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  2. Hdac2 - histone deacetylase 2 Gene

Hdac2 - histone deacetylase 2 Gene

Mus musculus

Also known as YAF1; Yy1bp; mRPD3; D10Wsu179e

Gene ID: 15182 | Gene type: protein coding

About Hdac2

Chromosome 10: 36,850,540-36,877,885 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 43 phenotypes. Broad expression in CNS E11.5 (RPKM 72.6), CNS E14 (RPKM 53.5) and 19 other tissues.

Summary

Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including histone modification; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hdac2 Products(1)

mRNA Protein Name
NM_008229.2 NP_032255.2 histone deacetylase 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
33795231 MGI
enables Krueppel-associated box domain binding IPI
IPI: Inferred from physical interaction
21177534 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24137001 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
18458156 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17392792 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
20972425 MGI
enables histone H4K16 deacetylase activity IMP
IMP: Inferred from mutant phenotype
23516383 MGI
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
12975471 MGI
enables histone deacetylase activity IGI
IGI: Inferred from genetic interaction
12975471 MGI
enables histone decrotonylase activity IDA
IDA: Inferred from direct assay
30279482 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10888872 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
18754010 MGI
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
12007404 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of or within cellular response to trichostatin A IDA
IDA: Inferred from direct assay
24137001 MGI
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
15226430 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
18754010 MGI
involved in embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in epidermal cell differentiation IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in eyelid development in camera-type eye IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in fungiform papilla formation IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in hair follicle placode formation IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
19380719 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18754010 MGI
involved in negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19503085 MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in negative regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
24675724 MGI
involved in negative regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
24675724 MGI
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
18754010 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10431247 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
19380719 MGI
involved in odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
19503085 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20833366 MGI
involved in positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
19503085 MGI
involved in protein deacetylation IDA
IDA: Inferred from direct assay
18754010 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17322895 MGI
acts upstream of or within regulation of protein deacetylation IGI
IGI: Inferred from genetic interaction
20833366 MGI
acts upstream of or within regulation of sarcomere organization IMP
IMP: Inferred from mutant phenotype
17322895 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription repressor complex IDA
IDA: Inferred from direct assay
12007404 MGI
located in chromatin IDA
IDA: Inferred from direct assay
12007404 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
14519686 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20720167 MGI
located in replication fork IDA
IDA: Inferred from direct assay
10888872 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac2 Protein Structure

HDAC2

HDAC2: cd10011 (8 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

histone deacetylase 2

HD2

YY1 transcription factor-binding protein

protein deacylase HDAC2

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac2 NCBI NCBI:3066