptapeptide repeat kinase activity; chromatin binding activity; and nucleic acid binding activity. Involved in positive regulation of histone H2B ubiquitination and positive regulation of histone phosphorylation. Located in nucleus. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Apr 2022]

Cdk9 Products(1)

mRNA	Protein	Name
NM_130860.3	NP_570930.1	cyclin-dependent kinase 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IMP IMP: Inferred from mutant phenotype	22509028	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21245044	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16245309	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12037670	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	22547058	MGI
enables snRNA binding	IDA IDA: Inferred from direct assay	16109376	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20570862	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	19575011	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: Inferred from direct assay	23752591	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16109376	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk9 Protein Structure

STKc_CDK9

0
100
200
300
372 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 9

cell division protein kinase 9

Cdk9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cdk9	Q99J95	Max	Mus musculus	P28574	Anti Bait CoIP	20434984
Intra	Cdk9	Q99J95	Srsf2	Mus musculus	Q62093	Anti Bait CoIP	23663783
Intra	Cdk9	Q99J95	Brdt	Mus musculus	Q91Y44	Pull Down	20593818
Intra	Cdk9	Q99J95	Brdt	Mus musculus	Q91Y44	Anti Bait CoIP	22922464

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.36%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 3
HY-112088	AZD4573	Inhibitor	99.98%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-101212	Fadraciclib	Inhibitor	99.78%	Phase 2
HY-13914	Roniciclib	Inhibitor	98.09%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 2
HY-103712	Samuraciclib	Inhibitor	/	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-138293	SY-5609	Inhibitor	99.66%	Phase 1
HY-10008	SNS-032	Inhibitor	99.54%	Phase 1
HY-137478A	KB-0742 dihydrochloride	Inhibitor	99.24%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.85%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.77%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (105)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103618	THZ531	Inhibitor	99.86%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.90%	Unkown
HY-12214A	NVP-2	Inhibitor	99.60%	Unkown
HY-103019	(+)-Enitociclib	Inhibitor	99.66%	Unkown
HY-130665	TL12-186	Inhibitor	99.63%	Unkown
HY-101257	YKL-5-124	Inhibitor	98.79%	Unkown
HY-111388A	SEL120-34A monohydrochloride	Inhibitor	99.29%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.61%	Unkown
HY-11009	CGP60474	Inhibitor	99.23%	Unkown
HY-130709	PROTAC CDK2/9 Degrader-1	Inhibitor	99.85%	Unkown
HY-123954	BTX-A51	Inhibitor	98.58%	Unkown
HY-15878	LDC000067	Inhibitor	98.09%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	98.95%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-103628	PROTAC CDK9 Degrader-1	Inhibitor	98.03%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.97%	Unkown
HY-12293	LY2857785	Inhibitor	99.92%	Unkown
HY-111388B	SEL120-34A hydrochloride	Inhibitor	99.98%	Unkown
HY-13231	CDK9-IN-1	Inhibitor	98.52%	Unkown
HY-103019B	(-)-Enitociclib	Inhibitor	99.69%	Unkown
HY-16559	Riviciclib hydrochloride		98.89%	Unkown
HY-143584	AZ5576	Inhibitor	99.88%	Unkown
HY-16462	CDK9-IN-2	Inhibitor	99.37%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.44%	Unkown
HY-13033	CDK-IN-2	Inhibitor	98.97%	Unkown
HY-123955	Casein Kinase inhibitor A86	Inhibitor	99.26%	Unkown
HY-18944	FIT-039	Inhibitor	99.56%	Unkown
HY-103646	CK7	Inhibitor	99.72%	Unkown
HY-12871	Atuveciclib Racemate	Inhibitor	98.48%	Unkown
HY-102039	CDK9-IN-8	Inhibitor	99.65%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.22%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.81%	Unkown
HY-126251	CDK9-IN-7	Inhibitor	98.05%	Unkown
HY-153260	TP-1287	Inhibitor	95.10%	Unkown
HY-100429	CAN508	Inhibitor	99.59%	Unkown
HY-X0009	JSH-009	Inhibitor	99.21%	Unkown
HY-130852	CDK9-IN-11	Inhibitor	97.02%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-100950	ABC1183	Inhibitor	99.19%	Unkown
HY-124639	CDK9 inhibitor HH1	Inhibitor	99.56%	Unkown
HY-111427	CDK8/19-IN-1	Inhibitor	98.03%	Unkown
HY-139328	CDK12-IN-5	Inhibitor	99.01%	Unkown
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Unkown
HY-162037	CDDD11-8	Inhibitor	99.62%	Unkown
HY-115714	CDK9-IN-12	Inhibitor	99.65%	Unkown
HY-130850	CDK9-IN-10	Inhibitor	98.00%	Unkown
HY-12843	Bohemine	Inhibitor	98.93%	Unkown
HY-143585	CDK9-IN-14	Inhibitor	99.91%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-111388	SEL120-34A	Inhibitor	/	Unkown
HY-137478	KB-0742	Inhibitor	99.38%	Unkown
HY-14372	BS-194	Inhibitor	99.36%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-139329	CDK12-IN-6	Inhibitor	98.09%	Unkown
HY-13461	PHA-767491	Inhibitor	99.85%	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-130981	FN-1501-propionic acid		/	Unkown
HY-131063	CDK6/9-IN-1	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-130001	CDK9-IN-9	Inhibitor	/	Unkown
HY-168518	PROTAC CDK9 degrader-9	Degrader	/	Unkown
HY-136841	SLM6	Inhibitor	/	Unkown
HY-157980	CDK9-IN-32	Inhibitor	/	Unkown
HY-149495	CP-07	Degrader	/	Unkown
HY-169244	CDK-TCIP1	Inhibitor	/	Unkown
HY-155153	CDK9-IN-24	Inhibitor	/	Unkown
HY-111356	IIIM-290	Inhibitor	/	Unkown
HY-149870	PROTAC CDK9 degrader-8	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-112811	PROTAC CDK9 degrader-2	Inhibitor	/	Unkown
HY-155787	SHR5428	Inhibitor	/	Unkown
HY-153426	CDK9-IN-23	Inhibitor	/	Unkown
HY-161768	VCC972839:01	Inhibitor	/	Unkown
HY-151984	CDK9-IN-22	Inhibitor	/	Unkown
HY-161379	CLZX-205	Inhibitor	/	Unkown
HY-139327	CDK12-IN-4	Inhibitor	/	Unkown
HY-156795	PROTAC CDK9/CycT1 Degrader-2	Inhibitor	/	Unkown
HY-150573	CDK2-IN-12	Inhibitor	/	Unkown
HY-145408	CDK7/9-IN-1	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-149963	PROTAC CDK9 degrader-6	Inhibitor	/	Unkown
HY-156083	CDK9-IN-28	Inhibitor	/	Unkown
HY-147771	ZLWT-37	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-149962	PROTAC CDK9 degrader-5	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-150562	CDK9-IN-19	Inhibitor	/	Unkown
HY-162706	BSJ-5-63	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	/	Unkown
HY-119120	JTK-101	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	/	Unkown
HY-164619	CDK9-IN-34	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk9	NCBI	NCBI:1025

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