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77

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3

Biochemical Assay Reagents

7

Peptides

16

Natural
Products

5

Isotope-Labeled Compounds

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139303
    LUF5771

    		Others Endocrinology
    LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy .
    LUF5771
  • HY-119413
    9-Ethyladenine

    		Endogenous Metabolite Neurological Disease
    9-Ethyladenine is a partially effective inhibitor of APRT (adenine phosphoribosyltransferase) .
    9-Ethyladenine
  • HY-41840
    D-Glucurono-6,3-lactone acetonide

    		Biochemical Assay Reagents Others
    D-Glucurono-6,3-lactone acetonide can be converted to optically active and partially protected inositols .
    D-Glucurono-6,3-lactone acetonide
  • HY-121918
    RU 41656

    		Others Others
    RU 41656 partially alleviated triazolam-induced memory impairment but did not counteract the sedative effects of this agent .
    RU 41656
  • HY-126158
    SRI-29574

    		Dopamine Transporter Serotonin Transporter Neurological Disease
    SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT .
    SRI-29574
  • HY-131958
    D942

    		AMPK Cancer
    D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth .
    D942
  • HY-P5570
    Aurein 2.3

    		Antibiotic Bacterial Infection
    Aurein 2.3 is an antibiotic antimicrobial peptide. Aurein 2.3 partially inhibits E.coli ATPase activity and inhibits cell growth .
    Aurein 2.3
  • HY-121048
    AH 7725

    		Others Others
    AH 7725 is a sodium cromoglycate-like compound that is orally active and has the ability to inhibit (partially or completely) immediate asthmatic reactions in bronchial provocation tests for allergic asthma.
    AH 7725
  • HY-152194
    Tyrosinase-IN-10

    		Tyrosinase Cancer
    Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor with an IC50 of 1.6 μM against tyrosinase activity from human melanoma cell lysates .
    Tyrosinase-IN-10
  • HY-P5890
    YVAD-CHO

    		Interleukin Related Caspase Neurological Disease
    YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice .
    YVAD-CHO
  • HY-145724
    Drisapersen

    Kyndrisa; GSK2402968A; PRO051

    		 DNA/RNA Synthesis Others
    Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
    Drisapersen
  • HY-111006
    (+)-UH 232

    UH 232

    		 Dopamine Receptor Neurological Disease
    (+)-UH 232 is a partially selective agonist of the D3 receptor with an intrinsic activity of 0.2-0.4. (+)-UH 232 antagonized quinpirole-induced mitogenesis with a Ki value of 9.4 nM .
    (+)-UH 232
  • HY-103564
    ACDPP

    		mGluR Neurological Disease
    ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist) .
    ACDPP
  • HY-113847
    Nanterinone mesylate

    UK-61260-27

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Nanterinone mesylate (UK-61260-27) is an orally active and positive inotropic and balanced-type vasodilating agent, partially based on phosphodiesterase III inhibition with venodilating properties. Nanterinone mesylate is promising for research of cardiovascular diseases .
    Nanterinone mesylate
  • HY-113950
    Dichlorophenyl-ABA

    		Transthyretin (TTR) Neurological Disease
    Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells .
    Dichlorophenyl-ABA
  • HY-17461A
    Cortisone acetate
    2 Publications Verification

    Cortisone 21-acetate

    		 Glucocorticoid Receptor Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Endocrinology
    Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
    Cortisone acetate
  • HY-101796
    NSC-70220

    		Ras Cancer
    NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect .
    NSC-70220
  • HY-A0116A
    Trandolaprilate hydrate

    Trandolaprilat hydrate; RU 44403 hydrate

    		 Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Cardiovascular Disease
    Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .
    Trandolaprilate hydrate
  • HY-A0116
    Trandolaprilate

    Trandolaprilat; RU 44403

    		 Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Cardiovascular Disease
    Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .
    Trandolaprilate
  • HY-146380
    S1427

    		Histone Demethylase Cancer
    S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC50 of 390 nM and Ki of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells .
    S1427
  • HY-150237
    FITC-labeled Drisapersen sodium

    		DNA/RNA Synthesis Others
    FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
    FITC-labeled Drisapersen sodium
  • HY-17461
    Cortisone
    3 Publications Verification

    17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E

    		 Glucocorticoid Receptor Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Endocrinology
    Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
    Cortisone
  • HY-W718351
    (Z)-Octadec-8-enoic acid

    C18:1(8Z); cis-8-Octadecenoate; Δ8-cis-Octadecenoic acid

    		 Endogenous Metabolite Metabolic Disease
    cis-8-Octadecenoic acid is a monounsaturated fatty acid and an isomer of oleic acid (HY-N1446), trans-vaccenic acid (HY-113427), trans-petroselinic acid, and cis-petroselinic acid. It has been found in partially hydrogenated vegetable oil and milk fat.
    (Z)-Octadec-8-enoic acid
  • HY-121431
    FR-901235

    		Fungal Inflammation/Immunology
    FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice .
    FR-901235
  • HY-135784
    OSMI-2

    		OGT Acyltransferase Metabolic Disease
    OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-2 increases detained intron splicing in cells .
    OSMI-2
  • HY-125309
    ABT-299

    		Platelet-activating Factor Receptor (PAFR) Others
    ABT-299 is a prodrug of a platelet-activating factor (PAF) antagonist that exhibits significant inhibitory activity on PAF-induced β-platelet globulin release in vitro after in vivo administration in humans, an effect that may be partially attributed to the pyridine-N-oxide metabolite.
    ABT-299
  • HY-135785
    OSMI-3

    		OGT Acyltransferase Metabolic Disease
    OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .
    OSMI-3
  • HY-P2859
    Chitosanase

    		Endogenous Metabolite Metabolic Disease
    Chitosanase is a glycosyl hydrolase that catalyzes the endo hydrolysis of β-1,4-glycosidic bonds of partially acetylated chitosan to release chitosan oligosaccharides (COS). Chitosanases can convert high molecular weight chitosan into functional chitooligosaccharides with low molecular weight .
    Chitosanase
  • HY-A0116S1
    Trandolaprilate-d6

    		Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Cardiovascular Disease
    Trandolaprilate-d6 is the deuterium labeled Trandolaprilate[1]. Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[2][3].
    Trandolaprilate-d6
  • HY-17461AR
    Cortisone acetate (Standard)
    2 Publications Verification

    Cortisone 21-acetate (Standard)

    		 Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
    Cortisone acetate (Standard)
  • HY-A0116R
    Trandolaprilate (Standard)

    		Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Cardiovascular Disease
    Trandolaprilate (Standard) is the analytical standard of Trandolaprilate. This product is intended for research and analytical applications. Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .
    Trandolaprilate (Standard)
  • HY-136677
    Lnd 796

    		Others Cardiovascular Disease
    LND 796 is an aminosteroidal derivative with positive inotropic effects similar to those of digitalis. It exhibits electrophysiological, toxic, and inotropic effects in normal and partially potassium-depolarized ventricular muscles. LND 796 requires higher concentrations than digoxin to induce the same toxic symptoms. It exhibits a concentration-dependent positive inotropic effect on guinea pig papillary muscles in normal potassium solution. In partially potassium-depolarized papillary muscles, LND 796 enhances both components of contraction and increases the amplitude of slow action potentials. The mechanism of positive inotropic action of LND 796 involves enhanced calcium entry in calcium channels and inhibition of sodium-potassium ATPase. Due to its expanded positive inotropic range, LND 796 may have potential application in the treatment of congestive heart failure.
    Lnd 796
  • HY-103715
    NLRP3 modulators 1

    		NOD-like Receptor (NLR) Inflammation/Immunology
    NLRP3 modulators 1 is the potent modulator of NLRP3. NLRP3 modulators 1 agonizes or partially agonizes NLRP3 that are useful for researching a condition, disease or disorder in which a decrease in LRP3 activity contributes to the pathology (extracted from patent WO2017184746A1, compound 107) .
    NLRP3 modulators 1
  • HY-17461S1
    Cortisone-d8

    		Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
    Cortisone-d8
  • HY-B0254
    Glipizide

    CP 28720; K 4024

    		 Potassium Channel Metabolic Disease Cancer
    Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(KATP) channels among β cells of pancreatic islets of Langerhans .
    Glipizide
  • HY-17461S
    Cortisone-13C3

    		Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    Cortisone- 13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
    Cortisone-13C3
  • HY-106218
    Flurocitabine

    5-Fluorocyclocytidine; 5'-Fluorocyclocytidine

    		 Nucleoside Antimetabolite/Analog Cancer
    Flurocitabine (5-Fluorocyclocytidine) is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine (5-Fluorocyclocytidine) has antitumor activity during phase I studies in acute leukemia and solid tumors .
    Flurocitabine
  • HY-17461S3
    Cortisone-d2

    17-Hydroxy-11-dehydrocorticosterone-d2; Kendall's compound E-d2

    		 Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite Endocrinology
    Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].
    Cortisone-d2
  • HY-17461R
    Cortisone (Standard)
    3 Publications Verification

    17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard)

    		 Glucocorticoid Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
    Cortisone (Standard)
  • HY-17409
    Nystatin
    Maximum Cited Publications
    28 Publications Verification

    		 Fungal Antibiotic Apoptosis Bacterial Infection Cancer
    Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .
    Nystatin
  • HY-N11872
    Suffruticosol A

    		Others Neurological Disease
    Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora .
    Suffruticosol A
  • HY-160426
    Gcase activator 3

    		Glycosidase Neurological Disease
    Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies .
    Gcase activator 3
  • HY-13413
    Tofogliflozin hydrate
    4 Publications Verification

    CSG-452 hydrate

    		 SGLT Reactive Oxygen Species Metabolic Disease
    Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2 . Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells .
    Tofogliflozin hydrate
  • HY-116138
    RG-14467

    		Others Others
    RG-14467 is an epidermal growth factor receptor tyrosine kinase inhibitor with activity that inhibits enzyme activity. RG-14467 has similar inhibition kinetics to Lavendustin-A, with a dissociation constant of 3.4μM for the initial rapidly formed complex and an overall dissociation constant estimated to be less than or equal to 30nM, and is a partially competitive inhibitor for ATP.
    RG-14467
  • HY-N1457
    Chrysosplenetin

    		P-glycoprotein Cytochrome P450 Ferroptosis Metabolic Disease
    Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A .
    Chrysosplenetin
  • HY-126419
    Kobophenol A

    		SARS-CoV PKC Infection
    Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM .
    Kobophenol A
  • HY-B0254S
    Glipizide-d11

    		Potassium Channel Metabolic Disease
    Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].
    Glipizide-d11
  • HY-147259
    Dalmelitinib

    		c-Met/HGFR Cancer
    Dalmelitinib is an orally active selective c-Met kinase inhibitor (IC50: 2.9 nM) that binds to the ATP-binding region of c-Met. Dalmelitinib induces the phosphorylation of MET, partially or completely inhibits the phosphorylation of AKT and ERK. Dalmelitinib potently inhibits cancer cell (c-Met oncogene amplification) proliferation, and is used for the research of cancers like human non-small cell lung cancer (NSCLC) .
    Dalmelitinib
  • HY-N12763
    Sodium new houttuyfonate

    SNH

    		 Bacterial Renin Inflammation/Immunology
    Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .
    Sodium new houttuyfonate
  • HY-138657
    NCGC00378430
    1 Publications Verification

    		 Phosphatase Cancer
    NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model .
    NCGC00378430

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