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Cyclooxygenase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (20) Adrenergic Receptor (2) Antibiotic (4) Apoptosis (8) Arrestin (2) Autophagy (2) Bacterial (20) Biochemical Assay Reagents (6) CXCR (2) Deubiquitinase (1) EGFR (1) Endogenous Metabolite (9) Endothelin Receptor (2) ERK (1) Estrogen Receptor/ERR (1) Ferroptosis (3) Fungal (3) GHSR (1) HCV (1) HIF/HIF Prolyl-Hydroxylase (4) IFNAR (1) Influenza Virus (3) Integrin (11) Isotope-Labeled Compounds (1) Lipoxygenase (1) MMP (2) Neurokinin Receptor (1) NF-κB (2) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (2) Oxytocin Receptor (1) Parasite (1) PD-1/PD-L1 (1) PI3K (1) Proteasome (2) Radionuclide-Drug Conjugates (RDCs) (1) Raf (1) Ras (1) Reactive Oxygen Species (1) Somatostatin Receptor (5) STAT (1) Tyrosinase (1) Vasopressin Receptor (1) VEGFR (2) Virus Protease (2)
By Research Areas:	Cancer (54) Cardiovascular Disease (7) Endocrinology (4) Infection (25) Inflammation/Immunology (26) Metabolic Disease (9) Neurological Disease (7)

By Targets:

COX (20)

Adrenergic Receptor (2)

Antibiotic (4)

Apoptosis (8)

Arrestin (2)

Autophagy (2)

Bacterial (20)

Biochemical Assay Reagents (6)

CXCR (2)

Deubiquitinase (1)

EGFR (1)

Endogenous Metabolite (9)

Endothelin Receptor (2)

ERK (1)

Estrogen Receptor/ERR (1)

Ferroptosis (3)

Fungal (3)

GHSR (1)

HCV (1)

HIF/HIF Prolyl-Hydroxylase (4)

IFNAR (1)

Influenza Virus (3)

Integrin (11)

Isotope-Labeled Compounds (1)

Lipoxygenase (1)

MMP (2)

Neurokinin Receptor (1)

NF-κB (2)

Nuclear Factor of activated T Cells (NFAT) (1)

Opioid Receptor (2)

Oxytocin Receptor (1)

Parasite (1)

PD-1/PD-L1 (1)

PI3K (1)

Proteasome (2)

Radionuclide-Drug Conjugates (RDCs) (1)

Raf (1)

Ras (1)

Reactive Oxygen Species (1)

Somatostatin Receptor (5)

STAT (1)

Tyrosinase (1)

Vasopressin Receptor (1)

VEGFR (2)

Virus Protease (2)

By Research Areas:

Cancer (54)

Cardiovascular Disease (7)

Endocrinology (4)

Infection (25)

Inflammation/Immunology (26)

Metabolic Disease (9)

Neurological Disease (7)

Inhibitors & Agonists

118

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cyclooxygenase 1, sheep COX-1	Endogenous Metabolite	Metabolic Disease
Cyclooxygenase 1, sheep (COX-1) is a 71 kDa membrane bound protein predominantly present in endoplasmic reticulum. Cyclooxygenase 1 has three domains, the epidermal growth factor (EGF) like domain, enzymatic and membrane binding domain. Cyclooxygenase 1 mediates prostaglandin synthesis and is modulated by anti-inflammatory nonsteroidal drugs ^[1].

CP-74006	COX	Inflammation/Immunology
CP-74006 (compound11h) is a selective *Cyclooxygenase-1* inhibitor ^[1].

(+)-Catechin hydrate Maximum Cited Publications 12 Publications Verification	COX	Cancer
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

Catechin Maximum Cited Publications 12 Publications Verification (+)-Catechin; Cianidanol; Catechuic acid	COX Apoptosis Influenza Virus Endogenous Metabolite	Cancer
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX Endogenous Metabolite	Metabolic Disease
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

(-)-Epicatechin gallate 4 Publications Verification Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate	COX Autophagy Virus Protease	Cancer
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

Valeryl salicylate Valeroyl salicylate	COX	Inflammation/Immunology
Valeryl salicylate is a potent and irreversible **cyclooxygenase-1 (COX-1)** inhibitor. Valeryl salicylate shows anti-inflammatory effect ^[1].

Dehydroperilloxin	COX	Inflammation/Immunology
Dehydroperilloxin is a natural compound isolated from the dichloromethane extract of the stems of Perilla frutescens var. acuta. Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC₅₀ value of 30.4 μM ^[1].

Catechin (Standard)	COX Apoptosis Influenza Virus Endogenous Metabolite	Cancer
Catechin (Standard) is the analytical standard of Catechin. This product is intended for research and analytical applications. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

(-)-Epicatechin gallate (Standard) Epicatechin gallate(Standard); ECG(Standard); (-)-Epicatechin 3-O-gallate (Standard)	COX Autophagy Virus Protease	Cancer
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

Otenaproxesul ATB-346	COX Apoptosis	Inflammation/Immunology
Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities ^[1] .

(+)-Catechin pentaacetate	COX	Cancer
(+)-Catechin pentaacetate is a precursor for the production of (+) catechin (HY-N0898 ). (+) catechin is a useful natural herbicide and antimicrobial. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM ^[1] .

(-)-Epicatechin 3 Publications Verification (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Enflicoxib E 6087	COX	Inflammation/Immunology
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits *cyclooxygenase-2* (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models ^[1].

(-)-Epicatechin (Standard) (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

(±)-Catechin (Standard)	COX	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
(±)-Catechin (Standard) is the analytical standard of (±)-Catechin. This product is intended for research and analytical applications. (±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects ^[1] .

ZXX2-77	Others	Others
ZXX2-77 is a cyclooxygenase-1 (COX-1) selective inhibitor belonging to the benzenesulfonylanilide class of compounds. It is reported as a novel analgesic that does not cause gastric damage. ZXX2-77 has a weak analgesic effect but exhibits potent COX-1 inhibitory activity in vitro. The low oral absorption rate of ZXX2-77 leads to its weak analgesic effect in vivo. At a dose of 30 mg/kg, the maximum plasma concentration of ZXX2-77 (1.2 mM) did not reach its COX-1 IC50 value (3.2 mM). In contrast, its derivative ZXX2-79, although weaker in vitro COX inhibitory activity, is better absorbed, exhibits stronger analgesic effect and hardly causes gastric damage. These findings suggest that ZXX2-77 and its derivatives as COX-1 selective inhibitors may become effective analgesics that do not cause gastric damage.

Atractylochromene	Lipoxygenase COX	Inflammation/Immunology
Atractylochromene is a potent dual inhibitor of *5-LOX/COX-1* with IC₅₀s of 0.6 and 3.3 μM, respectively ^[1].

Prifelone R 830; R 830T; S 16820	COX	Inflammation/Immunology
Prifelone (R 830; R 830T; S 16820) is a di-tert-butylphenol with anti-inflammatory and antioxidant activity. Prifelone inhibits guinea pig lung oxygenase and bovine seminal vesicle cyclooxygenase .

Cyclo(Pro-Ala)	Biochemical Assay Reagents	Cancer
Cyclo(Pro-Ala) is an anticancer agent that has toxic to cancer cells such as A549, HCT-116, and HepG2 ^[1].

cyclo(CLLFVY)	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC₅₀ of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers ^[1].

Cyclo(CKLIIF) TFA	HIF/HIF Prolyl-Hydroxylase	Cancer
Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains K_D of 2.6 and 2.2 μM, respectively ^[1].

Desotamide Desotamide A	Bacterial	Infection
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).

Cyclo(L-Phe-L-Pro)	Fungal IFNAR Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide ^[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research ^[1].

Cyclo(RADfK) 1 Publications Verification	Integrin	Others
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone ^[1]. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

Cyclo(-RGDfK) Maximum Cited Publications 12 Publications Verification	Integrin	Cancer
Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM ^[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

AZP-531 2 Publications Verification	GHSR	Metabolic Disease Endocrinology
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

Cyclo(Phe-Pro) 4 Publications Verification Cyclo(phenylalanylprolyl); A-64863	HCV	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses ^[1].

NP213 TFA	Fungal	Infection
NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections ^[1] .

Cyclo(-RGDfK) TFA Maximum Cited Publications 12 Publications Verification	Integrin	Cancer
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM ^[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

NP213	Fungal	Infection
NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections ^[1] .

Segetalin B 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease
Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity ^[1] .

Cyclo(Arg-Gly-Asp-D-Phe-Cys) Cyclo(RGDfC)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors ^[1].

Cyclo(L-Pro-L-Val)	Bacterial	Infection
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide ^[1].

Cyclo(Gly-His)	Bacterial	Cancer
Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC₅₀ values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems ^[1].

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 ^[1].

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP)	Integrin	Cancer
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells ^[1].

Cyclopetide 1	Bacterial	Infection
Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL ^[1].

Cyclopetide 2	Bacterial	Infection
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL ^[1].

CBO-P11	VEGFR	Cancer
CBO-P11 specifically binds to receptor of VEGFR-2 and is used as targeting ligand for tumor angiogenesis. CBO-P11 is modified with a nearinfrared cyanine dye bearing an alkyne function, allowing both “click” coupling on azido-modified nanoparticles and fluorescence labelling ^[1].

Cyclo(CRLLIF)	HIF/HIF Prolyl-Hydroxylase	Cancer
Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains K_D of 14.5 and 10.2 μM, respectively ^[1].

Cyclo(CRVIIF)	HIF/HIF Prolyl-Hydroxylase	Cancer
Cyclo CRVIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains K_D of 65 and 123 μM, respectively ^[1].

Cat. No.	Product Name	Chemical Structure

HY-N0898S

Catechin-13C3
Catechin- ¹³C₃ is the ¹³C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

HY-N0001S

(±)-Epicatechin-13C3
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82792

	Cyclooxygenase 1 Antibody (YA2537) PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Cyclooxygenase 1 Antibody (YA2537) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2537), targeting Cyclooxygenase 1, with a predicted molecular weight of 69 kDa (observed band size: 69 kDa). Cyclooxygenase 1 Antibody (YA2537) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

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