Cdk2 - cyclin-dependent kinase 2 Gene

Mus musculus

Also known as A630093N05Rik

Gene ID: 12566 | Gene type: protein coding

About Cdk2

Chromosome 10: 128,533,808-128,540,900 reverse strand.GRCm39:CM001003.3

This gene has 7 transcripts (splice variants), 203 orthologues, 25 paralogues and is associated with 31 phenotypes. Broad expression in limb E14.5 (RPKM 35.9), thymus adult (RPKM 24.5) and 25 other tissues.

Summary

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in peptidyl-serine phosphorylation and positive regulation of cell population proliferation. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of cellular macromolecule biosynthetic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; integumental system; and limb. Human ortholog(s) of this gene implicated in prostate Cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdk2 Products(2)

mRNA	Protein	Name
NM_183417.3	NP_904326.1	cyclin-dependent kinase 2 isoform 1
NM_016756.4	NP_058036.1	cyclin-dependent kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IDA IDA: Inferred from direct assay	24380855	MGI
enables cyclin binding	IPI IPI: Inferred from physical interaction	11981756	MGI
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12970171	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	12124778	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	23599433	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8033213	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	21508411	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	23599433	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	16137671	MGI
acts upstream of or within G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	12970171	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7797074	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	23599433	MGI
acts upstream of or within positive regulation of DNA-templated DNA replication initiation	IGI IGI: Inferred from genetic interaction	20215406	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	16137671	MGI
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	23904268	MGI
acts upstream of or within potassium ion transport	IGI IGI: Inferred from genetic interaction	16393152	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12124778	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in X chromosome	IDA IDA: Inferred from direct assay	17784788	MGI
located in Y chromosome	IDA IDA: Inferred from direct assay	17784788	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	17784788	MGI
located in condensed chromosome	IDA IDA: Inferred from direct assay	17784788	MGI
part of cyclin A1-CDK2 complex	IDA IDA: Inferred from direct assay	7739547	MGI
part of cyclin A2-CDK2 complex	IDA IDA: Inferred from direct assay	7739547	MGI
part of cyclin E1-CDK2 complex	IDA IDA: Inferred from direct assay	7739547	MGI
part of cyclin E2-CDK2 complex	IDA IDA: Inferred from direct assay	7739547	MGI
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	12970760	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	24891606	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	28031483	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19773423	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	10082561	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk2 Protein Structure

STKc_CDK2_3

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 2

cell division protein kinase 2

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.64%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes
HY-B0402	Amantadine	Inhibitor	99.90%	Unkown
HY-B0402A	Amantadine hydrochloride	Inhibitor	≥98.0%	Yes
HY-B0263	Thiabendazole	Inhibitor	99.77%	Unkown
HY-B0402B	Amantadine sulfate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.74%	Phase 4
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 3
HY-10005	Flavopiridol	Inhibitor	99.73%	Phase 2
HY-30237	(R)-Roscovitine	Inhibitor	99.53%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-101212	Fadraciclib	Inhibitor	99.78%	Phase 2
HY-10006	Flavopiridol Hydrochloride	Inhibitor	99.73%	Phase 2
HY-10424	Milciclib	Inhibitor	99.90%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	96.62%	Phase 2
HY-103712	Samuraciclib	Inhibitor	/	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-138293	SY-5609	Inhibitor	99.33%	Phase 1
HY-10008	SNS-032	Inhibitor	99.54%	Phase 1
HY-141680	CPS2	Inhibitor	99.33%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-111361	FN-1501	Inhibitor	99.08%	Phase 1
HY-137443	Ipivivint	Inhibitor	99.95%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1

Pre-clinical Phase

Bioactive Molecules (162)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12529	Ro-3306	Inhibitor	99.83%	Unkown
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.78%	Unkown
HY-137894A	Tagtociclib hydrate	Inhibitor	99.95%	Unkown
HY-10329	JNJ-7706621	Inhibitor	99.91%	Unkown
HY-124719	hSMG-1 inhibitor 11j	Inhibitor	99.82%	Unkown
HY-15339	CVT-313	Inhibitor	99.90%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.61%	Unkown
HY-101257	YKL-5-124	Inhibitor	98.79%	Unkown
HY-130665	TL12-186	Inhibitor	99.63%	Unkown
HY-11009	CGP60474	Inhibitor	99.23%	Unkown
HY-15166	(E/Z)-Zotiraciclib	Inhibitor	99.96%	Unkown
HY-124760	hSMG-1 inhibitor 11e	Inhibitor	99.81%	Unkown
HY-114177	Ebvaciclib	Inhibitor	99.98%	Unkown
HY-130709	PROTAC CDK2/9 Degrader-1	Inhibitor	99.85%	Unkown
HY-15004	AUZ 454	Inhibitor	99.57%	Unkown
HY-127104	FMF-04-159-2	Inhibitor	99.48%	Unkown
HY-18930	NU6300	Inhibitor	98.44%	Unkown
HY-13914	Roniciclib	Inhibitor	98.09%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-15275	BMS-265246	Inhibitor	98.92%	Unkown
HY-15878	LDC000067	Inhibitor	99.00%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.30%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-117535	CDK2-IN-4	Inhibitor	99.85%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	98.95%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-18629	SU9516	Inhibitor	99.81%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-123772	CDK5 inhibitor 20-223	Inhibitor	99.78%	Unkown
HY-18299	Purvalanol B	Inhibitor	≥97.0%	Unkown
HY-X0150	JSH-150	Inhibitor	98.66%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-16559	Riviciclib hydrochloride		98.89%	Unkown
HY-108359	Alsterpaullone	Inhibitor	99.85%	Unkown
HY-145694	CDK5-IN-3	Inhibitor	99.49%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.97%	Unkown
HY-108136A	Bisindolylmaleimide X hydrochloride	Antagonist	98.90%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.74%	Unkown
HY-15889	AMG 925	Inhibitor	98.20%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-122609	XO44		99.38%	Unkown
HY-W011428	Olomoucine	Inhibitor	99.87%	Unkown
HY-112460	CDK2-IN-3	Inhibitor	≥97.0%	Unkown
HY-107419	NU6140	Inhibitor	99.07%	Unkown
HY-103647	K00546	Inhibitor	98.08%	Unkown
HY-112358	GW8510	Inhibitor	99.64%	Unkown
HY-142076	CDK4/6-IN-15	Inhibitor	99.32%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.81%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.94%	Unkown
HY-103646	CK7	Inhibitor	99.72%	Unkown
HY-19316	NU2058	Inhibitor	99.66%	Unkown
HY-154851	GSK-3 inhibitor 3	Inhibitor	98.72%	Unkown
HY-100600	BGG463	Inhibitor	≥98.0%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	98.98%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-15166B	(E/Z)-Zotiraciclib citrate	Inhibitor	98.06%	Unkown
HY-41076	Ca2+ channel agonist 1	Inhibitor	99.71%	Unkown
HY-111207	CA224	Inhibitor	99.94%	Unkown
HY-100429	CAN508	Inhibitor	99.59%	Unkown
HY-13816	NU6027	Inhibitor	99.04%	Unkown
HY-15166A	(E/Z)-Zotiraciclib hydrochloride	Inhibitor	99.90%	Unkown
HY-139328	CDK12-IN-5	Inhibitor	99.01%	Unkown
HY-W019806	Lacto-N-fucopentaose I	Activator	99.92%	Unkown
HY-112468	PNU112455A hydrochloride	Inhibitor	99.56%	Unkown
HY-14372	BS-194	Inhibitor	99.36%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-12843	Bohemine	Inhibitor	98.93%	Unkown
HY-112346	RGB-286147	Inhibitor	98.60%	Unkown
HY-164664	CDK2-IN-30	Inhibitor	/	Unkown
HY-13461	PHA-767491	Inhibitor	99.85%	Unkown
HY-157516	CDK2-IN-22	Inhibitor	98.64%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-139011	IV-361	Inhibitor	99.60%	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	/	Unkown
HY-148868A	Akt1&PKA-IN-2	Inhibitor	/	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-139329	CDK12-IN-6	Inhibitor	98.09%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-148214	CDK2/4/6-IN-2	Inhibitor	/	Unkown
HY-100035	PT-262	Inhibitor	99.21%	Unkown
HY-148868	Akt1&PKA-IN-1	Inhibitor	/	Unkown
HY-164827	CDK2 degrader 3	Degrader	/	Unkown
HY-169912	CDK2 degrader 5	Degrader	/	Unkown
HY-169910	CDK2 degrader 4	Inhibitor	/	Unkown
HY-123045	PNU-292137	Inhibitor	/	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-130001	CDK9-IN-9	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-143497	HDAC1/2 and CDK2-IN-1	Inhibitor	/	Unkown
HY-130981	FN-1501-propionic acid		/	Unkown
HY-147771	ZLWT-37	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-148213	CDK2/4/6-IN-1	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-160941	CDK2-IN-29	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-156470	Multi-kinase-IN-6	Inhibitor	/	Unkown
HY-170965	Anticancer agent 264	Inhibitor	/	Unkown
HY-161776	P-gp/CDK2-IN-1	Inhibitor	/	Unkown
HY-148651	CDK2-IN-15	Inhibitor	/	Unkown
HY-168845	CDK2/9-IN-1	Inhibitor	/	Unkown
HY-115943	Anticancer agent 30	Inhibitor	/	Unkown
HY-161708	PROTAC FLT3/CDKs degrader-1	Degrader	/	Unkown
HY-150570	Carbonic anhydrase inhibitor 14	Inhibitor	/	Unkown
HY-155218	TMX-2172	Degrader	/	Unkown
HY-115942	Anticancer agent 29	Inhibitor	/	Unkown
HY-155787	SHR5428	Inhibitor	/	Unkown
HY-151580S	CDK2-IN-14-d3	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-111356	IIIM-290	Inhibitor	/	Unkown
HY-158170	CDK7-IN-28	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-160556	CDK2-IN-26	Inhibitor	/	Unkown
HY-145867	EGFR-IN-45	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-161690	EF-4-177	Inhibitor	/	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-145693	CDK5-IN-2	Inhibitor	/	Unkown
HY-172128	NUAK1-IN-2	Inhibitor	/	Unkown
HY-149407	Multi-kinase-IN-4	Inhibitor	/	Unkown
HY-151069	TMX-2039	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-154852	GSK-3 inhibitor 4	Inhibitor	/	Unkown
HY-172153	CDK2-IN-41	Inhibitor	/	Unkown
HY-170897	CDK2-IN-40	Inhibitor	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-144810	CDK2-IN-8	Inhibitor	/	Unkown
HY-155602	CDK2-IN-18	Inhibitor	/	Unkown
HY-139327	CDK12-IN-4	Inhibitor	/	Unkown
HY-168513	ALK-IN-29	Inhibitor	/	Unkown
HY-168067	CDK-IN-14	Inhibitor	/	Unkown
HY-159805	CDK2-IN-31	Inhibitor	/	Unkown
HY-170441	CDK2-IN-36	Inhibitor	/	Unkown
HY-162528	CDK12-IN-7	Inhibitor	/	Unkown
HY-150573	CDK2-IN-12	Inhibitor	/	Unkown
HY-147698	ZLHQ-5f	Inhibitor	/	Unkown
HY-155441	CDK2-IN-20	Inhibitor	/	Unkown
HY-162416	CDK7-IN-27	Inhibitor	/	Unkown
HY-146253	CDK1/2/4-IN-1	Inhibitor	/	Unkown
HY-151071	TMX-3013	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-151984	CDK9-IN-22	Inhibitor	/	Unkown
HY-139651	CDK2-IN-7	Inhibitor	/	Unkown
HY-159155	CDK2/4-IN-1	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-170442	CDK2-IN-37	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-144811	CDK2-IN-9	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	/	Unkown
HY-160643	CDK2-IN-27	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk2	NCBI	NCBI:1017

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