2. Gene
  3. Cdk2 - cyclin dependent kinase 2 Gene

Cdk2 - cyclin dependent kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 362817 | Gene type: protein coding

About Cdk2

Primary_assembly 7: 1,129,811-1,137,403 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 203 orthologues, 24 paralogues and is associated with 15 phenotypes. Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 69.2) and 9 other tissues.

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to Insulin stimulus; response to cAMP; and response to estradiol. Located in cytosol and nucleus. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in prostate Cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdk2 Products(1)

mRNA Protein Name
NM_199501.2 NP_955795.1 cyclin-dependent kinase 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
15809057 RGD
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11823715 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10952244 RGD
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
19151707 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16534847 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
15994754 RGD
involved in lens development in camera-type eye IEP
IEP: Inferred from expression pattern
10620399 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
15994754 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
16730872 RGD
involved in response to electrical stimulus IDA
IDA: Inferred from direct assay
15607308 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16019103 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16689928 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17343987 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17706465 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk2 Protein Structure

STKc_CDK2_3

STKc_CDK2_3: cd07860 (2 - 333)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 2

cell division protein kinase 2

cyclin dependent kinase 2-alpha

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-10492 Dinaciclib Inhibitor 99.64% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-B0402 Amantadine Inhibitor 99.90% Unkown
HY-B0402A Amantadine hydrochloride Inhibitor ≥98.0% Yes
HY-B0263 Thiabendazole Inhibitor 99.77% Unkown
HY-B0402B Amantadine sulfate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-10005 Flavopiridol Inhibitor 99.73% Phase 2
HY-30237 (R)-Roscovitine Inhibitor 99.53% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-101212 Fadraciclib Inhibitor 99.78% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 2
HY-103712 Samuraciclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-138293 SY-5609 Inhibitor 99.33% Phase 1
HY-10008 SNS-032 Inhibitor 99.54% Phase 1
HY-141680 CPS2 Inhibitor 99.33% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-137443 Ipivivint Inhibitor 99.95% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
Pre-clinical Phase
Bioactive Molecules (160)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12529 Ro-3306 Inhibitor 99.83% Unkown
HY-12302 Kenpaullone Inhibitor 98.20% Unkown
HY-103248 Toyocamycin Inhibitor 99.78% Unkown
HY-137894A Tagtociclib hydrate Inhibitor 99.95% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.82% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.91% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-101257 YKL-5-124 Inhibitor 98.79% Unkown
HY-130665 TL12-186 Inhibitor 99.63% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.61% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.81% Unkown
HY-130709 PROTAC CDK2/9 Degrader-1 Inhibitor 99.85% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-15004 AUZ 454 Inhibitor 99.57% Unkown
HY-18930 NU6300 Inhibitor 98.44% Unkown
HY-127104 FMF-04-159-2 Inhibitor 99.48% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% Unkown
HY-13914 Roniciclib Inhibitor 98.09% Unkown
HY-15275 BMS-265246 Inhibitor 98.92% Unkown
HY-18299A Purvalanol A Inhibitor 98.30% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-117535 CDK2-IN-4 Inhibitor 96.71% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% Unkown
HY-18629 SU9516 Inhibitor 99.81% Unkown
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.78% Unkown
HY-18299 Purvalanol B Inhibitor ≥97.0% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-X0150 JSH-150 Inhibitor 98.66% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-16559 Riviciclib hydrochloride 98.89% Unkown
HY-108359 Alsterpaullone Inhibitor 99.85% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-108136A Bisindolylmaleimide X hydrochloride Antagonist 98.90% Unkown
HY-145694 CDK5-IN-3 Inhibitor 99.49% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.03% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-15889 AMG 925 Inhibitor 98.20% Unkown
HY-112460 CDK2-IN-3 Inhibitor ≥97.0% Unkown
HY-107419 NU6140 Inhibitor 99.07% Unkown
HY-W011428 Olomoucine Inhibitor 99.87% Unkown
HY-103647 K00546 Inhibitor 98.08% Unkown
HY-112358 GW8510 Inhibitor 99.64% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 96.15% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.81% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-103646 CK7 Inhibitor 99.72% Unkown
HY-19316 NU2058 Inhibitor 99.66% Unkown
HY-154851 GSK-3 inhibitor 3 Inhibitor 98.72% Unkown
HY-N5072 Desmethylglycitein Inhibitor 98.98% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 98.06% Unkown
HY-41076 Ca2+ channel agonist 1 Inhibitor 99.71% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-100429 CAN508 Inhibitor 99.59% Unkown
HY-13816 NU6027 Inhibitor 99.04% Unkown
HY-100600 BGG463 Inhibitor ≥98.0% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.90% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-139328 CDK12-IN-5 Inhibitor 99.01% Unkown
HY-W019806 Lacto-N-fucopentaose I Activator 99.92% Unkown
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% Unkown
HY-14372 BS-194 Inhibitor 99.36% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-12843 Bohemine Inhibitor 98.93% Unkown
HY-13461 PHA-767491 Inhibitor 99.85% Unkown
HY-157516 CDK2-IN-22 Inhibitor 98.64% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-139011 IV-361 Inhibitor 99.60% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor / Unkown
HY-148868A Akt1&PKA-IN-2 Inhibitor / Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-X0009A JSH-009 dimaleate Inhibitor / Unkown
HY-139329 CDK12-IN-6 Inhibitor 98.09% Unkown
HY-100035 PT-262 Inhibitor 99.21% Unkown
HY-164827 CDK2 degrader 3 Degrader / Unkown
HY-164664 CDK2-IN-30 Inhibitor / Unkown
HY-148868 Akt1&PKA-IN-1 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-130001 CDK9-IN-9 Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-130981 FN-1501-propionic acid / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-170442 CDK2-IN-37 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-144811 CDK2-IN-9 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-147771 ZLWT-37 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-156470 Multi-kinase-IN-6 Inhibitor / Unkown
HY-148651 CDK2-IN-15 Inhibitor / Unkown
HY-168845 CDK2/9-IN-1 Inhibitor / Unkown
HY-170965 Anticancer agent 264 Inhibitor / Unkown
HY-169910 CDK2 degrader 4 Inhibitor / Unkown
HY-115943 Anticancer agent 30 Inhibitor / Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader / Unkown
HY-150573 CDK2-IN-12 Inhibitor / Unkown
HY-150570 Carbonic anhydrase inhibitor 14 Inhibitor / Unkown
HY-155218 TMX-2172 Degrader / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-151580S CDK2-IN-14-d3 Inhibitor / Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-111356 IIIM-290 Inhibitor / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-160556 CDK2-IN-26 Inhibitor / Unkown
HY-145867 EGFR-IN-45 Inhibitor / Unkown
HY-161595 CDK5-IN-4 Inhibitor / Unkown
HY-161690 EF-4-177 Inhibitor / Unkown
HY-164906 TMX-2138 Degrader / Unkown
HY-145693 CDK5-IN-2 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-151069 TMX-2039 Inhibitor / Unkown
HY-149407 Multi-kinase-IN-4 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-154852 GSK-3 inhibitor 4 Inhibitor / Unkown
HY-170897 CDK2-IN-40 Inhibitor / Unkown
HY-161776 P-gp/CDK2-IN-1 Inhibitor / Unkown
HY-144810 CDK2-IN-8 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-168513 ALK-IN-29 Inhibitor / Unkown
HY-168067 CDK-IN-14 Inhibitor / Unkown
HY-170441 CDK2-IN-36 Inhibitor / Unkown
HY-169912 CDK2 degrader 5 Degrader / Unkown
HY-159805 CDK2-IN-31 Inhibitor / Unkown
HY-147698 ZLHQ-5f Inhibitor / Unkown
HY-162528 CDK12-IN-7 Inhibitor / Unkown
HY-155441 CDK2-IN-20 Inhibitor / Unkown
HY-151071 TMX-3013 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-162416 CDK7-IN-27 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-151984 CDK9-IN-22 Inhibitor / Unkown
HY-139651 CDK2-IN-7 Inhibitor / Unkown
HY-112450 Olomoucine II Inhibitor / Unkown
HY-123045 PNU-292137 Inhibitor / Unkown
HY-112403 (S)-Roscovitine Inhibitor / Unkown
HY-160643 CDK2-IN-27 Inhibitor / Unkown
HY-123826 CCT68127 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk2 NCBI NCBI:1017
Mus musculus Cdk2 NCBI NCBI:12566