Flt3 - FMS-like tyrosine kinase 3 Gene

Mus musculus

Also known as Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04

Gene ID: 14255 | Gene type: protein coding

About Flt3

Chromosome 5: 147,267,551-147,337,299 reverse strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 134 orthologues, 53 paralogues and is associated with 56 phenotypes. Biased expression in cerebellum adult (RPKM 4.3), spleen adult (RPKM 2.2) and 14 other tissues.

Summary

Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hemopoiesis; and lymphocyte proliferation. Acts upstream of or within several processes, including dendritic cell homeostasis; hematopoietic or lymphoid organ development; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including brain; dorsal aorta; immune system; reproductive system; and spinal cord. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; colorectal adenocarcinoma; hepatocellular carcinoma; and prostate Cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Flt3 Products(1)

mRNA	Protein	Name
NM_010229.2	NP_034359.2	receptor-type tyrosine-protein kinase FLT3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine receptor activity	IMP IMP: Inferred from mutant phenotype	18469816	MGI
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	8183574	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7505204	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8384358	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	23418353	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	21228325	MGI
acts upstream of or within antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7919361	MGI
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	18469816	MGI
acts upstream of or within cellular response to virus	IMP IMP: Inferred from mutant phenotype	20457904	MGI
involved in common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	21813452	MGI
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18469816	MGI
involved in dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	18469816	MGI
acts upstream of or within dendritic cell homeostasis	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	22674806	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	20457904	MGI
involved in leukocyte homeostasis	IMP IMP: Inferred from mutant phenotype	18469816	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within lymphocyte differentiation	IDA IDA: Inferred from direct assay	12387740	MGI
involved in lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	18469816	MGI
acts upstream of or within lymphoid progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	7621074	MGI
acts upstream of or within myeloid progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	7621074	MGI
acts upstream of or within myeloid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	18245664	MGI
involved in myeloid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	18469816	MGI
acts upstream of or within negative regulation of B cell differentiation	IDA IDA: Inferred from direct assay	16618805	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7919361	MGI
acts upstream of or within negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	20360400	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	20457904	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	22674806	MGI
acts upstream of or within pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	7621074	MGI
involved in pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	21228325	MGI
acts upstream of or within pro-T cell differentiation	IMP IMP: Inferred from mutant phenotype	7621074	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	8183574	MGI
acts upstream of protein phosphorylation	IGI IGI: Inferred from genetic interaction	20360400	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	22674806	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	7630197	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23528453	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Flt3 Protein Structure

7tm_GPCRs

PKc_like

0
200
400
600
800
1000 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein kinase FLT3

FL cytokine receptor	fetal liver kinase 2
tyrosine-protein kinase FLT3	tyrosine-protein kinase receptor flk-2

Recombinant Flt3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74151	FLT3 Protein, Mouse (HEK293, His)	Q3UEW6/NP_034359.2 (N28-S544)	≥95%

Related Agents

Approval

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10201	Sorafenib	Inhibitor	99.92%	Yes
HY-13016	Cabozantinib	Inhibitor	99.96%	Yes
HY-12432	Gilteritinib	Inhibitor	99.69%	Yes
HY-13001	Quizartinib	Inhibitor	99.01%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-10201A	Sorafenib Tosylate	Inhibitor	99.91%	Yes
HY-13038A	Fostamatinib	Inhibitor	99.50%	Yes
HY-112306	Ripretinib	Inhibitor	98.90%	Yes
HY-10201S	Sorafenib-d3	Inhibitor	99.57%	Unkown
HY-50867	Lestaurtinib	Inhibitor	99.17%	Unkown
HY-12432A	Gilteritinib hemifumarate	Inhibitor	99.75%	Yes
HY-13038	Fostamatinib Disodium	Inhibitor	99.88%	Yes
HY-13038B	Fostamatinib disodium hexahydrate	Inhibitor	99.73%	Yes
HY-12432R	Gilteritinib (Standard)	Inhibitor	/	Unkown
HY-14217	Quizartinib dihydrochloride	Inhibitor	99.81%	Yes
HY-10201R	Sorafenib (Standard)	Inhibitor	99.71%	Unkown
HY-13016A	Cabozantinib hydrochloride	Inhibitor	/	Unkown
HY-16379B	Pacritinib citrate	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50514	AT9283	Inhibitor	99.67%	Phase 3
HY-50751	Linifanib	Inhibitor	99.28%	Phase 3
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-13024	Rebastinib	Inhibitor	99.91%	Phase 2
HY-135317	Emavusertib	Inhibitor	99.94%	Phase 2
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-101549	MRX-2843	Inhibitor	99.70%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-10206	Amuvatinib	Inhibitor	99.47%	Phase 2
HY-10987A	ENMD-2076	Inhibitor	99.12%	Phase 2
HY-100867A	Mivavotinib monohydrochloride	Inhibitor	99.91%	Phase 2
HY-10202	Tandutinib	Inhibitor	99.48%	Phase 2
HY-145015	Tuspetinib	Inhibitor	99.85%	Phase 2
HY-10987	ENMD-2076 Tartrate	Inhibitor	99.42%	Phase 2
HY-10202A	Tandutinib hydrochloride	Inhibitor	99.78%	Phase 2
HY-118304B	AKN-028 acetate	Inhibitor	99.95%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2
HY-15496	E6201	Inhibitor	/	Phase 2
HY-100867	Mivavotinib	Inhibitor	/	Phase 2
HY-135317B	Emavusertib hydrochloride	Inhibitor	/	Phase 2
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Phase 2
HY-145723A	MAX-40279 hydrochloride	Inhibitor	/	Phase 2
HY-15163	Zotiraciclib	Inhibitor	/	Phase 2
HY-10058	AT9283 lactic acid	Inhibitor	/	Phase 2
HY-145015A	Tuspetinib hydrate	Inhibitor	/	Phase 2
HY-118304	AKN-028	Inhibitor	/	Phase 2
HY-10339	KW-2449	Inhibitor	99.69%	Phase 1
HY-10032	PF 477736	Inhibitor	99.21%	Phase 1
HY-B0791	Altiratinib	Inhibitor	98.05%	Phase 1
HY-111361	FN-1501	Inhibitor	99.08%	Phase 1
HY-139535	Luxeptinib	Inhibitor	99.30%	Phase 1
HY-13072	Cenisertib	Inhibitor	99.86%	Phase 1
HY-19897	4SC-203	Inhibitor	98.98%	Phase 1
HY-13223A	Crenolanib benzenesulfonate	Inhibitor	/	Phase 1
HY-118084	LS-104	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (144)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12067	R406	Inhibitor	98.72%	Unkown
HY-13223	Crenolanib	Inhibitor	99.68%	Yes
HY-12344	UNC2025	Inhibitor	99.83%	Unkown
HY-15166	(E/Z)-Zotiraciclib	Inhibitor	99.96%	Unkown
HY-13263	CHIR-124	Inhibitor	98.57%	Unkown
HY-153886	Wu-5	Inhibitor	99.34%	Unkown
HY-11108	R406 free base	Inhibitor	99.80%	Unkown
HY-12461	WS6	Modulator	99.94%	Unkown
HY-15002	AST 487	Inhibitor	99.42%	Unkown
HY-10410	TG101209	Inhibitor	99.22%	Unkown
HY-12344A	UNC2025 hydrochloride	Inhibitor	99.87%	Unkown
HY-13894	Tyrphostin AG1296	Inhibitor	99.69%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.64%	Unkown
HY-132200	UNC5293	Inhibitor	95.07%	Unkown
HY-12333	Denfivontinib	Inhibitor	≥98.0%	Unkown
HY-145723	MAX-40279	Inhibitor	97.10%	Unkown
HY-15889	AMG 925	Inhibitor	98.20%	Unkown
HY-153857	PHI-101	Inhibitor	98.97%	Unkown
HY-120758	SEL24-B489	Inhibitor	99.02%	Unkown
HY-130247	Flonoltinib	Inhibitor	99.79%	Unkown
HY-12420	JNJ-47117096 hydrochloride	Inhibitor	99.68%	Unkown
HY-15003	ATH686	Inhibitor	99.38%	Unkown
HY-15166B	(E/Z)-Zotiraciclib citrate	Inhibitor	98.06%	Unkown
HY-18952A	(Z)-SU5614	Inhibitor	98.43%	Unkown
HY-13907	TCS 359	Inhibitor	99.89%	Unkown
HY-114323	PROTAC FLT-3 degrader 1	Inhibitor	99.74%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	99.15%	Unkown
HY-18161	CCT241736	Inhibitor	99.88%	Unkown
HY-13016S	Cabozantinib-d6	Inhibitor	98.14%	Unkown
HY-112145	FLT3-IN-3	Inhibitor	99.95%	Unkown
HY-18744	FLT3-IN-2	Inhibitor	98.80%	Unkown
HY-120590	Ruserontinib	Inhibitor	99.82%	Unkown
HY-15166A	(E/Z)-Zotiraciclib hydrochloride	Inhibitor	99.90%	Unkown
HY-18179	AZD2932	Inhibitor	99.04%	Unkown
HY-130247A	Flonoltinib TFA	Inhibitor	99.77%	Unkown
HY-162037	CDDD11-8	Inhibitor	99.62%	Unkown
HY-132150A	HPK1-IN-2 dihydrochloride	Inhibitor	98.69%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-148070	FLT3-IN-17	Inhibitor	99.56%	Unkown
HY-107417	Hypothemycin	Inhibitor	≥98.0%	Unkown
HY-13493	AC710	Inhibitor	98.56%	Unkown
HY-151904	AXL-IN-13		98.03%	Unkown
HY-148036	FLT3-IN-16	Inhibitor	98.98%	Unkown
HY-110293	CHMFL-FLT3-122	Inhibitor	98.47%	Unkown
HY-12432S1	Gilteritinib-d8	Inhibitor	≥98.0%	Unkown
HY-12960	SKLB4771	Inhibitor	98.08%	Unkown
HY-100865	BPR1K871	Inhibitor	99.12%	Unkown
HY-144869	OTS447	Inhibitor	99.83%	Unkown
HY-128572	FLT3-IN-6	Inhibitor	99.14%	Unkown
HY-145723C	MAX-40279 hemiadipate	Inhibitor	99.26%	Unkown
HY-128571	FLT3-IN-4	Inhibitor	98.19%	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-13537A	BPR1J-097 Hydrochloride	Inhibitor	99.20%	Unkown
HY-108263	3-Hydroxy Midostaurin	Inhibitor	97.02%	Unkown
HY-134481	FLT3-IN-10	Inhibitor	98.80%	Unkown
HY-143286A	PF15 TFA	Degrader	99.72%	Unkown
HY-15889A	AMG 925 HCl	Inhibitor	/	Unkown
HY-153473	FLT3-IN-19	Inhibitor	99.19%	Unkown
HY-13537	BPR1J-097	Inhibitor	/	Unkown
HY-110026	GTP-14564	Inhibitor	99.91%	Unkown
HY-146749	FLT3/TrKA-IN-1	Inhibitor	/	Unkown
HY-111545	BSc5371	Inhibitor	/	Unkown
HY-145723B	MAX-40279 hemifumarate	Inhibitor	99.56%	Unkown
HY-169076	FLT3/HDAC-IN-1	Inhibitor	/	Unkown
HY-155341	HSK205	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-145904	PDGFRα/FLT3-ITD-IN-3	Inhibitor	/	Unkown
HY-144711	FLT3/ITD-IN-3	Inhibitor	/	Unkown
HY-144709	FLT3/ITD-IN-1	Inhibitor	/	Unkown
HY-143286	PF15	Inhibitor	/	Unkown
HY-155112	Antiproliferative agent-30	Inhibitor	/	Unkown
HY-123237	KRC-108	Inhibitor	/	Unkown
HY-161323	FLT3-ITD/D835Y-IN-1	Inhibitor	/	Unkown
HY-158325	PROTAC FLT-3 degrader 4	Inhibitor	/	Unkown
HY-148521	PROTAC FLT3/CDK9 degrader-1	Degrader	/	Unkown
HY-155302	FLT3-IN-22	Inhibitor	/	Unkown
HY-161280	PROTAC FLT-3 degrader 3	Degrader	/	Unkown
HY-112378	D-65476	Inhibitor	/	Unkown
HY-112475	Flt-3 Inhibitor III	Inhibitor	/	Unkown
HY-149539	PLM-101	Inhibitor	/	Unkown
HY-15163A	Zotiraciclib hydrochloride	Inhibitor	/	Unkown
HY-103464	5'-Fluoroindirubinoxime	Inhibitor	≥98.0%	Unkown
HY-139619	LT-850-166	Inhibitor	/	Unkown
HY-144710	FLT3/ITD-IN-2	Inhibitor	/	Unkown
HY-15519	LBW242	Inhibitor	/	Unkown
HY-145690	HP1328	Inhibitor	/	Unkown
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-155594	LT-540-717	Inhibitor	/	Unkown
HY-150582	c-Met-IN-14	Inhibitor	/	Unkown
HY-50905S	Dovitinib-d8	Inhibitor	/	Unkown
HY-162936	SILA-123	Inhibitor	/	Unkown
HY-161709	FLT3/CDKs ligand-1	Degrader	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-157213	LWY713	Degrader	/	Unkown
HY-149474	HDAC-IN-63	Inhibitor	/	Unkown
HY-160848	FLT3/ITD-IN-5	Inhibitor	/	Unkown
HY-155226	FLT3-IN-21	Inhibitor	/	Unkown
HY-161967	JAK2/FLT3-IN-3	Inhibitor	/	Unkown
HY-146680	FLT3/ITD-IN-4	Inhibitor	/	Unkown
HY-162367	FLT3/CHK1-IN-2	Inhibitor	/	Unkown
HY-151961	RSH-7	Inhibitor	99.07%	Unkown
HY-115906	K783-0308	Inhibitor	/	Unkown
HY-143895	FLT3-IN-12	Inhibitor	/	Unkown
HY-146886	FLT3-IN-15	Inhibitor	/	Unkown
HY-108263S	3-Hydroxy Midostaurin-d5	Inhibitor	/	Unkown
HY-156410	FLT3-IN-23	Inhibitor	/	Unkown
HY-18949	JI6	Inhibitor	/	Unkown
HY-151945	TRK II-IN-1	Inhibitor	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib	Inhibitor	/	Unkown
HY-143434	FLT3/D835Y-IN-1	Inhibitor	/	Unkown
HY-10201S2	Sorafenib-13C,d3	Inhibitor	98.35%	Unkown
HY-108263A	(S)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-10201S1	Sorafenib-d4	Inhibitor	/	Unkown
HY-161708	PROTAC FLT3/CDKs degrader-1	Degrader	/	Unkown
HY-144777	FLT3-IN-14	Inhibitor	/	Unkown
HY-162032	FLT3-IN-25	Inhibitor	/	Unkown
HY-162906	FLT3/HDAC-IN-2	Inhibitor	/	Unkown
HY-145902	PDGFRα/FLT3-ITD-IN-1	Inhibitor	/	Unkown
HY-148522	FLT3-IN-18	Inhibitor	/	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-163068	FLT3-IN-24	Inhibitor	/	Unkown
HY-13016S1	Cabozantinib-d4	Inhibitor	/	Unkown
HY-155770	FLT3-IN-20	Inhibitor	/	Unkown
HY-111249	TTT 3002	Inhibitor	/	Unkown
HY-145691	HP1142	Inhibitor	/	Unkown
HY-115904	FLT3/CDK4-IN-1	Inhibitor	/	Unkown
HY-125051	SG3-179	Inhibitor	/	Unkown
HY-145903	PDGFRα/FLT3-ITD-IN-2	Inhibitor	/	Unkown
HY-143278	FLT3-IN-13	Inhibitor	/	Unkown
HY-158265	FLT3D835Y/F691L-IN-1	Inhibitor	/	Unkown
HY-112350	AGL 2043	Inhibitor	/	Unkown
HY-123201	KRN383 analog	Inhibitor	/	Unkown
HY-13072B	Cenisertib benzoate	Inhibitor	/	Unkown
HY-112417	Ki11502	Inhibitor	/	Unkown
HY-130247B	Flonoltinib monomaleate	Inhibitor	/	Unkown
HY-116129	BPR1J-340	Inhibitor	/	Unkown
HY-118304A	AKN-028 TFA	Inhibitor	/	Unkown
HY-101549A	MRX-2843 hydrochloride	Inhibitor	/	Unkown
HY-168213	FLT3-IN-27	Inhibitor	/	Unkown
HY-10202B	Tandutinib sulfate	Inhibitor	/	Unkown
HY-148036S	FLT3-IN-16-d1	Inhibitor	/	Unkown
HY-50751S	Linifanib-d4	Inhibitor	/	Unkown
HY-122240	AAE871	Inhibitor	/	Unkown
HY-126920	AFG206	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99916	Emirodatamab		/	Unkown
HY-P990786	Anti-FLT3 Antibody (AGS62P)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flt3	NCBI	NCBI:2322
Macaca fascicularis	Flt3	NCBI	NCBI:102144988
Susscrofa domestica	Flt3	NCBI
Rattus norvegicus	Flt3	NCBI	NCBI:140635
Macaca mulatta	Flt3	NCBI	NCBI:721712

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