2. Gene
  3. Maob - monoamine oxidase B Gene

Maob - monoamine oxidase B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25750 | Gene type: protein coding

About Maob

Primary_assembly X: 5,907,266-6,011,003 forward strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 333 orthologues, 10 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 548.4), Lung (RPKM 237.7) and 5 other tissues.

Summary

Enables flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Involved in several processes, including negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; and response to corticosterone. Located in mitochondrial outer membrane. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (Monoamine Oxidase B). [provided by Alliance of Genome Resources, Apr 2022]

Maob Products(1)

mRNA Protein Name
NM_013198.1 NP_037330.1 amine oxidase [flavin-containing] B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
18424170 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
18198902 RGD
enables monoamine oxidase activity IDA
IDA: Inferred from direct assay
20493079 RGD
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
18424170 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of serotonin secretion IMP
IMP: Inferred from mutant phenotype
12175458 RGD
involved in phenylethylamine catabolic process IDA
IDA: Inferred from direct assay
18539264 RGD
involved in positive regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
12175458 RGD
involved in response to aluminum ion IEP
IEP: Inferred from expression pattern
19526156 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
15919584 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20022592 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19779138 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
18304392 RGD
involved in response to steroid hormone IDA
IDA: Inferred from direct assay
18539264 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16904659 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18256746 RGD
Cellular Component GO Annotation Evidence Reference Source
located in dendrite IDA
IDA: Inferred from direct assay
12379239 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
12379239 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12379239 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Maob Protein Structure

YobN

YobN: COG1231 (4 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

amine oxidase [flavin-containing] B

MAO-B

monoamine oxidase type B

Related Agents

Approval
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0159 Paeonol 99.98% Unkown
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-14199 Selegiline hydrochloride Inhibitor 99.94% Unkown
HY-A0091A Pargyline Inhibitor 99.82% Unkown
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% Unkown
HY-70057 Safinamide Inhibitor 99.89% Yes
HY-14855B Tedizolid phosphate Inhibitor 99.65% Yes
HY-70057A Safinamide mesylate Inhibitor 99.87% Yes
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% Unkown
HY-14198 Selegiline Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-N0529 Rosmarinic acid 99.70% Phase 4
HY-154977 ETAP Inhibitor / Phase 3
HY-129388B Pulrodemstat benzenesulfonate Inhibitor 99.12% Phase 2
HY-112623 Vafidemstat Inhibitor 99.53% Phase 2
HY-10399A Ladostigil hydrochloride Inhibitor 99.94% Phase 2
HY-10400 Ladostigil hemitartrate Inhibitor 98.90% Phase 2
HY-129388A Pulrodemstat Inhibitor / Phase 2
HY-10399 Ladostigil Inhibitor / Phase 2
HY-129388 Pulrodemstat Methylbenzenesulfonate Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (124)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W008566 Norharmane Inhibitor 99.46% Unkown
HY-19333 OG-L002 Inhibitor 99.81% Unkown
HY-N0918 Desmethoxyyangonin Inhibitor 99.47% Unkown
HY-110130 RN-1 dihydrochloride Inhibitor 99.13% Unkown
HY-N7204 4-Hydroxyderricin 99.97% Unkown
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% Unkown
HY-E70074 Monoamine oxidase, plasma / Unkown
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 99.25% Unkown
HY-127109 Tisolagiline Inhibitor 99.97% Unkown
HY-14201 Lazabemide Inhibitor 99.95% Unkown
HY-100588 VU0364770 Agonist 99.93% Unkown
HY-103164 (E)-8-(3-Chlorostyryl)caffeine 99.00% Unkown
HY-156255 MAO-B-IN-25 Inhibitor 99.11% Unkown
HY-N9540 Methyl citrate Inhibitor ≥98.0% Unkown
HY-W001601 Budipine Antagonist 99.41% Unkown
HY-N2336 Rosmarinic acid racemate Inhibitor 98.01% Unkown
HY-119532 Nordeprenyl 95.03% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-132907 MAO-B-IN-2 Inhibitor 99.05% Unkown
HY-14280S Entacapone-d10 Inhibitor ≥98.0% Unkown
HY-146958 MAO-B-IN-8 Inhibitor 98.03% Unkown
HY-D0004 Azure B Inhibitor 98.13% Unkown
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% Unkown
HY-117173 (Rac)-Rasagiline Inhibitor / Unkown
HY-114915 PSB-1434 Inhibitor 98.05% Unkown
HY-115986 MAO-B-IN-5 Inhibitor / Unkown
HY-115987 MAO-B-IN-6 Inhibitor / Unkown
HY-116097 PSB-1491 Inhibitor / Unkown
HY-117502 SL-25.1188 Inhibitor / Unkown
HY-120419 PF9601N Inhibitor 99.85% Unkown
HY-120826 A2AAR/hMAO-B-IN-1 Inhibitor / Unkown
HY-127109A Tisolagiline methylsulfate Inhibitor / Unkown
HY-130205 Milacemide hydrochloride Inhibitor / Unkown
HY-14202 Lazabemide hydrochloride Inhibitor / Unkown
HY-14203 (R)-Safinamide Inhibitor 99.88% Unkown
HY-143244 Monoamine Oxidase B inhibitor 1 Inhibitor / Unkown
HY-143245 Monoamine Oxidase B inhibitor 2 Inhibitor / Unkown
HY-143329 MAO-B-IN-3 Inhibitor / Unkown
HY-143330 MAO-B-IN-4 Inhibitor / Unkown
HY-143438 2-PAT Inhibitor / Unkown
HY-144673 LSD1-IN-12 Inhibitor / Unkown
HY-144756 LSD1-IN-15 Inhibitor / Unkown
HY-144757 LSD1-IN-16 Inhibitor / Unkown
HY-144758 LSD1-IN-17 Inhibitor / Unkown
HY-144824 Monoamine oxidase/Aromatase-IN-1 Inhibitor / Unkown
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / Unkown
HY-146149 MAO-B-IN-11 Inhibitor / Unkown
HY-146150 MAO-B-IN-12 Inhibitor / Unkown
HY-146312 AChE/BChE/MAO-B-IN-1 Inhibitor 99.57% Unkown
HY-146314 MAO-B-IN-9 Inhibitor 99.70% Unkown
HY-146347 MAO-B-IN-10 Inhibitor / Unkown
HY-146677 5-HT6R/MAO-B modulator 1 / Unkown
HY-146762 MAO-B-IN-7 Inhibitor / Unkown
HY-147362 MAO-B-IN-14 Inhibitor / Unkown
HY-147953 MAO-B-IN-13 Inhibitor / Unkown
HY-149242 MAO-B-IN-20 Inhibitor / Unkown
HY-149477 IHC3 Inhibitor / Unkown
HY-149527 MAO-B-IN-23 Inhibitor / Unkown
HY-149528 MAO-B-IN-24 Inhibitor / Unkown
HY-149820 MAO-B-IN-22 Inhibitor / Unkown
HY-149978 LSD1-IN-26 / Unkown
HY-149984 MAO-B-IN-21 Inhibitor / Unkown
HY-150563 Neuroinflammatory-IN-2 Inhibitor / Unkown
HY-151094 FTEAA Inhibitor / Unkown
HY-151208 MAO-B-IN-16 Inhibitor / Unkown
HY-151209 MAO-B-IN-15 Inhibitor / Unkown
HY-151210 MAO-B-IN-17 Inhibitor ≥99.0% Unkown
HY-151800 MAO-A/B-IN-2 Inhibitor / Unkown
HY-152109 AChE/MAO-IN-1 Inhibitor / Unkown
HY-152110 AChE/MAO-IN-2 Inhibitor / Unkown
HY-152111 AChE/MAO-B-IN-3 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-152114 AChE/BChE/MAO-B-IN-4 Inhibitor / Unkown
HY-155330 PZ-1922 / Unkown
HY-155330A PZ-1922 free base / Unkown
HY-156348 MAO-B-IN-26 Inhibitor / Unkown
HY-157087 AChE/MAO-B-IN-4 Inhibitor / Unkown
HY-157089 AChE/MAO-B-IN-5 Inhibitor / Unkown
HY-157517 MAO-B-IN-29 Inhibitor / Unkown
HY-157934 MAO-IN-4 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-158732 MAO-B-IN-33 Inhibitor / Unkown
HY-159106 MeSeI / Unkown
HY-160002 MAO-B-IN-27 Inhibitor / Unkown
HY-161240 MAO-B-IN-30 Inhibitor 98.53% Unkown
HY-162061 ChEs/MAOs-IN-1 Inhibitor / Unkown
HY-162303 C175-0062 Inhibitor / Unkown
HY-162606 MAO-A/B-IN-3 Inhibitor / Unkown
HY-162760 COMT-IN-1 Inhibitor / Unkown
HY-163322 MAO-A inhibitor 2 Inhibitor / Unkown
HY-163380 CA/MAO-B-IN-1 Inhibitor 98.34% Unkown
HY-163474 MAO-B-IN-32 Inhibitor / Unkown
HY-163879 hMAO-B-IN-9 Inhibitor / Unkown
HY-16731 Sembragiline Inhibitor / Unkown
HY-168138 MAO-B-IN-34 Inhibitor / Unkown
HY-168590 MAO-B-IN-36 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor / Unkown
HY-N12134 Methyl piperate Inhibitor / Unkown
HY-N1636 1-Methyl-2-nonyl-4(1H)-quinolone Inhibitor / Unkown
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / Unkown
HY-RS08022 MAOB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08023 Maob Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08024 Maob Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W035384 MAO-B ligand-1 Inhibitor / Unkown
HY-W205529 RO 16-6491 free base / Unkown
HY-W269511 NW-1689 / Unkown
HY-W335927 MAO-B-IN-19 Inhibitor / Unkown
HY-W845607 Milacemide Inhibitor / Unkown
HY-103164A 8-(3-Chlorostyryl)caffeine / Unkown
HY-10399B (S)-Ladostigil Inhibitor / Unkown
HY-105041 Tedizolid phosphate sodium Inhibitor / Unkown
HY-116765 MAO-B-IN-35 / Unkown
HY-123556 SZV-558 Inhibitor / Unkown
HY-123665 PSB-1410 Inhibitor / Unkown
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / Unkown
HY-164649 Atibeprone Inhibitor / Unkown
HY-19333A OG-L002 hydrochloride Inhibitor / Unkown
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / Unkown
HY-W029600 6,7-Dimethylisatin Inhibitor / Unkown
HY-W792513 WAY-620147 Inhibitor ≥98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Maob NCBI NCBI:4129