1. Gene
  2. Src - Rous sarcoma oncogene Gene

Src - Rous sarcoma oncogene Gene

Mus musculus

Also known as pp60c-src

Gene ID: 20779 | Gene type: protein coding

About Src

Chromosome 2: 157,260,364-157,313,782 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 261 orthologues, 32 paralogues and is associated with 54 phenotypes. Ubiquitous expression in duodenum adult (RPKM 49.), colon adult (RPKM 48.4) and 23 other tissues.

Summary

Enables several functions, including connexin binding activity; Ephrin Receptor binding activity; and scaffold protein binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; positive regulation of signal transduction; and protein destabilization. Acts upstream of or within several processes, including animal organ development; cellular response to growth factor stimulus; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal Cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human Src (Src proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Src Products(13)

mRNA Protein Name
NM_001412690.1 NP_001399619.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412691.1 NP_001399620.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001025395.3 NP_001020566.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412689.1 NP_001399618.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412693.1 NP_001399622.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412682.1 NP_001399611.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412683.1 NP_001399612.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_009271.4 NP_033297.2 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412687.1 NP_001399616.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412686.1 NP_001399615.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412684.1 NP_001399613.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412685.1 NP_001399614.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412688.1 NP_001399617.1 proto-oncogene tyrosine-protein kinase Src isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables connexin binding IPI
IPI: Inferred from physical interaction
14699011 MGI
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
12925710 MGI
enables kinase activity IMP
IMP: Inferred from mutant phenotype
12808090 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7518772 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
8438166 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
11274221 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
23100514 MGI
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
22759635 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8910389 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
12091389 MGI
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12091389 MGI
Biological Process GO Annotation Evidence Reference Source
involved in angiotensin-activated signaling pathway IGI
IGI: Inferred from genetic interaction
25017399 MGI
acts upstream of or within bone resorption IMP
IMP: Inferred from mutant phenotype
19448635 MGI
involved in bone resorption IMP
IMP: Inferred from mutant phenotype
14739300 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
16007215 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
15292044 MGI
acts upstream of or within cellular response to fluid shear stress IMP
IMP: Inferred from mutant phenotype
24841674 MGI
acts upstream of or within cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
23651497 MGI
involved in cellular response to peptide hormone stimulus IGI
IGI: Inferred from genetic interaction
25017399 MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
17623777 MGI
acts upstream of or within cellular response to reactive oxygen species IDA
IDA: Inferred from direct assay
24190966 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IGI
IGI: Inferred from genetic interaction
21829547 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
16162939 MGI
involved in interleukin-6-mediated signaling pathway IDA
IDA: Inferred from direct assay
25731159 MGI
involved in intestinal epithelial cell development IDA
IDA: Inferred from direct assay
25731159 MGI
acts upstream of or within intracellular signal transduction IGI
IGI: Inferred from genetic interaction
23526378 MGI
acts upstream of or within odontogenesis IMP
IMP: Inferred from mutant phenotype
23174213 MGI
acts upstream of or within oogenesis IMP
IMP: Inferred from mutant phenotype
16007215 MGI
acts upstream of or within osteoclast development IGI
IGI: Inferred from genetic interaction
23526378 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
12526740 MGI
involved in peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
27505886 MGI
involved in phosphorylation IMP
IMP: Inferred from mutant phenotype
12091389 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17045821 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25731159 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19920076 MGI
involved in positive regulation of glycolytic process IDA
IDA: Inferred from direct assay
35263589 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IGI
IGI: Inferred from genetic interaction
17344476 MGI
acts upstream of or within positive regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
23651497 MGI
acts upstream of or within positive regulation of podosome assembly IDA
IDA: Inferred from direct assay
21525037 MGI
acts upstream of or within positive regulation of podosome assembly IGI
IGI: Inferred from genetic interaction
21525037 MGI
acts upstream of or within positive regulation of protein localization to nucleus IGI
IGI: Inferred from genetic interaction
17344476 MGI
acts upstream of or within positive regulation of protein processing IGI
IGI: Inferred from genetic interaction
17344476 MGI
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
25259869 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
11274221 MGI
acts upstream of or within regulation of cell projection assembly IGI
IGI: Inferred from genetic interaction
11864995 MGI
involved in regulation of heart rate by cardiac conduction IGI
IGI: Inferred from genetic interaction
25017399 MGI
acts upstream of or within regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16007215 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
22027834 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
11864995 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
16007215 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin filament IDA
IDA: Inferred from direct assay
17623777 MGI
located in caveola IDA
IDA: Inferred from direct assay
12091389 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14699011 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
12615910 MGI
located in focal adhesion IMP
IMP: Inferred from mutant phenotype
22801373 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
22801373 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
12615910 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12615910 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12615910 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17623777 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12615910 MGI
located in podosome IDA
IDA: Inferred from direct assay
17893324 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
17623777 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Src Protein Structure

SH3_Src

SH3_Src: cd12008 (86 - 141)

SH2_Src_Src

SH2_Src_Src: cd10365 (145 - 245)

PTKc_Src

PTKc_Src: cd05071 (258 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase Src

neuronal proto-oncogene tyrosine-protein kinase Src

p60-Src

proto-oncogene c-Src

Recombinant Src Proteins

Cat. No. Product Name Accession Purity
HY-P73423 Src Protein, Mouse (sf9, His-GST) P05480-2 (M1-L535) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Src NCBI NCBI:6714