Search Result

Results for "

anxiolytic-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (67) Adenosine Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (5) Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (7) Bacterial (5) Bcl-2 Family (3) Biochemical Assay Reagents (1) Calcium Channel (2) CFTR (1) Chloride Channel (1) Cholecystokinin Receptor (6) CRFR (7) Dopamine Receptor (17) Drug Metabolite (5) Endogenous Metabolite (5) Epigenetic Reader Domain (2) ERK (2) FAAH (2) Formyl Peptide Receptor (FPR) (2) GABA Receptor (50) GnRH Receptor (2) Guanylate Cyclase (1) Histamine Receptor (8) IGF-1R (1) iGluR (8) Interleukin Related (2) MCHR1 (GPR24) (3) Melatonin Receptor (4) mGluR (18) MMP (1) Monoamine Oxidase (2) mTOR (1) nAChR (9) Neurokinin Receptor (4) Neuropeptide Y Receptor (4) Neurotensin Receptor (1) NO Synthase (2) Nucleoside Antimetabolite/Analog (59) Opioid Receptor (3) P2X Receptor (1) PAK (1) Parasite (3) PGC-1α (2) Phosphodiesterase (PDE) (1) PI3K (3) Potassium Channel (2) Reactive Oxygen Species (3) Sigma Receptor (2) SOD (2) Sodium Channel (1) TET Protein (1) TNF Receptor (3) Trk Receptor (2) TRP Channel (2) Tyrosinase (1) Vasopressin Receptor (1)
By Research Areas:	Cancer (47) Cardiovascular Disease (4) Endocrinology (8) Infection (5) Inflammation/Immunology (19) Metabolic Disease (6) Neurological Disease (262)
Click Chemistry:	Azide (5) Alkynes (2)
Oligonucleotides:	Nucleosides and their Analogs (51) Nucleoside Phosphoramidites (5)

331

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14551

Osanetant SR142801	Neurokinin Receptor	Neurological Disease
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-14895

Fabomotizole CM346	Others	Neurological Disease
Fabomotizole (CM346) is an anxiolytic agent. Fabomotizole produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

HY-14895A

Fabomotizole hydrochloride CM346 hydrochloride	Others	Neurological Disease
Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic agent. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

HY-103521

Anxiolytic/nonsedative agent-1	GABA Receptor	Neurological Disease
Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with K_is of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo .

HY-14895B

Fabomotizole di(hydrochloride) CM346 dihydrochloride	Others	Neurological Disease
Fabomotizole dihydrochloride is an anxiolytic agent. Fabomotizole dihydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

HY-123106

MCL-0129	Others	Others
MCL-0129 is a compound with anxiolytic and antidepressant activity and is a selective MC4 receptor antagonist that exhibits anxiolytic and antidepressant-like behaviors in multiple rodent models.

HY-14895R

Fabomotizole (Standard)	Others	Neurological Disease
Fabomotizole (Standard) is the analytical standard of Fabomotizole. This product is intended for research and analytical applications. Fabomotizole (CM346) is an anxiolytic agent. Fabomotizole produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

HY-116236

THIIC LY2607540	Others	Others
THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu? receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.

HY-U00078

Ro 22-3245	Others	Neurological Disease
Ro 22-3245 is an anxiolytic used in the treatment of anxiety.

HY-117955

GMA-839 WAY 141839; Co 2-6749	GABA Receptor	Neurological Disease
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABA_A) with an IC₅₀ value of 230 nM. GMA-839 exhibits potent anxiolytic-like activity, demonstrating significant dose-dependent anxiolytic effects in animal models, with an effective oral dose of 1.6 mg/kg. Significant increases in punished responding were observed in squirrel monkeys and pigeons. GMA-839 shows promise for research in the field of anxiolytics .

HY-P1501

δ-Sleep Inducing Peptide Delta-Sleep Inducing Peptide	SOD	Neurological Disease
δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.

HY-U00199

Norzopiclone N-Desmethyl zopiclone; RP 32273	Drug Metabolite	Neurological Disease
Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-118842

Sunepitron hydrochloride CP-93,393 hydrochloride	Others	Neurological Disease
Sunepitron (CP-93,393) hydrochloride is a potent anxiolytic/antidepressantcan agent .

HY-119404

Diproqualone (±)-Diproqualone	GABA Receptor	Neurological Disease Inflammation/Immunology
diproqualone is methaqualone analogous with sedative, anxiolytic, anti-inflammatory and analgesic properties .

HY-101808

Doxefazepam SAS-643	GABA Receptor	Neurological Disease
Doxefazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsan and skeletal muscle relaxant properties.

HY-19250

U-101017 PNU 101017	GABA Receptor	Neurological Disease
U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects.

HY-100140

Pipequaline 1 Publications Verification PK-8165	GABA Receptor	Neurological Disease
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-N6648

Cirsimaritin	GABA Receptor	Neurological Disease
Cirsimaritin binds weakly to the benzodiazepine site on GABA_A receptors, with antidepressant, anxiolytic and antinociceptive activities.

HY-A0165

Tofisopam	Others	Neurological Disease
Tofisopam, a 2,3-benzodiazepine compound, is an orally active anxiolytic agent .

HY-P1501A

δ-Sleep Inducing Peptide acetate Delta-Sleep Inducing Peptide acetate	SOD	Neurological Disease
δ-Sleep Inducing Peptide acetate is a neuropeptide, with antioxidant and anxiolytic properties .

HY-100050

4-Hydroxymidazolam	GABA Receptor Drug Metabolite	Neurological Disease
4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.

HY-121393

Imidazenil	GABA Receptor	Neurological Disease
Imidazenil is a partial positive allosteric modulator of GABA_A receptors with anxiolytic, antipanic and anticonvulsant activities.

HY-100140A

Pipequaline hydrochloride PK-8165 hydrochloride	GABA Receptor	Neurological Disease
Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-105845

Phenaglycodol	Others	Neurological Disease
Phenaglycodol belongs to the group of butanediolsa with anxiolytic and anticonvulsant porperties. Phenaglycodol has orally bioactivity .

HY-116590

(±)-Glaziovine	Others	Neurological Disease
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .

HY-N13227

Valerian Extract	Others	Neurological Disease
Valerian Extract is a valerian extract. Valerian Extract has potential sedative and anxiolytic effects. .

HY-B1018A

Phenelzine sulfate 4 Publications Verification	Monoamine Oxidase	Neurological Disease
Phenelzine sulfate is a non-selective and irreversible monoamine oxidase inhibitor (MAOI), used as an antidepressant and anxiolytic.

HY-167665

Fluprazine	Biochemical Assay Reagents	Neurological Disease
Fluprazine is an anti-corrosive compound with anxiolytic properties. Fluprazine is used in the study of psychiatric disorders .

HY-101596

Ethyl dirazepate	GABA Receptor	Neurological Disease
Ethyl dirazepate is a agent which is a benzodiazepine derivative. It has anxiolytic and possibly other characteristic benzodiazepine properties.

HY-116195

L-Linalool (-)-Linalool	Others	Neurological Disease
L-Linalool, a monoterpene with sedative and anxiolytic potential, has been used in Parkinson's disease research .

HY-10867

PF-622	FAAH	Metabolic Disease
PF-622 is a selective FAAH inhibitor, and can be used for study of analgesic and anxiolytic/antidepressant .

HY-A0198

Adinazolam U 41123	GABA Receptor	Neurological Disease
Adinazolam (U 41123) is a benzodiazepine agonist. Adinazolam, a triazolobenzodiazepine, has dual anxiolytic and antidepressant activities .

HY-A0198A

Adinazolam mesylate U 41123F mesylate	GABA Receptor	Neurological Disease
Adinazolam mesylate (U 41123) is a benzodiazepine agonist. Adinazolam mesylate, a triazolobenzodiazepine, has dual anxiolytic and antidepressant activities .

HY-N3940

Gelsevirine	Others	Neurological Disease Cancer
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC₅₀ values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively .

HY-B0353

Chlormezanone	GABA Receptor	Neurological Disease
Chlormezanone resembles benzodiazepine. The action of Chlormezanone is similar to benzodiazepine-type agents. Chlormezanone is used as an anxiolytic and a muscle relaxant.

HY-19658

Serazapine CPDD-0035	5-HT Receptor	Neurological Disease
Serazapine (CPDD-0035) is a selective 5-HT₂ antagonist. Serazapine is an anxiolytic .

HY-167650

Fletazepam	GABA Receptor	Neurological Disease
Fletazepam is a benzodiazepine derivative with sedative, anxiolytic and muscle relaxant effects. Fletazepam can be utilized in neurological research .

HY-101105A

SB-224289 hydrochloride 2 Publications Verification SB-224289A	5-HT Receptor	Neurological Disease
SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

HY-118657

Ripazepam Cl-683; Pyrazapon	Others	Neurological Disease
Ripazepam (Cl-683) is a potential antianxiety agent. Ripazepam also is a pyrazolodiazepinone derivative and has anxiolytic effects .

HY-103535

GBLD345	GABA Receptor	Neurological Disease
GBLD345, a nonbenzodiazepine anxiolytic agent, is a non- selective, potent GABAA receptor positive allosteric modulator (PAM) .

HY-105332

CRA1000	CRFR	Neurological Disease
CRA1000 is an orally active, selective and competitive CRF1 receptor antagonist with anxiolytic- and antidepressant-like properties .

HY-121002

Alstonine	Parasite	Infection Neurological Disease Cancer
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .

HY-101105

SB-224289	5-HT Receptor	Neurological Disease
SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect .

HY-14953

Imepitoin AWD 131-138	GABA Receptor	Neurological Disease
Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

HY-N0920

Dihydrokavain 7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin	Others	Neurological Disease
Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.

HY-141795

Posovolone Co 134444	Others	Neurological Disease
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects .

HY-N12098

d-Laserpitin	Others	Neurological Disease
d-Laserpitin, pyranocoumarin, is a nature product with anxiolytic activity. d-Laserpitin can be isolated from the fruits of Seseli devenyense Simonk .

HY-137951

Metizolam	Others	Neurological Disease
Metizolam, a thienotriazolodiazepine, is the demethylated analogue of Etizolam. Metizolam exhibits psychomotor stabilizing, anxiolytic, sedative, myo-relaxant and amnestic effects .

HY-19134

EMD 56551	5-HT Receptor	Neurological Disease
EMD 56551 is a potent and selective 5-HT1A receptor agonist. EMD 56551 exerts anxiolytic activity .

HY-N5126

Juncusol	Others	Neurological Disease
Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice .

Cat. No.	Product Name	Type

HY-W015715

5-Methylresorcinol monohydrate Orcinol monohydrate	Indicators
5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent .

Cat. No.	Product Name	Target	Research Area

HY-P1501A

δ-Sleep Inducing Peptide acetate Delta-Sleep Inducing Peptide acetate	SOD	Neurological Disease
δ-Sleep Inducing Peptide acetate is a neuropeptide, with antioxidant and anxiolytic properties .

HY-105042A

Selank diacetate Selanc diacetate; TP-7 diacetate	Peptides	Neurological Disease
Selank (Selanc) acetate is a synthetic peptide derived from tuftsin. Selank acetate has anxiolytic activity, and is a nootropic, neuropsychotropic, antidepressant, and antistress compound .

HY-P2287

Cortagine 1 Publications Verification	CRFR	Neurological Disease
Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an EC₅₀ of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive agent in the mouse model .

HY-P5762

Phoenixin-14 PNX-14	GnRH Receptor	Neurological Disease
Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia .

HY-P0046

Glycyl-L-histidyl-L-lysine 2 Publications Verification GHK; Tripeptide-1	Peptides	Neurological Disease Inflammation/Immunology
Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance .

HY-P0208

[Leu31,Pro34]-Neuropeptide Y (porcine) 1 Publications Verification	Neuropeptide Y Receptor	Neurological Disease
[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects .

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P10397

YHIEPV rALP-2, Rubisco anxiolytic-like peptide 2	Peptides	Neurological Disease Metabolic Disease
YHIEPV (rALP-2, Rubisco anxiolytic-like peptide 2) is a potent and orally active peptide. YHIEPV shows anxiolytic effects. YHIEPV increases leptin sensitivity to exert its anti-obesity effects .

HY-P1501

δ-Sleep Inducing Peptide Delta-Sleep Inducing Peptide	SOD	Neurological Disease
δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P3355

p-fin4	iGluR	Neurological Disease
p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-P5763

Phoenixin-20 PNX-20	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect .

HY-P5763A

Phoenixin-20 TFA PNX-20 TFA	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 (TFA) has anxiolytic effect .

HY-P3354

p3Ysh-3	iGluR	Neurological Disease
p3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	GnRH Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA, a BBB-penatrable neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor	Metabolic Disease
Spexin TFA is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Spexin TFA exhibits no significant activity at galanin receptor 1. Spexin TFA is an endogenous satiety-inducing peptide; Spexin TFA inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Spexin TFA attenuates LH secretion in goldfish. Spexin TFA exhibits anxiolytic effects in vivo.

HY-P1117

MMK1	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6648

Cirsimaritin	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Abrus precatorius Linn. Plants	GABA Receptor
Cirsimaritin binds weakly to the benzodiazepine site on GABA_A receptors, with antidepressant, anxiolytic and antinociceptive activities.

HY-N3940

Gelsevirine	Alkaloids Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Others
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC₅₀ values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively .

HY-N0920

Dihydrokavain 7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin	Structural Classification Natural Products other families Source classification Plants	Others
Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.

HY-N9502

Linalool oxide	Natural Products Neurological Disease Classification of Application Fields Source classification Brazilian taheebo Myrtaceae Plants Disease Research Fields	Others
Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity .

HY-N2096

Kavain	Structural Classification Natural Products Source classification Piper methysticum G.Forst. Piperaceae Plants	GABA Receptor
Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor .

HY-116590

(±)-Glaziovine	Structural Classification Alkaloids Other Alkaloids Source classification Unonopsis duckei R.E.Fr. Plants Annonaceae	Others
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .

HY-116195

L-Linalool (-)-Linalool	Structural Classification Natural Products Cupressaceae Source classification Plants Chamaecyparis formosensis Matsum.	Others
L-Linalool, a monoterpene with sedative and anxiolytic potential, has been used in Parkinson's disease research .

HY-121002

Alstonine	Infection Apocynaceae Alkaloids Structural Classification Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids	Parasite
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .

HY-N12098

d-Laserpitin	Structural Classification Source classification Clerodendrum japonicum (Thunb.) Sweet Coumarins Phenylpropanoids Plants Umbelliferae	Others
d-Laserpitin, pyranocoumarin, is a nature product with anxiolytic activity. d-Laserpitin can be isolated from the fruits of Seseli devenyense Simonk .

HY-N5126

Juncusol	Natural Products other families Source classification Phenols Polyphenols Plants	Others
Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice .

HY-N2439

Methyl isoeugenol	Natural Products other families Neurological Disease Classification of Application Fields Source classification Plants Pteris semipinnata L. Sp. Disease Research Fields	Others
Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active .

HY-N10497

Dihydro-β-erythroidine	Alkaloids Leguminosae Plants	nAChR
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced .

HY-116195R

L-Linalool (Standard)	Structural Classification Natural Products Cupressaceae Source classification Plants Chamaecyparis formosensis Matsum.	Others
L-Linalool (Standard) is the analytical standard of L-Linalool. This product is intended for research and analytical applications. L-Linalool, a monoterpene with sedative and anxiolytic potential, has been used in Parkinson's disease research .

HY-N0420A

Succinic acid tromethamine Wormwood acid tromethamine	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Succinic acid tromethamine is a potent and orally active *anxiolytic* agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries .

HY-N2096R

Kavain (Standard)	Structural Classification Natural Products Source classification Piper methysticum G.Forst. Piperaceae Plants	GABA Receptor
Kavain (Standard) is the analytical standard of Kavain. This product is intended for research and analytical applications. Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor .

HY-B1229

Isovaleramide 3-Methylbutanamide	Structural Classification Natural Products other families Source classification Plants	Others
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant that modulates central nervous system activity. Isovaleramide has anticonvulsant, anxiolytic, sedative, and sleep aid activities. Isovaleramide is promising for research of ethylene glycol (EG) poisoning-induced acute kidney injury and epilepsy .

HY-N8303

Gardenin A	Structural Classification Flavonoids Flavones Source classification Rutaceae Plants Citrus reticulata Blanco	ERK PAK
Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .

HY-N2439R

Methyl isoeugenol (Standard)	Natural Products other families Source classification Plants Pteris semipinnata L. Sp.	Others
Methyl isoeugenol (Standard) is the analytical standard of Methyl isoeugenol. This product is intended for research and analytical applications. Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active .

HY-N0368

Linalool 2 Publications Verification	Cardiovascular Disease Structural Classification Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields	TNF Receptor Apoptosis iGluR Endogenous Metabolite Bacterial
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-167825

Barakol	Seeds of Cassia tora Linn. Structural Classification Natural Products Leguminosae Source classification Plants	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N0507

Rosavin	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	TNF Receptor Interleukin Related
Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

HY-N0507R

Rosavin (Standard)	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	TNF Receptor Interleukin Related
Rosavin (Standard) is the analytical standard of Rosavin. This product is intended for research and analytical applications. Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

Cat. No.	Product Name	Chemical Structure

HY-N0420S2

Succinic acid-13C4
Succinic acid- ¹³C₄ is the ¹³C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].

HY-N0420S3

Butanedioic acid-13C2
Butanedioic acid- ¹³C₂ is the ¹³C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].

HY-N0420S4

Succinic acid-13C2
Succinic acid- ¹³C₂ is the ¹³C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].

Cat. No.	Product Name		Classification

HY-152476

3’-β-C-Ethynyluridine		Alkynes
3’-β-C-Ethynyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-β-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154736

N3-(Butyn-3-yl)uridine		Alkynes
N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-77650

4'-C-Azidouridine 4'-Azidouridine		Azide
4'-C-azidouridine (4'-Azidouridine) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4'-C-Azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152985

3’-Azido-3’-deoxy-4-deoxyuridine		Azide
6-Chloro-N1-(trimethylsilylethoxymethyl)pseudouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-Azido-3’-deoxy-4-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154590

2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine		Azide
2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154357

4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine		Azide
4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152782

4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine		Azide
4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

anxiolytic-

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products