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N-terminal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JNK (10) 5-HT Receptor (1) ADC Cytotoxin (1) ADC Linker (1) Amino Acid Derivatives (2) Aminopeptidase (1) Amyloid-β (3) Androgen Receptor (8) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (5) Apolipoprotein (1) Apoptosis (12) Autophagy (3) Bacterial (10) Bcl-2 Family (2) Biochemical Assay Reagents (1) c-Myc (1) Cannabinoid Receptor (1) Caspase (1) CD47 (1) CDK (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) ERK (1) FGFR (1) Fluorescent Dye (6) Formyl Peptide Receptor (FPR) (2) Galectin (1) GCGR (3) GLP Receptor (1) Histone Methyltransferase (2) HIV (2) HSP (7) IFNAR (1) IKK (1) Influenza Virus (3) Isotope-Labeled Compounds (1) Liposome (1) Macrophage migration inhibitory factor (MIF) (1) MAP3K (1) Microtubule/Tubulin (1) MMP (1) mTOR (2) Neuropeptide Y Receptor (2) NF-κB (3) Opioid Receptor (4) p38 MAPK (1) PACAP Receptor (2) PDGFR (1) Proteasome (2) RIP kinase (1) ROCK (1) SARS-CoV (2) Somatostatin Receptor (2) Src (2) Tau Protein (3) TGF-beta/Smad (1) VEGFR (1) β-catenin (1)
By Research Areas:	Cancer (39) Cardiovascular Disease (8) Endocrinology (3) Infection (21) Inflammation/Immunology (21) Metabolic Disease (14) Neurological Disease (31)
Click Chemistry:	Azide (1) Alkynes (4)
Oligonucleotides:	Phospholipids (1)

118

Inhibitors & Agonists

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Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

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Targets Recommended: JNK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-E70196

Endoproteinase Asp-N Asp-N	MMP	Others
Endoproteinase Asp-N (Asp-N) is a metalloprotease that can specifically cleave the N-terminal side of aspartyl and cysteic acid residues .

HY-127002

Squarunkin A	Src	Cancer
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC₅₀=10 nM). Squarunkin A interferes with the activation of Src kinase in cells .

HY-106723A

AMP-PCP disodium	HSP	Cancer
AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a K_d value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90 .

HY-123875A

Ralaniten triacetate EPI-506	Androgen Receptor	Cancer
Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active *androgen receptor (AR) N-terminal* domain (NTD)** inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7 .

HY-P5748

Bac5(1-25)	ADC Cytotoxin	Others
Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5 .

HY-169314

JNK-IN-19	JNK	Others
JNK-IN-19 (Compound Q8) is a *c-Jun N-terminal* kinase** inhibitor that is used for treating and/or preventing an injury before, during, or after a surgical procedure .

HY-106723

AMP-PCP	HSP	Cancer
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a K_d value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90 .

HY-127002A

Squarunkin A hydrochloride	Src	Cancer
Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC₅₀ of 10 nM for inhibiting the *UNC119A-myristoylated Src N-terminal* peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase** in cells .

HY-125564

Acetyltrialanine	Aminopeptidase	Others
Acetyltrialanine is a peptide containing three amino acid residues in which the N-terminal amino acid is acetylated and used as a substrate for Nα-acetyl alanine aminopeptidase in order to study the activity and properties of the enzyme. Acetyltrialanine can be used in the study of protein degradation and N-terminal regulation .

HY-P1228

HAEGTFT	GCGR	Metabolic Disease
HAEGTFT is the first N-terminal 1-7 residues of GLP-1 peptide.

HY-P1224

HAEGTFTSDVS	GCGR	Metabolic Disease
HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.

HY-P1499

Somatostatin-28 (1-14)	Somatostatin Receptor	Neurological Disease
Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28.

HY-138304

CC-90001 1 Publications Verification	JNK	Inflammation/Immunology
CC-90001 is a potent, selective and orally active inhibitor of *c-Jun N-terminal* kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2** in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis .

HY-P1319

Nociceptin(1-7)	Opioid Receptor	Inflammation/Immunology
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL₁ (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo .

HY-P1062

Lauryl-LF 11	Bacterial Antibiotic	Infection
Lauryl-LF 11, N-terminally acylated analogue of LF11, is a peptide with antibacterial activity .

HY-P1459

*Sphistin Synthetic Peptide(12-38,Fitc in N-Terminal-Fluorescently Labeled Peptide)*	Bacterial	Infection
Sphistin Synthetic Peptide (12-38, Fitc in N-Terminal-Fluorescently Labeled Peptide) is a truncated fragments of Sphistin Synthetic Peptide that shows potent antimicrobial activity.

HY-P1062A

Lauryl-LF 11 TFA	Bacterial Antibiotic	Infection
Lauryl-LF 11 TFA, N-terminally acylated analogue of LF11, is a peptide with antibacterial activity .

HY-139623

A4B17	Androgen Receptor	Cancer
A4B17 is an androgen receptor N-terminal inhibitor for researching androgen-responsive prostate cancer.

HY-P1319A

Nociceptin(1-7) TFA	Opioid Receptor	Inflammation/Immunology
Nociceptin (1-7) TFA is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) TFA is a potent ORL₁ (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) TFA combines with nociceptin reduces hyperalgesia in vivo .

HY-103076

EZ-482 1 Publications Verification	Apolipoprotein	Neurological Disease
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas .

HY-123587

PR-924	Proteasome Apoptosis	Cancer
PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC₅₀ of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities .

HY-150102

EPI-7170	Androgen Receptor	Cancer
EPI-7170, a ralaniten analogue, is a potent *androgen receptor N-terminal* structural domain** antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC) .

HY-P99777

Ontorpacept TTI-621	CD47	Cancer
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity .

HY-P0266

N-Acetyl-Ser-Asp-Lys-Pro Ac-SDKP	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-P1225

{Val1}-Exendin-3/4	GCGR	Metabolic Disease
{Val1}-Exendin-3/4 is the first N-terminal 1-28 residues of Exendin-4 peptide.

HY-P0266A

N-Acetyl-Ser-Asp-Lys-Pro TFA Ac-SDKP TFA	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-P1230

HAEGT	Dipeptidyl Peptidase GLP Receptor	Metabolic Disease
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

HY-123587A

(R)-PR-924	Others	Cancer
(R)-PR-924 is the isomer of PR-924 (HY-123587), and can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC₅₀ of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities .

HY-E70199

Aminopeptidase N (rat) APN/CD13	Others	Others
A Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺ dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid .

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-152078

Influenza virus-IN-6	Influenza Virus	Infection
Influenza virus-IN-6 (Compound 35) is a potent influenza N-terminal domain of the polymerase acidic protein subunit (PA_N) endonuclease inhibitor with an IC₅₀ of 0.20 μM .

HY-P5969

Cys-V5 Peptide	Biochemical Assay Reagents	Others
Cys-V5 Peptide, a tag peptide, is the V5 Peptide with an N-terminal cysteine. Cys-V5 Peptide can be used to label proteins

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-W007798S1

Fmoc-Cys(Trt)-OH-d2	Isotope-Labeled Compounds	Others
Fmoc-Cys(Trt)-OH-d₂ is the deuterium labeled Fmoc-Cys(Trt)-OH. Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative[1].

HY-16663

ITX3 2 Publications Verification	ROCK Others	Others
ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC₅₀ value of 76 μM. ITX3 can be used for the research of agent .

HY-P99859

Donanemab LY3002813	Amyloid-β	Neurological Disease
Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research .

HY-P5826

Dynorphin B (1-9)	Opioid Receptor	Neurological Disease
Dynorphin B (1-9) is a neuropeptide and N-terminal cleavage product of dynorphin B. The formation of dynorphin B (1-9) is blocked by N-ethylmaleimide (NEM), a non-selective inhibitor of cysteine peptidases .

HY-P3897

[Tyr12] Somatostatin 28 (1-14)	Somatostatin Receptor	Neurological Disease
[Tyr12] Somatostatin 28 (1-14) is an analogue of Somatostatin-28 (1-14) (HY-P1499). Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28 .

HY-P4290

Antiulcer Agent 2	Endogenous Metabolite	Endocrinology
Antiulcer Agent 2 is a tetrapeptide containing aspartic acid, alanine, histidine, and lysine. Antiulcer Agent 2 is present at the N-terminal of human albumin. Antiulcer Agent 2 has potential applications in ulcers and active oxygen generation .

HY-P10396

Elf18	Bacterial	Infection Inflammation/Immunology
Elf18 is the bacterial N-terminal fragment of Elongation Factor Thermus (EF-Tu). Elf18 is recognized by pattern recognition receptors (PRRs) as a pathogen-associated molecular pattern (PAMP), and thus induces immune response in Arabidopsis .

HY-W015461

2-Aminooctanoic acid DL-α-Aminocaprylic acid; DL-2-Aminocaprylic acid	Bacterial	Infection
2-Aminooctanoic acid (DL-α-Aminocaprylic acid) is a fatty acid with an amino functional group that can be directly coupled at both the C-terminal and N-terminal with antimicrobial peptides (AMP) derived from lactoferrin B to enhance antibacterial activity .

HY-115715

EN219	E1/E2/E3 Enzyme	Cancer
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination .

HY-E70128

Leucyl aminopeptidase	Others	Others
Leucyl aminopeptidase is a metallopeptidase that cleave N-terminal residues from proteins and peptides. Leucyl aminopeptidase serves as transcriptional repressors to control pyrimidine, alginate and cholera toxin biosynthesis, as well as mediate site-specific recombination events in plasmids and phages .

HY-123054

BTSA1 1 Publications Verification	Bcl-2 Family Apoptosis	Cancer
BTSA1 is a potent, high affinity and orally active BAX activator with an IC₅₀ of 250 nM and an EC₅₀ of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis .

HY-107598

JNK Inhibitor VIII 2 Publications Verification TCS JNK 6o	JNK	Cancer
JNK Inhibitor VIII (TCS JNK 6o) is a *c-Jun N-terminal* kinases (JNK-1, -2, and -3) inhibitor with K_i values of 2 nM, 4 nM, 52 nM, respectively, and has IC₅₀** values of 45 nM and 160 nM for JNK-1 and -2, respectively .

HY-P99399

Semorinemab RG 6100; RO7105705; MTAU-9937A	Tau Protein	Neurological Disease
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a K_d value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease .

HY-150226

Enzyme-IN-1	Proteasome	Inflammation/Immunology
Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties .

HY-147097A

EDA-DA TFA	Bacterial	Infection
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114365

UDP-GalNAc disodium UDP-N-acetyl-D-galactosamine disodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .

HY-119906

Conglobatin FW-04-806	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N7394A

(-)-Zuonin A 1 Publications Verification D-Epigalbacin	Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	JNK
(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC₅₀s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively .

HY-125564

Acetyltrialanine	Structural Classification Natural Products Microorganisms Source classification	Aminopeptidase
Acetyltrialanine is a peptide containing three amino acid residues in which the N-terminal amino acid is acetylated and used as a substrate for Nα-acetyl alanine aminopeptidase in order to study the activity and properties of the enzyme. Acetyltrialanine can be used in the study of protein degradation and N-terminal regulation .

HY-P0266A

N-Acetyl-Ser-Asp-Lys-Pro TFA Ac-SDKP TFA	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Angiotensin-converting Enzyme (ACE)
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-N1455

Falcarinol Panaxynol; Carotatoxin	Structural Classification Natural Products Classification of Application Fields Ambrosia psilostachya DC. Source classification Umbelliferae Plants Disease Research Fields Cancer	HSP Apoptosis
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis . Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Chemical Structure

HY-W007798S1

Fmoc-Cys(Trt)-OH-d2
Fmoc-Cys(Trt)-OH-d₂ is the deuterium labeled Fmoc-Cys(Trt)-OH. Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative[1].

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Species:	Human (16)
Tag:	His (6) Tag Free (5) Avi (2) GST (4) Fc (3)
Source:	HEK293 (3) Sf9 insect cells (4) P. pastoris (1) E. coli (8)


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N-terminal

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Natural
Products