1. Gene
  2. SIRT1 - sirtuin 1 Gene

SIRT1 - sirtuin 1 Gene

Homo sapiens

Also known as SIR2; SIR2L1; SIR2alpha

Gene ID: 23411 | Gene type: protein coding

About SIRT1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:67,884,656-67,918,390 (from NCBI)

This gene has 6 transcripts (splice variants), 156 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the Sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

SIRT1 Products(3)

mRNA Protein Name
NM_001142498.2 NP_001135970.1 NAD-dependent protein deacetylase sirtuin-1 isoform b
NM_001314049.1 NP_001300978.1 NAD-dependent protein deacetylase sirtuin-1 isoform c
NM_012238.5 NP_036370.2 NAD-dependent protein deacetylase sirtuin-1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20955178 GOA
enables HLH domain binding IPI
IPI: Inferred from physical interaction
12535671 GOA
enables NAD-dependent histone H3K14 deacetylase activity IDA
IDA: Inferred from direct assay
15469825 GOA
enables NAD-dependent histone H3K9 deacetylase activity IDA
IDA: Inferred from direct assay
15469825 GOA
enables NAD-dependent histone H4K16 deacetylase activity IDA
IDA: Inferred from direct assay
15469825 GOA
enables NAD-dependent histone deacetylase activity IDA
IDA: Inferred from direct assay
12006491 GOA
enables NAD-dependent histone decrotonylase activity IDA
IDA: Inferred from direct assay
28497810 GOA
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
15692560 GOA
enables NAD-dependent protein lysine deacetylase activity IMP
IMP: Inferred from mutant phenotype
11672523 GOA
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
12535671 GOA
enables deacetylase activity IDA
IDA: Inferred from direct assay
18203716 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables histone H3K deacetylase activity IDA
IDA: Inferred from direct assay
20027304 GOA
enables histone H4K12 deacetylase activity IDA
IDA: Inferred from direct assay
15469825 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
15469825 GOA
enables histone deacetylase activity EXP
EXP: Inferred from Experiment
18485871 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15469825 GOA
enables keratin filament binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables mitogen-activated protein kinase binding IPI
IPI: Inferred from physical interaction
20027304 GOA
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
24043310 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
11672523 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11672523 GOA
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
19934257 GOA
enables protein lysine deacetylase activity IMP
IMP: Inferred from mutant phenotype
20203304 GOA
enables protein lysine delactylase activity IDA
IDA: Inferred from direct assay
38512451 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12535671 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
17505061 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
18203716 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
20100829 GOA
involved in UV-damage excision repair IMP
IMP: Inferred from mutant phenotype
20670893 GOA
involved in angiogenesis IDA
IDA: Inferred from direct assay
20620956 GOA
involved in cellular response to glucose starvation IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
20027304 GOA
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
20620956 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
15152190 GOA
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
22956909 GOA
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18662546 GOA
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in heterochromatin formation IDA
IDA: Inferred from direct assay
15469825 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
20100829 GOA
involved in maintenance of nucleus location IDA
IDA: Inferred from direct assay
15692560 GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
11672523 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11672523 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11672523 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15152190 GOA
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
20169165 GOA
involved in negative regulation of androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17505061 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16892051 GOA
involved in negative regulation of attachment of mitotic spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
30409912 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
17680780 GOA
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in negative regulation of cellular response to testosterone stimulus IMP
IMP: Inferred from mutant phenotype
17505061 GOA
involved in negative regulation of cellular senescence IDA
IDA: Inferred from direct assay
20203304 GOA
involved in negative regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
20424141 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17916362 GOA
involved in negative regulation of helicase activity IDA
IDA: Inferred from direct assay
18203716 GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17317627 GOA
involved in negative regulation of peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
20100829 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
21149730 GOA
involved in negative regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
17612497 GOA
involved in negative regulation of protein acetylation IMP
IMP: Inferred from mutant phenotype
17916362 GOA
involved in negative regulation of signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
29681526 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12535671 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17505061 GOA
involved in negative regulation of triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
29765047 GOA
involved in peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
18004385 GOA
involved in positive regulation of DNA repair IMP
IMP: Inferred from mutant phenotype
19934257 GOA
involved in positive regulation of MHC class II biosynthetic process IDA
IDA: Inferred from direct assay
21890893 GOA
involved in positive regulation of adaptive immune response IDA
IDA: Inferred from direct assay
21890893 GOA
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
23960241 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20424141 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
15152190 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19047049 GOA
involved in positive regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
23960241 GOA
involved in positive regulation of cAMP-dependent protein kinase activity IMP
IMP: Inferred from mutant phenotype
18687677 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21807113 GOA
involved in positive regulation of cellular senescence IDA
IDA: Inferred from direct assay
18687677 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
19047049 GOA
involved in positive regulation of double-strand break repair IDA
IDA: Inferred from direct assay
32538779 GOA
involved in positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20203304 GOA
involved in positive regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
15692560 GOA
involved in positive regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
21241768 GOA
involved in positive regulation of macroautophagy IDA
IDA: Inferred from direct assay
18296641 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20203304 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12837246 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
21841822 GOA
involved in protein deacetylation IDA
IDA: Inferred from direct assay
18203716 GOA
involved in protein deacetylation IMP
IMP: Inferred from mutant phenotype
11672523 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
21841822 GOA
involved in pyrimidine dimer repair by nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
21149730 GOA
involved in rDNA heterochromatin formation IDA
IDA: Inferred from direct assay
18485871 GOA
involved in rDNA heterochromatin formation IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19934257 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12006491 GOA
involved in regulation of centrosome duplication IDA
IDA: Inferred from direct assay
31722219 GOA
involved in regulation of endodeoxyribonuclease activity IMP
IMP: Inferred from mutant phenotype
19934257 GOA
involved in regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
15692560 GOA
involved in regulation of transcription by glucose IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
19934257 GOA
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
14976264 GOA
involved in single strand break repair IMP
IMP: Inferred from mutant phenotype
20097625 GOA
involved in stress-induced premature senescence IMP
IMP: Inferred from mutant phenotype
17916362 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
23960241 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
15684044 GOA
located in PML body IDA
IDA: Inferred from direct assay
12006491 GOA
located in chromatin IDA
IDA: Inferred from direct assay
17505061 GOA
part of chromatin silencing complex IDA
IDA: Inferred from direct assay
18485871 GOA
NOT located in cytoplasm IDA
IDA: Inferred from direct assay
15469825 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20027304 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
20027304 GOA
part of eNoSc complex IPI
IPI: Inferred from physical interaction
18485871 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
15469825 GOA
located in heterochromatin IDA
IDA: Inferred from direct assay
15469825 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
15469825 GOA
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
15469825 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16079181 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
15469825 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16079181 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11672523 GOA
located in rDNA heterochromatin IDA
IDA: Inferred from direct assay
18485871 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT1 Protein Structure

SIR2

SIR2: Sir2 family (261 - 447)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-1

NAD-dependent protein deacylase sirtuin-1

SIR2-like protein 1

regulatory protein SIR2 homolog 1

sirtuin type 1

SIRT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SIRT1 Q96EB6 APEX1 Homo sapiens P27695
Deacetylase Assay
19934257
Intra SIRT1 Q96EB6 APEX1 Homo sapiens P27695
IF
19934257
Intra SIRT1 Q96EB6 IRS2 Homo sapiens Q9Y4H2
Anti Bait CoIP
21241768
Intra SIRT1 Q96EB6 IRS2 Homo sapiens Q9Y4H2
Anti Bait CoIP
17901049
Intra SIRT1 Q96EB6 FOXO1 Homo sapiens Q12778
Anti Tag CoIP
15692560
Intra SIRT1 Q96EB6 FOXO1 Homo sapiens Q12778
Anti Tag CoIP
18235501
Intra SIRT1 Q96EB6 SETD7 Homo sapiens Q8WTS6
Anti Bait CoIP
21245319
Cross SIRT1 Q96EB6 Foxo1 Mus musculus Q9R1E0
Anti Tag CoIP
22510882
Intra SIRT1 Q96EB6 MECOM Homo sapiens Q03112
Anti Bait CoIP
21555002
Intra SIRT1 Q96EB6 CIITA Homo sapiens P33076
Anti Bait CoIP
21890893
Intra SIRT1 Q96EB6 RPTOR Homo sapiens Q8N122
Anti Bait CoIP
21471201
Intra SIRT1 Q96EB6 FOXO3 Homo sapiens O43524
Anti Bait CoIP
15126506
Intra SIRT1 Q96EB6 FOXO3 Homo sapiens O43524
Deacetylase Assay
14976264
Intra SIRT1 Q96EB6 FOXO3 Homo sapiens O43524
Anti Tag CoIP
14976264
Intra SIRT1 Q96EB6 CSAG2 Homo sapiens Q9Y5P2
Anti Tag CoIP
32761762
Intra SIRT1 Q96EB6 CSAG2 Homo sapiens Q9Y5P2
Pull Down
32761762
Intra SIRT1 Q96EB6 CSAG2 Homo sapiens Q9Y5P2
Enzymatic Study
32761762
Intra SIRT1 Q96EB6 HES1 Homo sapiens Q14469
Pull Down
12535671
Intra SIRT1 Q96EB6 XPA Homo sapiens P23025
Anti Tag CoIP
20670893
Intra SIRT1 Q96EB6 XPA Homo sapiens P23025
Anti Bait CoIP
20670893
Intra SIRT1 Q96EB6 AKT1 Homo sapiens P31749
Anti Bait CoIP
21775285
Intra SIRT1 Q96EB6 AKT1 Homo sapiens P31749
Pull Down
21775285
Intra SIRT1 Q96EB6 CSNK2A1 Homo sapiens P68400
Anti Bait CoIP
21968188
Intra SIRT1 Q96EB6 CSNK2A1 Homo sapiens P68400
Anti Bait CoIP
19680552
Intra SIRT1 Q96EB6 CSNK2A1 Homo sapiens P68400
Anti Bait CoIP
20439735
Intra SIRT1 Q96EB6 CSNK2B Homo sapiens P67870
Y2H
21968188
Intra SIRT1 Q96EB6 CSNK2B Homo sapiens P67870
Anti Bait CoIP
21968188
Intra SIRT1 Q96EB6 CSNK2B Homo sapiens P67870
Pull Down
21968188
Cross SIRT1 Q96EB6 Ncor1 Mus musculus Q60974
Pull Down
15175761
Intra SIRT1 Q96EB6 SUV39H1 Homo sapiens O43463
Deacetylase Assay
18004385
Intra SIRT1 Q96EB6 SUV39H1 Homo sapiens O43463
Anti Tag CoIP
18004385
Intra SIRT1 Q96EB6 XRCC6 Homo sapiens P12956
Anti Bait CoIP
17334224
Intra SIRT1 Q96EB6 XRCC6 Homo sapiens P12956
Deacetylase Assay
15205477
Intra SIRT1 Q96EB6 XRCC6 Homo sapiens P12956
Anti Bait CoIP
15205477
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
Pull Down
18235501
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
Anti Tag CoIP
18235502
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
Pull Down
18235502
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
Anti Bait CoIP
18235502
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
GMS
18235502
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
Anti Tag CoIP
18235501
Intra SIRT1 Q96EB6 CCAR2 Homo sapiens Q8N163
Anti Bait CoIP
18235501
Intra SIRT1 Q96EB6 MTOR Homo sapiens P42345
Anti Bait CoIP
21471201
Intra SIRT1 Q96EB6 MTOR Homo sapiens P42345
Protein Kinase Assay
21471201
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Acetylase Assay
18235502
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Anti Bait CoIP
11672523
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Anti Tag CoIP
18235502
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Anti Bait CoIP
12006491
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Anti Bait CoIP
21245319
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Enzymatic Study
32761762
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Deacetylase Assay
18235501
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Anti Tag CoIP
18235501
Intra SIRT1 Q96EB6 TP53 Homo sapiens P04637
Deacetylase Assay
17964266
Intra SIRT1 Q96EB6 WRN Homo sapiens Q14191
Anti Tag CoIP
19343720
Intra SIRT1 Q96EB6 WRN Homo sapiens Q14191
Pull Down
18203716
Intra SIRT1 Q96EB6 WRN Homo sapiens Q14191
Pull Down
19343720
Intra SIRT1 Q96EB6 MAP1LC3B Homo sapiens Q9GZQ8
Deacetylase Assay
18296641
Intra SIRT1 Q96EB6 MAP1LC3B Homo sapiens Q9GZQ8
Anti Tag CoIP
18296641
Intra SIRT1 Q96EB6 TP73 Homo sapiens O15350
Anti Tag CoIP
16998810
Intra SIRT1 Q96EB6 NR0B2 Homo sapiens Q15466
Anti Tag CoIP
20375098
Intra SIRT1 Q96EB6 NR0B2 Homo sapiens Q15466
Anti Bait CoIP
20375098
Intra SIRT1 Q96EB6 NR0B2 Homo sapiens Q15466
Pull Down
20375098
Intra SIRT1 Q96EB6 NMNAT1 Homo sapiens Q9HAN9
Pull Down
19478080
Intra SIRT1 Q96EB6 HCFC1 Homo sapiens P51610
Anti Tag CoIP
21909281
Intra SIRT1 Q96EB6 TSC2 Homo sapiens P49815
Anti Bait CoIP
20169165
Intra SIRT1 Q96EB6 RARA Homo sapiens P10276
Pull Down
19934264
Intra SIRT1 Q96EB6 EP300 Homo sapiens Q09472
Anti Bait CoIP
19047049
Intra SIRT1 Q96EB6 EP300 Homo sapiens Q09472
CH-IP
20660480
Intra SIRT1 Q96EB6 MYC Homo sapiens P01106
Deacetylase Assay
21807113
Intra SIRT1 Q96EB6 MYC Homo sapiens P01106
Anti Tag CoIP
21807113
Intra SIRT1 Q96EB6 RPS19BP1 Homo sapiens Q86WX3
Anti Bait CoIP
17964266
Intra SIRT1 Q96EB6 RPS19BP1 Homo sapiens Q86WX3
Pull Down
17964266
Intra SIRT1 Q96EB6 RPS19BP1 Homo sapiens Q86WX3
Y2H
17964266
Intra SIRT1 Q96EB6 FOXO4 Homo sapiens P98177
Deacetylase Assay
15126506
Intra SIRT1 Q96EB6 E2F1 Homo sapiens Q01094
Anti Bait CoIP
19188449
Intra SIRT1 Q96EB6 E2F1 Homo sapiens Q01094
Pull Down
16892051
Intra SIRT1 Q96EB6 KAT2B Homo sapiens Q92831
Deacetylase Assay
19188449
Intra SIRT1 Q96EB6 KAT2B Homo sapiens Q92831
Anti Bait CoIP
19188449
Intra SIRT1 Q96EB6 NBN Homo sapiens O60934
Pull Down
17612497
Intra SIRT1 Q96EB6 NBN Homo sapiens O60934
Anti Bait CoIP
17612497
Intra SIRT1 Q96EB6 NBN Homo sapiens O60934
Anti Tag CoIP
17612497
Cross SIRT1 Q96EB6 Pparg Mus musculus P37238
Anti Tag CoIP
22863012
Cross SIRT1 Q96EB6 Nr1h3 Mus musculus Q9Z0Y9
Anti Tag CoIP
17936707
Intra SIRT1 Q96EB6 NHLH2 Homo sapiens Q02577
Anti Tag CoIP
22169038
Cross SIRT1 Q96EB6 Pparg Mus musculus P37238-1
Deacetylase Assay
22863012
Cross SIRT1 Q96EB6 Pparg Mus musculus P37238-1
Anti Tag CoIP
22863012
Intra SIRT1 Q96EB6 SNW1 Homo sapiens Q13573
IF
19934264
Intra SIRT1 Q96EB6 SNW1 Homo sapiens Q13573
Pull Down
19934264
Intra SIRT1 Q96EB6 SNW1 Homo sapiens Q13573
Y2H
19934264
Intra SIRT1 Q96EB6 FHL2 Homo sapiens Q14192
Anti Tag CoIP
15692560
Intra SIRT1 Q96EB6 TLE1 Homo sapiens Q04724
Y2H
17680780
Intra SIRT1 Q96EB6 ACACA Homo sapiens Q13085
Pull Down
19343720
Intra SIRT1 Q96EB6 ACACA Homo sapiens Q13085
Anti Tag CoIP
19343720
Intra SIRT1 Q96EB6 DNMT1 Homo sapiens P26358
Imaging
21947282
Intra SIRT1 Q96EB6 DNMT1 Homo sapiens P26358
Anti Bait CoIP
22094255
Intra SIRT1 Q96EB6 DNMT1 Homo sapiens P26358
Deacetylase Assay
21947282
Intra SIRT1 Q96EB6 DNMT1 Homo sapiens P26358
Anti Bait CoIP
21947282
Intra SIRT1 Q96EB6 DNMT1 Homo sapiens P26358
Anti Tag CoIP
21947282
Intra SIRT1 Q96EB6 DVL1 Homo sapiens O14640
Anti Bait CoIP
20439735
Intra SIRT1 Q96EB6 RELA Homo sapiens Q04206
Anti Bait CoIP
15152190
Intra SIRT1 Q96EB6 RELA Homo sapiens Q04206
Anti Tag CoIP
15152190
Intra SIRT1 Q96EB6 DVL3 Homo sapiens Q92997
Anti Bait CoIP
20439735
Intra SIRT1 Q96EB6 DVL3 Homo sapiens Q92997
Anti Tag CoIP
20439735
Intra SIRT1 Q96EB6 PPARG Homo sapiens P37231
Pull Down
20660480
Intra SIRT1 Q96EB6 PPARG Homo sapiens P37231
CH-IP
20660480
Intra SIRT1 Q96EB6 PPARG Homo sapiens P37231
Anti Tag CoIP
20660480
Intra SIRT1 Q96EB6 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
21241768
Intra SIRT1 Q96EB6 MYCN Homo sapiens P04198
Anti Bait CoIP
21698133
Intra SIRT1 Q96EB6 SREBF1 Homo sapiens P36956-3
Deacetylase Assay
20817729
Intra SIRT1 Q96EB6 SREBF1 Homo sapiens P36956-3
Pull Down
20817729
Intra SIRT1 Q96EB6 ATG7 Homo sapiens O95352
Deacetylase Assay
18296641
Intra SIRT1 Q96EB6 ATG7 Homo sapiens O95352
Anti Tag CoIP
18296641
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRT1 Proteins

Cat. No. Product Name Accession Purity
HY-P71596 SIRT1 Protein, Human (His) Q96EB6 (A2-S747) ≥95%

Related Diseases

Diseases Alias
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Osteonecrosis Of The Jaw
Aging
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability

Diabetic Encephalopathy
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Pulpitis

Pulp Stones

Pulpitis Nos

Fatty Liver Disease

Alcoholic Fatty Liver

Fatty Liver

Fatty Liver, Alcoholic

Fatty Change Of Liver

Hepatic Lipidosis

Steatosis Of Liver

Fatty Liver Alcoholic

Steatohepatitis

Etoh Fatty Liver

Etoh Fatty Liver Metamorphosis

Fatty Etoh Liver Necrosis

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis

Nash

Nash - [Non-Alcoholic Steatohepatitis]

Non-Alcoholic Steatohepatosis

Myopathy

Muscular Diseases

Myopathies

Acquired Metabolic Disease
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Overnutrition
Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Cardiovascular Disease

Werner Syndrome

Werner'S Syndrome

WRN

Adult Progeria

Ws

Adult Premature Ageing Syndrome

Adult Premature Aging Syndrome

Werners Syndrome

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Periapical Periodontitis

Apical Periodontitis

Periodontitis Apical

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Inclusion Body Myositis

Ibm

Sporadic Inclusion Body Myositis

Myositis, Inclusion Body

Inflammatory Myopathy

Inflammatory Myopathies

Sibm

Myositis Inclusion Body

Nonaka Myopathy

Inclusion Body Myopathy, Autosomal Recessive

Inclusion Body Myopathy, Autosomal Dominant

Myositis

Inclusion Body Myopathy, Sporadic

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Diabetes Mellitus

Diabetes

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Hyperphosphatemia
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash

Laron Syndrome

Growth Hormone Insensitivity Syndrome

Growth Hormone Receptor Deficiency

Laron Dwarfism

Pituitary Dwarfism Ii

Laron-Type Isolated Somatotropin Defect

Primary Growth Hormone Resistance

Laron-Type Dwarfism

Laron Type Pituitary Dwarfism I

Primary Growth Hormone Insensitivity

Primary Gh Resistance

Gh-R Deficiency

Growth Hormone Receptor Defect

Laron-Type Pituitary Dwarfism

Laron-Type Short Stature

Severe Gh Insensitivity

Ghis

Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway

Complete Growth Hormone Insensitivity

Gh Receptor Deficiency

Primary Gh Insensitivity

Short Stature Due To Growth Hormone Resistance

LARS

Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Myositis

Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myositis

Iim

Imm

Idiopathic Inflammatory Myopathies

Myopathy, Familial Idiopathic Inflammatory

Inflammatory Disorder Of Muscle

Idiopathic Inflammatory Myopathy, Familial

Inflammatory Myopathy, Idiopathic

Myopathies Idiopathic Inflammatory

Familial Idiopathic Inflammatory Myopathy

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Lipomatosis

Benign Symmetrical Lipomatosis

Lipid Storage Disease

Lipoidosis

Inborn Lipid Storage Disorder

Lipoid Storage Diseas

Lipid Storage Diseases

Lipidoses

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta SIRT1 VGNC VGNC:77233
Mus musculus SIRT1 MGD MGI:2135607
Bos taurus SIRT1 VGNC VGNC:34630
Felis catus SIRT1 VGNC VGNC:65155
Rattus norvegicus SIRT1 RGD RGD:1308542
Canis familiaris SIRT1 VGNC VGNC:46183
Others SIRT1 NCBI