1. Gene
  2. CDK2 - cyclin dependent kinase 2 Gene

CDK2 - cyclin dependent kinase 2 Gene

Homo sapiens

Also known as CDKN2; p33(CDK2)

Gene ID: 1017 | Gene type: protein coding

About CDK2

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,966,830-55,972,789 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 26 paralogues. Ubiquitous expression in placenta (RPKM 29.3), bone marrow (RPKM 14.9) and 24 other tissues.

Summary

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by Other subunits of the complex including cyclin A or E, CDK Inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

CDK2 Products(4)

mRNA Protein Name
NM_001798.5 NP_001789.2 cyclin-dependent kinase 2 isoform 1
NM_001290230.2 NP_001277159.1 cyclin-dependent kinase 2 isoform 3
XM_011537732.2 XP_011536034.1 cyclin-dependent kinase 2 isoform X1
NM_052827.4 NP_439892.2 cyclin-dependent kinase 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IDA
IDA: Inferred from direct assay
1653904 GOA
enables cyclin binding IPI
IPI: Inferred from physical interaction
1312467 GOA
enables cyclin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
1312467 GOA
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21596315 GOA
contributes to histone kinase activity IDA
IDA: Inferred from direct assay
8692841 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
2227411 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
8876165 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11953320 GOA
enables protein serine/threonine kinase activity IGI
IGI: Inferred from genetic interaction
26996940 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Ras protein signal transduction IEP
IEP: Inferred from expression pattern
9054499 GOA
involved in centriole replication IMP
IMP: Inferred from mutant phenotype
26297806 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
23184662 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10767298 GOA
involved in positive regulation of heterochromatin formation IDA
IDA: Inferred from direct assay
20935635 GOA
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
11746698 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12944431 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
29203878 GOA
involved in telomere maintenance in response to DNA damage IDA
IDA: Inferred from direct assay
28216226 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Cajal body IDA
IDA: Inferred from direct assay
10995387 GOA
part of cyclin A2-CDK2 complex IDA
IDA: Inferred from direct assay
1312467 GOA
part of cyclin A2-CDK2 complex IPI
IPI: Inferred from physical interaction
12244298 GOA
part of cyclin E1-CDK2 complex IPI
IPI: Inferred from physical interaction
8756624 GOA
part of cyclin E2-CDK2 complex IPI
IPI: Inferred from physical interaction
15232106 GOA
part of cyclin-dependent protein kinase holoenzyme complex IDA
IDA: Inferred from direct assay
1312467 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10767298 GOA
located in endosome IDA
IDA: Inferred from direct assay
21262353 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
8245034 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10767298 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 286)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 2

cdc2-related protein kinase

cell division protein kinase 2

p33 protein kinase

CDK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CDK2 P24941 CDKN3 Homo sapiens Q16667
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CDKN3 Homo sapiens Q16667
Y2H
8242750
Intra
CDK2 P24941 CDKN3 Homo sapiens Q16667
Anti Tag CoIP
25852190
Intra
CDK2 P24941 CDKN3 Homo sapiens Q16667
X-Ray Diffraction
11463386
Intra
CDK2 P24941 CDK7 Homo sapiens P50613
Protein Kinase Assay
15530371
Intra
CDK2 P24941 CDK7 Homo sapiens P50613
TAP
23455922
Intra
CDK2 P24941 MAPK15 Homo sapiens Q8TD08
Anti Tag CoIP
33961781
Intra
CDK2 P24941 MAPK15 Homo sapiens Q8TD08
Anti Tag CoIP
25852190
Intra
CDK2 P24941 MAPK15 Homo sapiens Q8TD08
TAP
23455922
Intra
CDK2 P24941 SCML2 Homo sapiens Q9UQR0-1
Anti Bait CoIP
24358021
Intra
CDK2 P24941 SCML2 Homo sapiens Q9UQR0-1
GMS
24358021
Intra
CDK2 P24941 SCML2 Homo sapiens Q9UQR0
Anti Bait CoIP
24358021
Intra
CDK2 P24941 STOML1 Homo sapiens Q9UBI4
Anti Tag CoIP
23082202
Intra
CDK2 P24941 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
CDK2 P24941 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
CDK2 P24941 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
CDK2 P24941 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
CDK2 P24941 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
CDK2 P24941 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
CDK2 P24941 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
CDK2 P24941 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
CDK2 P24941 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
CDK2 P24941 CCND1 Homo sapiens P24385
TAP
23455922
Intra
CDK2 P24941 CCND1 Homo sapiens P24385
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CCND1 Homo sapiens P24385
Anti Tag CoIP
26496610
Intra
CDK2 P24941 CCNB2 Homo sapiens O95067
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CCNB2 Homo sapiens O95067
TAP
23455922
Intra
CDK2 P24941 CCNB2 Homo sapiens O95067
Anti Tag CoIP
28514442
Intra
CDK2 P24941 CCNB2 Homo sapiens O95067
Protein Array
15232106
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
TAP
23455922
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Y2H
9840943
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Protein Array
15232106
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Anti Tag CoIP
35271311
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Anti Tag CoIP
25852190
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
TAP
23602568
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Anti Tag CoIP
26496610
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CCNE2 Homo sapiens O96020
Anti Tag CoIP
28514442
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
MAPPIT
25416956
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
SPR
15890360
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Anti Bait CoIP
17698606
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Anti Bait CoIP
16962592
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Anti Bait CoIP
24358021
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Pull Down
9284049
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Anti Tag CoIP
26496610
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
TAP
23602568
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Pull Down
8756624
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
TAP
23455922
Intra
CDK2 P24941 CDKN1A Homo sapiens P38936
Anti Tag CoIP
28514442
Intra
CDK2 P24941 LATS1 Homo sapiens O95835
Anti Tag CoIP
25218637
Intra
CDK2 P24941 EP300 Homo sapiens Q09472
TAP
23455922
Intra
CDK2 P24941 EP300 Homo sapiens Q09472
Anti Tag CoIP
33961781
Intra
CDK2 P24941 EP300 Homo sapiens Q09472
Pull Down
10330164
Intra
CDK2 P24941 EP300 Homo sapiens Q09472
Anti Tag CoIP
28514442
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
BRET
37398436
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
Anti Tag CoIP
25852190
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
TAP
23602568
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
Anti Tag CoIP
26496610
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
TAP
23455922
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
Y2H Array
31467278
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
BRET
29997244
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
SLC
31467278
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
Complementation
31467278
Intra
CDK2 P24941 CKS1B Homo sapiens P61024
MAPPIT
31467278
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
Anti Bait CoIP
16431923
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
Pull Down
24358021
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
TAP
23602568
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
X-Ray Diffraction
12244298
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
TAP
23455922
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
X-Ray Diffraction
15239650
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
Anti Bait CoIP
17254966
Intra
CDK2 P24941 CCNA2 Homo sapiens P20248
Anti Tag CoIP
25852190
Intra
CDK2 P24941 RB1 Homo sapiens P06400
Protein Kinase Assay
8756624
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Bait CoIP
17053782
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
PLA
25241761
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Bait CoIP
17418410
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Bait CoIP
24358021
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
GMS
24358021
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Tag CoIP
35271311
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
SPR
17254966
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Bait CoIP
17698606
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Tag CoIP
26496610
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Tag CoIP
28514442
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Bait CoIP
17254967
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Tag CoIP
25852190
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
TAP
23602568
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
SPR
15890360
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
TAP
23455922
Intra
CDK2 P24941 CDKN1B Homo sapiens P46527
Anti Bait CoIP
17254966
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Protein Kinase Assay
23853094
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Tag CoIP
28514442
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Tag CoIP
21092281
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
TAP
23602568
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
TAP
23455922
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Bait CoIP
17254967
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Tag CoIP
16223725
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Pull Down
24358021
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Bait CoIP
16431923
Intra
CDK2 P24941 CCNE1 Homo sapiens P24864
Anti Tag CoIP
25852190
Intra
CDK2 P24941 UHRF2 Homo sapiens Q96PU4
Antibody Array
21952639
Intra
CDK2 P24941 UHRF2 Homo sapiens Q96PU4
Anti Tag CoIP
15178429
Intra
CDK2 P24941 FBXW7 Homo sapiens Q969H0-4
Anti Tag CoIP
23082202
Intra
CDK2 P24941 CCNH Homo sapiens P51946
Anti Tag CoIP
28514442
Intra
CDK2 P24941 CCNH Homo sapiens P51946
Y2H
9840943
Intra
CDK2 P24941 CCNH Homo sapiens P51946
Anti Tag CoIP
33961781
Intra
CDK2 P24941 CCNH Homo sapiens P51946
Anti Tag CoIP
26496610
Intra
CDK2 P24941 IKBKG Homo sapiens Q9Y6K9
Pull Down
20098747
Cross
CDK2 P24941 E7 Human papillomavirus P03129
Affinity Chrom
16061792
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDK2 Proteins

Cat. No. Product Name Accession Purity
HY-P70014 CDK2 Protein, Human (His) P24941 (E2-L298) ≥95%

Related Diseases

Diseases Alias
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Cecum Adenoma

Caecum Adenoma

Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina

Leiomyosarcoma

Leiomyosarcomas

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Sensory System Disease
Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

CMM1

Melanoma, Cutaneous Malignant

Cmm

Melanoma, Malignant

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders

Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Larynx

Squamous Cell Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Head And Neck

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3

DRS3

Robinow, Autosomal Dominant Syndrome, Type 3

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Leiomyoma

Leiomyomatous Neoplasm

Leiomyomatous Tumor

Leiomyomas

Fibroid Tumor

Uterine Fibroids

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Cecal Benign Neoplasm

Cecal Neoplasms

Cecum Neoplasm

Neoplasm Of Caecum

Cecal Neoplasm

Cecum Carcinoma

Malignant Neoplasm Of Cecum

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Endometrial Hyperplasia
Ocular Cancer

Eye Carcinoma

Eye Neoplasm

Eye Cancer

Eye Neoplasms

Malignant Eye Neoplasm

Neoplasm Of Eye

Neoplasm Of Eye Proper

Ocular Tumor

Carcinoma Of Eye

Ocular Carcinoma

Malignant Tumor Of Eye

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Tetraploidy

Tetraploidy Syndrome

Pancreatic Adenocarcinoma

Adenocarcinoma Of Pancreas

Adenocarcinoma Of The Pancreas

Pancreas Adenocarcinoma

Malignant Exocrine Neoplasm

Primary Pancreatic Adenocarcinoma

Adenocarcinoma Of Islet Cell Of Pancreas

Islet Cell Adenocarcinoma Of Unspecified Site

Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDK2 RGD RGD:70486
Felis catus CDK2 VGNC VGNC:60697
Bos taurus CDK2 VGNC VGNC:27123
Canis familiaris CDK2 VGNC VGNC:39051
Mus musculus CDK2 MGD MGI:104772
Macaca mulatta CDK2 VGNC VGNC:70979
Others CDK2 NCBI