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Results for "

Folate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Folate Receptor (FR) (6) ADC Linker (2) Amino Acid Derivatives (1) Antibiotic (17) Antibody-Drug Conjugates (ADCs) (2) Antifolate (27) Apoptosis (1) Bacterial (21) Biochemical Assay Reagents (21) Dihydrofolate reductase (DHFR) (5) DNA/RNA Synthesis (5) Drug Intermediate (2) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (19) Fluorescent Dye (4) Influenza Virus (4) Isotope-Labeled Compounds (5) Liposome (5) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Microtubule/Tubulin (1) Nucleoside Antimetabolite/Analog (1) Parasite (9) Peptide-Drug Conjugates (PDCs) (1) PROTAC Linkers (6) PROTACs (1) PSMA (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (5) SHMT (1) Thymidylate Synthase (6) TRP Channel (1)
By Research Areas:	Cancer (66) Endocrinology (1) Infection (23) Inflammation/Immunology (9) Metabolic Disease (7) Neurological Disease (4)
Click Chemistry:	DBCO (1) PROTAC Synthesis (1) Alkynes (5)
Oligonucleotides:	Pegylated Lipids (4) Polymers (7) Cholesterol (1)

122

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Folate Receptor (FR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-47373

Folate-PEG3-C2-acid	PROTAC Linkers	Cancer
Folate-PEG3-C2-acid is the acid fragment of Folate-PEG3-NHS ester (HY-133493), which belongs to the PEG-type PROTAC linker and is used to synthesize PROTAC molecules.

HY-138484

Folate-PEG3-amine	ADC Linker	Cancer
Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W440888

*DSPE-PEG-Folate, MW 2000* DSPE-PEG(2000) Folate	Liposome	Others
DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.

HY-115873

Folate-MS432	PROTACs	Cancer
Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

HY-13615

Folate-FTIC EC-17	Fluorescent Dye	Others Cancer
Folate-FTIC (EC-17) is a folic acid derivative that binds to fluorescein isothiocyanate (FITC) to give it fluorescent labeling properties. Folate-ftic is used to induce the formation of pseudo-immunological synapses between anti-FITC CAR T cells and target cells expressing Folate receptors (FRα or FRβ). Folate-FTIC can be used to develop controlled CAR-T cell therapies for research in non-small cell lung cancer (NSCLC) .

HY-133496

Folate-PEG3-alkyne	PROTAC Linkers	Cancer
Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Folate-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133494

Folate-PEG1-mal	PROTAC Linkers	Cancer
Folate-PEG1-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-133495

Folate-PEG2-amine	PROTAC Linkers	Cancer
Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-133493

Folate-PEG3-NHS ester	PROTAC Linkers	Cancer
Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-122378

Diopterin Pteroyl diglutamic acid; Folate monoglutamate	Antifolate	Cancer
Diopterin is a folic acid analog that is used in leukemia research .

HY-133383

DSPE-PEG46-Folate	PROTAC Linkers	Cancer
DSPE-PEG46-Folate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-126806

Pyrrofolic acid	Antibiotic	Cancer
Pyrrofolic acid is a folate antagonist with a low activity as a folate antagonist for Streptococcus faecalis .

HY-144009

*DSPE-PEG-Folate, MW 3350*	Liposome	Cancer
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .

HY-W440890

*DSPE-PEG-Folate, MW 5000*	Liposome	Cancer
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .

HY-W440715

*Cholesterol-PEG-Folate, MW 2000*	Liposome	Others
Cholesterol-PEG-Folate, MW 2000 is an excipient and can be used for the preparation of folate-conjugated PEG-liposomes .

HY-W440714

*Cholesterol-PEG-Folate* (MW 1000)**	Biochemical Assay Reagents	Others
Cholesterol-PEG-Folate (MW 1000) is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG-Folate (MW 1000) can be used in drug delivery research .

HY-W440716

*Cholesterol-PEG-Folate* (MW 3400)**	Biochemical Assay Reagents	Others
Cholesterol-PEG-Folate (MW 3400) is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG-Folate (MW 3400) can be used in drug delivery research .

HY-W440717

*Cholesterol-PEG-Folate* (MW 5000)**	Biochemical Assay Reagents	Others
Cholesterol-PEG-Folate (MW 5000) is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG-Folate (MW 5000) can be used in drug delivery research .

HY-127118

Pteropterin Pteroyltriglutamic	Drug Metabolite	Cancer
Pteropterin (Pteroyltriglutamic) is an active form of folate. Pteropterin shows inhibiting effect on tumor growth and has broad anticancer activity .

HY-127118A

Pteropterin monohydrate Pteroyltriglutamic monohydrate	Drug Metabolite Folate Receptor (FR)	Cancer
Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity .

HY-121927

Mobiletrex CH-1504	Antifolate Dihydrofolate reductase (DHFR)	Inflammation/Immunology
Mobiletrex is an anti *folate* and dihydrofolate reductase inhibitor that can be used in research on rheumatoid arthritis .

HY-W037823

Pterin-6-carboxylic acid	Biochemical Assay Reagents	Others
Pterin-6-carboxylic acid serves as a precursor for the formation of folate, which plays a critical role in cell growth, development, and repair. Pterine-6-carboxylic acid has been studied for its potential as a fluorescent dye .

HY-10822A

ONX 0801 trisodium BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium	Thymidylate Synthase	Cancer
ONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to α-folate receptor–overexpressing tumors .

HY-137267

10-Methyl-10-deazaaminopterin	Antifolate	Cancer
10-Methyl-10-deazaaminopterin is a folate analog and an antifolate. 10-Methyl-10-deazaaminopterin can be used for the research of cancer .

HY-109051

Arfolitixorin	Endogenous Metabolite	Cancer
Arfolitixorin is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin is potent for the research of metastatic colorectal cancer .

HY-109051C

Arfolitixorin sulfate	Endogenous Metabolite	Cancer
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-13728

Plevitrexed ZD 9331; BGC9331	Thymidylate Synthase	Cancer
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a K_i of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147699

FRα-IN-1	Antifolate	Cancer
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells .

HY-124093

8-Deazahomofolic acid	Thymidylate Synthase Bacterial	Infection Cancer
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC₅₀ value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors .

HY-121256

Chlorasquin	Thymidylate Synthase Antifolate Dihydrofolate reductase (DHFR)	Others
Chlorasquin inhibits thymidylate synthetase with an approximate K_i value of 4.9 μM. Chlorasquin is also a *folate* antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents .

HY-W040821

DL-Homocysteine 2 Publications Verification	Endogenous Metabolite	Neurological Disease
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-167411

PLLA5000-PEG5000-FOL	Biochemical Assay Reagents	Others
PLLA5000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA5000-PEG5000-FOL can be used in drug delivery research .

HY-167412

PLLA5000-PEG2000-FOL	Biochemical Assay Reagents	Others
PLLA5000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA5000-PEG2000-FOL can be used in drug delivery research .

HY-167413

PLLA20000-PEG5000-FOL	Biochemical Assay Reagents	Others
PLLA20000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA20000-PEG5000-FOL can be used in drug delivery research .

HY-167414

PLLA20000-PEG2000-FOL	Biochemical Assay Reagents	Others
PLLA20000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA20000-PEG2000-FOL can be used in drug delivery research .

HY-167415

PLLA10000-PEG5000-FOL	Biochemical Assay Reagents	Others
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .

HY-167416

PLLA10000-PEG2000-FOL	Biochemical Assay Reagents	Others
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folate receptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .

HY-B1497

Silver sulfadiazine AgSD	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication .

HY-P10501

FRα-targeting peptide C7	Antifolate	Cancer
FRα-targeting peptide C7 is a selective peptide ligand for folate receptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment .

HY-P99153

Farletuzumab MORAb-003	Antibiotic	Cancer
Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .

HY-B1497R

Silver sulfadiazine (Standard)	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Silver sulfadiazine (Standard) is the analytical standard of Silver sulfadiazine. This product is intended for research and analytical applications. Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication .

HY-10824

Talotrexin PT523	Antifolate Dihydrofolate reductase (DHFR)	Cancer
Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a *RFC (reduced folate* carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR** to inhibit tumor growth .

HY-14520

Tetrahydrofolic acid 3 Publications Verification L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .

HY-14520B

Tetrahydrofolic acid trihydrochloride L-5,6,7,8-Tetrahydrofolic acid trihydrochloride; L-Tetrahydrofolic acid trihydrochloride	Endogenous Metabolite	Metabolic Disease
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid trihydrochloride is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid trihydrochloride serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .

HY-10824A

Talotrexin monoammonium PT523 monoammonium	Dihydrofolate reductase (DHFR) Antifolate	Cancer
Talotrexin monoammonium is the monoammonium salt form of Talotrexin (HY-10824). Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a *reduced folate* carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR** to inhibit tumor growth .

HY-P99612

Farletuzumab ecteribulin MORAb-202	Antibody-Drug Conjugates (ADCs)	Cancer
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.

HY-155880

mPEG-amine (MW 350) mPEG-NH2 (MW 350)	Biochemical Assay Reagents	Cancer
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155881

mPEG-amine (MW 550) mPEG-NH2 (MW 550)	Biochemical Assay Reagents	Cancer
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155882

mPEG-amine (MW 750) mPEG-NH2 (MW 750)	Biochemical Assay Reagents	Cancer
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155883

mPEG-amine (MW 3400) mPEG-NH2 (MW 3400)	Biochemical Assay Reagents	Cancer
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040821

DL-Homocysteine 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-14520

Tetrahydrofolic acid 3 Publications Verification L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .

HY-14769

Folitixorin 2 Publications Verification 5,10-MethylenetetraFolate; ANX-510 free acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research .

HY-109051

Arfolitixorin	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Arfolitixorin is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin is potent for the research of metastatic colorectal cancer .

HY-109051C

Arfolitixorin sulfate	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-111647R

N2-Methylguanosine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Nucleoside Antimetabolite/Analog Endogenous Metabolite
Levomefolate (calcium) (Standard) is the analytical standard of Levomefolate (calcium). This product is intended for research and analytical applications. Levomefolate calcium is an orally active, blood-brain barrier-crossing form of folate that can be used as a folate food supplement .

HY-137129

10-Formyl-7,8-dihydrofolic acid	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate .

HY-117224

Rhizopterin Formylpteroic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial Endogenous Metabolite
Rhizopterin is a growth factor that can form rhizobactin de novo in synthetic medium lacking folate .

HY-N7719R

Oosporein (Standard)	Quinones Structural Classification Microorganisms Source classification Benzene Quinones	Endogenous Metabolite
Acetylpyrazine (Standard) is the analytical standard of Acetylpyrazine. This product is intended for research and analytical applications. Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .

HY-14520A

(6S)-Tetrahydrofolic acid (6S)-5,6,7,8-Tetrahydrofolic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
(6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .

HY-W040821R

DL-Homocysteine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
Metoprolol acid (Standard) is the analytical standard of Metoprolol acid. This product is intended for research and analytical applications. Metoprolol acid (Atenolol acid) is a urinary metabolite with no pharmacological activity. Metoprolol acid does not exert its pharmacological effects in vivo. Metoprolol acid can be detected by solid phase extraction and reversed phase high performance liquid chromatography. The analysis of metoprolol acid requires specific conditions, such as the use of fluorescence detection and specific eluents .

HY-16637D

Folic acid disodium Maximum Cited Publications 12 Publications Verification Vitamin B9 disodium; Vitamin M disodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite DNA/RNA Synthesis
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

HY-113325R

NADP (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
NADP (Standard) is the analytical standard of NADP. This product is intended for research and analytical applications. NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes . In Vitro:NADP can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival . NADP forms NAADP through IL-8-driven CD38 to mobilize Ca ²⁺ and influence cell migration . NADP de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis . NADP is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress .

Cat. No.	Product Name	Chemical Structure

HY-113046S

5-Methyltetrahydrofolic acid-13C5
5-Methyltetrahydrofolic acid- ¹³C₅ is the ¹³C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].

HY-B1008S

4-Aminobenzoic acid-d4
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

HY-17383S

Levomefolate-13C5 calcium
Levomefolate- ¹³C₅ (calcium) is the ¹³C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

HY-W089800S

trans-2-Nonenal-d2
trans-2-Nonenal-d₂ is deuterated labeled Acetylpyrazine (HY-W007692). Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .

HY-14520S

Tetrahydrofolic acid-d4

Tetrahydrofolic acid-d₄ is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

HY-B0688S2

Dapsone-13C12

Dapsone- ¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

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