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Results for "

anti-neoplastic agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (11) Akt (2) Amylin Receptor (3) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (5) Antifolate (6) Apoptosis (43) Autophagy (18) Bacterial (5) Biochemical Assay Reagents (1) c-Met/HGFR (4) Caspase (1) CDK (1) Cholinesterase (ChE) (1) DNA Alkylator/Crosslinker (19) DNA/RNA Synthesis (15) Drug-Linker Conjugates for ADC (2) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) Ferroptosis (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Isotope-Labeled Compounds (8) Lipoxygenase (1) MEK (1) Microtubule/Tubulin (14) NAMPT (1) Necroptosis (1) Nucleoside Antimetabolite/Analog (10) Parasite (3) Phosphatase (3) PI3K (1) Pyroptosis (1) Reactive Oxygen Species (5) Reverse Transcriptase (3) SARS-CoV (3) Sirtuin (3) TGF-β Receptor (1) Topoisomerase (16)
By Research Areas:	Cancer (123) Cardiovascular Disease (3) Endocrinology (1) Infection (6) Inflammation/Immunology (17) Metabolic Disease (5)
Click Chemistry:	Azide (1)

113

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141431

Cbl-b-IN-2	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology Cancer
Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent .

HY-B0879A

Suramin sodium salt 10+ Cited Publications Suramin hexasodium salt	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-B0181

Altretamine 2 Publications Verification ENT-50852; RB-1515; WR-95704	DNA Alkylator/Crosslinker	Cancer
Altretamine is an alkylating antineoplastic agent.

HY-121261

Antineoplastic agent-1	Necroptosis Apoptosis	Cancer
Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research .

HY-130564

Didemnin C	Others	Cancer
Didemnin C is a cyclic depsipeptide that can be used as an anti-neoplastic agent .

HY-19437

Bimolane AT-1727	Topoisomerase	Cancer
Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes .

HY-B0879

Suramin	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor .Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-B0181A

Altretamine hydrochloride ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride	DNA Alkylator/Crosslinker	Cancer
Altretamine hydrochloride is an alkylating antineoplastic agent.

HY-109140

Tuvatexib	Others	Cancer
Tuvatexib is an antineoplastic agent .

HY-B0879AR

Suramin sodium salt (Standard)	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin (sodium salt) (Standard) is the analytical standard of Suramin (sodium salt). This product is intended for research and analytical applications. Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-132844

Tunlametinib HL-085	MEK	Cancer
Tunlametinib, an *antineoplastic* agent, is a MEK1/2 inhibitor .

HY-116280

Aceratioside	Others	Cancer
Aceratioside, a tetralin glucoside, is a weakly cytostatic constituent. Aceratioside is an antineoplastic agent .

HY-17420

Cyclophosphamide 25+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-17420A

Cyclophosphamide hydrate 25+ Cited Publications Cyclophosphamide monohydrate	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Topoisomerase	Cancer
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Topoisomerase	Cancer
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-156633

Rezatapopt PC14586	Others	Cancer
Rezatapopt is an antineoplastic agent, used to inhibit solid tumor with p53 mutation .

HY-P0058

Pramlintide	Amylin Receptor	Metabolic Disease Cancer
Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P0058B

Pramlintide acetate	Amylin Receptor	Metabolic Disease Cancer
Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-152850

Gumelutamide	Androgen Receptor	Endocrinology
Gumelutamide is a tetrahydropyridopyrimidine compound, acting as an antiandrogen, antineoplastic agent. Gumelutamide is an androgen antagonist .

HY-N10591

Bruceantarin	Others	Cancer
Bruceantarin is a potent *antineoplastic* agent. Bruceantarin can be used for leukemia and breast cancer research .

HY-N9271

Grifolin 1 Publications Verification	Apoptosis	Cancer
Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .

HY-B0078

Dacarbazine 20+ Cited Publications Imidazole Carboxamide	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC₅₀ of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .

HY-105815

Chlornaphazine	DNA Alkylator/Crosslinker	Cancer
Chlornaphazine, a nitrogen mustard derivative, is a bifunctional alkylating agent. Chlornaphazine is an antineoplastic agent, which can be used for the study of polycythemia vera and Hodgkin’s disease .

HY-112822

ON-013100 2 Publications Verification	CDK	Cancer
ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

HY-P0058A

Pramlintide TFA	Amylin Receptor	Metabolic Disease Cancer
Pramlintide TFA is a polypeptide analogue of human amylin. Pramlintide TFA, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-B0181R

Altretamine (Standard)	DNA Alkylator/Crosslinker	Cancer
Altretamine (Standard) is the analytical standard of Altretamine. This product is intended for research and analytical applications. Altretamine is an alkylating antineoplastic agent.

HY-13551B

Amsacrine (gluconate) m-AMSA (gluconate); Acridinyl anisidide (gluconate)	Topoisomerase Autophagy	Cancer
Amsacrine gluconate is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

HY-W415824A

Mannomustine dihydrochloride	Others	Cancer
Mannomustine dihydrochloride is an alkylating agent with antineoplastic activity. Mannomustine dihydrochloride causes severe bone marrow depression. Mannomustine dihydrochloride is a powerful vesicant.

HY-U00130

1-Acetyl-3-o-toluyl-5-fluorouracil A-OT-Fu	Others	Cancer
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

HY-78828A

(S)-Dolaphenine hydrochloride	Microtubule/Tubulin	Others Cancer
(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization .

HY-13551

Amsacrine 5 Publications Verification m-AMSA; acridinyl anisidide	Topoisomerase Autophagy	Cancer
Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

HY-13551A

Amsacrine hydrochloride 5 Publications Verification m-AMSA hydrochloride; acridinyl anisidide hydrochloride	Topoisomerase Autophagy	Cancer
Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

HY-14941

Elacytarabine CP 4055	Nucleoside Antimetabolite/Analog	Cancer
Elacytarabine (CP 4055) is a lipid-conjugated derivative of the nucleoside analog cytarabine. Elacytarabine (CP 4055) is an antineoplastic agent with cytotoxicity in solid tumors.

HY-B0015S

Paclitaxel-d5	Microtubule/Tubulin ADC Cytotoxin	Cancer
Paclitaxel-d₅ is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

HY-152845

Ficonalkib	Anaplastic lymphoma kinase (ALK)	Cancer
Ficonalkib is a potent inhibitor of Anaplastic lymphoma kinase (ALK), the tyrosine kinase receptor. Ficonalkib, can be used as an antineoplastic agent .

HY-B0078S

Dacarbazine-d6 Imidazole Carboxamide-d₆	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Dacarbazine-d₆ is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.

HY-17420S1

Cyclophosphamide-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-N12262

(+)-Epieudesmin	Bacterial	Infection Cancer
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .

HY-17026

Gemcitabine 145+ Cited Publications LY 188011	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis	Cancer
Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-B0003

Gemcitabine hydrochloride 145+ Cited Publications LY 188011 hydrochloride	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-121401

Myrtenal (±)-Myrtenal	Others	Cancer
Myrtenal ((±)-Myrtenal) is a monoterpene that acts as an antineoplastic agent. Myrtenal inhibits liver cancer by preventing DEN-PB-induced upregulation of TNF-α protein expression.

HY-B0078R

Dacarbazine (Standard) Imidazole Carboxamide (Standard)	Apoptosis Nucleoside Antimetabolite/Analog	Cancer
Dacarbazine (Standard) is the analytical standard of Dacarbazine. This product is intended for research and analytical applications. Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC₅₀ of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-133887

Methotrexate α-tert-butyl ester	Antifolate DNA/RNA Synthesis	Cancer
Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a Indoleamine 2,3-Dioxygenase (IDO) peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

HY-17394

Cisplatin Maximum Cited Publications 464 Publications Verification cis-Platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-17420S

Cyclophosphamide-d4	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-17420AS

Cyclophosphamide-d8 hydrate	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

Cat. No.	Product Name	Target	Research Area

HY-P99658

Imaprelimab PRX-003	Inhibitory Antibodies	Cancer
Imaprelimab (PRX-003) is a humanized IgG1κ anti-melanoma cell adhesion molecule (MCAM) monoclonal antibody. Imaprelimab is an antineoplastic agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-N9271

Grifolin 1 Publications Verification	Structural Classification Microorganisms Source classification Phenols Polyphenols	Apoptosis
Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .

HY-78828A

(S)-Dolaphenine hydrochloride	Classification of Application Fields Disease Research Fields Cancer	Microtubule/Tubulin
(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization .

HY-N10470

Bleomycin A5 1 Publications Verification Pingyangmycin	Structural Classification Natural Products Microorganisms Animals Source classification	Apoptosis
Bleomycin A5 (Pingyangmycin) is an orally active glycopeptide antibiotics. Bleomycin A5 has a role as an antineoplastic agent, an apoptosis inducer and a bacterial metabolite .

HY-B0015

Paclitaxel Maximum Cited Publications 224 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin ADC Cytotoxin Apoptosis Autophagy
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-116280

Aceratioside	Structural Classification Monophenols Elaeocarpaceae Source classification Phenols Plants Aceratium megalospermum (F.Muell.) Balgooy Saccharides Monosaccharides	Others
Aceratioside, a tetralin glucoside, is a weakly cytostatic constituent. Aceratioside is an antineoplastic agent .

HY-N10591

Bruceantarin	Structural Classification Natural Products Simaroubaceae Plants Brucea javanica (L.) Merr.	Others
Bruceantarin is a potent *antineoplastic* agent. Bruceantarin can be used for leukemia and breast cancer research .

HY-N12262

(+)-Epieudesmin	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Bacterial
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .

HY-121401

Myrtenal (±)-Myrtenal	Structural Classification Other Monoterpenes Terpenoids Labiatae Source classification Erythrina poeppigiana Plants	Others
Myrtenal ((±)-Myrtenal) is a monoterpene that acts as an antineoplastic agent. Myrtenal inhibits liver cancer by preventing DEN-PB-induced upregulation of TNF-α protein expression.

HY-121199

Germanicol	Triterpenes Structural Classification Euphorbia boetica Terpenoids Source classification Euphorbiaceae Plants	Apoptosis
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-N11912

Soladulcoside A	Structural Classification Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Biochemical Assay Reagents
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-B0015R

Paclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Cytotoxin Apoptosis Autophagy
Paclitaxel (Standard) is the analytical standard of Paclitaxel. This product is intended for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-134008

Protoapigenone	Structural Classification Flavonoids Flavones Source classification Plants Macrothelypteris torresiana (Gaud.) Ching Thelypteridaceae	Others
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-12033

2-Methoxyestradiol 20+ Cited Publications 2-ME2; NSC-659853	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Microtubule/Tubulin Reactive Oxygen Species Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

Cat. No.	Product Name	Chemical Structure

HY-B0015S

Paclitaxel-d5
Paclitaxel-d₅ is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-B0078S

Dacarbazine-d6
Dacarbazine-d₆ is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.

HY-17420S1

Cyclophosphamide-d8
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-17420S

Cyclophosphamide-d4
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-17420AS

Cyclophosphamide-d8 hydrate
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-B0015S1

Paclitaxel-d5 (benzoyloxy)
Paclitaxel-d₅ (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].

HY-14519S

Methotrexate-d3

Methotrexate-d₃ (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

HY-B0003S

Gemcitabine-13C,15N2 hydrochloride
Gemcitabine- ¹³C, ¹⁵N₂ (hydrochloride) is the ¹³C and ¹⁵N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].

HY-13690S1

Mitotane-13C6

Mitotane- ¹³C₆ is the ¹³C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-13690S2

Mitotane-d8

Mitotane-d₈ is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

Cat. No.	Product Name		Classification

HY-147275

Tazide		Azide
Tazide is an antineoplastic agent . Tazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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