2. Gene
  3. PAM - peptidylglycine alpha-amidating monooxygenase Gene

PAM - peptidylglycine alpha-amidating monooxygenase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAL; PHM

Gene ID: 5066 | Gene type: protein coding

About PAM

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:102,754,783-103,031,105 (from NCBI)

This gene has 32 transcripts (splice variants) and 208 orthologues. Broad expression in heart (RPKM 269.6), adrenal (RPKM 54.3) and 15 other tissues.

Summary

This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine Peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PAM Products(19)

mRNA Protein Name
NM_000919.4 NP_000910.2 peptidyl-glycine alpha-amidating monooxygenase isoform a precursor
NM_001177306.2 NP_001170777.1 peptidyl-glycine alpha-amidating monooxygenase isoform e preproprotein
NM_001319943.1 NP_001306872.1 peptidyl-glycine alpha-amidating monooxygenase isoform f precursor
NM_001364582.2 NP_001351511.1 peptidyl-glycine alpha-amidating monooxygenase isoform g precursor
NM_001364583.2 NP_001351512.1 peptidyl-glycine alpha-amidating monooxygenase isoform h precursor
NM_001364584.2 NP_001351513.1 peptidyl-glycine alpha-amidating monooxygenase isoform i precursor
NM_001364585.2 NP_001351514.1 peptidyl-glycine alpha-amidating monooxygenase isoform j precursor
NM_001364586.2 NP_001351515.1 peptidyl-glycine alpha-amidating monooxygenase isoform k precursor
NM_001364587.2 NP_001351516.1 peptidyl-glycine alpha-amidating monooxygenase isoform l precursor
NM_001364588.2 NP_001351517.1 peptidyl-glycine alpha-amidating monooxygenase isoform m precursor
NM_001364589.2 NP_001351518.1 peptidyl-glycine alpha-amidating monooxygenase isoform n precursor
NM_001364590.2 NP_001351519.1 peptidyl-glycine alpha-amidating monooxygenase isoform o
NM_001364591.2 NP_001351520.1 peptidyl-glycine alpha-amidating monooxygenase isoform p precursor
NM_001364592.2 NP_001351521.1 peptidyl-glycine alpha-amidating monooxygenase isoform q precursor
NM_001364593.2 NP_001351522.1 peptidyl-glycine alpha-amidating monooxygenase isoform r precursor
NM_001364594.2 NP_001351523.1 peptidyl-glycine alpha-amidating monooxygenase isoform s precursor
NM_138766.2 NP_620121.1 peptidyl-glycine alpha-amidating monooxygenase isoform b precursor
NM_138821.2 NP_620176.1 peptidyl-glycine alpha-amidating monooxygenase isoform c precursor
NM_138822.2 NP_620177.1 peptidyl-glycine alpha-amidating monooxygenase isoform d precursor

PAM Protein Structure

Cu2_monooxygen

Cu2_monooxygen: Copper type II ascorbate-dependent monooxygenase, N-terminal domain (59 - 174)

Cu2_monoox_C

Cu2_monoox_C: Copper type II ascorbate-dependent monooxygenase, C-terminal domain (196 - 344)

NHL

NHL: NHL repeat (578 - 605)

NHL

NHL: NHL repeat (630 - 659)

NHL

NHL: NHL repeat (683 - 711)

NHL

NHL: NHL repeat (779 - 806)

  • 0
  • 200
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  • 600
  • 800
  • 973 a.a.
Protein Preferred Names Protein Names

peptidyl-glycine alpha-amidating monooxygenase

pancreatic peptidylglycine alpha-amidating monooxygenase

Recombinant PAM Proteins

Cat. No. Product Name Accession Purity
HY-P73731 PAM Protein, Human (HEK293, His) P19021-2/NP_620176.1 (F21-S866) ≥95%
HY-P73732 PAM Protein, Human (HEK293, Fc) P19021-2/NP_620176.1 (F21-V710) ≥95%

Related Diseases

Diseases Alias
Menkes Disease

Copper Transport Disease

Menkes Syndrome

MNK

Kinky Hair Disease

Steely Hair Disease

Menkes Kinky-Hair Syndrome

Mk

Steely Hair Syndrome

Menkea Syndrome

Md

Menkes Kinky Hair Syndrome

Hypocupremia, Congenital

Kinky Hair Syndrome

X-Linked Copper Deficiency

Menkes Kinky Hair Disease
Spinal Muscular Atrophy, Distal, X-Linked 3

SMAX3

Dsmax

X-Linked Distal Spinal Muscular Atrophy Type 3

X-Linked Distal Spinal Muscular Atrophy 3

Atp7a-Related Distal Motor Neuropathy

X-Linked Dhmn3

X-Linked Distal Hereditary Motor Neuropathy Type 3

X-Linked Dsma3

Spinal Muscular Atrophy, Distal, X-Linked Recessive

X-Linked Recessive Distal Spinal Muscular Atrophy

Distal Spinal Muscular Atrophy, X-Linked, 3

DSMAX3

Spinal Muscular Atrophy Distal X-Linked Recessive

Atrophy, Muscular, Spinal, Distal, X-Linked, Type 3
Schizophrenia 1

SCZD1

Schizophrenia Susceptibility Locus, Chromosome 5-Related

Schizophrenia 1 With Or Without An Affective Disorder
Copper Deficiency Myelopathy

Swayback

Human Swayback
Occipital Horn Syndrome

OHS

Eds Ix

Cutis Laxa X-Linked

Cutis Laxa, X-Linked

Cutis Laxa, X-Linked, Formerly

Ehlers-Danlos Syndrome, Occipital Horn Type, Formerly

Eds Ix, Formerly

Eds9, Formerly

Ehlers-Danlos Syndrome Type 9

Ehlers-Danlos Syndrome Type Ix

X-Linked Cutis Laxa

Ehlers-Danlos Syndrome, Occipital Horn Type

Eds9

Ehlers-Danlos Syndrome Occipital Horn Type
Postpoliomyelitis Syndrome

Postpolio Syndrome

Post-Polio Syndrome

Post Polio Syndrome

Polio Late Effects

Post-Polio Muscular Atrophy

Post-Polio Sequelae

Post-Poliomyelitic Syndrome

Postpolio Sequelae

Postpoliomyelitic Syndrome

Postpoliomyelitis Sequelae
Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma

Mednik Syndrome

Erythrokeratodermia Variabilis 3

MEDNIK

Ekv3

Erythrokeratodermia Variabilis, Kamouraska Type

Mental Retardation, Enteropathy, Deafness, Neuropathy, Ichthyosis, Keratodermia

Intellectual Disability-Enteropathy-Deafness-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome

Intellectual Disability-Enteropathy-Hearing Loss-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome

Intellectual Disability, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma

Erythrokeratodermia Variabilis Kamouraska Type

Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, Keratoderma
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0106 Levamisole 99.96% Yes
HY-B1200 Pralidoxime chloride Activator 99.73% Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-128770 LY3154207 Agonist 99.87% Phase 2
HY-132806 Alogabat Activator 99.93% Phase 2
HY-108703 Foliglurax Agonist / Phase 2
HY-144291 LY3154885 Agonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (133)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1180A Pam3CSK4 TFA Agonist 99.66% Unkown
HY-108471 CU-CPT22 Inhibitor ≥99.0% Unkown
HY-110279 Ogerin Modulator 99.58% Unkown
HY-112146 MMG-11 Antagonist 99.11% Unkown
HY-115467 MitoBloCK-10 98.89% Unkown
HY-113320 Etiocholanolone Modulator 99.31% Unkown
HY-120023 VU0453595 Agonist 99.90% Unkown
HY-120874 PF-06372865 Activator 99.29% Unkown
HY-111052 AZD7325 99.27% Unkown
HY-108703A Foliglurax monohydrochloride Agonist 98.93% Yes
HY-120613 BMS-986187 Activator 98.93% Unkown
HY-124419 RO0711401 Agonist 98.42% Unkown
HY-143312 V-0219 Modulator 98.65% Unkown
HY-114933 VU0119498 Modulator 99.52% Unkown
HY-12158 VU0238441 Activator 99.88% Unkown
HY-12439 ML380 Agonist 99.91% Unkown
HY-14418 VU0361737 Agonist 99.79% Unkown
HY-18654 ADX88178 Agonist 99.69% Unkown
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% Unkown
HY-129086 BPAM344 Agonist 99.68% Unkown
HY-141899 MK-6884 Modulator 99.11% Unkown
HY-143312A V-0219 hydrochloride Modulator 99.65% Unkown
HY-14417 VU0155041 Agonist 99.32% Unkown
HY-113346 Tetrahydrodeoxycorticosterone Agonist 99.45% Unkown
HY-13058 ADX-47273 Agonist 99.94% Unkown
HY-131004 CB2R PAM Agonist 98.46% Unkown
HY-136190 TRPC6-PAM-C20 Agonist 99.90% Unkown
HY-P1181A Pam2CSK4 TFA Agonist 99.28% Unkown
HY-100588 VU0364770 Agonist 99.93% Unkown
HY-100605 VU0483605 Modulator 97.03% Unkown
HY-113689 GAT211 Agonist 99.98% Unkown
HY-120184 VU0467485 Agonist ≥99.0% Unkown
HY-122255 LY487379 Inhibitor 98.88% Unkown
HY-148867 UCM-1306 Modulator 99.61% Unkown
HY-15476 VU 0364439 Agonist 98.36% Unkown
HY-112146A MMG-11 quarterhydrate Antagonist 99.09% Unkown
HY-14612 CPPHA Modulator 98.04% Unkown
HY-103475 GS39783 Agonist 99.72% Unkown
HY-113320S Etiocholanolone-d5 Modulator 99.20% Unkown
HY-116463 E1R Agonist 99.83% Unkown
HY-116819 VU0453379 Modulator ≥98.0% Unkown
HY-119078 VU0080241 Modulator 99.69% Unkown
HY-122819 Calindol hydrochloride Agonist 99.88% Unkown
HY-126327 UNC4976 Antagonist / Unkown
HY-126327A UNC4976 TFA Antagonist ≥98.0% Unkown
HY-137204 COR659 Activator 99.94% Unkown
HY-143312D (R)-V-0219 hydrochloride Modulator 99.37% Unkown
HY-143312E (S)-V-0219 hydrochloride Modulator 99.71% Unkown
HY-12149 A-867744 Agonist 99.76% Unkown
HY-114863 PHCCC(4Me) Modulator / Unkown
HY-116855 TASP0433864 Modulator 99.9% Unkown
HY-119226 VU0152099 Agonist 98.35% Unkown
HY-120530 JNJ-46281222 Inhibitor 98.77% Unkown
HY-139044 VU6000918 Activator 99.36% Unkown
HY-141515 BMS-986121 Modulator 98.89% Unkown
HY-14419 TCN238 Modulator 99.57% Unkown
HY-149453 MCUF-651 Modulator 99.85% Unkown
HY-162455 NA-014 Agonist 99.49% Unkown
HY-16951 VU-1545 Agonist 99.00% Unkown
HY-P1180 Pam3CSK4 Agonist / Unkown
HY-W115727A Polyacrylamide,Anion,Mw 14-16 million / Unkown
HY-11048 NS11394 Modulator 99.77% Unkown
HY-113346S Tetrahydrodeoxycorticosterone-d3 Agonist 98.50% Unkown
HY-15393 VU 0357121 Agonist 99.97% Unkown
HY-W338852 Gentisuric acid 99.65% Unkown
HY-112814 VU6001376 / Unkown
HY-128584 VU6005806 Agonist / Unkown
HY-101841 LY 2033298 Activator / Unkown
HY-103552 LY487379 hydrochloride Modulator / Unkown
HY-103571 VU0285683 Antagonist / Unkown
HY-107423 GNE 6901 Agonist / Unkown
HY-107504 VU0360172 hydrochloride Agonist / Unkown
HY-107506 Ro 67-4853 Agonist 99.90% Unkown
HY-113320S1 Etiocholanolone-d2 Modulator / Unkown
HY-113608 VCP171 Modulator / Unkown
HY-114978 VU0424465 Agonist / Unkown
HY-116463A (2R,3S)-E1R Agonist 98.84% Unkown
HY-116463B (2S,3S)-E1R Agonist 98.24% Unkown
HY-116463C (2R,3R)-E1R Agonist 98.79% Unkown
HY-116463D (Rac)-E1R Agonist 98.48% Unkown
HY-117408 VU6004256 Modulator / Unkown
HY-117611 GAT107 Modulator / Unkown
HY-117851 AC-265347 Agonist 99.97% Unkown
HY-118179 VU0486321 / Unkown
HY-118256 LSN2814617 Modulator / Unkown
HY-120004 PF-06827443 / Unkown
HY-120576 ML169 Modulator / Unkown
HY-120727 VU0364289 Activator 99.52% Unkown
HY-121806 VU0486846 Modulator / Unkown
HY-124112 PAM 1392 Inhibitor / Unkown
HY-124372 JNJ-46356479 Modulator / Unkown
HY-124821 VA012 Modulator / Unkown
HY-128783 VU0090157 Modulator / Unkown
HY-136258 nAChR agonist CMPI hydrochloride Agonist / Unkown
HY-143312B (R)-V-0219 Modulator / Unkown
HY-143312C (S)-V-0219 Modulator / Unkown
HY-14417B VU0155041 sodium Agonist / Unkown
HY-147260B (Rac)-Dalzanemdor Modulator / Unkown
HY-147421 Xilmenolone Modulator / Unkown
HY-149975 AMPA receptor modulator-4 Activator / Unkown
HY-151899 A3AR modulator 1 Agonist / Unkown
HY-155628 AMPA receptor modulator-6 Modulator / Unkown
HY-157421 Nampt activator-4 Modulator / Unkown
HY-159177 M4 mAChR Modulator-1 Modulator / Unkown
HY-159509 Claziprotamidum / Unkown
HY-159624 KK-92A Modulator / Unkown
HY-160529 α7 nAChR Modulator-2 Modulator / Unkown
HY-161810 MRS8247 Modulator / Unkown
HY-162454 DA-023 Modulator / Unkown
HY-162662 VU6008677 / Unkown
HY-163280 JGB-1-155 Activator / Unkown
HY-168025 VU6007496 / Unkown
HY-18679 TC-N 22A Agonist / Unkown
HY-19623 VU0092273 Agonist / Unkown
HY-P1180B Pam3CSK4 trihydrochloride / Unkown
HY-P1181 Pam2CSK4 Agonist / Unkown
HY-P1405 Pam3CSK4-Biotin Agonist / Unkown
HY-RS10011 PAM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10012 PAM16 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W115727 Polyacrylamide,Anion,Mw 10-12 million / Unkown
HY-W115727B Polyacrylamide,Anion,Mw 18 million / Unkown
HY-103535 GBLD345 Agonist / Unkown
HY-118022 VU0361747 / Unkown
HY-119772 VU0366369 Modulator / Unkown
HY-122164 LY-503430 Agonist / Unkown
HY-123667 NCFP Modulator / Unkown
HY-123934 VU6007477 Modulator / Unkown
HY-129517 UBP714 Agonist / Unkown
HY-155467 MRS7935 Modulator / Unkown
HY-161113 Z8554052021 Activator / Unkown
HY-161118 MB327 / Unkown
HY-W115727D Polyacrylamide,average Mn 40000 / Unkown
HY-W115727E Polyacrylamide,average Mn 150000 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PAM RGD RGD:3252
Bos taurus PAM VGNC VGNC:32561
Macaca mulatta PAM VGNC VGNC:75752
Mus musculus PAM MGD MGI:97475
Canis familiaris PAM VGNC VGNC:44250
Felis catus PAM VGNC VGNC:68690
Others PAM NCBI