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Results for "

Protective effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Adrenergic Receptor (2) AMPK (1) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (1) Antibiotic (1) Apoptosis (8) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (3) Calcium Channel (6) Cholinesterase (ChE) (1) CMV (2) COX (2) Cuproptosis (1) Drug Metabolite (1) Endogenous Metabolite (10) ERK (1) FAK (2) Ferroptosis (1) Fungal (1) Glucokinase (1) Histamine Receptor (2) iGluR (2) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (2) LDLR (1) Leukotriene Receptor (1) MALT1 (1) Mitochondrial Metabolism (2) NF-κB (6) NO Synthase (5) OAT (2) P2Y Receptor (1) p38 MAPK (4) Parasite (2) PARP (2) Phosphatase (2) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (8) Thrombin (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Topoisomerase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (31) Infection (11) Inflammation/Immunology (32) Metabolic Disease (14) Neurological Disease (20)

By Targets:

Adenosine Receptor (2)

Adrenergic Receptor (2)

AMPK (1)

Amyloid-β (3)

Anaplastic lymphoma kinase (ALK) (1)

Angiotensin Receptor (1)

Antibiotic (1)

Apoptosis (8)

Autophagy (1)

Bacterial (2)

Biochemical Assay Reagents (3)

Calcium Channel (6)

Cholinesterase (ChE) (1)

CMV (2)

COX (2)

Cuproptosis (1)

Drug Metabolite (1)

Endogenous Metabolite (10)

ERK (1)

FAK (2)

Ferroptosis (1)

Fungal (1)

Glucokinase (1)

Histamine Receptor (2)

iGluR (2)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

LDLR (1)

Leukotriene Receptor (1)

MALT1 (1)

Mitochondrial Metabolism (2)

NF-κB (6)

NO Synthase (5)

OAT (2)

P2Y Receptor (1)

p38 MAPK (4)

Parasite (2)

PARP (2)

Phosphatase (2)

Potassium Channel (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (8)

Thrombin (1)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

Topoisomerase (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (31)

Infection (11)

Inflammation/Immunology (32)

Metabolic Disease (14)

Neurological Disease (20)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145552

Azilsartan mepixetil QR-01019	Angiotensin Receptor	Cardiovascular Disease
Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A) .

HY-116057

Stemazole	Others	Others
Stemazole is a protective agent that promotes stem cell survival. Stemazole has the protective effect of human embryonic stem cells (hESCs). Stemazole enhances clonal expansion of single cells and decreases apoptosis. Stemazole for the study of stem cell survival in starvation culture .

HY-106449

Recoflavone DA-6034 free acid	Others	Inflammation/Immunology Cancer
Recoflavone is a synthetic derivative of eupatilin that has a protective effect on gastric mucosa. Recoflavone has the potential to be used to research peptic ulcer disease.

HY-116690

Daimuron	Others	Others
Daimuron is a herbicide safener. Daimuron has a protective effect against the inhibition of seed root elongation by chloroacetanilide herbicides .

HY-108649A

MRS2768 tetrasodium salt	P2Y Receptor	Cardiovascular Disease
MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro .

HY-123589

Gyramide A	Others	Others
Gyramide A is a compound mentioned in the study of the protective effect of Qnr protein on bacterial topoisomerase. Qnr has no protective effect on it, and its activity is different from that of other topoisomerase inhibitors.

HY-116682

GKA-71	Glucokinase	Metabolic Disease
GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect .

HY-106831

R 56865	Others	Cardiovascular Disease
R 56865 is a cardiomyocyte protective agent that protects against digitoxin (Ouabain)-induced myocardial calcium overload. R 56865 has a protective effect against digitoxin-induced intoxication in guinea pig papillary muscle .

HY-N0499A

Cyanidin	Others	Inflammation/Immunology
Cyanidin, an antioxidant, has protective effect on DNA cleavage, free radical scavenging activity and significant inhibition of XO activity .

HY-W740088

Adrenochrome monoguanylhydrazone methanesulfonate S-Adchnone	Others	Cardiovascular Disease
Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone) is an adrenochrome derivative that has a protective effect against radiation-induced damage of hematopoietic organs .

HY-123260

S12340	LDLR	Cardiovascular Disease
S12340 is a a inhibitor of the oxidative modification of low-density lipoprotein and shows protective effect on cardiac cells exposed to oxidative stress .

HY-N8103

Heishuixiecaoline A	Amyloid-β	Neurological Disease
Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ_25-35 .

HY-B0612DS1

Lercanidipine-d3 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-N4073

6"-O-Malonyldaidzin 1 Publications Verification	Others	Inflammation/Immunology
6"-O-Malonyldaidzin is a malonylated isoflavone isolated from soybean seeds. 6"-O-Malonyldaidzin may has protective effect on eye .

HY-119580

Leucocyanidin	Others	Inflammation/Immunology
Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .

HY-N12432

Glomeratide A	Others	Metabolic Disease
Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.

HY-N12426

Heilaohuguosu F	Others	Metabolic Disease
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-A0032A

Valganciclovir hydrochloride	CMV	Infection Inflammation/Immunology
Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus .

HY-N12001

6-Epiagarotetrol	Others	Neurological Disease
6-Epiagarotetrol is a neuroprotective agent can be extracted from Aquilaria sinensis. 6-Epiagarotetrol has a protective effect on corticosterone-induced PC12 cell damage .

HY-N2140

Herpetone	Others	Infection
Herpetone, the ethylacetate extract, is a lignan compound. Herpetone can be isolated from the seeds of Herpetospermum caudigerum. Herpetone significantly improved the cell viability, and has a protective effect on hepatocytes in vitro .

HY-105507

PF-10040	Others	Inflammation/Immunology
PF-10040 is a quinoline derivative that can inhibit PAF-induced airway hyperresponsiveness. PF-10040 also shows protective effect in experimental NSAID-gastritis .

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-112248A

HAMI 3379	Leukotriene Receptor	Cardiovascular Disease Inflammation/Immunology
HAMI 3379 is a potent and selective CysLT₂ receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation .

HY-N13073

6-Gingediol	Others	Others
6-Gingediol (compound 13) is a pungent component of ginger with potential anti-serotonin and gastric mucosal protective effects. 6-Gingediol has no pungent effect at concentrations below 10 μM, but the pungent effect is significant at concentrations above 100 μM or even 1000 μM .

HY-W097994

DHMB 2,3-Dihydroxy-4-methoxybenzaldehyde	Fungal	Infection Inflammation/Immunology
DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells .

HY-N8248

Eleutherin (+)-Eleutherin	Topoisomerase	Cardiovascular Disease
Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong) .

HY-122517

Mirincamycin hydrochloride U-24729 A	Others	Others
Mirincamycin (hydrochloride) (U-24729 A), a compound used to inhibit malaria, has a protective effect against the early liver stages of Plasmodium but fails to kill dormant liver stages of Plasmodium in a rhesus monkey model.

HY-119580B

(+)-Leucocyanidin 2,3-trans-3,4-trans-Leucocyanidin; 3,4-trans-Leucocyanidin; (2R,3S,4R)-Leucocyanidin	Others	Inflammation/Immunology
(+)-Leucocyanidin is the isoform of Leucocyanidin (HY-119580), is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

HY-106110

OP-2507	Others	Metabolic Disease
OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema .

HY-77490A

1,3-Butanediol	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N8730

7,8,3′,4′-Tetramethoxyflavone	Others	Neurological Disease
7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .

HY-121018

Daltroban BM-13505; SKF 96148	Prostaglandin Receptor	Cardiovascular Disease
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury .

HY-128530

Tetrathiomolybdate	Cuproptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma .

HY-129406

AF 698	Others	Cardiovascular Disease
AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice .

HY-112554

PDM11	Others	Others
PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays .

HY-N2627

Isorhamnetin 3-O-robinobioside	Others	Cancer
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-N7513

Homovanillyl alcohol	TNF Receptor Drug Metabolite	Cardiovascular Disease
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homovanillyl alcohol protects red blood cells (RBCs) from oxidative injury and has protective effect on cardiovascular disease .

HY-127093

Sedecamycin	Antibiotic Bacterial	Infection
Sedecamycin is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Sedecamycin inhibits Treponema hyodysenteriae, with MIC of 0.78 to 12.5 µg/ml. Sedecamycin exhibits protective and therapeutic effect against the swine dysentery in mouse models .

HY-126410

Petunidin chloride 1 Publications Verification	FAK	Metabolic Disease
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-161042

Neuroprotective agent 2	Others	Neurological Disease
Neuroprotective agent 2 (Compd 28) is a potent neuroprotective agent which has a protective effect in both salsolinol and glutamate-induced neurodegeneration models. Neuroprotective agent 2 reduces oxidative stress and caspase-3/7 activity in the glutamate model .

HY-W250311

DL-Aspartic acid hemimagnesium salt	Biochemical Assay Reagents	Others
DL-Aspartic acid (hemimagnesium salt is DL-aspartic acid salt. DL-aspartic acid hemimagnesium salt is a commonly used food supplement and food additive, because it can promote the synthesis of protein in the human body, and has a positive effect on the nervous system and The production of cardiovascular system has a certain protective effect. In addition, due to some chemical reactions in the industry, DL-aspartic acid semi-magnesium salt can also be obtained.

HY-N1994

Swertianine	Others	Inflammation/Immunology
Swertianine is a hydroxyexanthone that can be isolated from Swertia decussata. Swertianine has antioxidant activity by inhibiting lipid peroxidation, scavenging DPPH and superoxide free radicals. Swertianine also inhibits γ-ray induced DNA damage of pBR322 with protective effect .

HY-N0513

Loganic acid	Others	Cardiovascular Disease Inflammation/Immunology
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity .

HY-149719

Ferroptosis-IN-4	Ferroptosis	Metabolic Disease
Ferroptosis-IN-4 (compound 6k) is a ferroptosis inhibitor with EC₅₀ value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction .

HY-A0032AR

Valganciclovir hydrochloride (Standard)	CMV	Infection Inflammation/Immunology
Valganciclovir (hydrochloride) (Standard) is the analytical standard of Valganciclovir (hydrochloride). This product is intended for research and analytical applications. Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus .

HY-N0651

Spinosin	Amyloid-β	Neurological Disease
Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ_1-42's production and combination .

HY-125773

β-cyano-L-Alanine Beta-cyano-l-alanine	Endogenous Metabolite	Neurological Disease
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates . β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury .

HY-12724

Guanabenz	Adrenergic Receptor Parasite	Cardiovascular Disease
Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure .

HY-12724A

Guanabenz hydrochloride 2 Publications Verification	Parasite Adrenergic Receptor	Cardiovascular Disease
Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure .

Cat. No.	Product Name	Type

HY-P1956

Human serum albumin

1 Publications Verification

HSA

Native Proteins

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-W250311

DL-Aspartic acid hemimagnesium salt

Biochemical Assay Reagents

DL-Aspartic acid (hemimagnesium salt is DL-aspartic acid salt. DL-aspartic acid hemimagnesium salt is a commonly used food supplement and food additive, because it can promote the synthesis of protein in the human body, and has a positive effect on the nervous system and The production of cardiovascular system has a certain protective effect. In addition, due to some chemical reactions in the industry, DL-aspartic acid semi-magnesium salt can also be obtained.

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)

HSA (Cell culture grade, Endotoxin<0.125 EU/mg)

Native Proteins

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4073

6"-O-Malonyldaidzin 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Plants Inflammation/Immunology Disease Research Fields Isoflavones	Others
6"-O-Malonyldaidzin is a malonylated isoflavone isolated from soybean seeds. 6"-O-Malonyldaidzin may has protective effect on eye .

HY-119580

Leucocyanidin	Structural Classification Classification of Application Fields Litchi Chinensis Sonn. Source classification Plants Flavonoids Microorganisms Flavanols Sapindaceae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Others
Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .

HY-123589

Gyramide A	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Others
Gyramide A is a compound mentioned in the study of the protective effect of Qnr protein on bacterial topoisomerase. Qnr has no protective effect on it, and its activity is different from that of other topoisomerase inhibitors.

HY-N0499A

Cyanidin	Structural Classification Caprifoliaceae Source classification Phenols Polyphenols Sambucus williamsii Hance Plants	Others
Cyanidin, an antioxidant, has protective effect on DNA cleavage, free radical scavenging activity and significant inhibition of XO activity .

HY-N8103

Heishuixiecaoline A	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana amurensis Smir. ex Komarov Plants Valerianaceae	Amyloid-β
Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ_25-35 .

HY-N12432

Glomeratide A	Structural Classification Polygala chinensis Linnaeus Source classification Polygalaceae Phenols Polyphenols Plants	Others
Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.

HY-N12426

Heilaohuguosu F	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-N12001

6-Epiagarotetrol	Structural Classification Natural Products Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	Others
6-Epiagarotetrol is a neuroprotective agent can be extracted from Aquilaria sinensis. 6-Epiagarotetrol has a protective effect on corticosterone-induced PC12 cell damage .

HY-N2140

Herpetone	Structural Classification Herpetospermum pedunculosum (Ser.) C. B. Clarke Source classification Lignans Cucurbitaceae Phenylpropanoids Plants	Others
Herpetone, the ethylacetate extract, is a lignan compound. Herpetone can be isolated from the seeds of Herpetospermum caudigerum. Herpetone significantly improved the cell viability, and has a protective effect on hepatocytes in vitro .

HY-N13073

6-Gingediol	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Others
6-Gingediol (compound 13) is a pungent component of ginger with potential anti-serotonin and gastric mucosal protective effects. 6-Gingediol has no pungent effect at concentrations below 10 μM, but the pungent effect is significant at concentrations above 100 μM or even 1000 μM .

HY-N8248

Eleutherin (+)-Eleutherin	Quinones Structural Classification Iridaceae Classification of Application Fields Anthraquinones Source classification Eleutherine plicata Herb. Plants Disease Research Fields Cancer	Topoisomerase
Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong) .

HY-77490A

1,3-Butanediol	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N8730

7,8,3′,4′-Tetramethoxyflavone	Structural Classification Flavonoids Punica granatum L. Flavones Source classification Punicaceae Plants	Others
7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .

HY-N2627

Isorhamnetin 3-O-robinobioside	Structural Classification Flavonoids Cactaceae Flavones Source classification Opuntia ficus-indica (L.) Mill. Plants	Others
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-N7513

Homovanillyl alcohol	Cardiovascular Disease Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	TNF Receptor Drug Metabolite
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homovanillyl alcohol protects red blood cells (RBCs) from oxidative injury and has protective effect on cardiovascular disease .

HY-126410

Petunidin chloride 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Etunia hybrida (J. D. Hooker) Vilmorin Anthocyans Flavonoids Microorganisms Phenols Polyphenols Solanaceae Disease Research Fields	FAK
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-N1994

Swertianine	Structural Classification Flavonoids Xanthones Flavones Source classification Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Phenols Plants	Others
Swertianine is a hydroxyexanthone that can be isolated from Swertia decussata. Swertianine has antioxidant activity by inhibiting lipid peroxidation, scavenging DPPH and superoxide free radicals. Swertianine also inhibits γ-ray induced DNA damage of pBR322 with protective effect .

HY-N0513

Loganic acid	Cardiovascular Disease Structural Classification Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Disease Research Fields	Others
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity .

HY-N0651

Spinosin	Structural Classification Flavonoids Flavones Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Phenols Polyphenols Plants Rhamnaceae	Amyloid-β
Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ_1-42's production and combination .

HY-125773

β-cyano-L-Alanine Beta-cyano-l-alanine	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates . β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury .

HY-N3240

Mulberrofuran C	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Others
Mulberrofuran C (compound 11) is an isoprene based flavonoid compound that can be extracted from the root bark of mulberry trees. Mulberrofuran C has protective effect on t-BHP induced oxidative stress with EC₅₀ value of 1.02 μM. Mulberrofuran C has hepatoprotective and neuroprotective activities .

HY-N7905

Myricetin 3'-glucoside	Structural Classification Flavonoids Flavones Source classification Myrtaceae Syzygium malaccense (L.) Merr. et Perry Plants	Others
Myricetin 3'-glucoside is a glycoside derivative of quercetin. Myricetin 3'-glucoside significantly prevents ethanol-induced hepatotoxicity by reducing hepatic transaminase activity and inflammatory response in HepG2 cells. Myricetin 3'-glucoside has a certain protective effect on alcohol-induced liver injury .

HY-101981

Uridine 5'-monophosphate 5'-Uridylic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Cholinesterase (ChE) Potassium Channel Apoptosis
Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea .

HY-N9602

6,7,4'-Trihydroxyflavanone	Structural Classification Flavonoids Dalbergia odorifera T. Chen Leguminosae Flavonones Source classification Plants	Others
6,7,4'-Trihydroxyflavanone is a compound with multiple pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic and protective T-cells from METH-induced deactivation. 6,7,4'-Trihydroxyflavanone has shown potential protective effects in neurotoxicity studies and can be used to inhibit patients with neurodegenerative diseases caused by METH. 6,7,4'-Trihydroxyflavanone inhibits METH-induced neurotoxicity by upregulating the Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways. 6,7,4'-Trihydroxyflavanone can also induce Nrf2 nuclear translocation and HO-1 expression, further enhancing its protective effect on neuronal cells .

HY-N0513R

Loganic acid (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Loganic acid (Standard) is the analytical standard of Loganic acid. This product is intended for research and analytical applications. Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity .

HY-126410R

Petunidin chloride (Standard)	Structural Classification Anthocyans Flavonoids Microorganisms Source classification Phenols Polyphenols Solanaceae Plants Etunia hybrida (J. D. Hooker) Vilmorin	FAK
Petunidin (chloride) (Standard) is the analytical standard of Petunidin (chloride). This product is intended for research and analytical applications. Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-77490AR

1,3-Butanediol (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
1,3-Butanediol (Standard) is the analytical standard of 1,3-Butanediol. This product is intended for research and analytical applications. 1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N0396

Harpagoside 1 Publications Verification	Structural Classification Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Harpagophytum procumbens Inflammation/Immunology Disease Research Fields	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) .

HY-Z0283

Benzamide Benzenecarboxamide; Phenylamide	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-N12123

Peimisine 3-O-β-D-glucopyranoside	Structural Classification Alkaloids Liliaceae Other Alkaloids Source classification Plants Fritillaria unibracteata Hsiao et K. C. Hsia	Others
Peimisine 3-O-β-D-glucopyranoside (Compound 1) is a steroid alkaloid. Peimisine 3-O-β-D-glucopyranoside can be isolated and purified from natural Fritillaria unibracteata. Peimisine 3-O-β-D-glucopyranoside shows moderate protective effect on rotenone-induced neurotoxicity of PC12 cell line .

HY-N0651R

Spinosin (Standard)	Structural Classification Flavonoids Flavones Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Phenols Polyphenols Plants Rhamnaceae	Amyloid-β
Spinosin (Standard) is the analytical standard of Spinosin. This product is intended for research and analytical applications. Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ1-42's production and combination .

HY-N0396R

Harpagoside (Standard)	Structural Classification Iridoids Terpenoids Pedaliaceae Plants Harpagophytum procumbens	COX NO Synthase
Harpagoside (Standard) is the analytical standard of Harpagoside. This product is intended for research and analytical applications. Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) .

HY-N12007

OAT1/3-IN-1	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	OAT
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

HY-N12008

OAT1/3-IN-2	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	OAT
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

HY-Y0836

Diethyl succinate 1 Publications Verification Diethyl Butanedioate	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Biochemical Assay Reagents Reactive Oxygen Species
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-101981R

Uridine 5'-monophosphate (Standard) 5'-Uridylic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

HY-Z0283R

Benzamide (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Other Alkaloids Source classification Endogenous metabolite	Endogenous Metabolite PARP
Benzamide (Standard) is the analytical standard of Benzamide. This product is intended for research and analytical applications. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-Y0836R

Diethyl succinate (Standard)	Structural Classification Natural Products Microorganisms other families Source classification Plants	Biochemical Assay Reagents Reactive Oxygen Species
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-W015229R

3-Indolepropionic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

Cat. No.	Product Name	Chemical Structure

HY-B0612DS1

Lercanidipine-d3 hydrochloride
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

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