2. Search Result
Search Result
Results for "

protein analog

" in MedChemExpress (MCE) Product Catalog:

112

Inhibitors & Agonists

2

Screening Libraries

6

Fluorescent Dye

5

Biochemical Assay Reagents

5

Peptides

7

Natural
Products

7

Click Chemistry

6

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-43722
    Lenalidomide-Br

    		Ligands for E3 Ligase Cancer
    Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .
    Lenalidomide-Br
  • HY-141894
    5-Ph-IAA-AM

    		Histone Acetyltransferase Metabolic Disease
    5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .
    5-Ph-IAA-AM
  • HY-108391
    C8-Ceramide

    N-Octanoyl-D-erythro-sphingosine

    		 Apoptosis PKC Autophagy Inflammation/Immunology Cancer
    C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro .
    C8-Ceramide
  • HY-12801A
    DiZPK hydrochloride
    2 Publications Verification

    		 Biochemical Assay Reagents Others
    DiZPK hydrochloride is a structural analog of pyrrolysine (Pyl), acting as a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.
    DiZPK hydrochloride
  • HY-P0315
    Crosstide
    2 Publications Verification

    		 Akt Others
    Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.
    Crosstide
  • HY-P3943
    Calmodulin Dependent Protein Kinase Substrate Analog

    		CaMK Neurological Disease
    Calmodulin Dependent Protein Kinase Substrate Analog is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases .
    Calmodulin Dependent Protein Kinase Substrate Analog
  • HY-127178
    ML120 analog 1

    		Phosphatase Cancer
    ML120 analog 1 (compound 1) is a competitive inhibitor with a Ki of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) .
    ML120 analog 1
  • HY-W844796
    2-Amino-5-methyl-5-hexenoic acid

    (S)-2-Amino-5-methylhex-5-enoic acid

    		 Bacterial Amino Acid Derivatives Infection
    2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) is a Methionine analog that competes with methionine and resulting in inhibition of cell growth. 2-Amino-5-methyl-5-hexenoic acid inhibits protein synthesis but not DNA or RNA synthesis in S. typhimurium TA1535 and E. coli K-12 . X
    2-Amino-5-methyl-5-hexenoic acid
  • HY-137623
    Sp-cCMPS

    		Biochemical Assay Reagents Others
    Sp-cCMPS is a cCMP analog that activates the binding protein of cCMP .
    Sp-cCMPS
  • HY-141453
    Desmethyl-WEHI-345 analog

    		RIP kinase Cancer
    Desmethyl-WEHI-345 analog is a protein kinase inhibitor extracted from patent WO2012003544A1, example 12. Desmethyl-WEHI-345 analog can be used for the research of colon cancer .
    Desmethyl-WEHI-345 analog
  • HY-32341
    Seocalcitol
    2 Publications Verification

    EB 1089

    		 VD/VDR Cancer
    Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with Kd of 0.27 nM.
    Seocalcitol
  • HY-133144
    Lenalidomide-OH

    		Ligands for E3 Ligase Cancer
    Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137) .
    Lenalidomide-OH
  • HY-W744780
    Docosahexaenoic acid N-succinimide

    		Biochemical Assay Reagents Others
    Docosahexaenoic Acid N-Succinimide is the succinimide analog of Docosahexaenoic Acid. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
    Docosahexaenoic acid N-succinimide
  • HY-134391
    6-Phe-ADP

    		Biochemical Assay Reagents Others
    6-Phe-ADP is an ATP analog used as a precursor to prepare the corresponding radiolabeled triphosphate for chemical genetics approaches to study substrate specificity and catalytic efficiency of protein kinases .
    6-Phe-ADP
  • HY-134801
    CID1231538

    		GPR35 Metabolic Disease Inflammation/Immunology
    CID1231538, a benzothiazole analog, is a potent GPR35 antagonist with no significant activity against rodent orthologs of GPR35, which is also a G protein-coupled receptor (GPCR) .
    CID1231538
  • HY-131318
    Lenalidomide-I

    		Ligands for E3 Ligase Cancer
    Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609) .
    Lenalidomide-I
  • HY-118384
    Sangivamycin
    3 Publications Verification

    NSC 65346; BA-90912

    		 PKC Nucleoside Antimetabolite/Analog Cancer
    Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .
    Sangivamycin
  • HY-124292
    Honokiol DCA
    1 Publications Verification

    Honokiol dichloroacetate

    		 Androgen Receptor Cancer
    Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level .
    Honokiol DCA
  • HY-168638
    PROTAC SOS1 ligand 1

    		Ligands for Target Protein for PROTAC Cancer
    PROTAC SOS1 ligand 1, a BI-3406 (HY-125817) analog, is a ligand for target SOS1 protein for PROTACT SIAIS562055 (HY-168637) .
    PROTAC SOS1 ligand 1
  • HY-118563
    Farnesylthioacetic acid

    		Biochemical Assay Reagents Others
    S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine, which is a prenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase) competitive inhibitors. It also inhibits the methylation of farnesylated and geranylgeranylated substrates.
    Farnesylthioacetic acid
  • HY-44432
    Navitoclax-piperazine

    ABT-263-piperazine

    		 Bcl-2 Family Ligands for Target Protein for PROTAC Cancer
    Navitoclax-piperazine is a Navitoclax analog. Navitoclax is a BCL-XL inhibitor. Navitoclax can be used as a target protein ligand (Ligands for Target Protein for PROTAC) to develop and design PROTAC BCL-XL degraders with anti-tumor activity. Navitoclax can be used in the synthesis of PROTAC DT2216 (HY-130604) .
    Navitoclax-piperazine
  • HY-164745
    L-β-Ethynylserine

    		Fluorescent Dye Others
    L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags, respectively.
    L-β-Ethynylserine
  • HY-147747
    HSP90-IN-12

    		HSP Cancer
    Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.
    HSP90-IN-12
  • HY-137530
    8-MA-cAMP

    8-Methylamino-cAMP

    		 PKA Others
    8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that acts as a site-selective PKA agonist with similar affinity for the B site of type I and type II protein kinase A. 8-MA-cAMP is used in conjunction with priming analogs that show site A preference, such as 8-piperidinyl cAMP, to achieve selective stimulation of type I .
    8-MA-cAMP
  • HY-134311
    8-NBD-cGMP

    		Fluorescent Dye Others
    8-NBD-cGMP is a fluorescent analog of cyclic guanosine monophosphate and a potent, membrane-permeable, fluorescent activator of cGMP-dependent protein kinase isozymes I α and I β. 8-NBD-cGMP is barely fluorescent in aqueous solution but fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites
    8-NBD-cGMP
  • HY-120931
    LY329146

    		P-glycoprotein Leukotriene Receptor Cancer
    LY329146, a Raloxifene (HY-13738) analog, is multidrug resistance protein (MRP1) inhibitor. LY329146 inhibits leucotriene C4 ( LTC4) transport with an IC50 of 0.8 μM .
    LY329146
  • HY-131777
    2-Cl-cAMP

    		PKA Others
    2-Cl-cAMP is an analog of cAMP and a potent stimulator of cAMP-dependent protein kinases such as PKA type I and II. 2-Cl-cAMP can be used as starting material for cyclic nucleotides .
    2-Cl-cAMP
  • HY-167635
    Decarbamoylmitomycin C

    		MDM-2/p53 Drug Derivative ATM/ATR Cancer
    Decarbamoylmitomycin C, an analog of Mitomycin C (MC), is an DNA-alkylating agent. Decarbamoylmitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction .
    Decarbamoylmitomycin C
  • HY-N11669
    Demycarosyl-3D-β-D-digitoxosylmithramycin SK

    		DNA/RNA Synthesis Cancer
    Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .
    Demycarosyl-3D-β-D-digitoxosylmithramycin SK
  • HY-W244657
    3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

    		Ligands for E3 Ligase Cancer
    3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that can be useful in PROTAC research because it is applicable to the recruitment of the CRBN protein.
    3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • HY-107621
    U0124

    		MEK Cancer
    U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM .
    U0124
  • HY-141898
    Biotin-4-aminophenol

    		Fluorescent Dye Others
    Biotin-4-aminophenol is a biotin-phenol analog. Biotin-4-aminophenol generates free radicals and conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1 .
    Biotin-4-aminophenol
  • HY-P3728
    Interleukin II (60-70)

    		Interleukin Related Inflammation/Immunology
    Interleukin II (60-70) is a 60-70 fragment of the cytokine Interleukin II polypeptide .
    Interleukin II (60-70)
  • HY-W782122
    Photoclick cholesterol

    		Biochemical Assay Reagents Others
    Photoclick cholesterol is a sterol lipid cholesterol analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group. Photoclick cholesterol has the ability to photoaffinity label the mitochondrial outer membrane transport protein (TSPO) and is able to specifically bind cholesterol to TSPO. However, using excessive amounts of Photoclick cholesterol will reduce the photolabeling of total mitochondrial proteins and TSPO .
    Photoclick cholesterol
  • HY-124648
    SMN-C2

    		DNA/RNA Synthesis Inflammation/Immunology
    SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research .
    SMN-C2
  • HY-162768
    Grp94 Inhibitor-2

    		HSP Cancer
    Grp94 Inhibitor-2 (compound 23), a cyclopropane analog, exhibits high affinity for glucose-regulated protein 94 (Grp94) with a Kd of 0.48 µM and 0.65 µM for Grp94 and Hsp90α, respectively .
    Grp94 Inhibitor-2
  • HY-15680
    O-Propargyl-Puromycin
    15+ Cited Publications

    		 Biochemical Assay Reagents Others
    O-Propargyl-Puromycin, an alkyne analog of puromycin, is a potent protein synthesis inhibitor. O-Propargyl-Puromycin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    O-Propargyl-Puromycin
  • HY-12306A
    8-Bromo-cAMP
    20+ Cited Publications

    8-Br-Camp

    		 PKA Apoptosis Cancer
    8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells .
    8-Bromo-cAMP
  • HY-151227
    VL285 Phenol

    		Ligands for E3 Ligase Cancer
    VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).
    VL285 Phenol
  • HY-12306
    8-Bromo-cAMP sodium salt
    20+ Cited Publications

    8-Br-Camp sodium salt

    		 PKA Apoptosis Cancer
    8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells .
    8-Bromo-cAMP sodium salt
  • HY-B0764A
    Bucladesine calcium
    Maximum Cited Publications
    32 Publications Verification

    Dibutyryl cAMP calcium salt; DBcAMP calcium salt

    		 PKA Phosphodiesterase (PDE) Apoptosis Others
    Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.
    Bucladesine calcium
  • HY-400882
    Tosylate-DPA-714

    		Drug Derivative Neurological Disease Inflammation/Immunology
    Tosylate-DPA-714 (compound 2) is a DPA-714 (HY-122607) tosylate analog. Tosylate-DPA-714 is a precursor for 18F-DPA-714. DPA-714 is a translocator protein (TSPO)-specific ligand .
    Tosylate-DPA-714
  • HY-163785
    1"-α-Azido-RDPr

    		SARS-CoV Infection
    1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain SARS-CoV-2 NSP3 Mac1 with an IC50 of 30 nM .
    1
  • HY-131648
    1-Oleoyl-2-acetyl-sn-glycerol

    		PKC Metabolic Disease
    1-Oleoyl-2-acetyl-sn glycerol is a synthetic, cell permeable diacylglycerol analog. 1-Oleoyl-2-acetyl-sn glycerol activates calcium-dependent protein kinase C (PKC) and induces the superoxide-production.
    1-Oleoyl-2-acetyl-sn-glycerol
  • HY-112464
    PKR Inhibitor, negative control

    		Pyruvate Kinase Neurological Disease
    PKR Inhibitor, negative control is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitor, which can be used as a negative control. PKR Inhibitor, negative control can also inhibit LK-induced neuronal death, exhibiting significant neuroprotective effects .
    PKR Inhibitor, negative control
  • HY-137640A
    Sp-8-Br-cAMPS sodium

    		PKA Inflammation/Immunology
    Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve .
    Sp-8-Br-cAMPS sodium
  • HY-118384R
    Sangivamycin (Standard)

    NSC 65346 (Standard); BA-90912 (Standard)

    		 PKC Nucleoside Antimetabolite/Analog Cancer
    Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
    Sangivamycin (Standard)
  • HY-14833
    Atiratecan

    TP300

    		 Topoisomerase Cancer
    Atiratecan (TP300) is a proagent of camptothecin analog CH0793076 (HY-107096). Atiratecan does not inhibit acetylcholinesterase (AChE) activities. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models .
    Atiratecan
  • HY-18399
    YM-1
    1 Publications Verification

    		 HSP NO Synthase Cancer
    YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins .
    YM-1
  • HY-N6732
    K-252a
    15+ Cited Publications

    SF2370; Antibiotic K 252a; Antibiotic SF 2370

    		 PKC PKA CaMK Trk Receptor Autophagy Antibiotic Infection Inflammation/Immunology
    K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca 2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .
    K-252a

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: