Hdac2 - histone deacetylase 2 Gene

Mus musculus

Also known as YAF1; Yy1bp; mRPD3; D10Wsu179e

Gene ID: 15182 | Gene type: protein coding

About Hdac2

Chromosome 10: 36,850,540-36,877,885 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 43 phenotypes. Broad expression in CNS E11.5 (RPKM 72.6), CNS E14 (RPKM 53.5) and 19 other tissues.

Summary

Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including histone modification; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hdac2 Products(1)

mRNA	Protein	Name
NM_008229.2	NP_032255.2	histone deacetylase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	33795231	MGI
enables Krueppel-associated box domain binding	IPI IPI: Inferred from physical interaction	21177534	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24137001	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	18458156	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17392792	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	20972425	MGI
enables histone H4K16 deacetylase activity	IMP IMP: Inferred from mutant phenotype	23516383	MGI
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	12975471	MGI
enables histone deacetylase activity	IGI IGI: Inferred from genetic interaction	12975471	MGI
enables histone decrotonylase activity	IDA IDA: Inferred from direct assay	30279482	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10888872	MGI
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	18754010	MGI
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	12007404	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	17322895	MGI
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17322895	MGI
acts upstream of or within cellular response to trichostatin A	IDA IDA: Inferred from direct assay	24137001	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	15226430	MGI
involved in dendrite development	IMP IMP: Inferred from mutant phenotype	18754010	MGI
involved in embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	21093383	MGI
involved in epidermal cell differentiation	IGI IGI: Inferred from genetic interaction	21093383	MGI
involved in eyelid development in camera-type eye	IGI IGI: Inferred from genetic interaction	21093383	MGI
involved in fungiform papilla formation	IGI IGI: Inferred from genetic interaction	21093383	MGI
involved in hair follicle placode formation	IGI IGI: Inferred from genetic interaction	21093383	MGI
acts upstream of or within hippocampus development	IGI IGI: Inferred from genetic interaction	19380719	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18754010	MGI
involved in negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	21093383	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19503085	MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17322895	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	21093383	MGI
involved in negative regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	24675724	MGI
involved in negative regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	24675724	MGI
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	18754010	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10431247	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21093383	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	19380719	MGI
involved in odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	21093383	MGI
acts upstream of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	19503085	MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20833366	MGI
involved in positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	21093383	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	19503085	MGI
involved in protein deacetylation	IDA IDA: Inferred from direct assay	18754010	MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17322895	MGI
acts upstream of or within regulation of protein deacetylation	IGI IGI: Inferred from genetic interaction	20833366	MGI
acts upstream of or within regulation of sarcomere organization	IMP IMP: Inferred from mutant phenotype	17322895	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription repressor complex	IDA IDA: Inferred from direct assay	12007404	MGI
located in chromatin	IDA IDA: Inferred from direct assay	12007404	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	14519686	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20720167	MGI
located in replication fork	IDA IDA: Inferred from direct assay	10888872	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	17182846	MGI
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	17182846	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac2 Protein Structure

HDAC2

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 2

HD2	YY1 transcription factor-binding protein
protein deacylase HDAC2

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10221	Vorinostat	Inhibitor	99.95%	Yes
HY-10585	Valproic acid	Inhibitor	99.19%	Unkown
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-109015	Tucidinostat	Inhibitor	98.60%	Unkown
HY-10585A	Valproic acid sodium	Inhibitor	≥99.0%	Unkown
HY-12164	Mocetinostat	Inhibitor	99.68%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-10585B	Valproic acid (sodium)(2:1)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12163	Entinostat	Inhibitor	99.82%	Phase 3
HY-50934	Tacedinaline	Inhibitor	99.32%	Phase 3
HY-10990	Abexinostat	Inhibitor	99.00%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.02%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-100748	Zabadinostat	Inhibitor	99.81%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.64%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.30%	Phase 1

Pre-clinical Phase

Bioactive Molecules (124)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-N0931	Santacruzamate A	Inhibitor	99.54%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-19618	BRD3308	Inhibitor	98.82%	Unkown
HY-100719	BRD-6929	Inhibitor	≥99.0%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-19328	ACY-775	Inhibitor	99.71%	Unkown
HY-111400	SR-4370	Inhibitor	99.95%	Unkown
HY-104008	ACY-957	Inhibitor	99.66%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-100871	WT-161	Inhibitor	98.36%	Unkown
HY-19348	Pimelic Diphenylamide 106	Inhibitor	98.54%	Unkown
HY-116818	Crebinostat	Inhibitor	99.79%	Unkown
HY-18712	BG45	Inhibitor	99.96%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-10585R	Valproic acid (Standard)	Inhibitor	/	Unkown
HY-124295	Imofinostat	Inhibitor	99.40%	Unkown
HY-117709	BRD6688	Inhibitor	98.90%	Unkown
HY-100384	NKL 22	Inhibitor	97.26%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-124053	BRD2492	Inhibitor	99.18%	Unkown
HY-146346	HD-TAC7	Inhibitor	98.75%	Unkown
HY-117583	cis-BG47	Inhibitor	98.02%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-18700	BRD73954	Inhibitor	≥98.0%	Unkown
HY-102083	BRD4884	Inhibitor	≥99.0%	Unkown
HY-156422	KPZ560	Inhibitor	99.72%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-142690A	HDAC-IN-27 dihydrochloride	Inhibitor	/	Unkown
HY-152174	HDAC-IN-52	Inhibitor	99.46%	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	95.17%	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-143497	HDAC1/2 and CDK2-IN-1	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-168962	HDAC-IN-88	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-154855	HDAC-IN-56	Inhibitor	/	Unkown
HY-172159	FF2039	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-151248	HDAC2-IN-1	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-152173	HDAC-IN-51	Inhibitor	/	Unkown
HY-173330	HDAC-IN-89	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-142690	HDAC-IN-27	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-144332	PHD2/HDACs-IN-1	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-109015S	Tucidinostat-d4	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-157481	HDAC1-IN-6	Inhibitor	/	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-173064	DS-103	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-146392	HDAC-IN-39	Inhibitor	/	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-162487	HDAC-IN-72	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-144293	HDAC-IN-31	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-125645	M122	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-161667	GSK-3β/HDAC-IN-1	Inhibitor	/	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-162319	Tubulin/HDAC-IN-4	Inhibitor	/	Unkown
HY-147840	HDAC-IN-41	Inhibitor	/	Unkown
HY-172359	PROTAC HDAC6 degrader 4	Degrader	/	Unkown
HY-162769	HDAC3-IN-5	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-117374	HDAC3-IN-1	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-117583A	BG47	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-150109A	Purinostat	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-124337	BG48	Inhibitor	/	Unkown
HY-172167	PD-L1/HDAC-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hdac2	NCBI	NCBI:3066

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