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Results for "

AChE activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Aldehyde Dehydrogenase (ALDH) (1) AMPK (1) Amylases (1) Amyloid-β (19) Antibiotic (2) Apoptosis (13) Autophagy (2) Bacterial (12) Bcl-2 Family (1) Beta-secretase (9) Biochemical Assay Reagents (4) Calcium Channel (2) Cannabinoid Receptor (1) Caspase (2) CDK (1) Chemerin Receptor (1) Cholinesterase (ChE) (169) COX (3) Endogenous Metabolite (8) Enterovirus (2) Epigenetic Reader Domain (1) ERK (4) Ferroptosis (1) Fungal (7) Glycosidase (2) GSK-3 (1) HDAC (3) Histamine Receptor (2) Histone Acetyltransferase (2) HIV (2) iGluR (3) Influenza Virus (2) Insecticide (3) Interleukin Related (1) Isotope-Labeled Compounds (6) JNK (1) Keap1-Nrf2 (7) LOX-1 (1) mAChR (1) Mitochondrial Metabolism (1) MMP (4) Monoamine Oxidase (15) NF-κB (4) NO Synthase (1) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (2) p38 MAPK (2) Parasite (6) Phosphatase (3) Phosphodiesterase (PDE) (1) PKA (2) PPAR (1) Reactive Oxygen Species (ROS) (14) Reference Standards (24) ROS Kinase (2) SOD (1) Tau Protein (2) TNF Receptor (2) Toll-like Receptor (TLR) (1) Topoisomerase (1) β-glucuronidase (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (4) Infection (29) Inflammation/Immunology (37) Metabolic Disease (14) Neurological Disease (142)
Click Chemistry:	Alkynes (3)

186

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4206

Leptomerine	Cholinesterase (ChE)	Neurological Disease
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

HY-N4142

Cyanidin-3-O-galactoside chloride 4 Publications Verification Ideain chloride	Cholinesterase (ChE)	Cardiovascular Disease
Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong *AChE* inhibitory activity .

HY-145112

AChE-IN-3	Cholinesterase (ChE)	Neurological Disease
AChE-IN-3 shows moderate inhibitory activity against *AChE* and strong NO inhibitory activity with an EC₅₀ of 0.57 μM.

HY-N2912

Axillaridine A	Cholinesterase (ChE)	Neurological Disease
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of *AChE* .

HY-152112

AChE/BChE/MAO-B-IN-2	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/BChE/MAO-B-IN-2 is a potent *AChE, BChE, and MAO-B* enzymes inhibitor with IC₅₀ values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively. AChE/BChE/MAO-B-IN-2 has significant antioxidant activity, and can be used for Parkinson’s disease research .

HY-N8764

Decaffeoylacteoside Decaffeoylverbascoside; Verbasoside	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease Cancer
Decaffeoylacteoside is an inhibitor of *AChE/BChE/LOX* with moderate activity .

HY-144324

AChE-IN-6	Cholinesterase (ChE)	Neurological Disease
AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC₅₀ = 0.20 μM; HuAChE, IC₅₀ = 37.02 nM) and anti-Aβ activity (IC₅₀ = 1.92 μM for self-induced Aβ1-42 aggregation; IC₅₀ = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC₅₀ = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC₅₀ = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease .

HY-N4142R

Cyanidin-3-O-galactoside chloride (Standard) Ideain chloride (Standard)	Reference Standards Cholinesterase (ChE)	Cardiovascular Disease
Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

HY-170925

AChE-IN-81	Cholinesterase (ChE) Apoptosis	Neurological Disease
AChE-IN-81 (compound 22) is a potent, irreversible and selective *AChE* inhibitor. AChE-IN-81 inhibits activity on *AChE* with inhibitory rates of 80.0%, with an IC₅₀ of 3.7 μM. AChE-IN-81 binds to *AChE* with a binding affinity (K_d) of 5.37 μM. AChE-IN-81 effectively reduces in zebrafish brain cells. AChE-IN-81 exhibits potential neuroprotective activities on H₂O₂-induced SH-SY5Y cell injury model .

HY-161311

AChE/BChE-IN-18	Cholinesterase (ChE) Cannabinoid Receptor	Neurological Disease
AChE/BChE-IN-18 (Compound 4g) is a *dual inhibitor of AChE/BChE* , with a IC₅₀ value of 0.315 μM for AchE. AChE/BChE-IN-18 is also a CB2R antagonist with a K_i value of 31 nM. AChE/BChE-IN-18 has neuroprotective activity .

HY-159148

AChE-IN-70	Cholinesterase (ChE)	Others
AChE-IN-70 (compound 4) is a *AChE* inhibitor. AChE-IN-70 shows larvicidal activity against mosquito larvae (Culex pipiens L.). and can be used for study of mosquito control .

HY-173263

AChE-IN-86	Cholinesterase (ChE)	Neurological Disease
AChE-IN-86 (Compound 6f) is an inhibitor of enzyme acetylcholinesterase (AChE) with IC₅₀ values of 25.33 μg/mL. AChE-IN-86 exerts inhibitory activity against AChE through forming hydrogen bonds, π-π and π-alkyl interactions with amino acid residues at the key catalytic sites of AChE. AChE-IN-86 can be used for Alzheimer's disease study .

HY-151152

AChE-IN-24	Cholinesterase (ChE)	Neurological Disease
AChE-IN-24 is a potent *AChE* inhibitor and can penetrate the BBB. AChE-IN-24 has the mighty inhibitory activity to hAChE with an IC₅₀ value of 0.053 μM. AChE-IN-24 can be used for the research of Alzheimer s disease (AD) .

HY-162145

AChE-IN-54	Cholinesterase (ChE)	Inflammation/Immunology
AChE-IN-54 (compound 3c) is an inhibitor of acetylcholinesterase (AChE) and has anti-lipid oxidation activity .

HY-149473

AChE-IN-39	Cholinesterase (ChE)	Neurological Disease
AChE-IN-39 (Compound 7c) is an *AChE* inhibitor (IC₅₀: 0.058 μM). AChE-IN-39 has DPPH scavenging activity. AChE-IN-39 improves the cognitive impairment in AlCl₃-induced amnesia animal model. AChE-IN-39 can be used for research of Alzheimer's disease .

HY-161842

AChE-IN-67	Cholinesterase (ChE)	Neurological Disease
AChE-IN-67 (compound 8n) is a potent *AChE* inhibitor, with an IC₅₀ of 0.033 μM. AChE-IN-67 exhibits activity similar to Donepezil (HY-14566). AChE-IN-67 exhibits high blood-brain barrier (BBB) permeability. AChE-IN-67 can be used for Alzheimer's disease research .

HY-N12027

AChE/BChE-IN-14	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

HY-152037

AChE/Nrf2 modulator 1	Cholinesterase (ChE) Keap1-Nrf2	Neurological Disease
AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC₅₀ values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease .

HY-175006

AChE-IN-91	Cholinesterase (ChE)	Neurological Disease
AChE-IN-91 (Compound 8u) is a *AChE* inhibitor with an IC₅₀ of 0.05 μM. AChE-IN-91 has significant anticholinesterase activity, promising for neurological diseases like Alzheimer's disease (AD) research .

HY-B0034

Donepezil Hydrochloride Maximum Cited Publications 21 Publications Verification E2020	Cholinesterase (ChE)	Neurological Disease Cancer
Donepezil Hydrochloride (E2020) is a reversible, selective *AChE* inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-157087

AChE/MAO-B-IN-4	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/MAO-B-IN-4 (compound 4a) is a selective dual *AChE* and MAO-B inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research .

HY-155345

AChE-IN-45	Cholinesterase (ChE)	Neurological Disease Cancer
AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor with IC₅₀ of 11.57±0.45 nM that shows antioxidant and neuroprotective activities .

HY-155022

AChE-IN-30	Cholinesterase (ChE)	Neurological Disease
AChE-IN-30 is an *AChE* inhibitor with an IC₅₀ value of 4.4 μM. AChE-IN-30 has neuroprotective activity, and inhibits H₂O₂-induced apoptosis by suppressing intracellular ROS accumulation. AChE-IN-30 can be used for research of Alzheimer's disease .

HY-174399

AChE/BChE-IN-27	Cholinesterase (ChE) Reactive Oxygen Species (ROS)	Neurological Disease
AChE/BChE-IN-27 is a blood-brain barrier-permeable mixed inhibitor (Pe = 4.12) of *AChE* and BChE, with IC₅₀ values of 3.72 μM and 9.65 μM, respectively. AChE/BChE-IN-27 has potent antioxidant activity with an IC₅₀ value of 6.32 μM in the DPPH (HY-112053) assay and also exhibits potent in vitro antioxidant activity. AChE/BChE-IN-27 exhibits metal chelating properties. AChE/BChE-IN-27 has neuroprotective potential against oxidative stress. AChE/BChE-IN-27 significantly reduces intracellular reactive oxygen species (ROS). In in vivo experiments, AChE/BChE-IN-27 effectively restored *AChE* and BChE levels, improved cognition, and can be used for Alzheimer's disease (AD) .

HY-163537

AChE/BuChE-IN-5	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-5 (compound 5a) is a dual target inhibitor. AChE/BuChE-IN-5 has excellent nanomolar inhibitory activity on acetylcholinesterase (AChE) (IC₅₀=46.9 nM) and butyryl cholinesterase (BuChE) (IC₅₀=3.5 nM). AChE/BuChE-IN-5 can be used for Alzheimer's Disease research .

HY-175658

AChE/BChE-IN-29	Cholinesterase (ChE) Amyloid-β Tau Protein	Neurological Disease
AChE/BChE-IN-29 is an *AChE/BChE* inhibitor. AChE/BChE-IN-29 exhibits balanced dual cholinesterase inhibitory activity with IC₅₀ values of 2.1 μM for Electrophorus electricus AChE (eeAChE) and 6.3 μM for equine serum butyrylcholinesterase (eqBChE). AChE/BChE-IN-29 effectively inhibits amyloid-β (Aβ₄₂) aggregation and tau protein aggregation in E. coli cell models. AChE/BChE-IN-29 can be used for the study of Alzheimer’s disease (AD) .

HY-147939

AChE/BuChE-IN-3	Cholinesterase (ChE) Amyloid-β	Cancer
AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant *AChE* and BuChE dual inhibitor with IC₅₀s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ_1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease .

HY-115973

AChE-IN-11	Cholinesterase (ChE)	Neurological Disease
AChE-IN-11 (compound 5C) is a triple inhibitor targeting *AChE/MAO-B/BACE1* (IC₅₀=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease .

HY-147938

AChE-IN-19	Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE-IN-19 (compound A15) is a highly potent *AChE* inhibitor with an IC₅₀ value of 0.56 μM, also inhibits Aβ aggregation. AChE-IN-19 has potent neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE-IN-19 can be used for researching Alzheimer's disease .

HY-152110

AChE/MAO-IN-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual *AChE/MAO-B* inhibitior with IC₅₀ values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research .

HY-170658

AChE-IN-80	Autophagy Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
AChE-IN-80 (Compound 1) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-80 can inhibit inflammation and the production of reactive oxygen species (ROS) in vitro- cultured neurons and microglia, trigger autophagy responses, and block the propagation of β-amyloid (Aβ) fibrils. AChE-IN-80 possesses antioxidant activity and neuroprotective effects and can be used in the study of Alzheimer's disease .

HY-144392

AChE/BuChE-IN-1	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC₅₀ of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC₅₀ of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ_1-42 aggregation (self-, Cu₂₊-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research .

HY-B0034S

Donepezil-d5 hydrochloride E2020-d₅	Cholinesterase (ChE)	Neurological Disease
Donepezil-d₅ (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-B0034S1

Donepezil-d4 hydrochloride E2020-d₄	Cholinesterase (ChE)	Neurological Disease
Donepezil-d₄ (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-N0804A

Isonaringin	Cholinesterase (ChE)	Neurological Disease
Isonaringin shows anti-Alzheimer’s activity by inhibiting *AChE* .

HY-B0034R

Donepezil Hydrochloride (Standard) E2020 (Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease Cancer
Donepezil (Hydrochloride) (Standard) is the analytical standard of Donepezil (Hydrochloride). This product is intended for research and analytical applications. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-152113

AChE/BChE/MAO-B-IN-3	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC₅₀ of 0.0359 μM for human MAO-B. AChE/BChE/MAO-B-IN-3 is a potent *AChE* and BChE enzyme inhibitor, with IC₅₀s of 0.0473 μM and 0.0782 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-3 shows significant antioxidant activity and has the potential for Alzheimer's disease (AD) research .

HY-152114

AChE/BChE/MAO-B-IN-4	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC₅₀ of 0.0393 μM for human MAO-B. AChE/BChE/MAO-B-IN-4 is a potent *AChE* and BChE enzyme inhibitor, with IC₅₀s of 0.0458 μM and 0.075 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-4 shows significant antioxidant activity and prevent β-amyloid plaque aggregation. AChE/BChE/MAO-B-IN-4 has the potential for Alzheimer's disease (AD) research .

HY-131971

AChE/BChE-IN-1	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC₅₀s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease .

HY-W014700

Glycyl-L-glutamic acid	Cholinesterase (ChE)	Neurological Disease
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of *AChE* content and activity. Glycyl-L-glutamic acid doesn’t act directly on *AChE* synthesis, and may prevent preganglionic neuronal degeneration .

HY-149817

AChE-IN-29	Cholinesterase (ChE)	Neurological Disease
AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC₅₀ values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease .

HY-N1089

Vincosamide	Cholinesterase (ChE)	Inflammation/Immunology
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity .

HY-N2898

Artanin	Cholinesterase (ChE)	Neurological Disease
Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including *AChE* inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with IC₅₀s of 51 μM, 98 μM, and 124 μM, respectively .

HY-159898

AChE/BChE-IN-23	Cholinesterase (ChE) Amyloid-β Tau Protein NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Neurological Disease
AChE/BChE-IN-23 (Compound 6e) is an *AChE/BChE* inhibitor (IC₅₀: 0.91 μM, 1.19 μM and 1.01 μM for hAChE, eq BChE and hBChE, respectively). AChE/BChE-IN-23 has antioxidant activity and inhibits Aβ1-42 and Tau protein aggregation. AChE/BChE-IN-23 also inhibits microglial activation by reducing ROS release and mitochondrial injury. AChE/BChE-IN-23 suppresses NLRP3 inflammasome and pro-inflammatory cytokines in human microglial cells. AChE/BChE-IN-23 also reverses the Scopolamine (HY-N0296)-induced memory impairment in mice model .

HY-N8755

Chikusetsusaponin Ib	Cholinesterase (ChE)	Neurological Disease
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent *AChE* inhibitor .

HY-N0810

Timosaponin AIII 1 Publications Verification	Cholinesterase (ChE)	Neurological Disease Cancer
Timosaponin AIII could inhibit acetylcholinesterase *(AChE)* activity, with an IC₅₀ of 35.4 μM.

HY-147658

AChE/BChE/BACE-1-IN-1	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of *AChE, BChE, and BACE-1* with IC₅₀ values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential .

HY-147659

AChE/BChE/BACE-1-IN-2	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of *AChE, BChE, and BACE-1* with IC₅₀ values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential .

HY-170561

AChE/BuChE-IN-6	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of *AChE* and BuChE, with IC₅₀ values of 1.24 and 1.85 μg/mL, respectively. AChE/BuChE-IN-6 also exhibits strong DPPH free radical scavenging activity (IC₅₀ = 3.15 μg/mL). In vivo toxicity studies indicate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical markers compared to the control group after long-term administration, and no abnormalities were observed in liver and kidney tissues. AChE/BuChE-IN-6 holds promise for research into Alzheimer's disease .

HY-168731

AChE/BChE-IN-25	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-25 (Compound 6e) is the orally active inhibitor for hAChE and eqBChE with IC₅₀ of 7.9 nM and 0.79 nM. AChE/BChE-IN-25 exhibits antioxidant activity, that scavenges free radical with IC₅₀ of 22.91 μM. AChE/BChE-IN-25 exhibits neuroprotective effects by reducing mitochondrial and cellular oxidative stress in the Drosophila Alzheimer's disease model. AChE/BChE-IN-25 ameliorates Scopolamine (HY-N0296)-induced spatial and cognitive memory impairment in mouse model .

Cat. No.	Product Name	Type

HY-W127493

1-Hexacosanol Ceryl Alcohol	Cell Assay Reagents
1-Hexacosanol can be used as an inhibitor of acetylcholinesterase (AChE). 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

HY-30139

4-Amino-2-chloropyrimidine	Biochemical Assay Reagents
4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for *AChE* (K_i = 0.18 μM) and BChE (K_i = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC₅₀ = 0.037 μM, K_i = 0.047 μM) in vitro .

HY-W127493R

1-Hexacosanol (Standard)

Ceryl Alcohol (Standard)

Cell Assay Reagents

1-Hexacosanol (Standard) is the analytical standard of 1-Hexacosanol. This product is intended for research and analytical applications. 1-Hexacosanol can be used as an inhibitor of acetylcholinesterase (AChE). 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects.

Cat. No.	Product Name	Target	Research Area

HY-W014700

Glycyl-L-glutamic acid	Cholinesterase (ChE)	Neurological Disease
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of *AChE* content and activity. Glycyl-L-glutamic acid doesn’t act directly on *AChE* synthesis, and may prevent preganglionic neuronal degeneration .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4206

Leptomerine	Alkaloids other families Source classification Quinoline Alkaloids Plants	Cholinesterase (ChE)
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

HY-N4142

Cyanidin-3-O-galactoside chloride 4 Publications Verification Ideain chloride	Cardiovascular Disease Structural Classification Anthocyans Flavonoids Classification of Application Fields Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Disease Research Fields	Cholinesterase (ChE)
Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong *AChE* inhibitory activity .

HY-N1089

Vincosamide	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Source classification Rubiaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Cholinesterase (ChE)
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity .

HY-N2912

Axillaridine A	Structural Classification Buxaceae Terpenoids Source classification Diterpenoids Sarcococca hookeriana Baill. Sarcococca hookeriana var. digyna Franch. Plants	Cholinesterase (ChE)
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of *AChE* .

HY-N8764

Decaffeoylacteoside Decaffeoylverbascoside; Verbasoside	Structural Classification Labiatae Source classification Phenols Polyphenols Plants Ambrosia hispida	Monoamine Oxidase Cholinesterase (ChE)
Decaffeoylacteoside is an inhibitor of *AChE/BChE/LOX* with moderate activity .

HY-N4142R

Cyanidin-3-O-galactoside chloride (Standard) Ideain chloride (Standard)	Structural Classification Anthocyans Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants	Reference Standards Cholinesterase (ChE)
Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

HY-N12027

AChE/BChE-IN-14	Structural Classification Alkaloids Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Isoquinoline Alkaloids	Cholinesterase (ChE)
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

HY-N0804A

Isonaringin	Citrus × aurantium Linnaeus Flavonoids Flavonones Source classification Rutaceae Phenols Polyphenols Plants	Cholinesterase (ChE)
Isonaringin shows anti-Alzheimer’s activity by inhibiting *AChE* .

HY-N2898

Artanin	Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Coumarins Phenylpropanoids Plants	Cholinesterase (ChE)
Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including *AChE* inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with IC₅₀s of 51 μM, 98 μM, and 124 μM, respectively .

HY-N8755

Chikusetsusaponin Ib	Triterpenes other families Terpenoids Source classification Plants	Cholinesterase (ChE)
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent *AChE* inhibitor .

HY-N0810

Timosaponin AIII 1 Publications Verification	Structural Classification Liliaceae Neurological Disease Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids Cancer	Cholinesterase (ChE)
Timosaponin AIII could inhibit acetylcholinesterase *(AChE)* activity, with an IC₅₀ of 35.4 μM.

HY-N7993

Manghaslin	Flavonols Structural Classification Flavonoids Cactaceae Classification of Application Fields Opuntia dillenii (Ker Gawl.) Haw. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE)
Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against *AChE* with an IC₅₀ of 94.92 μM .

HY-123887

Manumycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Cholinesterase (ChE)
Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC₅₀ of 15 mM .

HY-N9513

Echimidine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Plants Boraginaceae Echium vulgare L.	Cholinesterase (ChE)
Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC_{50=0.347 mM) .}

HY-N2511

Trimyristin	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N13925

Arisugacin E	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Arisugacin E, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin E shows no activity against AChE .

HY-N13927

Arisugacin G	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Cholinesterase (ChE)
Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE .

HY-N0825

Nodakenin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Bidens parviflora Willd.	Cholinesterase (ChE)
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase *(AChE)* activity with an IC₅₀ of 84.7 μM .

HY-N13928

Arisugacin H	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Arisugacin H, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin H shows no activity against AChE .

HY-N13926

Arisugacin F	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Arisugacin F, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin F shows no activity against AChE .

HY-N0804AR

Isonaringin (Standard)	Structural Classification Citrus × aurantium Linnaeus Flavonoids Flavonones Source classification Rutaceae Phenols Polyphenols Plants	Reference Standards Cholinesterase (ChE)
Isonaringin (Standard) is the analytical standard of Isonaringin. This product is intended for research and analytical applications. Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE .

HY-N0826

Corynoline 5 Publications Verification	Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Cholinesterase (ChE) Keap1-Nrf2
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating Nrf2 .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Structural Classification Natural Products Verbenaceae Source classification Plants Endogenous metabolite Lantana camaraLinn.	Cholinesterase (ChE) Endogenous Metabolite Parasite
Coumaran (2,3-Dihydrobenzofuran) is an *AChE* inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N6895

Violanthin	Structural Classification Classification of Application Fields Flavones Source classification Plants Dendrobium officinale Kimura et Migo Flavonoids other families Orchidaceae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE)
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 79.80 μM .

HY-N2511R

Trimyristin (Standard)	Structural Classification Natural Products Microorganisms Source classification Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite	Reference Standards Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-134006

Stemoninine	Structural Classification Alkaloids Stichoneuron halabalensis Stemonaceae Other Alkaloids Source classification Plants	Cholinesterase (ChE)
Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC₅₀=5.52 μM) .

HY-W009708R

Bis(2-methyl-3-furyl)disulfide (Standard)	Structural Classification Natural Products Microorganisms Animals Source classification	Biochemical Assay Reagents Reference Standards
Timosaponin AIII (Standard) is the analytical standard of Timosaponin AIII. This product is intended for research and analytical applications. Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.

HY-N0810R

Timosaponin AIII (Standard)	Structural Classification Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants Steroids	Reference Standards Cholinesterase (ChE)
Timosaponin AIII (Standard) is the analytical standard of Timosaponin AIII. This product is intended for research and analytical applications. Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.

HY-N4191

Isorosmanol 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Source classification Phenols Polyphenols Diterpenoids Plants Disease Research Fields	Cholinesterase (ChE)
Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits *AChE* activity and melanin synthesis .

HY-N12075

Dehydrodiscretamine chloride	Structural Classification Alkaloids Piperidine Alkaloids Nandina domestica Thunb. Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Berberidaceae	Cholinesterase (ChE)
Dehydrodiscretamine chloride is a dual inhibitor of *AChE* and BChE with IC₅₀s of 17.8 and 118.8 μM, respectively. Dehydrodiscretamine chloride has antioxidant activity. Dehydrodiscretamine chloride can be used in study Alzheimer’s disease .

HY-127087

Isogarcinol Cambogin	Structural Classification Source classification Guttiferae Phenols Polyphenols Plants Symphonia globulifera L.f.	Cholinesterase (ChE) Parasite
Isogarcinol (Cambogin) is a potent *AChE* and BChE inhibitor, with IC₅₀ values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC₅₀ of 0.33 μM against L. donovani .

HY-N6894

Pseudocoptisine acetate Isocoptisine acetate	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology	Cholinesterase (ChE)
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects .

HY-N6894A

Pseudocoptisine chloride Isocoptisine chloride	Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae Corydalis turtschaninovii Bess.	Cholinesterase (ChE)
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects .

HY-N4119

Neoeriocitrin	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Cholinesterase (ChE)
Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor .

HY-N0825R

Nodakenin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Plants Bidens parviflora Willd.	Reference Standards Cholinesterase (ChE)
Nodakenin (Standard) is the analytical standard of Nodakenin. This product is intended for research and analytical applications. Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-75247R

Coumaran (Standard)	Structural Classification Natural Products Verbenaceae Source classification Plants Endogenous metabolite Lantana camaraLinn.	Cholinesterase (ChE) Endogenous Metabolite Parasite
Coumaran (Standard) is the analytical standard of Coumaran. This product is intended for research and analytical applications. Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N8290

Lactupicrin Lactucopicrin	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Source classification Phenols Plants Compositae	LOX-1 NF-κB Cholinesterase (ChE) Parasite
Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-N0826R

Corynoline (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids	Reference Standards Cholinesterase (ChE) Keap1-Nrf2
Corynoline (Standard) is the analytical standard of Corynoline. This product is intended for research and analytical applications. Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating Nrf2 .

HY-N9928

Echinenone	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Cholinesterase (ChE)
Echinenone is an acetylcholinesterase (AChE) inhibitor (IC₅₀=16.29 μg/mL) with anti-Aβ(25-35) activity. Echinenone can inhibit MDA content and increase superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities to cope with oxidative stress damage .

HY-W750970

2-Acetoxyacorenone	Structural Classification Natural Products Araceae Source classification Acorus gramineus Soland. Plants	Beta-secretase Cholinesterase (ChE)
2-Acetoxyacorenone (compound 8) is a sesquiterpenoid, which can be isolated from the rhizome of Acorus tatarinowii. 2-Acetoxyacorenone has potent *AChE* and β-BACE1 inhibitory activity and can be used in the study of Alzheimer's disease .

HY-N8376

Fustin (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone	Flavanonols Flavonoids Source classification Plants Rhus glabra L. Anacardiaceae	Amyloid-β mAChR Cholinesterase (ChE)
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .

HY-N3185

N-Methylcalycinine	Structural Classification Alkaloids Other Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Cholinesterase (ChE)
N-Methylcalycinine is a nature product with AChE inhibitory activity. N-Methylcalycinine can be isolated from the roots of Stephania epigaea. N-Methylcalycinine can be used for the research of asthma, cancer, dysentery, fever, hyperglycemia, intestinal complaints, inflammation, sleep disturbances, tuberculosis and so on .

HY-W742564

Acacetin-7-O-β-D-galactopyranoside	Structural Classification Flavonoids Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae	Cholinesterase (ChE)
Acacetin-7-O-β-D-galactopyranoside is a flavonoid that can be isolated from flower heads of Chrysanthemum morifolium. Acacetin-7-O-β-D-galactopyranoside inhibits *AChE* activity and can be used for research of Alzheimer’s disease .

HY-N15710

Magnotriol B	Structural Classification Magnoliaceae Source classification Houpoea officinalis (Rehder & E. H. Wilson) N. H. Xia & C. Y. Wu Phenols Polyphenols Plants	Cholinesterase (ChE)
Magnotriol B is a cholinesterase inhibitor with IC₅₀ values of 12.63 nM and 14.5 nM against *AChE* and BChE, respectively. Magnotriol B also exhibits significant NO inhibitory activity with an IC₅₀ of 2.02 μM. Magnotriol B can be used in the research of neurodegenerative and inflammatory diseases .

HY-N0528

Linarin 1 Publications Verification Buddleoside; Linarine	Structural Classification Flavonoids Flavones Labiatae Source classification Erythrina poeppigiana Plants	TNF Receptor Cholinesterase (ChE) PKA Apoptosis Bacterial HIV Influenza Virus
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer .

HY-N4119R

Neoeriocitrin (Standard)	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Reference Standards Cholinesterase (ChE)
Neoeriocitrin (Standard) is the analytical standard of Neoeriocitrin. This product is intended for research and analytical applications. Neoeriocitrin, isolated from Drynaria Rhizome,?shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor .

HY-107805

Dihydroactinidiolide	Infection Structural Classification Microorganisms Iridoids Zantedeschia aethiopica (Linn.) Spreng. Neurological Disease Classification of Application Fields Araceae Terpenoids Source classification Plants Disease Research Fields	Cholinesterase (ChE) Bacterial
Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis. Dihydroactinidiolide has antioxidant activity, antibacterial activity, anticancer activity and neuroprotective effect . Dihydroactinidiolide is also an inhibitor of *AChE* (IC50=34.03 nM) and has scavenging activities for DPPH and (.NO). Dihydroactinidiolide is present in plant leaves and fruits and is a potent plant growth inhibitor, regulator of gene expression, and responsible for light adaptation in Arabidopsis.

HY-N2925

β-Amyrone β-Amyron	Triterpenes Structural Classification Caprifoliaceae Source classification Plants Sambucus adnata Wall. ex DC.	Fungal COX PPAR
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity .

HY-N8290R

Lactupicrin (Standard) Lactucopicrin (Standard)	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Source classification Phenols Plants Compositae	Autophagy NF-κB AMPK Reference Standards
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-119609

Ilicicolin C	Structural Classification Microorganisms Antibiotics Source classification	Bacterial Cholinesterase (ChE) β-glucuronidase
Ilicicolin C exhibits antibacterial activity against Pseudomonas syringae with IC₅₀ of 28.5 µg/mL. Ilicicolin C exhibits weak inhibitory activities against acetylcholinesterase (AChE) and β-glucuronidase with IC₅₀ of 30-43 µg/mL. Ilicicolin C exhibits weak cytoxicity in human lung fibroblasts with IC₅₀ of 64-120 µg/mL. Ilicicolin C affects seed germination and root tip growth of lettuce .

Cat. No.	Product Name	Chemical Structure

HY-B0034S

Donepezil-d5 hydrochloride
Donepezil-d₅ (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-B0034S1

Donepezil-d4 hydrochloride
Donepezil-d₄ (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-135761S

Penconazole-d7
Penconazole-d₇ is the deuterium labeled Penconazole . Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats .

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-132409S

Monocrotophos-d6
Monocrotophos-d₆ is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons .

HY-105853S

Pitofenone-d4
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-B0916S

Propoxur-d3

Propoxur-d₃ is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

HY-B0949AS

Protriptyline-d3
Protriptyline-d₃ is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits *AChE* activity with an IC₅₀ value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease .

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

Cat. No.	Product Name		Classification

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride		Alkynes
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and *AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities*. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate		Alkynes
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and *AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities*. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399

Ladostigil TV-3326		Alkynes
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and *AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities*. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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