YWHAB - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Gene

Homo sapiens

Also known as HS1; GW128; YWHAA; KCIP-1; HEL-S-1

Gene ID: 7529 | Gene type: protein coding

About YWHAB

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,885,705-44,908,532 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues.

Summary

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

YWHAB Products(2)

mRNA	Protein	Name
NM_003404.5	NP_003395.1	2014/3/3 protein beta/alpha
NM_139323.4	NP_647539.1	2014/3/3 protein beta/alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17255105	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17085597	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables phosphoserine residue binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7644510	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	11555644	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic sequestering of protein	IDA IDA: Inferred from direct assay	10869435	GOA
involved in negative regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21224381	GOA
involved in positive regulation of catalytic activity	IDA IDA: Inferred from direct assay	17255105	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10869435	GOA
located in cytosol	IDA IDA: Inferred from direct assay	31906564	GOA
located in nucleus	IDA IDA: Inferred from direct assay	31906564	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12963375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YWHAB Protein Structure

14-3-3

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

14-3-3 protein beta/alpha

14-3-3 alpha

Recombinant YWHAB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74439	14-3-3 beta Protein, Human (GST)	P31946 (M1-N246)	≥95%
HY-P74440	14-3-3 beta Protein, Human	P31946 (M1-N246)	≥95%
HY-P700304	14-3-3 beta Protein, Human (His)	P31946 (M1-N246)	≥95%

Related Diseases

Diseases

Alias

Chlamydia

Chlamydial Infection	Chlamydia Trachomatis Infectious Disease
Chlamydial Disease	Chlamydia Infections

Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Chronic Meningitis

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Granuloma Inguinale

Donovanosis	Pudendal Ulcer
Granuloma Inguinale Tropicum	Granuloma Pudendi Tropicum

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15940	YWHAB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	YWHAB	VGNC	VGNC:48508
Rattus norvegicus	YWHAB	RGD	RGD:61998
Mus musculus	YWHAB	MGD	MGI:1891917
Felis catus	YWHAB	VGNC	VGNC:67154
Macaca mulatta	YWHAB	VGNC	VGNC:78819
Bos taurus	YWHAB	VGNC	VGNC:37044
Macaca fascicularis	YWHAB	NCBI	NCBI:101926442
Others	YWHAB	NCBI

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