Search Result
Results for "
Lignans
" in MedChemExpress (MCE) Product Catalog:
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-119439
-
|
Others
|
Others
|
Lignan J1 is a lignan compound found in Justicia procumbens .
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-
-
- HY-N12377
-
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Others
|
Others
|
Isovaleroyl oxokadsuranol is a lignan isolated from Kadsura longipedunculata .
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-
-
- HY-N3693
-
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Others
|
Inflammation/Immunology
|
De-4’-O-methylyangambin is a lignan that can be isolated from Z. armatum. lignans are reported to has anti-inflammatory activity .
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-
-
- HY-N11798
-
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Others
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Others
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Ophioglonol is a lignan, which can be isolated from Ophioglossum petiolatum .
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-
-
- HY-N12379
-
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Others
|
Others
|
Interiotherin D is a lignan that can be isolated from Kadsura interior .
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-
-
- HY-N3832
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(-)-Epinortrachelogenin
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Others
|
Others
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Epinortrachelogenin ((-)-Epinortrachelogenin) is a natural lignan found in the plateau medicinal plant Daphne acutiloba Rehd .
|
-
-
- HY-N9233
-
|
Others
|
Others
|
Schisandrin C epoxide (compound 1) is a natural lignan found in Clerodendron inerme seeds .
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-
-
- HY-N11921
-
|
Others
|
Others
|
Kadsurin A analogue-1 (Compound 8) is a lignan can be extracted from Piper argyrophylum .
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-
-
- HY-N2265
-
|
Others
|
Others
|
Angeloyl-(+)-gomisin K3 is a dibenzocyclooctane lignan .
|
-
-
- HY-N3717
-
|
Others
|
Others
|
(7E)-7,8-Dehydroheliobuphthalmin is a lignan derivative from Platycladus orientalis .
|
-
-
- HY-N2987
-
|
Others
|
Others
|
(-)-Holostyligone is an aryltetralone lignan from Holostylis reniformis Duch .
|
-
-
- HY-N10797
-
|
Others
|
Cancer
|
(-)-Haplomyrfolin is a natural lignan with anticancer effects .
|
-
-
- HY-N11971
-
|
Others
|
Others
|
Yunnankadsurin B is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .
|
-
-
- HY-N3141
-
(-)-Olivile; Vladinol C
|
Others
|
Others
|
Olivil ((-)-Olivile) is a lignan that has weak DPPH radical-scavenging activity (EC50: 176 μM) .
|
-
-
- HY-N11936
-
|
Others
|
Others
|
Rubriflorin B is a lignan that can be isolated from Schisandra rubriflora .
|
-
-
- HY-N12048
-
|
Others
|
Others
|
Schisandrathera D is a lignan that can be isolated from Schisandra sphenanthera .
|
-
-
- HY-N12022
-
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Others
|
Neurological Disease
|
7(18)-Dehydroschisandro A (Compound 2) is a lignan can be isolated from Schizandra chinensis Baill. 7(18)-Dehydroschisandro A has inhibitory effects on stress gastric ulcer .
|
-
-
- HY-N9884
-
|
Others
|
Others
|
(-)-Galbelgin is a lignan diastereoisomer. (-)-Galbelgin can be isolated from Piper kadsura .
|
-
-
- HY-133720
-
|
Others
|
Others
|
4-Demethyltraxillaside is a lignan that can be isolated from Caulis Trachelospermi .
|
-
-
- HY-N12035
-
|
Others
|
Cancer
|
Picropodophyllin-4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (compound 17) is a lignan isolated from the roots and rhizomes of Podophyllum sinensis .
|
-
-
- HY-N12021
-
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Others
|
Neurological Disease
|
7(8)-Dehydroschisandrol A (Compound 4a) is a lignan can be isolated from Schizandra chinensis Baill. 7(8)-Dehydroschisandrol A has a weak inhibitory effect on stress-induced gastric ulcer .
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-
-
- HY-N3892
-
|
Others
|
Others
|
Fargesone B is a kind of lignan compound. Fargesone B can be isolated from Magnolia sprengeri .
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-
-
- HY-N3914
-
|
Others
|
Others
|
Futoenone is a lignan, which can be isolated from Magnolia sprengeri Pamp .
|
-
-
- HY-N0951
-
|
Others
|
Others
|
(+)-Isolariciresinol monoglucoside ((+)-Isolariciresinol 9'-O-glucoside) is a lignan glycoside isolated from several plants .
|
-
-
- HY-N7996
-
|
Bacterial
Fungal
|
Infection
|
Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity .
|
-
-
- HY-N12037
-
|
Others
|
Others
|
(+)-7'-Methoxylariciresinol is a lignan glucoside that can be isolated from Cyclea racemosa .
|
-
-
- HY-N10423
-
(-)-Cubebin
|
Others
|
Inflammation/Immunology
|
Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity .
|
-
-
- HY-N9289
-
|
Others
|
Inflammation/Immunology
|
Vitedoin A is a phenyldihydronaphthalene-type lignan. Vitedoin A has antioxidative activity and radical-scavenging effect. Vitedoin A can be isolated from Vitex negundo .
|
-
-
- HY-N1246
-
(-)-Savinin
|
Others
|
Inflammation/Immunology
|
Savinin is a lignan, whicn can serves as a valuable pharmacophore to exhibit anti-inflammatory effect .
|
-
-
- HY-N12094
-
|
Others
|
Others
|
Tanegoside is a lignan glycoside isolated from the stems of Tinospora sinensis .
|
-
-
- HY-N5107
-
(+)-epi-Magnolin
|
Parasite
|
Infection
|
Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .
|
-
-
- HY-N12046
-
|
HIV
|
Infection
Inflammation/Immunology
Cancer
|
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .
|
-
-
- HY-N12047
-
|
HIV
|
Infection
Inflammation/Immunology
Cancer
|
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .
|
-
-
- HY-N8631
-
Acetylschisantherin L
|
NO Synthase
|
Inflammation/Immunology
|
O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC50 of 23.1 μM .
|
-
-
- HY-N11069
-
|
Others
|
Others
|
Nemerosin is a lignan that can be isolated from Chaerophyllum aureum L. .
|
-
-
- HY-N11917
-
|
Others
|
Others
|
Schisantherin S is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .
|
-
-
- HY-N8021
-
(+)-Epipinoresinol-4′′-β-D-glucoside
|
Others
|
Others
|
Epipinoresinol-4-O-β-glucoside (Compound 3) is a lignan glucoside that can be isolated from Forsythia suspensa .
|
-
-
- HY-N7684
-
|
Fungal
|
Infection
|
Picropodophyllone, an aryltetralin lignan, is isolated from leaves of Podophyllum hexandrum, and has antifungal activities .
|
-
-
- HY-N12102
-
|
HBV
|
Infection
|
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside (compound 1) is a lignan with anti-HBC activity. Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside targets HBV surface antigen with IC50s of 0.58 mM (HBsAg) and >2.4 mM (HBeAg). Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside can be isolated from star anise .
|
-
-
- HY-122379
-
|
Others
|
Others
|
8-Hydroxypinoresinol is a tetrahydrofurofuran lignan that has cytoprotective effects against peroxynitrite-induced LLC-PK1 cell damage .
|
-
-
- HY-N8260
-
|
Others
|
Neurological Disease
|
Angeloylgomisin Q is a new dibenzocyclooctadiene lignan from the stems of Schisandra sphaerandra . Angeloylgomisin Q has the potential for alzheimer's disease research .
|
-
-
- HY-N12728
-
|
Others
|
Others
|
Heteroclitin G is a lignan which can be extracted from Dian-Jixueteng. Heteroclitin G (2.0 mg/kg, i.v.) exerts an C5min of 665.97 ± 29.89 ng/mL and T1/2z of 5.04 ± 1.84 h .
|
-
-
- HY-N8225
-
(-)-Manassantin B
|
Others
|
Others
|
Manassantin B (compound 6) is a kind of lignan. Manassantin B can be isolated from the ethyl acetate extract of the roots of Saururus chinensis. Manassantin B has cytotoxicities against HT-29 with an IC50 value of 12 μM .
|
-
-
- HY-N11708
-
|
Others
|
Cancer
|
(-)-Lariciresinol is a lignans that can be isolated from Sambucus williamsii. (-)-Lariciresinol stimulates UMR106 cell proliferation .
|
-
-
- HY-N1216
-
|
Others
|
Others
|
Ssioriside (compound 9) is a lignan xyloside, which can be isolated from the barks of Prunus ssiori and Prunus padus .
|
-
-
- HY-N11990
-
|
Others
|
Others
|
Nortrachelogenin 4'-O-β-gentiobioside (compound 20) is a lignan isolated from the aerial parts of Trachelospermius .
|
-
-
- HY-N8745
-
|
Fungal
|
Others
|
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .
|
-
-
- HY-N4147
-
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
Eleutheroside D is an active lignan isolated from the root of Eleutherococcus senticosus, has anti-inflammatory and hypoglycemic activities . Eleutheroside D is an optical isomer of Eleutheroside E (HY-N0272) .
|
-
-
- HY-N3761
-
(-)-Maculatin; Methylarctigenin
|
Others
|
Others
|
Dimethylmatairesinol (compound 8) is a lignan compound isolated from the seed of Hernandia nymphaeifolia. Dimethylmatairesinol shows cytotoxicity against the KKU-M156 and HepG2 cell line with IC50s of 5.4 μM (Emax 59%) and 5.2 μM (Emax 78%), respectively .
|
-
-
- HY-126030
-
-
- HY-N7543
-
|
HIV
|
Infection
|
Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC50 of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects .
|
-
- HY-N3745
-
|
Others
|
Others
|
(-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (compound 10) is a lignan isolated from Hedyotis uncinella .
|
-
- HY-N3307
-
-
- HY-N8107
-
|
Others
|
Others
|
Matairesinol monoglucoside, a lignan compound, exhibits low activity on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways with inhibition ratio of 5.8% and 7.0%, respectively .
|
-
- HY-N10092
-
(-)-Saucerneol
|
Others
|
Inflammation/Immunology
|
Saucerneol is a lignans that can be isolated from Saururus chinensis. Saucerneol inhibits LPS-induced or Con A-induced lymphocytes proliferation. Saucerneol inhibits mixed lymphocyte response. Saucerneol also inhibits mitogens-induced cytokines secretion .
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-
- HY-N2245
-
|
Others
|
Cancer
|
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .
|
-
- HY-N11945
-
Kadsulignan J
|
NO Synthase
|
Others
|
Schiarisanrin A (Kadsulignan J) is a lignan with inhibitory activity on NO production. Schiarisanrin A inhibits NO production in BV-2 cells with an IC50 of 9.6 μM .
|
-
- HY-N0064
-
-
- HY-N11943
-
|
NO Synthase
|
Others
|
Kadsulignan H (compound 13) is a lignan with inhibitory activity on NO production. Kadsulignan H inhibits NO production in BV-2 cells with an IC50 of 14.1 μM .
|
-
- HY-108695B
-
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
(±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .
|
-
- HY-N2168
-
(+)-Pinoresinol 4-O-β-D-glucopyranoside
|
Others
|
Cardiovascular Disease
|
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure reducing, and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects .
|
-
- HY-108695
-
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities .
|
-
- HY-N3348
-
|
Fungal
|
Infection
Inflammation/Immunology
|
Lyoniside is a lignan glycoside with antioxidant, allelopathic and antifungal activities, which can be isolated from the rhizomes and stems of bilberry (Vaccinium myrtillus L.). Lyoniside exhibits radical scavenging properties with an IC50 value of 23 μg/mL in DPPH assay. Lyoniside inhibits the mycelial growth of Fusarium oxysporum and Mucor hiemalis at 50 μg/mL with inhibitory rates of 78% and 80%, respectively .
|
-
- HY-14578
-
-
- HY-N3963
-
(+)-Gomisin M2
|
HIV
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC50 of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research .
|
-
- HY-N0064R
-
|
COX
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
Macelignan (Standard) is the analytical standard of Macelignan. This product is intended for research and analytical applications. Macelignan ((+)-Anwulignan; Anwuligan) is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities .
|
-
- HY-N11940
-
|
HIV Protease
|
Infection
|
Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC50 >100 μg/mL .
|
-
- HY-108695BR
-
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
(±)-Enterodiol (Standard) is the analytical standard of (±)-Enterodiol. This product is intended for research and analytical applications. (±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .
|
-
- HY-N12349
-
|
Others
|
Others
|
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED50 value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .
|
-
- HY-N0613
-
|
NF-κB
|
Inflammation/Immunology
|
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .
|
-
- HY-N0691
-
Schizandrin; Schizandrol; Schizandrol-A
|
Autophagy
|
Inflammation/Immunology
Cancer
|
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
|
-
- HY-N2168R
-
|
Others
|
Cardiovascular Disease
|
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure reducing, and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects .
|
-
- HY-N9237
-
|
Others
|
Others
|
2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide is a lignan with a γ-butenolide structure and 10-epi-olguine. 2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide is isolated from the aerial parts of the medicinal plant Hyptis capitata .
|
-
- HY-N11939
-
|
HIV
|
Infection
|
Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with EC50=2.23 μg/mL .
|
-
- HY-N0690
-
Schizandrin-C; Wuweizisu-C
|
Apoptosis
Virus Protease
|
Cancer
|
Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory?and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases?research . Schisandrin C induces cell apoptosis .
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-
- HY-N0613R
-
|
NF-κB
|
Inflammation/Immunology
|
Sauchinone (Standard) is the analytical standard of Sauchinone. This product is intended for research and analytical applications. Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .
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-
- HY-N0691R
-
|
Autophagy
|
Inflammation/Immunology
Cancer
|
Schisandrin (Standard) is the analytical standard of Schisandrin. This product is intended for research and analytical applications. Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
|
-
- HY-N2532
-
|
VSV
HIV
Proton Pump
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus . Diphyllin is a vacuolar type H +-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts . Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities .
|
-
- HY-N0690R
-
|
Apoptosis
Virus Protease
|
Cancer
|
Schisandrin C (Standard) is the analytical standard of Schisandrin C. This product is intended for research and analytical applications. Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .
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-
- HY-N9101
-
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Others
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Cancer
|
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC50s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .
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-
- HY-N6071
-
(-)-Secoisolariciresinol
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Others
|
Cancer
|
Secoisolariciresinol is a lignan, a type of phenylpropanoids.
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-
- HY-N8172
-
|
Others
|
Others
|
(+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol .
|
-
- HY-N8158
-
-
- HY-N8159
-
-
- HY-N7331
-
-
- HY-N11905
-
-
- HY-N12425
-
|
Others
|
Others
|
Heteroclitin A is a lignan isolated from the stems of Schisandra propinqua.
|
-
- HY-N9300
-
|
Others
|
Inflammation/Immunology
|
1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan, a lignan derivative from the ethyl acetate soluble fraction of twigs of Magnolia denudate (Magnoliaceae), exhibits anti-platelet-activating factor (PAF) activity. PAF is a potent lipid mediator in inflammation and asthma .
|
-
- HY-N5044
-
Arisanschinin L
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Others
|
Others
|
Schisanwilsonin B is a lignan from the fruits of Schisandra wilsoniana .
|
-
- HY-N3331
-
|
Others
|
Others
|
Magnolignan A is a natural lignan found in the heartwood of Streblus asper .
|
-
- HY-N3429
-
(-)-Kaerophylin
|
Others
|
Others
|
Kaerophyllin ((-)-Kaerophylin) is a lignan that can be found in Chaerophyllum maculatum .
|
-
- HY-N7284
-
-
- HY-N12809
-
|
Others
|
Others
|
Binankadsurin A is a lignan that can be isolated from Kadsura longipedunculata .
|
-
- HY-N12806
-
|
Others
|
Others
|
Ananonin A is a lignan and can be isolated from Kadsura ananosma .
|
-
- HY-N4276
-
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Others
|
Others
|
Nortracheloside is a lignan isolated from Trachelospermum jasminoides (Lindl.) Lem .
|
-
- HY-N7843
-
|
Others
|
Others
|
(+)-8-Methoxyisolariciresinol is a lignan that can be found in Illicium simonsii .
|
-
- HY-N12049
-
|
Others
|
Others
|
(+)-Diasyringaresinole is a lignan that can be isolated from the seeds of Aquilaria agallocha .
|
-
- HY-N3330
-
|
Others
|
Others
|
Magnolignan C is a lignan, that can be isolated from Magnoliae Cortex .
|
-
- HY-N11947
-
|
Others
|
Others
|
Schisanligone B is a lignan isolated from Schisandra chinensis seeds .
|
-
- HY-N12375
-
|
Others
|
Others
|
Kadsuphilin J is a lignan isolated from the roots of K. longipedunculata
|
-
- HY-N12725
-
|
Others
|
Others
|
Heteroclitin E is a lignan that can be obtained from Kadsura longipenduculata .
|
-
- HY-N12815
-
|
Others
|
Others
|
Benzoyl oxokadsuranol is a lignan and can be isolated from Kadsura longipedunculata .
|
-
- HY-N10829
-
|
Others
|
Others
|
4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum .
|
-
- HY-N2914
-
|
Others
|
Others
|
(±)-Balanophonin (compound 12) is a lignan first isolated from Otochilus fuscus .
|
-
- HY-N8622A
-
|
Others
|
Others
|
Heteroclitin B is a saturated dibenzocyclooctene lignan isolated from the stems of Schisandra chinensis.
|
-
- HY-116104
-
|
Others
|
Others
|
Americanol A is a lignan isolated from the methanol extract of Joannesia princeps seeds .
|
-
- HY-N7537
-
|
Others
|
Others
|
Manassantin A is a Lignans product that can be isolated from the herbs of Saururus chinensis .
|
-
- HY-N2823
-
|
Others
|
Others
|
Agatharesinol is a Lignans product that can be isolated from the barks of Cryptomeria japonica .
|
-
- HY-N9254
-
|
Others
|
Others
|
Demethoxyisodaphneticin is a Lignans product that can be isolated from the herbs of Buxus sinica .
|
-
- HY-N3728
-
|
Others
|
Others
|
Denudanolide A is a Lignans product that can be isolated from the herbs of Magnolia denudata .
|
-
- HY-136691
-
|
Others
|
Others
|
Episesartemin A is a Lignans product that can be isolated from the roots of Artemisia absinthium. .
|
-
- HY-N4060
-
|
Others
|
Others
|
Hedyotisol A is a Lignans product that can be isolated from the herbs of Cocculus orbiculatus. .
|
-
- HY-N13485
-
|
Others
|
Others
|
Hedyotol C is a lignan product that can be isolated from Forsythia suspensa. .
|
-
- HY-N3459
-
|
Others
|
Others
|
Isosalicifolin is a Lignans product that can be isolated from the herbs of Bupleurum candollei .
|
-
- HY-121221
-
|
Others
|
Others
|
Justiciresinol is a Lignans product that can be isolated from the herbs of Justicia glauca .
|
-
- HY-N3404
-
|
Others
|
Others
|
Lariciresinol acetate is a Lignans product that can be isolated from the herbs of Phyllanthus niruri .
|
-
- HY-N3372
-
|
Others
|
Others
|
Longifloroside A is a Lignans product that can be isolated from the seeds of Ligustrum lucidum .
|
-
- HY-N3334
-
|
Others
|
Others
|
Maglifloenone is a Lignans product that can be isolated from the flowers of Magnolia liliflora .
|
-
- HY-N3332
-
|
Others
|
Others
|
Magnolianin is a Lignans product that can be isolated from the barks of Magnolia obovata .
|
-
- HY-N10037
-
|
Others
|
Others
|
Marginatoxin is a Lignans product that can be isolated from the roots of Bupleurum marginatum .
|
-
- HY-N3314
-
|
Others
|
Others
|
Massoniresinol is a Lignans product that can be isolated from the herbs of Illicium burmanicum. .
|
-
- HY-N1311
-
|
Others
|
Others
|
Simonsinol is a Lignans product that can be isolated from the barks of Illicium simonsii .
|
-
- HY-N7365
-
|
Others
|
Others
|
Spathulatol is a Lignans product that can be isolated from the pericarps of Illicium spathulatum. .
|
-
- HY-N13512
-
|
Others
|
Others
|
Taiwanin E is a lignan product that can be isolated from Taiwania cryptomerioides .
|
-
- HY-N2845
-
|
Others
|
Others
|
Tsugalactone is a Lignans product that can be isolated from the barks of Tsuga dumosa .
|
-
- HY-N1114
-
|
Others
|
Others
|
Tupichilignan A is a Lignans product that can be isolated from the barks of Pseudolarix kaemp .
|
-
- HY-N7588
-
|
Others
|
Others
|
Acetylvirolin is a Lignans product that can be isolated from the herbs of Sambucus williamsii .
|
-
- HY-N8294
-
|
Others
|
Others
|
Kadsulignan L is a Lignans product that can be isolated from the stems of Kadsura japonica .
|
-
- HY-108692
-
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .
|
-
- HY-N9303
-
-
- HY-N2246
-
-
- HY-N8259
-
|
Others
|
Others
|
Obovatol is a biphenyl ether lignan isolated from the leaves of Magnolia obovata Thunb .
|
-
- HY-N12114
-
|
Others
|
Others
|
6′-Hydroxyjusticidin C is a lignan, that can be isolated from Justicia procumbens .
|
-
- HY-N11944
-
|
Others
|
Others
|
Schiarisanrin E (compound 5) is a lignan that can be isolated from Schisandra chinensis .
|
-
- HY-N13536
-
|
Others
|
Others
|
5-Methoxyjusticidin A is a lignan product that can be isolated from Protium unifoliolatum .
|
-
- HY-N2824
-
|
Others
|
Others
|
Agatharesinol acetonide is a Lignans product that can be isolated from the heartwoods of Sequoia sempervirens .
|
-
- HY-N7309
-
|
Others
|
Others
|
Benzoylgomisin H is a Lignans product that can be isolated from the fruits of Schizandra chinensis .
|
-
- HY-N10098
-
|
Others
|
Others
|
Citrusin B is a Lignans product that can be isolated from the stems of Sambucus williamsii .
|
-
- HY-N4059
-
|
Others
|
Others
|
Hedyotisol B is a Lignans product that can be isolated from the herbs of Campylotropis hirtella .
|
-
- HY-N3490
-
|
Others
|
Others
|
Isodihydrofutoquinol A is a Lignans product that can be isolated from the leaves and stems of Piper schmidtii. .
|
-
- HY-N3407
-
|
Others
|
Others
|
Lancifolin C is a Lignans product that can be isolated from the fruits of Piper wightii. .
|
-
- HY-N3333
-
|
Others
|
Others
|
Magnaldehyde D is a Lignans product that can be isolated from the barks of Magnolia officinalis .
|
-
- HY-N3293
-
|
Others
|
Others
|
Metasequirin D is a Lignans product that can be isolated from the heartwoods of Sequoia sempervirens .
|
-
- HY-N1288
-
|
Others
|
Others
|
Sequirin C is a Lignans product that can be isolated from the herbs of Cryptomeria japonica .
|
-
- HY-N1290
-
|
Others
|
Others
|
Sequosempervirin D is a Lignans product that can be isolated from the heartwoods of Sequoia sempervirens .
|
-
- HY-N3900
-
|
Others
|
Others
|
Tsugacetal is a Lignans product that can be isolated from the heartwoods of Juniperus formosana Hayata. .
|
-
- HY-N8622
-
|
Others
|
Others
|
Heteroclitin C is a Lignans product that can be isolated from the stems of Kadsura heteroclita .
|
-
- HY-N2564
-
|
Bacterial
|
Infection
|
Isomagnolol is a lignan with antimicrobial activity. Isomagnolol can be isolated from the root of tea plant .
|
-
- HY-N11991
-
|
Others
|
Others
|
5-Methoxytracheloside is a lignan lactone isolated from the stems and leaves of Trachelospermum jasminoides .
|
-
- HY-N1809
-
|
Others
|
Others
|
3a-Epiburchellin is a Lignans product that can be isolated from the herbs of Ocotea cymbarum. .
|
-
- HY-N2758
-
|
Others
|
Others
|
7-Oxohinokinin is a Lignans product that can be isolated from the heartwoods of Chamaecyparis obtusa .
|
-
- HY-N3727
-
|
Others
|
Others
|
Denudadione C is a Lignans product that can be isolated from the young fruits of Magnolia denudata. .
|
-
- HY-N3477
-
|
Others
|
Others
|
Isokadsurenin D is a Lignans product that can be isolated from the roots and stems of Kadsura coccinea. .
|
-
- HY-N3403
-
|
Others
|
Others
|
Lariciresinol dimethyl ether is a Lignans product that can be isolated from the herbs of Rostellularia procumbens .
|
-
- HY-N3252
-
|
Others
|
Others
|
Mirandin B is a Lignans product that can be isolated from the trunk woods of Nectandra miranda. .
|
-
- HY-N1325
-
|
Others
|
Others
|
Sanshodiol is a Lignans product that can be isolated from the stem barks of Xanthoxylum piperitum DC. .
|
-
- HY-N7344
-
|
Others
|
Others
|
Futokadsurin C is a Lignans product that can be isolated from the aerial parts of Piper futokadsura. .
|
-
- HY-N8694
-
|
Others
|
Others
|
Obtusafuran methyl ether is a Lignans product that can be isolated from the herbs of Dalbergia odorifera .
|
-
- HY-N0701
-
|
Others
|
Cancer
|
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
|
-
- HY-N5023
-
|
Others
|
Metabolic Disease
|
Veraguensin is a lignan compound derived from Magnolia sp.. Veraguensin can inhibit bone resorption
|
-
- HY-N3454
-
|
Others
|
Others
|
Isotaxiresinol is a lignan, which can be isolated from Taxus yunnanensis and has the function of plant metabolites .
|
-
- HY-N10663A
-
|
Others
|
Others
|
(±)-7-epi-Kadsurenone is a novel lignan with hydrobenzofuran and bicyclic [3.2.1] octane. .
|
-
- HY-N0701A
-
|
Others
|
Cancer
|
Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
|
-
- HY-N2800
-
|
Others
|
Others
|
9-O-Feruloyllariciresinol is a Lignans product that can be isolated from the herbs of Phyllanthus niruri .
|
-
- HY-N3758
-
|
Others
|
Others
|
Dihydrosesamin is a Lignans product that can be isolated from the young shoots of Chamaecyparis obtusa cv. Breviramea. .
|
-
- HY-N7958
-
|
Others
|
Others
|
Gomisin F is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .
|
-
- HY-N3481
-
|
Others
|
Others
|
Isogomisin O is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .
|
-
- HY-N3575
-
Chloramultilide C
|
Others
|
Others
|
Henriol A (Chloramultilide C) is a Lignans product that can be isolated from the heartwoods of Juniperus formosana Hayata. .
|
-
- HY-N7287
-
|
Others
|
Others
|
(+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells .
|
-
- HY-N11694
-
|
Others
|
Others
|
9-O-Acetyl-fargesol is a lignan, which can be isolated from the seeds of Magnolia praecocissima .
|
-
- HY-N3897
-
Phellodensin F
|
Others
|
Others
|
Flavaprin (Phellodensin F) is a Lignans product that can be isolated from the stem barks of Xanthoxylum piperitum DC. .
|
-
- HY-N1908
-
|
Others
|
Others
|
4-O-Demethylkadsurenin D is a Lignans product that can be isolated from the leaves of Magnolia ovata. .
|
-
- HY-N2648
-
|
Others
|
Others
|
5,5'-Dimethoxylariciresinol is a Lignans product that can be isolated from the barks of Phellodendron chinense Schneid. .
|
-
- HY-N2665
-
|
Others
|
Others
|
5-Acetoxymatairesinol dimethyl ether is a Lignans product that can be isolated from the barks of Pseudolarix kaemp .
|
-
- HY-N3453
-
|
Others
|
Others
|
Isotaxiresinol 9,9'-acetonide is a Lignans product that can be isolated from the branches of Taxus wallichiana .
|
-
- HY-N3438
-
|
Others
|
Others
|
Kadsurenin D is a Lignans product that can be isolated from the aerial parts of Piper kadsura (Choisy) Ohwi. .
|
-
- HY-108692S
-
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Cancer
|
Enterolactone-d6 is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].
|
-
- HY-N11542
-
|
Others
|
Others
|
Trachelogenin 4′-O-β-gentiobioside, a lignan, can be isolated from the leaves and stems of clover .
|
-
- HY-N8172R
-
|
Others
|
Others
|
(+)-Secoisolariciresinol (Standard) is the analytical standard of (+)-Secoisolariciresinol. This product is intended for research and analytical applications. (+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol .
|
-
- HY-N3475
-
|
Others
|
Others
|
9,9'-O-Isopropyllidene-isolariciresinol is a Lignans product that can be isolated from the barks of Pseudolarix kaempferi .
|
-
- HY-N0657
-
|
Others
|
Others
|
Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.
|
-
- HY-N9926
-
(-)-Pluviatolide
|
Others
|
Others
|
Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor .
|
-
- HY-N0694
-
Gomisin-C; Schizantherin-A; Wuweizi ester-A
|
NF-κB
|
Inflammation/Immunology
|
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.
|
-
- HY-N7534
-
|
Others
|
Others
|
(+)-Epipinoresinol is a lignan compound. CYP81Q3 specifically catalyzes methylenedioxy bridge (MDB) formation in (+)-Epipinoresinol to produce (+)-Pluviatilol .
|
-
- HY-N12376
-
|
Others
|
Others
|
Renchangianin B (compound 2) is dibenzo cyclooctene-type lignan. Renchangianin B can be isolated from the stems of Kadsura renchangiana .
|
-
- HY-W007972
-
3-Methoxyacrylic Acid Methyl Ester
|
Others
|
Others
|
Methyl 3-methoxyacrylate (3-Methoxyacrylic Acid Methyl Ester) is a Lignans product that can be isolated from the herbs of Lysimachia clethroides .
|
-
- HY-N1907
-
|
Others
|
Others
|
4-O-Demethylisokadsurenin D is a Lignans product that can be isolated from the aerial part of Piper kadsura (Choisy) Ohwi. .
|
-
- HY-N2649
-
|
Others
|
Others
|
5,5'-Dimethoxylariciresinol 4-O-glucoside is a Lignans product that can be isolated from the herbs of Lonicera maackii .
|
-
- HY-N7310
-
-
- HY-N3905
-
(+)-Fragransin A2
|
Others
|
Cancer
|
Fragransin A2 is a lignan that can be isolated from the stems of Knema furfuracea (Myristicaceae). Fragransin A2 shows anticancer activity .
|
-
- HY-N2752
-
|
Others
|
Others
|
7-O-Acetyl-4-O-demethylpolysyphorin is a Lignans product that can be isolated from the herbs of Liriodendron chinense .
|
-
- HY-N2799
-
|
Others
|
Others
|
9-O-Feruloyl-5,5'-dimethoxylariciresinol is a Lignans product that can be isolated from the herbs of Viburnum cylindricum .
|
-
- HY-N9153
-
|
Others
|
Others
|
erythro-Guaiacylglycerol-β-O-4’-sinapyl ether is a Lignans product that can be isolated from the stems of Sambucus williamsii. .
|
-
- HY-N8910
-
|
Others
|
Others
|
(7R)-Methoxy-8-epi-matairesinol is a Lignans product that can be isolated from the roots of Wikstroemia indica .
|
-
- HY-N8323
-
|
Others
|
Others
|
erythro-Guaiacylglycerol β-Sinapyl Ether 7-O-Glucoside is a Lignans product that can be isolated from the stems of Sambucus williamsii .
|
-
- HY-N9318
-
|
Others
|
Cancer
|
4'-Demethyldehydropodophyllotoxin is an aryltetralin lignan that can be isolated from leaves of Podophyllum hexandrum. 4'-Demethyldehydropodophyllotoxin exhibits some cytotoxic and antitumour activity .
|
-
- HY-N3349A
-
|
Others
|
Others
|
(-)-Lyoniresinol is a lignan isolated from the Tarenna attenuata with antioxidant activities. (-)-Lyoniresinol has radical scavenging activities against DPPH with an IC50 of 82.4 μM .
|
-
- HY-N8209
-
-
- HY-N2807
-
-
- HY-N3349
-
|
Others
|
Others
|
Lyoniresinol is a lignan isolated from the Tarenna attenuata with antioxidant activities. Lyoniresinol has radical scavenging activities against DPPH with an IC50 of 82.4 μM .
|
-
- HY-N8766
-
|
Others
|
Others
|
Dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside is a Lignans product that can be isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov. .
|
-
- HY-N1152
-
|
Others
|
Inflammation/Immunology
|
threo-Guaiacylglycerol beta-coniferyl ether is a lignan that can inhibit NO production. threo-Guaiacylglycerol beta-coniferyl ether exhibits anti-neuroinflammatory activities .
|
-
- HY-N3436
-
-
- HY-N12431
-
|
Others
|
Cancer
|
Machilin A is a lignan isolated from the methanolic extract of Phoebe bark. Machilin A inhibits melanin biosynthesis in B-16 mouse melanoma cells with an IC50 of 39.9 μM.
|
-
- HY-N0701R
-
|
Others
|
Cancer
|
(-)-Asarinin (Standard) is the analytical standard of (-)-Asarinin. This product is intended for research and analytical applications. (-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb .
|
-
- HY-N6849
-
|
HIV
|
Infection
Metabolic Disease
|
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent .
|
-
- HY-N2270
-
|
p38 MAPK
ERK
IKK
|
Inflammation/Immunology
|
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .
|
-
- HY-N2140
-
|
Others
|
Infection
|
Herpetone, the ethylacetate extract, is a lignan compound. Herpetone can be isolated from the seeds of Herpetospermum caudigerum. Herpetone significantly improved the cell viability, and has a protective effect on hepatocytes in vitro .
|
-
- HY-N7485
-
(-)-Gomisin K1
|
Others
|
Cancer
|
Gomisin K1 ((-)-Gomisin K1) is a lignan that exhibits anti-cancer activity. Gomisin K1 inhibits HeLa cell growth, with an IC50 of 5.46 μM .
|
-
- HY-N1712
-
3-Oxo-29-hydroxyfriedelane
|
Others
|
Others
|
29-Hydroxyfriedelan-3-one (3-Oxo-29-hydroxyfriedelane) is a Lignans product that can be isolated from the stems of Sambucus williamsii .
|
-
- HY-N0121
-
Sesamin
5 Publications Verification
|
Others
|
Neurological Disease
|
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
|
-
- HY-N6054
-
|
Parasite
Topoisomerase
|
Infection
Inflammation/Immunology
|
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.
|
-
- HY-N11056
-
|
Antibiotic
VSV
|
Infection
|
Justicidin C is an antiviral lignan. Justicidin C shows strong antiviral activity against vesicular stomatitis virus and low cytotoxicity against rabbit lung cells (RL-33) .
|
-
- HY-N7825
-
|
Others
|
Cancer
|
Gomisin L1 is a lignan, shows inhibitory effect on cell viability of A2780 and Ishikawa cells, with IC50s of 39.06 μM and 74.16 μM, respectively .
|
-
- HY-N9863
-
|
Others
|
Others
|
(7R,8R)-Dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside is a Lignans product that can be isolated from the herbs of Lysimachia clethroides .
|
-
- HY-N0163
-
-
- HY-N1060
-
|
HSV
Apoptosis
|
Infection
Cancer
|
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity . Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression .
|
-
- HY-N4020
-
|
Others
|
Others
|
Icariside E5 is a lignan glycoside isolated from the Capsicum annuum. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties .
|
-
- HY-N10417
-
|
Apoptosis
Autophagy
|
Cancer
|
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .
|
-
- HY-137430
-
GLPG1972; S201086
|
ADAMTS
|
Metabolic Disease
|
Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .
|
-
- HY-N12790
-
Ananonin B
|
Glucosidase
|
Metabolic Disease
|
Arisanschinin D (Ananonin B) is an α-Glucosidase inhibitor and can be isolated from Schisandra arisanensis Hay .
|
-
- HY-W647305
-
|
Others
|
Others
|
4-(5-(3-Hydroxypropyl)-7-methoxybenzofuran-2-yl)-2-methoxyphenol is a Lignans product that can be isolated from the herbs of Diospyros lotus .
|
-
- HY-N0694R
-
|
NF-κB
|
Inflammation/Immunology
|
Schisantherin A (Standard) is the analytical standard of Schisantherin A. This product is intended for research and analytical applications. Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.
|
-
- HY-105008
-
(S,S)-SDG; (S,S)-LGM2605
|
Others
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .
|
-
- HY-N4108
-
|
P-glycoprotein
|
Inflammation/Immunology
Cancer
|
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .
|
-
- HY-N0608
-
|
NF-κB
|
Inflammation/Immunology
|
Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation .
|
-
- HY-114275
-
|
Fungal
Parasite
Apoptosis
|
Infection
Cardiovascular Disease
Cancer
|
Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation .
|
-
- HY-N8307
-
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
|
Syringaresinol is a lignan that can be extracted from from Dragon’s Blood of Dracaena cambodiana. Syringaresinol has anti-inflammatory activity. Syringaresinol also causes vasorelaxation. Syringaresinol elevates NO production through the phosphorylation and dimerization of endothelial NO synthase .
|
-
- HY-N0608A
-
|
NF-κB
|
Inflammation/Immunology
|
(Rac)-Myrislignan is the racemate of Myrislignan. Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation .
|
-
- HY-N10079
-
Jatrophan
|
SHP2
|
Cancer
|
Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to SHP2 and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML) .
|
-
- HY-N7724
-
(+)-Cedrusin
|
Others
|
Others
|
Cedrusin is a benzofuran derivative that can be isolated from Styrax suberifolius .
|
-
- HY-N0035
-
-
- HY-126067
-
|
Glucosidase
Apoptosis
|
Inflammation/Immunology
|
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .
|
-
- HY-N2413
-
|
Others
|
Metabolic Disease
|
Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule .
|
-
- HY-N0121R
-
|
Others
|
Neurological Disease
|
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
|
-
- HY-N6054R
-
|
Parasite
Topoisomerase
|
Infection
Inflammation/Immunology
|
Niranthin (Standard) is the analytical standard of Niranthin. This product is intended for research and analytical applications. Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.
|
-
- HY-N2180
-
(+)-Eudesmin
|
PKC
PKA
|
Neurological Disease
|
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .
|
-
- HY-N1841
-
3'-Hydroxyrocaglamide
|
Others
|
Cancer
|
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC50s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .
|
-
- HY-N0163R
-
-
- HY-N0121S
-
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
|
-
- HY-N4108R
-
|
P-glycoprotein
|
Inflammation/Immunology
Cancer
|
Hypophyllanthin (Standard) is the analytical standard of Hypophyllanthin. This product is intended for research and analytical applications. Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .
|
-
- HY-N8805
-
|
Others
|
Cancer
|
Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence .
|
-
- HY-N10663
-
-
- HY-N9351
-
Diphyllin O-glucoside
|
SARS-CoV
|
Infection
Cardiovascular Disease
Metabolic Disease
Cancer
|
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .
|
-
- HY-122938
-
(2S,3R)-Ceplignan
|
Others
|
Others
|
Ceplignan ((2S,3R)-Ceplignan) is a neogenic lignan, which can be isolated from the rhizomes of Acorus tatarinowii Schott. (2S,3R)-Ceplignan and (2R,3S)-ceplignan are two isomers of Ceplignan .
|
-
- HY-N12870
-
|
Others
|
Endocrinology
|
(7S,8R)-4,9,9'-Trihydroxy-3,3',5-trimethoxy-8,4'-oxyneolignan 4-O-β-D-glucopyranoside (5) is a lignan compound that can be isolated from Smilax trinervula .
|
-
- HY-N0035R
-
-
- HY-N9071
-
|
Others
|
Others
|
5-Allyl-3-methoxy-6-methyl-7-(3,4,5-trimethoxyphenyl)bicyclo[3.2.1]oct-3-ene-2,8-dione is a Lignans product that can be isolated from the herbs of Cassia fistula .
|
-
- HY-N12262
-
|
Bacterial
|
Infection
Cancer
|
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .
|
-
- HY-N9257
-
|
Others
|
Neurological Disease
|
8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells .
|
-
- HY-N2500
-
|
Microtubule/Tubulin
Apoptosis
Autophagy
|
Infection
Cardiovascular Disease
|
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis . Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca 2+ concentrations in DRG neurons .
|
-
- HY-N2180R
-
|
PKC
PKA
|
Neurological Disease
|
Pinoresinol dimethyl ether (Standard) is the analytical standard of Pinoresinol dimethyl ether. This product is intended for research and analytical applications. Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .
|
-
- HY-N12336
-
|
Others
|
Metabolic Disease
|
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC50=2.63 μM) .
|
-
- HY-N10481
-
|
Apoptosis
Caspase
PARP
Bcl-2 Family
|
Cancer
|
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC50 of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio .
|
-
- HY-N6802
-
|
Others
|
Cancer
|
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .
|
-
- HY-N0385
-
|
AMPK
Calcium Channel
|
Cardiovascular Disease
Metabolic Disease
|
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity . Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca 2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease .
|
-
- HY-N11957
-
|
Others
|
Inflammation/Immunology
|
Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC50=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC50=19.9 μM, 21.93 μM) .
|
-
- HY-156731
-
|
Others
|
Others
|
(8R,8'R)-Matairesinol 4,4'-di-O-β-D-glucopyranoside (MDG) is a natural product isolated from Trachelospermum asiaticum .
|
-
- HY-N4267
-
|
Calcium Channel
|
Infection
Cardiovascular Disease
|
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca 2+ influx through voltage-gated Ca 2+ channels, leading to the reduction in [Ca 2+]i in vascular smooth muscle cells and consequent peripheral vasodilation . Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM .
|
-
- HY-N8618
-
|
Others
|
Others
|
Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .
|
-
- HY-N0692
-
Gomisin-A; TJN-101; Wuweizi alcohol-B
|
Reactive Oxygen Species
Cytochrome P450
Autophagy
|
Cancer
|
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
|
-
- HY-N0692R
-
|
Reactive Oxygen Species
Cytochrome P450
Autophagy
|
Cancer
|
Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
|
-
- HY-N1773
-
|
Others
|
Cancer
|
5,7,3' -tri-O-Methyl (-)-epicatechin (Compound 13) is a phospholipase Cγ1 (PLCγ1) inhibitor. 5,7,3' -tri-o-methyl (-)-epicatechin has a methylene dioxy benzene ring and can express inhibitory activity against PLCγ1. 5,7,3' -tri-O-Methyl (-)-epicatechin can be used in the study of chemotherapy and chemopexic agents for cancer .
|
-
- HY-N9903
-
TDDC
|
Others
|
Others
|
Tetrahydrodehydrodiconiferyl alcohol (TDDC) is a reduction product of dihydrodehydrodiconiferyl alcohol catalyzed by phenylcoumaran benzylic ether reductase. Tetrahydrodehydrodiconiferyl alcohol can be isolated from a hydrogenolysis product of protolignin .
|
-
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N3745
-
-
- HY-N3307
-
-
- HY-N8107
-
-
- HY-N10092
-
-
- HY-N2245
-
-
- HY-N11945
-
-
- HY-N0064
-
-
- HY-N11943
-
-
- HY-108695B
-
-
- HY-N2168
-
-
- HY-108695
-
-
- HY-N3348
-
-
- HY-14578
-
-
- HY-N3963
-
-
- HY-N0064R
-
-
- HY-N11940
-
-
- HY-108695BR
-
|
Structural Classification
Source classification
Phenols
Polyphenols
Endogenous metabolite
|
Apoptosis
Endogenous Metabolite
|
(±)-Enterodiol (Standard) is the analytical standard of (±)-Enterodiol. This product is intended for research and analytical applications. (±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .
|
-
- HY-N12349
-
-
- HY-N0613
-
-
- HY-N0691
-
-
- HY-N2168R
-
|
Structural Classification
Monophenols
other families
Source classification
Lignans
Phenols
Phenylpropanoids
Plants
|
Others
|
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure reducing, and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects .
|
-
- HY-N11939
-
-
- HY-N0690
-
-
- HY-N0613R
-
-
- HY-N0691R
-
-
- HY-N2532
-
-
- HY-N0690R
-
-
- HY-N9101
-
|
Structural Classification
Caprifoliaceae
Source classification
Lignans
Phenylpropanoids
Viburnum cylindricum Buch.-Ham. ex D. Don
Plants
|
Others
|
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC50s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .
|
-
- HY-N6071
-
-
- HY-N8172
-
-
- HY-N8158
-
-
- HY-N8159
-
-
- HY-N7331
-
-
- HY-N11905
-
-
- HY-N12425
-
-
- HY-N9300
-
-
- HY-N5044
-
-
- HY-N3331
-
-
- HY-N3429
-
-
- HY-N7284
-
-
- HY-N12809
-
-
- HY-N12806
-
-
- HY-N4276
-
-
- HY-N7843
-
-
- HY-N12049
-
-
- HY-N3330
-
-
- HY-N11947
-
-
- HY-N12375
-
-
- HY-N12725
-
-
- HY-N12815
-
-
- HY-N10829
-
-
- HY-N2914
-
-
- HY-N8622A
-
-
- HY-116104
-
-
- HY-N7537
-
-
- HY-N2823
-
-
- HY-N9254
-
-
- HY-N3728
-
-
- HY-136691
-
-
- HY-N4060
-
-
- HY-N13485
-
-
- HY-N3459
-
-
- HY-121221
-
-
- HY-N3404
-
-
- HY-N3372
-
-
- HY-N3334
-
-
- HY-N3332
-
-
- HY-N10037
-
-
- HY-N3314
-
-
- HY-N1311
-
-
- HY-N7365
-
-
- HY-N13512
-
-
- HY-N2845
-
-
- HY-N1114
-
-
- HY-N7588
-
-
- HY-N8294
-
-
- HY-108692
-
-
- HY-N9303
-
-
- HY-N2246
-
-
- HY-N8259
-
-
- HY-N12114
-
-
- HY-N11944
-
-
- HY-N13536
-
-
- HY-N2824
-
-
- HY-N7309
-
-
- HY-N10098
-
-
- HY-N4059
-
-
- HY-N3490
-
-
- HY-N3407
-
-
- HY-N3333
-
-
- HY-N3293
-
-
- HY-N1288
-
-
- HY-N1290
-
-
- HY-N3900
-
-
- HY-N8622
-
-
- HY-N2564
-
-
- HY-N11991
-
-
- HY-N1809
-
-
- HY-N2758
-
-
- HY-N3727
-
-
- HY-N3477
-
-
- HY-N3403
-
-
- HY-N3252
-
-
- HY-N1325
-
-
- HY-N7344
-
-
- HY-N8694
-
-
- HY-N0701
-
-
- HY-N5023
-
-
- HY-N3454
-
-
- HY-N10663A
-
-
- HY-N0701A
-
-
- HY-N2800
-
-
- HY-N3758
-
-
- HY-N7958
-
-
- HY-N3481
-
-
- HY-N3575
-
-
- HY-N7287
-
-
- HY-N11694
-
-
- HY-N3897
-
-
- HY-N1908
-
-
- HY-N2648
-
-
- HY-N2665
-
-
- HY-N3453
-
-
- HY-N3438
-
-
- HY-N11542
-
-
- HY-N8172R
-
-
- HY-N3475
-
-
- HY-N0657
-
-
- HY-N9926
-
-
- HY-N0694
-
-
- HY-N7534
-
-
- HY-N12376
-
-
- HY-W007972
-
-
- HY-N1907
-
-
- HY-N2649
-
-
- HY-N7310
-
-
- HY-N3905
-
-
- HY-N2752
-
-
- HY-N2799
-
-
- HY-N9153
-
-
- HY-N8910
-
-
- HY-N8323
-
-
- HY-N9318
-
-
- HY-N3349A
-
-
- HY-N8209
-
-
- HY-N2807
-
-
- HY-N3349
-
-
- HY-N8766
-
-
- HY-N1152
-
-
- HY-N3436
-
-
- HY-N12431
-
-
- HY-N0701R
-
-
- HY-N6849
-
-
- HY-N2270
-
-
- HY-N2140
-
-
- HY-N7485
-
-
- HY-N1712
-
-
- HY-N0121
-
-
- HY-N6054
-
-
- HY-N11056
-
-
- HY-N7825
-
-
- HY-N9863
-
-
- HY-N0163
-
-
- HY-N1060
-
-
- HY-N4020
-
-
- HY-N10417
-
-
- HY-N12790
-
-
- HY-W647305
-
-
- HY-N0694R
-
-
- HY-105008
-
(S,S)-SDG; (S,S)-LGM2605
|
Cardiovascular Disease
Classification of Application Fields
Neurological Disease
Source classification
Lignans
Plants
Linum usitatissimum Linn.
Microorganisms
Linaceae
Phenols
Polyphenols
Phenylpropanoids
Disease Research Fields
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Others
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Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .
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- HY-N4108
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- HY-N0608
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- HY-114275
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- HY-N8307
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- HY-N0608A
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- HY-N10079
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- HY-N7724
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- HY-N0035
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- HY-126067
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- HY-N2413
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- HY-N0121R
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- HY-N6054R
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- HY-N2180
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- HY-N1841
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- HY-N0163R
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- HY-N4108R
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- HY-N8805
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- HY-N10663
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- HY-N9351
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- HY-122938
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- HY-N12870
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- HY-N0035R
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- HY-N9071
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- HY-N12262
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- HY-N9257
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- HY-N2500
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- HY-N2180R
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- HY-N12336
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- HY-N10481
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- HY-N6802
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- HY-N0385
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- HY-N11957
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- HY-N4267
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- HY-N8618
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Structural Classification
Monophenols
Source classification
Sapindaceae
Phenols
Acer saccharum Marshall
Plants
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Others
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Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .
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- HY-N0692
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- HY-N0692R
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- HY-N1773
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- HY-N9903
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-108692S
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Enterolactone-d6 is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].
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- HY-N0121S
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Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
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