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Fluorescent substrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fluorescent Dye (85) 5-HT Receptor (1) Adrenergic Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Beta-secretase (2) Biochemical Assay Reagents (13) Carboxylesterase (1) Caspase (6) Cathepsin (4) Cytochrome P450 (3) DNA Stain (3) DNA/RNA Synthesis (2) Endogenous Metabolite (3) Glucosidase (1) HDAC (1) HIV (1) Isotope-Labeled Compounds (2) MAGL (1) MetAP (1) MMP (5) Monoamine Oxidase (2) Monoamine Transporter (2) Parasite (1) Phospholipase (2) PSMA (1) Ser/Thr Protease (1) Thrombin (1) Transthyretin (TTR) (1) UGT (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (6)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Cap Analogs (2)

142

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Fluorescent Dye MARCKS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3949

Fluorescent Substrate for Glu-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .

HY-129096

IDT307	Fluorescent Dye	Others
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-137834

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dye	Others
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

HY-137845

4-Methylumbelliferyl β-D-galactopyranoside 1 Publications Verification	Fluorescent Dye	Others
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer .

HY-P3948

Fluorescent Substrate for Pro-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .

HY-P3947

Fluorescent Substrate for Subtillsin	Ser/Thr Protease	Infection
Fluorescent Substrate for Subtillsin can be used to detect the enzyme activity of subtillsin. Subtilisin is a bacterial serine protease .

HY-P3950

Fluorescent Substrate for Asp-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond .

HY-P3951

**Fluorescent HIV Substrate**	Fluorescent Dye HIV	Others
Fluorescent HIV Substrate is a HIV substrate.

HY-P10450

(Asp)2-Rhodamine 110 D2R; (D)2-Rhodamine 110	Caspase	Others
(Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .

HY-W040116

MUF-diNAG 4-Methylumbelliferyl N,N-diacetyl-β-D-chitobioside	Biochemical Assay Reagents	Others
MUF-diNAG (4-Methylumbelliferyl N,N-diacetyl-β-D-chitobioside) can be used as a fluorescent substrate. MUF-diNAG is a kind of biological materials or organic compounds that are widely used in life science research .

HY-P4465

Gly-Arg-pNA	Fluorescent Dye	Others
Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .

HY-129887

Fluorescein diphosphate tetraammonium	Fluorescent Dye	Others
Fluorescein diphosphate tetraammonium is a fluorescent dye, it can be used as a fluorogenic substrate and generats fluorescein as a fluorescent product .

HY-P4417

Ac-IEPD-AMC	Fluorescent Dye	Others
Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .

HY-P10615

Abz-YGGRASDQ-EDDnp	Fluorescent Dye Transthyretin (TTR)	Others
Abz-YGGRASDQ-EDDnp is a fluorescent substrate of transthyretin (TTR) protein and is used to detect the hydrolytic activity of TTR protein .

HY-141575

C12-NBD-ceramide	Fluorescent Dye	Others
C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

HY-P4417A

Ac-IEPD-AMC TFA	Fluorescent Dye	Others
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .

HY-P4323

Boc-Gln-Arg-Arg-AMC	Fluorescent Dye	Others
Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .

HY-P4408

Ac-Arg-Gly-Lys-AMC	Fluorescent Dye	Others
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .

HY-P4323A

Boc-Gln-Arg-Arg-AMC acetate	Fluorescent Dye	Others
Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .

HY-D1342

Coumberol	Fluorescent Dye	Cancer
Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3 .

HY-P4416

Ac-Gly-Ala-Lys(Ac)-AMC	Fluorescent Dye	Others
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .

HY-P4419

Boc-Asp(OBzl)-Pro-Arg-AMC	Fluorescent Dye	Others
Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .

HY-W345102

4-Methylumbelliferyl β-cellotrioside	Fluorescent Dye	Metabolic Disease
4-Methylumbelliferyl β-cellotrioside, a chromogenic substrate for β-glycosidases, is a cellulose fluorescent derivative .

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dye	Others
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P3791

N-Succinyl-Ile-Ile-Trp-AMC	Fluorescent Dye	Others
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .

HY-P4400

Z-VDVAD-AFC	Fluorescent Dye	Others
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .

HY-P4406

Abz-AGLA-Nba	Fluorescent Dye	Others
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-141577

C12-NBD Sphinganine	Biochemical Assay Reagents	Others
C12-NBD Sphinganine is a fluorescent ceramidase substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources .

HY-D1678

5(6)-Carboxynaphthofluorescein diacetate	Fluorescent Dye	Others
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .

HY-P10144

Ac-Orn-Phe-Arg-AMC	Fluorescent Dye	Others
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .

HY-113862

PHOME	Fluorescent Dye	Others
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-148073

MeO-Succ-Arg-Pro-Tyr-AMC	Fluorescent Dye	Others
MeO-Succ-Arg-Pro-Tyr-AMC is an analogue of 7-amido-4-methylcoumarin (HY-D0027). MeO-Succ-Arg-Pro-Tyr-AMC is a sensitive fluorescent substrate chymotrypsin-like protease. (λ_ex=341 nm, λ_em=441 nm).

HY-157744

Coumarin–quinone conjugate	Others	Cancer
Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific **fluorescent substrate**. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-W030319

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate	Fluorescent Dye	Others
Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection .

HY-P2615A

Ac-VDVAD-AFC TFA	Fluorescent Dye	Cancer
Ac-VDVAD-AFC TFA is a caspase-specific **fluorescent substrate**. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-W927376

Boc-Val-Arg-AMC	Fluorescent Dye	Others
Boc-Val-Arg-AMC is a synthetic peptide compound. As a specific fluorescent substrate, Boc-Val-Arg-AMC can be specifically cleaved by specific enzymes, especially thrombin, to release a fluorescent molecule AMC (7-amino-4-methylcoumarin), which can be used to monitor thrombin activity. Boc-Val-Arg-AMC can be used to detect thrombin activity in plasma samples .

HY-118155

9-Amino-6-chloro-2-methoxyacridine	Fluorescent Dye	Others
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H ⁺/solute antiport system .

HY-123633

4-Methylumbelliferyl β-D-Glucopyranoside	Glucosidase	Others
4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity . 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively .

HY-P10174

ADAM-17 Substrate	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-D1685

BZiPAR	Fluorescent Dye	Others
BZiPAR is a fluorescent probe. BZiPAR also is a substrate of trypsin that becomes fluorescent after cleavage by the protease .

HY-P4931

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	MMP	Cancer
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate is a prostate specific antigen (PSA) fluorescent substrate. Prostate Specific Antigen Substrate can be used for detect enzymatic activity of PSA .

HY-P4401

Z-VEID-AFC	Caspase	Others
Z-VEID-AFC is a fluorescent substrate for caspase-6 .

HY-D1740

Dihydrotetramethylrosamine DHTM Ros	Fluorescent Dye	Others
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.

HY-W019823

4-MUNANA	Fluorescent Dye	Infection Neurological Disease
4-MUNANA is a fluorescent substrate used for neuraminidase activity assay .

HY-P4344

Met-Gly-Pro-AMC	MetAP	Others
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .

Cat. No.	Product Name	Type

HY-129096

IDT307	Chromogenic Substrates
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-137834

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dyes/Probes
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

HY-137845

4-Methylumbelliferyl β-D-galactopyranoside 1 Publications Verification	Fluorescent Dyes/Probes
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer .

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dyes/Probes
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .

HY-129887

Fluorescein diphosphate tetraammonium	Fluorescent Dyes/Probes
Fluorescein diphosphate tetraammonium is a fluorescent dye, it can be used as a fluorogenic substrate and generats fluorescein as a fluorescent product .

HY-141575

C12-NBD-ceramide	Fluorescent Dyes/Probes
C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

HY-W345102

4-Methylumbelliferyl β-cellotrioside	Chromogenic Substrates
4-Methylumbelliferyl β-cellotrioside, a chromogenic substrate for β-glycosidases, is a cellulose fluorescent derivative .

HY-P2065

Ac-VEID-AMC	Fluorescent Dyes/Probes
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P3791

N-Succinyl-Ile-Ile-Trp-AMC	Fluorescent Dyes/Probes
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .

HY-141577

C12-NBD Sphinganine	Dyes
C12-NBD Sphinganine is a fluorescent ceramidase substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources .

HY-D1678

5(6)-Carboxynaphthofluorescein diacetate	Fluorescent Dyes/Probes
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .

HY-113862

PHOME	Dyes
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) .

HY-148073

MeO-Succ-Arg-Pro-Tyr-AMC	Chromogenic Substrates
MeO-Succ-Arg-Pro-Tyr-AMC is an analogue of 7-amido-4-methylcoumarin (HY-D0027). MeO-Succ-Arg-Pro-Tyr-AMC is a sensitive fluorescent substrate chymotrypsin-like protease. (λ_ex=341 nm, λ_em=441 nm).

HY-118155

9-Amino-6-chloro-2-methoxyacridine	Fluorescent Dyes/Probes
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H ⁺/solute antiport system .

HY-D1740

Dihydrotetramethylrosamine DHTM Ros	Fluorescent Dyes/Probes
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.

HY-W019823

4-MUNANA	Fluorescent Dyes/Probes
4-MUNANA is a fluorescent substrate used for neuraminidase activity assay .

HY-D2205

Cy7 tyramide Cy7 TSA	Fluorescent Dyes/Probes
Cy7 tyramide, a red fluorescent dye, is utilized as reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition that is signal amplification technique in immunoassay and in situ hybridization of nucleic acids.

HY-D1529

4-Methylumbelliferyl phosphate (2-amino-2-methyl-1,3-propanediol)	Fluorescent Dyes/Probes
4-Methylumbelliferyl phosphate (2-amino-2-methyl-1,3-propanediol) is a fluorescent substrate, can be used as substrate buffer of enzyme assay .

HY-D0149

4-(Trifluoromethyl)umbelliferone	Fluorescent Dyes/Probes
4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes .

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Chromogenic Substrates
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-D1582

C12 NBD Phytoceramide	Chromogenic Substrates
C12 NBD Phytoceramide, a ceramide analogue, is a fluorescent substrate, can be used to detect ceramidase activity .

HY-137834A

Gly-Pro-AMC	Fluorescent Dyes/Probes
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)

HY-D0091

7-Ethoxy-4-trifluoromethylcoumarin	Fluorescent Dyes/Probes
7-Ethoxy-4-trifluoromethylcoumarin is a fluorescent substrate of various enzymes of the cytochrome P450 superfamily

HY-136247

Cyanine 5 Tyramide Tyramide-Cy5	Fluorescent Dyes/Probes
Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, is utilized as reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition that is signal amplification technique in immunoassay and in situ hybridization of nucleic acids .

HY-D1699

PFB-FDG	Fluorescent Dyes/Probes
PFB-FDG is a non-fluorescent galactosidase substrate that can be hydrolysed to green fluorescent PFB-F (Ex=485 nm, Em=535 nm). PFB-FDG can be used for the determination of β-galactosidase activity .

HY-136248

Cyanine 3 Tyramide Tyramide-Cy3	Fluorescent Dyes/Probes
Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, is utilized as reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition that is signal amplification technique in immunoassay and in situ hybridization of nucleic acids .

HY-D0055

3-Cyano-7-ethoxycoumarin	Chromogenic Substrates
3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage Target: Cytochrome P450 3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies.

HY-136248A

Cyanine 3 Tyramide methyl indole	Fluorescent Dyes/Probes
Cyanine 3 Tyramide methyl indole is a derivative of Cyanine 3 Tyramide (HY-136248). Cyanine 3 Tyramide is an orange fluorescent dye, and is utilized as reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition that is signal amplification technique in immunoassay and in situ hybridization of nucleic acids .

HY-D1532

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS	Fluorescent Dyes/Probes
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

HY-D1609

BODIPY FL Verapamil hydrochloride	Dyes
BODIPY FL Verapamil hydrochloride is a fluorescent dye, it can be used as a molecular probe to label tissues and cells. BODIPY FL Verapamil hydrochloride is a substrate for both ABCB1 and ABCC1 .

HY-D1577

C6 NBD Lactosylceramide	Fluorescent Dyes/Probes
C6 NBD Lactosylceramide is a derivative of lactosylceramides, and can be used in lactosylceramide synthase assay as a fluorescent acceptor substrate. C6 NBD Lactosylceramide can also be used in cancer research .

HY-W027544

MCA	Fluorescent Dyes/Probes
MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .

HY-121941

Epoxy Fluor 7	Fluorescent Dyes/Probes
Epoxy Fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used for human and mouse enzymes. Epoxy Fluor 7 is hydrolyzed to yield fluorescence used for monitoring the activity of sEH.

HY-110210

BODIPY-FL NHS ester BODIPY FL,SE	Fluorescent Dyes/Probes
BODIPY-FL NHS ester (BODIPY FL, SE) is an amine-reactive fluorescent probe. The maximum excitation/emission values are 502/511 nm. BODIPY-FL NHS ester can be used to synthesize protease substrates .

HY-D1523

Z-Arg-Arg-4MβNA triacetate	Fluorescent Dyes/Probes
Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λ_ex = 355 nm, λ_em = 430 nm) .

HY-120649

SKM 4-45-1	Fluorescent Dyes/Probes
SKM 4-45-1 is an analog of Anandamide (AEA)(HY-10863). SKM 4-45-1 is a fluorescent substrate, that can be used to study the transmembrane carrier-mediated transport of AEA across cell membranes .

HY-137928

H-Ala-4MβNA hydrochloride	Fluorescent Dyes/Probes
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dyes/Probes
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-W277900

2-Methoxy-2,4-diphenylfuran-3-one	Fluorescent Dyes/Probes
2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading MMP-2 and MMP-9 by zymography .

HY-P3749

Mca-(ala7,lys(dnp)9)-bradykinin	Fluorescent Dyes/Probes
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .

HY-D1670

Z-Gly-Pro-AMC	Chromogenic Substrates
Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-amido-4-methylcoumarin (HY-D0027). (λ_ex=380 nm, λ_em=465 nm) .

HY-P3110

Ac-DNLD-AMC	Dyes
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

HY-D2335

SERTlight

Dyes

SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB_5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems .

HY-D1584

C12 NBD Sphingomyelin	Fluorescent Dyes/Probes
C12 NBD sphingomyelin is an active derivative of sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm) .

HY-D1575

C6 NBD Galactosylceramide	Dyes
C6 NBD galactosylceramide is an active derivative of galactosylceramide that is tagged with fluorescent C6 nitrobenzoxadiazole (C6 NBD). C6 NBD galactosylceramide can be used as a substrate for neutral β-glycosylceramidase (GCase) to study intracellular localization and metabolism of galactosylceramide (Ex=nm, Em=525) .

HY-126839

C12FDG 5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside	Fluorescent Dyes/Probes
C12FDG (5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside) is a lipophilic green fluorescent substrate for β-galactosidase detection. C12-FDG is more sensitive than FDG (HY-101895) for beta-galactosidase activity determinations in animal cells .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Chromogenic Substrates
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-D1739

DDAO phosphate diammonium	Fluorescent Dyes/Probes
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.

HY-137858

H-Gly-Arg-pNA hydrochloride Gly-Arg-4-NA hydrochloride; GR-pNA hydrochloride; GR p-itoailide hydrochloride	Dyes
H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity .

HY-124324

4-Nitrophenyl β-D-cellotrioside p-Nitopheyl β-D-cellotioside	Fluorescent Dyes/Probes
4-Nitrophenyl β-D-cellotrioside (p-Nitopheyl β-D-cellotioside) is a chromogenic substrate for endoglucanases and cellulose biohydrolases. As a fluorescent dye, nitrophenyl β-D-Cellotrioside can be hydrolyzed by enzymes to release 4-nitrophenol, producing a yellow color. The activity of the enzyme can be quantitatively analyzed by monitoring the change in absorbance at 405 nm .

Cat. No.	Product Name	Type

HY-W009122

4-Methylumbelliferyl-α-d-mannoside 4-Methylumbelliferyl-alpha-d-mannoside	Carbohydrates
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase.

HY-137855

4-Methylumbelliferyl sulfate potassium

Enzyme Substrates

4-Methylumbelliferyl sulfate (potassium), a fluorescent substrate, is commonly used to detect sulfatase activity in biochemical and biomedical research. It consists of a sulfate group attached to a fluorescent molecule, which can be cleaved by sulfatase enzymes. Upon cleavage, 4-Methylumbelliferyl sulfate releases a highly fluorescent product that can be detected using fluorescence microscopy or spectroscopy. The use of 4-Methylumbelliferyl sulfate as a substrate for sulfatase enzymes allows accurate detection and quantification of these enzymes in a variety of biological samples.

HY-W040116

MUF-diNAG 4-Methylumbelliferyl N,N-diacetyl-β-D-chitobioside	Enzyme Substrates
MUF-diNAG (4-Methylumbelliferyl N,N-diacetyl-β-D-chitobioside) can be used as a fluorescent substrate. MUF-diNAG is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W283888

5-Bromo-4-chloro-1H-indol-3-yl nonanoate	Cell Assay Reagents
5-Bromo-4-chloro-1H-indol-3-yl nonanoate is a fluorescent substrate used to detect enzymes. The substrate reacts with various enzymes to produce a fluorescent product, which has been shown to be active against β-galactosidase, α-chymotrypsin, and β-glucuronidase.

HY-137828

4-Nitrophenyl N,N′-diacetyl-β-D-chitobioside pNP-chitobiose	Carbohydrates
4-Nitrophenyl N,N′-diacetyl-β-D-chitobioside (pNP-chitobiose) is a fluorescent substrate that can be used to detect chitinase activity.

HY-137785

2-Chloro-4-nitrophenyl-β-D-maltotrioside	Cell Assay Reagents
2-Chloro-4-nitrophenyl-β-D-maltotrioside is a chromogenic substrate used in bioluminescent and fluorescent assays to detect α-amylase.

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA	Gene Sequencing and Synthesis
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog .

HY-W394025

Biotinyl-6-aminoquinoline	Biochemical Assay Reagents
Biotinyl-6-aminoquinoline is a fluorescent biotinylated biochemical assay reagent, which can be utilized as a substrate in the assay of biotinidase activity. Biotinyl-6-aminoquinoline exhibits an excitation wanelength of 350 nm and an emission wavelength of 550 nm .

HY-W750190

L-Arginine 7-amido-4-methylcoumarin dihydrochloride

Enzyme Substrates

L-Arginine 7-amido-4-methylcoumarin dihydrochloride is a special fluorescent substrate with the potential to be used for detecting cathepsin H activity. L-Arginine 7-amido-4-methylcoumarin dihydrochloride can be used to provide highly sensitive fluorescent signals for biological research. L-Arginine 7-amido-4-methylcoumarin dihydrochloride has important applications in enzyme activity analysis.

HY-W777429

Ceratamine B	Cell Assay Reagents
Ceratamine B is a fluorescent substrate with significant biological activity and can be used for cell imaging and biolabeling. Ceratamine B can effectively penetrate cell membranes, facilitating the study of cellular processes. Ceratamine B also shows broad application potential in compound screening and biosensor development.

HY-W699926

(R)-Naproxen acyl-β-D-glucuronide (R)-Naproxen-β-D-glucuronide	Cell Assay Reagents
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.

HY-W928283

L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride

Enzyme Substrates

L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride is a fluorescent substrate with biological activity for enzyme activity detection. L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride is often used in biochemical research to detect reactions associated with specific enzymes. L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride helps scientists monitor the progress of reactions through its fluorescent properties. L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride has important application value in compound development and basic biological research.

HY-137249

Resorufin-β-D-galactopyranoside

Enzyme Substrates

Resorufin-β-D-galactopyranoside is a commonly used substrate in various biochemical assays to measure the activity of β-galactosidase, an important enzyme involved in lactose metabolism and regulation of gene expression. Resorufin-β-D-galactopyranoside has unique chemical properties and can be hydrolyzed by β-galactosidase to form a red fluorescent product called resorufin. This makes it a useful tool for detecting and quantifying β-galactosidase activity in biological samples such as bacteria or mammalian cells.

HY-W777640

6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside

Enzyme Substrates

6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside is a specific fluorescent substrate with the function of detecting galactosidase activity. 6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside can be used in biomedical research to observe the efficiency of enzyme-catalyzed reactions. 6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside is also widely used in the analysis of polysaccharides and carbohydrate enzymology.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog .

Cat. No.	Product Name	Chemical Structure

HY-W027544S

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d₃ is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].

HY-W027544S1

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d₆ is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-W027544S1

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide		Alkynes
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d₆ is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-139101A

Guanosine 5'-triphosphate-5'-adenosine triammonium GpppA triammonium		Cap Analogs
Guanosine 5'-triphosphate-5'-adenosine (GpppA) triammonium, a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine triammonium is a fluorescent substrate analog .

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA		Cap Analogs
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog .

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