2. Gene
  3. Cit - citron rho-interacting serine/threonine kinase Gene

Cit - citron rho-interacting serine/threonine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CRIK

Gene ID: 83620 | Gene type: protein coding

About Cit

Summary

Predicted to enable several functions, including PDZ domain binding activity; scaffold protein binding activity; and transcription coactivator binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; liver development; and regulation of actin polymerization or depolymerization. Located in several cellular components, including Golgi cisterna; cleavage furrow; and midbody. Used to study epilepsy; microcephaly; and visual epilepsy. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Cit Products(1)

mRNA Protein Name
NM_001029911.1 NP_001025082.1 citron rho-interacting kinase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
9870942 RGD
Biological Process GO Annotation Evidence Reference Source
involved in G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12411428 RGD
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
14595335 RGD
involved in gamma-aminobutyric acid signaling pathway IDA
IDA: Inferred from direct assay
9870942 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
12411428 RGD
involved in postsynaptic cytoskeleton organization IDA
IDA: Inferred from direct assay
9870942 RGD
involved in postsynaptic density protein 95 clustering IDA
IDA: Inferred from direct assay
9870942 RGD
involved in regulation of actin polymerization or depolymerization IDA
IDA: Inferred from direct assay
14595335 RGD
Cellular Component GO Annotation Evidence Reference Source
located in GABA-ergic synapse IDA
IDA: Inferred from direct assay
9870942 RGD
located in Golgi cisterna IDA
IDA: Inferred from direct assay
14595335 RGD
located in cleavage furrow IDA
IDA: Inferred from direct assay
11932363 RGD
located in glutamatergic postsynaptic density IDA
IDA: Inferred from direct assay
9870942 RGD
located in midbody IDA
IDA: Inferred from direct assay
17534152 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
14595335 RGD
located in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
9870942 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

citron rho-interacting kinase

citron (rho-interacting, serine/threonine kinase 21)

citron Rho-interacting kinase

citron kinase

citron-K kinase

postsynaptic density protein (citron)

rho-interacting, serine/threonine-protein kinase 21

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-160441 MC-Val-Cit-PAB-Ispinesib Inhibitor 99.85% Phase 3
HY-141601 Telisotuzumab vedotin Inhibitor 99.90% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99612 Farletuzumab ecteribulin 98.10% Phase 2
Pre-clinical Phase
Bioactive Molecules (176)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15575 VcMMAE Inhibitor 99.97% Unkown
HY-20336 Mc-Val-Cit-PABC-PNP 98.89% Unkown
HY-100374 Val-Cit-PAB-MMAE 99.83% Unkown
HY-112786 MC-Val-Cit-PAB-MMAF 98.16% Unkown
HY-78738 MC-Val-Cit-PAB 99.55% Unkown
HY-145929 MC-Val-Cit-PAB-Exatecan Inhibitor 99.57% Unkown
HY-12362 Val-cit-PAB-OH 99.64% Unkown
HY-41189 Fmoc-Val-Cit-PAB-PNP 98.99% Unkown
HY-130990 DBCO-PEG4-Val-Cit-PAB-MMAF 99.99% Unkown
HY-131296 5-A-RU-PABC-Val-Cit-Fmoc 98.85% Unkown
HY-19318 Fmoc-Val-Cit-PAB 99.39% Unkown
HY-139642 Mal-(CH2)5-Val-Cit-PAB-Eribulin 99.82% Unkown
HY-141156 Mal-PEG8-Val-Cit-PAB-MMAE 99.67% Unkown
HY-141154 Amino-PEG4-Val-Cit-PAB-MMAE 99.93% Unkown
HY-128904 MC-Val-Cit-PAB-duocarmycin chloride 98.77% Unkown
HY-100566 SuO-Val-Cit-PAB-MMAE 99.24% Unkown
HY-141155 endo-BCN-PEG4-Val-Cit-PAB-MMAE 99.95% Unkown
HY-100115 TA-02 Inhibitor 99.85% Unkown
HY-15575G VcMMAE (GMP) / Unkown
HY-100567 MAL-di-EG-Val-Cit-PAB-MMAE 98.04% Unkown
HY-141142 Boc-Val-Cit-PAB-PNP 99.55% Unkown
HY-130989 SuO-Glu-Val-Cit-PAB-MMAE 99.20% Unkown
HY-140150 Azido-PEG3-Val-Cit-PAB-PNP 99.09% Unkown
HY-136154 Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP 96.67% Unkown
HY-141833 Bi-Mc-VC-PAB-MMAE 99.78% Unkown
HY-153263 (Aminooxy)acetamide-Val-Cit-PAB-MMAE 97.01% Unkown
HY-W008064 Fmoc-Cit-OH 99.32% Unkown
HY-19812 Acetylene-linker-Val-Cit-PABC-MMAE 95.21% Unkown
HY-148875 Py-MAA-Val-Cit-PAB-MMAE 99.78% Unkown
HY-130937 DBCO-Val-Cit-PABC-PNP 96.54% Unkown
HY-W038702 Boc-Val-Cit-OH ≥98.0% Unkown
HY-128902 MC-Val-Cit-PAB-vinblastine 92.87% Unkown
HY-147286 Ac-Lys-Val-Cit-PABC-MMAE 99.99% Unkown
HY-15742 Vc-MMAD Inhibitor 99.96% Unkown
HY-153031 Val-Cit-PAB-Exatecan Inhibitor 99.79% Unkown
HY-19813A mDPR-Val-Cit-PAB-MMAE TFA 99.51% Unkown
HY-44177 Val-Cit-PAB-MMAF sodium 98.43% Unkown
HY-140145 Mal-PEG4-Val-Cit-PAB-PNP 97.05% Unkown
HY-P4160 PDC31 Inhibitor 99.76% Unkown
HY-112099 Mc-Val-Cit-PAB-Cl 99.67% Unkown
HY-130944 Mal-PEG1-Val-Cit-PABC-OH 95.05% Unkown
HY-140147 Mal-amido-PEG2-Val-Cit-PAB-PNP 98.40% Unkown
HY-148245 OH-Glu-Val-Cit-PAB-MMAE 99.92% Unkown
HY-19811 Fmoc-Val-Cit-PAB-MMAE Inhibitor 98.89% Unkown
HY-139726 Mal-PEG4-Val-Cit-PAB-MMAE 98.64% Unkown
HY-155052A PAD4-IN-2 TFA Inhibitor 95.64% Unkown
HY-141860 PSMA-Val-Cit-PAB-MMAE Inhibitor 99.52% Unkown
HY-128903 MC-Val-Cit-PAB-carfilzomib iodide 96.58% Unkown
HY-138106 Fmoc-D-Cit-OH / Unkown
HY-140014 Val-Cit 99.38% Unkown
HY-140149 Azido-PEG4-Val-Cit-PAB-OH ≥98.0% Unkown
HY-141141 Boc-Val-Cit-PAB 99.99% Unkown
HY-W190943 Azido-PEG4-Val-Cit-PAB-MMAE 99.43% Unkown
HY-78736 Val-Cit-PAB-OSBT 99.55% Unkown
HY-126532 Fmoc-Val-Cit-PAB-Duocarmycin TM 99.44% Unkown
HY-128899 MC-Val-Cit-PAB-Auristatin E 96.97% Unkown
HY-130222 Mal-PEG2-Val-Cit-PAB-OH 99.49% Unkown
HY-145489 Mal-PEG2-Val-Cit-PABA 98.91% Unkown
HY-15575S VcMMAE-d8 Inhibitor 97.56% Unkown
HY-156758 Mal-PEG8-Val-Cit-PAB-MMAF 96.50% Unkown
HY-160774 Val-Cit-PABC-DOX Inhibitor 95.06% Unkown
HY-19697 Aminocaproyl-Val-Cit-PABC-MMAE 99.89% Unkown
HY-W591408 DBCO-Val-Cit-PAB-MMAE 98.33% Unkown
HY-153031A Val-Cit-PAB-Exatecan TFA Inhibitor 99.73% Unkown
HY-W190927 MC-Val-Cit-Doxorubicin / Unkown
HY-Z0922 (R,R)-MC-Val-Cit-PAB Control 97.06% Unkown
HY-128906 MC-Val-Cit-PAB-Retapamulin 99.00% Unkown
HY-128909 MC-Val-Cit-PAB-rifabutin 95.33% Unkown
HY-131156 Mal-PEG2-Val-Cit-PABA-PNP 96.82% Unkown
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% Unkown
HY-126672 Mal-PEG4-Val-Cit-PAB 98.87% Unkown
HY-128711 MAL-di-EG-Val-Cit-PAB-MMAF 98.56% Unkown
HY-128907 MC-Val-Cit-PAB-clindamycin 99.99% Unkown
HY-128908 MC-Val-Cit-PAB-Indibulin 95.82% Unkown
HY-130923 BCN-PEG1-Val-Cit-PABC-OH ≥95.0% Unkown
HY-140143 Mal-PEG4-Val-Cit-PAB-OH 96.92% Unkown
HY-147021 MC-Val-D-Cit-PAB-PNP / Unkown
HY-147286A Ac-Lys-Val-Cit-PABC-MMAE formic 99.96% Unkown
HY-148871 Mc-Val-Cit-PAB-Gefitinib chloride 98.69% Unkown
HY-155052 PAD4-IN-2 Inhibitor / Unkown
HY-19318A Fmoc-Val-D-Cit-PAB / Unkown
HY-19318B Fmoc-D-Val-Cit-PAB / Unkown
HY-19318C Fmoc-D-Val-D-Cit-PAB 98.97% Unkown
HY-126492 Vat-Cit-PAB-Monomethyl Dolastatin 10 / Unkown
HY-128893 MC-Sq-Cit-PAB-Gefitinib / Unkown
HY-128905 MC-Val-Cit-PAB-dimethylDNA31 / Unkown
HY-130936 DBCO-Val-Cit-PABC-OH / Unkown
HY-101909 Val-Cit-PAB-MMAF / Unkown
HY-100374G Val-Cit-PAB-MMAE (GMP) / Unkown
HY-111121 cBu-Cit-OH / Unkown
HY-12362G Val-cit-PAB-OH (GMP) / Unkown
HY-126533 PDP-C1-Ph-Val-Cit / Unkown
HY-126667 SC-Val-Cit-PAB / Unkown
HY-126670 mDPR(Boc)-Val-Cit-PAB / Unkown
HY-126671 Mal-Phe-C4-Val-Cit-PAB / Unkown
HY-126674 Mal-Phe-C4-Val-Cit-PAB-DMEA / Unkown
HY-126676 DBCO-(PEG2-Val-Cit-PAB)2 / Unkown
HY-128894 MC-Sq-Cit-PAB-Dolastatin10 / Unkown
HY-130922 BCN-PEG1-Val-Cit-OH / Unkown
HY-130930 Acid-propionylamino-Val-Cit-OH / Unkown
HY-130934 TCO-PEG1-Val-Cit-OH / Unkown
HY-130935 DBCO-Val-Cit-OH / Unkown
HY-130966 TCO-PEG1-Val-Cit-PABC-OH / Unkown
HY-132973 MC-Val-Cit-PAB-NH-C2-NH-Boc ≥95.0% Unkown
HY-133459 Mal-PEG1-Val-Cit-OH / Unkown
HY-136034 Azido-PEG1-Val-Cit-OH / Unkown
HY-136098 DBCO-PEG4-acetic-Val-Cit-PAB 98.21% Unkown
HY-136100 TCO-PEG1-Val-Cit-PABC-PNP / Unkown
HY-136103 DBCO-PEG4-Propionic-Val-Cit-PAB / Unkown
HY-136105 Azido-PEG1-Val-Cit-PABC-PNP / Unkown
HY-136106 Fmoc-Gly3-Val-Cit-PAB ≥98.0% Unkown
HY-136108 Fmoc-Gly3-Val-Cit-PAB-PNP / Unkown
HY-136137 Azide-PEG1-Val-Cit-PABC-OH / Unkown
HY-140144 Mal-PEG1-Val-Cit-PAB-PNP 98.41% Unkown
HY-140146 Mal-amido-PEG2-Val-Cit-PAB-OH / Unkown
HY-140148 Azido-PEG3-Val-Cit-PAB-OH / Unkown
HY-141143 MC(C5)-Val-Cit / Unkown
HY-141144 OPSS-Val-Cit-PAB-OH / Unkown
HY-141145 OPSS-Val-Cit-PAB-PNP / Unkown
HY-147021A MC-D-Val-Cit-PAB-PNP / Unkown
HY-148326 Glu(OtBu)-Val-Cit-PAB-OH / Unkown
HY-151700 6-Azidohexanoyl-Val-Cit-PAB / Unkown
HY-153236 Py-MAA-Val-Cit-PAB-DX8951 / Unkown
HY-153373 4A3-Cit / Unkown
HY-156727 Val-Cit-PABC-Ahx-May / Unkown
HY-156727A Val-Cit-PABC-Ahx-May TFA / Unkown
HY-156896 Val-Cit-amide-Cbz-N(Me)-Maytansine 97.92% Unkown
HY-156897 Val-Cit-amide-Ph-Maytansine 98.01% Unkown
HY-158135 Val-Cit-PAB-DEA-COOH / Unkown
HY-158137 Val-Cit-PAB-DEA-Dxd / Unkown
HY-160756A Val-Cit-Exatecan TFA / Unkown
HY-164303 Val-Cit-PAB-DEA-Duo-DM Inhibitor / Unkown
HY-164309 DBCO-PEG3-Glu-Val-Cit-PABC-MMAE / Unkown
HY-164310 TCO-PEG3-Glu-Val-Cit-PABC-MMAF Inhibitor / Unkown
HY-171159 MC-Val-Cit-PAB-Sunitinib / Unkown
HY-173161 Mc-d-Val-d-Cit-PAB-PNP / Unkown
HY-19318G Fmoc-Val-Cit-PAB (GMP) / Unkown
HY-20336G Mc-Val-Cit-PABC-PNP (GMP) / Unkown
HY-78736G Val-Cit-PAB-OSBT (GMP) / Unkown
HY-78738G MC-Val-Cit-PAB (GMP) / Unkown
HY-P4007 [Pmp1,DTyr(OEt)2,Val4,Cit8] Vasopressin / Unkown
HY-P4810 Polyphemusin II-Derived Peptide Inhibitor / Unkown
HY-P5372 Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Agonist / Unkown
HY-P5836 Citrullinated LL-37 1cit Inhibitor / Unkown
HY-P5837 Citrullinated LL-37 2cit Inhibitor / Unkown
HY-P5838 Citrullinated LL-37 5cit Inhibitor / Unkown
HY-P5842 Citrullinated LL-37 3cit Inhibitor / Unkown
HY-P5843 Citrullinated LL-37 4cit Inhibitor / Unkown
HY-RS02727 CIT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W016733 D-Citrulline / Unkown
HY-W800847 Mal-Amide-PEG4-Val-Cit-PAB-PNP / Unkown
HY-151699 6-Azidohexanoyl-Val-Cit-PAB-PNP / Unkown
HY-151709 N3-L-Cit-OH / Unkown
HY-151709A N3-L-Cit-OH (DCHA) / Unkown
HY-151726 Azido-PEG(4)-Val-Cit-PAB-PNP / Unkown
HY-152919 Mal-amide-PEG8-Val-Cit-PAB-OH / Unkown
HY-160694 cBu-Cit-PROTAC BRD4 Degrader-5 / Unkown
HY-164273 Azidoacetyl-Val-Cit-PAB-OH / Unkown
HY-164275 Alkyne-Val-Cit-PAB-OH / Unkown
HY-172287 DBCO-PEG2-Val-Cit-PAB-MMAE / Unkown
HY-172291 Mal-amide-PEG8-Val-Cit-PAB-PNP / Unkown
HY-W141765 Fmoc-Cit-PAB-OH / Unkown
HY-W190913 DBCO-PEG4-Val-Cit-PAB-PNP / Unkown
HY-W591286 Alkyne-Val-Cit-PAB-PNP / Unkown
HY-W591440 Fmoc-Cit-PAB-PNP / Unkown
HY-W800617 NH2-PEG1-Val-Cit-PAB-OH / Unkown
HY-W800618 NH2-PEG3-Val-Cit-PAB-OH / Unkown
HY-W800619 NH2-PEG4-Val-Cit-PAB-OH / Unkown
HY-W800620 NH2-PEG6-Val-Cit-PAB-OH / Unkown
HY-W800621 Fmoc-PEG2-Val-Cit-PAB-OH / Unkown
HY-W800622 Fmoc-PEG4-Val-Cit-PAB-OH / Unkown
HY-W800623 Fmoc-PEG6-Val-Cit-PAB-OH / Unkown
HY-W800624 Boc-PEG2-Val-Cit-PAB-OH / Unkown
HY-W800625 Boc-PEG4-Val-Cit-PAB-OH / Unkown
HY-W800814 Azido-PEG8-Amido-Val-Cit-PAB / Unkown
HY-W800837 t-Boc-N-amido-PEG4-Val-Cit / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-164154 ADC Control Human IgG1-vcMMAF Inhibitor 98.02% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cit NCBI NCBI:11113
Macaca fascicularis Cit NCBI NCBI:102134813
Mus musculus Cit NCBI NCBI:12704
Macaca mulatta Cit NCBI NCBI:695846