HDAC8 - histone deacetylase 8 Gene

Homo sapiens

Also known as HD8; WTS; RPD3; CDA07; CDLS5; KDAC8; MRXS6; HDACL1

Gene ID: 55869 | Gene type: protein coding

About HDAC8

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,329,516-72,572,843 (from NCBI)

This gene has 60 transcripts (splice variants), 202 orthologues, 10 paralogues and is associated with 5 phenotypes.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

HDAC8 Products(27)

mRNA	Protein	Name
XM_017029641.3	XP_016885130.2	histone deacetylase 8 isoform X3
XM_047442256.1	XP_047298212.1	histone deacetylase 8 isoform X11
XM_047442252.1	XP_047298208.1	histone deacetylase 8 isoform X4
NM_001410730.1	NP_001397659.1	histone deacetylase 8 isoform 11
NR_051952.2
XM_011530986.4	XP_011529288.3	histone deacetylase 8 isoform X1
NM_001166422.2	NP_001159894.1	histone deacetylase 8 isoform 5
NM_018486.3	NP_060956.1	histone deacetylase 8 isoform 1
NM_001166418.2	NP_001159890.1	histone deacetylase 8 isoform 2
XM_017029644.3	XP_016885133.2	histone deacetylase 8 isoform X8
NM_001410725.1	NP_001397654.1	histone deacetylase 8 isoform 7
XM_047442257.1	XP_047298213.1	histone deacetylase 8 isoform X13
XM_017029647.3	XP_016885136.2	histone deacetylase 8 isoform X12
XR_938402.4
XM_047442255.1	XP_047298211.1	histone deacetylase 8 isoform X10
NM_001410727.1	NP_001397656.1	histone deacetylase 8 isoform 8
NM_001410729.1	NP_001397658.1	histone deacetylase 8 isoform 10
NM_001410728.1	NP_001397657.1	histone deacetylase 8 isoform 9
XM_017029640.3	XP_016885129.2	histone deacetylase 8 isoform X2
XM_017029643.3	XP_016885132.2	histone deacetylase 8 isoform X7
XM_017029645.3	XP_016885134.2	histone deacetylase 8 isoform X9
XM_017029642.2	XP_016885131.2	histone deacetylase 8 isoform X5
XM_047442253.1	XP_047298209.1	histone deacetylase 8 isoform X6
NM_001166419.2	NP_001159891.1	histone deacetylase 8 isoform 3
NM_001166448.2	NP_001159920.1	histone deacetylase 8 isoform 6
NM_001166420.2	NP_001159892.1	histone deacetylase 8 isoform 4
XM_047442252.1	XP_047298208.1	histone deacetylase 8 isoform X2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables histone decrotonylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	22885700	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	22885700	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16809764	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	16809764	GOA
involved in regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	16809764	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC8 Protein Structure

Hist_deacetyl

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 8

histone deacetylase-like 1	protein deacetylase HDAC8
protein decrotonylase HDAC8

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome	WTS
Mrxs6	Mental Retardation, X-Linked, Syndromic 6
Mental Retardation, X-Linked, With Gynecomastia And Obesity	X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome
Mrxswt	Wilson-Turner X-Linked Mental Retardation Syndrome
Wilson Turner Mental Retardation Syndrome	X-Linked Intellectual Disability - Gynecomastia - Obesity

Familial Isolated Trichomegaly

Long Eyelashes

Tcmgly

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies	Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome
Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Hypomelia Hypotrichosis Facial Hemangioma Syndrome
Tetraphocomelia-Cleft Palate Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Cornelia De Lange Syndrome 5

CDLS5

Cornelia De Lange Syndrome, Type 5

Cornelia De Lange Syndrome 1

De Lange Syndrome	CDLS1
Cdl	Cdls
Typus Degenerativus Amstelodamensis	Brachmann-De Lange Syndrome
Bdls	Amstelodamensis Typus Degenerativus
Cornelia De Lange Syndrome, Type 1

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Syndactyly, Type Iii

Syndactyly Type 3	SDTY3
Ring And Little Finger Syndactyly	Syndactyly Of Fingers Iv And V
Syndactyly Of Fingers 4 And 5	Ringand Little Finger Syndactyly
Syndactyly Of Fingers Four And Five	Syndactyly Of The Ring And Little Finger
Sd3	Syndactyly 3
Syndactyly Type Iii	4-5 Finger Syndactyly
Syndactyly, Type 3

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

White-Sutton Syndrome

WHSUS	Mrd37
Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome	Mental Retardation, Autosomal Dominant 37
Autosomal Dominant Mental Retardation 37	Pogz-Related Intellectual Disability Syndrome

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Interatrial Communication

Asd	Atrial Septal Defect
Interauricular Communication

Atrial Heart Septal Defect

Atrial Septal Defect	Atrial Septal Defects
Atrioseptal Defect	Auricular Septal Defect
Congenital Atrial Septal Defect	Interatrial Septal Defect
Interauricular Septal Defect	Heart Septal Defects, Atrial
Septal Defect, Atrial

Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10	Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures
Optic Atrophy 10	Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects

Cornelia De Lange Syndrome 4	CDLS4
Cornelia De Lange Syndrome, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109015	Tucidinostat	Inhibitor	98.70%	Unkown
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10990	Abexinostat	Inhibitor	98.63%	Phase 3
HY-14842	Givinostat	Inhibitor	98.16%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.28%	Phase 2
HY-14718A	Resminostat hydrochloride	Inhibitor	99.68%	Phase 2
HY-138799	KA2507	Inhibitor	99.24%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.42%	Phase 2
HY-14718	Resminostat	Inhibitor	99.84%	Phase 2
HY-10223	CUDC-101	Inhibitor	98.84%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.30%	Phase 1
HY-124295	MPT0E028	Inhibitor	99.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (112)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13271A	Tubastatin A	Inhibitor	98.37%	Unkown
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-15224	PCI-34051	Inhibitor	99.75%	Unkown
HY-13271	Tubastatin A Hydrochloride	Inhibitor	98.19%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-N6735	Apicidin	Inhibitor	99.87%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-111818	TH34	Inhibitor	99.52%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.59%	Unkown
HY-111342	HDAC8-IN-1	Inhibitor	99.82%	Unkown
HY-111400	SR-4370	Inhibitor	99.95%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-144779	HDAC10-IN-1	Inhibitor	99.11%	Unkown
HY-100871	WT-161	Inhibitor	98.36%	Unkown
HY-19348	Pimelic Diphenylamide 106	Inhibitor	98.54%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-13267	Droxinostat	Inhibitor	98.91%	Unkown
HY-117348	NCC-149	Inhibitor	99.14%	Unkown
HY-130538	1-Naphthohydroxamic acid	Inhibitor	99.72%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-18700	BRD73954	Inhibitor	≥98.0%	Unkown
HY-100384	NKL 22	Inhibitor	97.27%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-114483	AES-135	Inhibitor	98.21%	Unkown
HY-124782	HDAC8-IN-8	Inhibitor	/	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-162616	SelSA	Inhibitor	99.83%	Unkown
HY-164233	YX968	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-152147	SZUH280	Degrader	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-126829	Coumarin-SAHA		/	Unkown
HY-151366	HDAC8/BRPF1-IN-1	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-146539	HDAC-IN-35	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-150772	Tubulin/HDAC-IN-1	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-151248	HDAC2-IN-1	Inhibitor	/	Unkown
HY-150694	HDAC6-IN-11	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-10226	JNJ-16241199	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-159172	HDAC3-IN-4	Inhibitor	/	Unkown
HY-157314	HDAC6-IN-27	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-149578	Tubulin/HDAC-IN-3	Inhibitor	/	Unkown
HY-161350	ALK/HDAC-IN-1	Inhibitor	/	Unkown
HY-158308	HDAC6-IN-41	Inhibitor	/	Unkown
HY-146392	HDAC-IN-39	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-151364	HDAC6/8/BRPF1-IN-1	Inhibitor	/	Unkown
HY-146750	HDAC-IN-37	Inhibitor	/	Unkown
HY-147991	PDE5/HDAC-IN-1	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-153583	HDAC8-IN-4	Inhibitor	/	Unkown
HY-146293	HDAC6/HSP90-IN-1	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-141701	mTOR/HDAC-IN-1	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-163846	HDAC8-IN-10	Inhibitor	/	Unkown
HY-162658	Leuxinostat	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-144098	HDAC8-IN-2	Inhibitor	/	Unkown
HY-168175	PROTAC HDAC8 Degrader-2	Degrader	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-144293	HDAC-IN-31	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-144782	HDAC10-IN-2	Inhibitor	/	Unkown
HY-163143	HDAC8-IN-6	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-119550	J1075	Inhibitor	/	Unkown
HY-139795	ZYJ-25e	Inhibitor	/	Unkown
HY-139815	ZYJ-34c	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HDAC8	VGNC	VGNC:56708
Rattus norvegicus	HDAC8	RGD	RGD:1562895
Mus musculus	HDAC8	MGD	MGI:1917565
Canis familiaris	HDAC8	VGNC	VGNC:50631
Others	HDAC8	NCBI

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