MAP1LC3B - microtubule associated protein 1 light chain 3 beta Gene

Homo sapiens

Also known as LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3

Gene ID: 81631 | Gene type: protein coding

About MAP1LC3B

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:87,392,336-87,404,774 (from NCBI)

This gene has 6 transcripts (splice variants), 173 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 94.3), brain (RPKM 58.8) and 25 other tissues.

Summary

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in Autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

MAP1LC3B Products(1)

mRNA	Protein	Name
NM_022818.5	NP_073729.1	microtubule-associated proteins 1A/1B light chain 3B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide binding	IDA IDA: Inferred from direct assay	22922758	GOA
enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	15355958	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15187094	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	37943659	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	28223137	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	23629966	GOA
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	28223137	GOA
involved in macroautophagy	IDA IDA: Inferred from direct assay	28223137	GOA
involved in mitophagy	IDA IDA: Inferred from direct assay	28017329	GOA
involved in mitophagy	IGI IGI: Inferred from genetic interaction	19279012	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	22948227	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	33499712	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	30420355	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25215947	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP1LC3B Protein Structure

Atg8

0
100
125 a.a.

Protein Preferred Names

Protein Names

microtubule-associated proteins 1A/1B light chain 3B

MAP1 light chain 3-like protein 2

MAP1LC3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP1LC3B	Q9GZQ8	ATG5	Homo sapiens	Q9H1Y0	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	IRGQ	Homo sapiens	Q8WZA9	BioID	34524948
Intra	MAP1LC3B	Q9GZQ8	HSPA1A	Homo sapiens	P0DMV8	Validated Y2H	32814053
Intra	MAP1LC3B	Q9GZQ8	HSPA1A	Homo sapiens	P0DMV8	Y2H Array	32814053
Intra	MAP1LC3B	Q9GZQ8	HSPA1A	Homo sapiens	P0DMV8	Y2H Pooling	32814053
Intra	MAP1LC3B	Q9GZQ8	CLINT1	Homo sapiens	Q14677	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	WDFY3	Homo sapiens	Q8IZQ1	Anti Tag CoIP	18083104
Intra	MAP1LC3B	Q9GZQ8	WDFY3	Homo sapiens	Q8IZQ1	IF	24668264
Intra	MAP1LC3B	Q9GZQ8	WDFY3	Homo sapiens	Q8IZQ1	Pull Down	24668264
Cross	MAP1LC3B	Q9GZQ8	Bnip3l	Mus musculus	Q9Z2F7	NMR	20010802
Cross	MAP1LC3B	Q9GZQ8	Bnip3l	Mus musculus	Q9Z2F7	ITC	20010802
Intra	MAP1LC3B	Q9GZQ8	KBTBD6	Homo sapiens	Q86V97	Pull Down	25684205
Cross	MAP1LC3B	Q9GZQ8	ATG7	Saccharomyces cerevisiae	P38862	GMS	22056771
Intra	MAP1LC3B	Q9GZQ8	ATG13	Homo sapiens	O75143	Pull Down	24290141
Intra	MAP1LC3B	Q9GZQ8	FYCO1	Homo sapiens	Q9BQS8	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	FYCO1	Homo sapiens	Q9BQS8	TAP	24089205
Intra	MAP1LC3B	Q9GZQ8	FYCO1	Homo sapiens	Q9BQS8	Anti Tag CoIP	35271311
Intra	MAP1LC3B	Q9GZQ8	STBD1	Homo sapiens	O95210	Pull Down	20562859
Intra	MAP1LC3B	Q9GZQ8	TBC1D2B	Homo sapiens	Q9UPU7	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	TBC1D2B	Homo sapiens	Q9UPU7	Pull Down	20562859
Intra	MAP1LC3B	Q9GZQ8	FUNDC1	Homo sapiens	Q8IVP5	IF	24671035
Intra	MAP1LC3B	Q9GZQ8	FUNDC1	Homo sapiens	Q8IVP5	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	FUNDC1	Homo sapiens	Q8IVP5	Y2H Prey Pooling	25416956
Intra	MAP1LC3B	Q9GZQ8	FUNDC1	Homo sapiens	Q8IVP5	Anti Bait CoIP	24671035
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	18083104
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Y2H Pooling	16169070
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	FPS	37219487
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Y2H	20010802
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Pull Down	24668264
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Pull Down	18083104
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	26524528
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	FPS	39009827
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Y2H	21900206
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Y2H Prey Pooling	32296183
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Phage Display	37219487
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	ITC	20010802
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Pull Down	19250911
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	TAP	24089205
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	SQSTM1	Homo sapiens	Q13501	Phage Display	39009827
Intra	MAP1LC3B	Q9GZQ8	NIPSNAP2	Homo sapiens	O75323	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	WIPF1	Homo sapiens	O43516	IF	36935496
Intra	MAP1LC3B	Q9GZQ8	WIPF1	Homo sapiens	O43516	Anti Bait CoIP	36935496
Intra	MAP1LC3B	Q9GZQ8	SAFB	Homo sapiens	Q15424	Y2H	21900206
Intra	MAP1LC3B	Q9GZQ8	SAFB	Homo sapiens	Q15424	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	LUC7L2	Homo sapiens	Q9Y383	Y2H Pooling	16169070
Intra	MAP1LC3B	Q9GZQ8	LUC7L2	Homo sapiens	Q9Y383	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	SAFB2	Homo sapiens	Q14151	Pull Down	20562859
Intra	MAP1LC3B	Q9GZQ8	SAFB2	Homo sapiens	Q14151	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	TBK1	Homo sapiens	Q9UHD2	FPS	37219487
Intra	MAP1LC3B	Q9GZQ8	TBK1	Homo sapiens	Q9UHD2	ITC	37219487
Intra	MAP1LC3B	Q9GZQ8	HADHA	Homo sapiens	P40939	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	TNIP1	Homo sapiens	Q15025	Y2H Array	31515488
Intra	MAP1LC3B	Q9GZQ8	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	MAP1LC3B	Q9GZQ8	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	MAP1LC3B	Q9GZQ8	STK4	Homo sapiens	Q13043	Anti Tag CoIP	35271311
Intra	MAP1LC3B	Q9GZQ8	STK4	Homo sapiens	Q13043	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	RASSF5	Homo sapiens	Q8WWW0	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	KBTBD7	Homo sapiens	Q8WVZ9	Pull Down	25684205
Intra	MAP1LC3B	Q9GZQ8	KBTBD7	Homo sapiens	Q8WVZ9	Pull Down	20562859
Intra	MAP1LC3B	Q9GZQ8	KBTBD7	Homo sapiens	Q8WVZ9	Y2H Pooling	16169070
Intra	MAP1LC3B	Q9GZQ8	CTNNB1	Homo sapiens	P35222	Pull Down	23736261
Intra	MAP1LC3B	Q9GZQ8	ATG16L1	Homo sapiens	Q676U5	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	20956295
Intra	MAP1LC3B	Q9GZQ8	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	MAP1LC3B	Q9GZQ8	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Cross	MAP1LC3B	Q9GZQ8	Sqstm1	Mus musculus	Q64337	Pull Down	18083104
Cross	MAP1LC3B	Q9GZQ8	Sqstm1	Mus musculus	Q64337	IF	18083104
Cross	MAP1LC3B	Q9GZQ8	Sqstm1	Mus musculus	Q64337	EM	18083104
Cross	MAP1LC3B	Q9GZQ8	Sqstm1	Mus musculus	Q64337	Anti Tag CoIP	18083104
Intra	MAP1LC3B	Q9GZQ8	TTN	Homo sapiens	Q8WZ42	Phage Display	35044719
Intra	MAP1LC3B	Q9GZQ8	TTN	Homo sapiens	Q8WZ42	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Y2H Pooling	16169070
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Validated Y2H	32296183
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Y2H Array	32296183
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Y2H	20010802
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Y2H	21900206
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Y2H Prey Pooling	32296183
Intra	MAP1LC3B	Q9GZQ8	ATG4B	Homo sapiens	Q9Y4P1	Anti Tag CoIP	18083104
Intra	MAP1LC3B	Q9GZQ8	RETREG2	Homo sapiens	Q8NC44	Y2H	21900206
Intra	MAP1LC3B	Q9GZQ8	OFD1	Homo sapiens	O75665	IF	33368531
Intra	MAP1LC3B	Q9GZQ8	OFD1	Homo sapiens	O75665	TAP	24089205
Intra	MAP1LC3B	Q9GZQ8	OFD1	Homo sapiens	O75665	Anti Bait CoIP	24089205
Intra	MAP1LC3B	Q9GZQ8	OFD1	Homo sapiens	O75665	Pull Down	33368531
Intra	MAP1LC3B	Q9GZQ8	NEDD4	Homo sapiens	P46934	Phage Display	35044719
Intra	MAP1LC3B	Q9GZQ8	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	MAP1LC3B	Q9GZQ8	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	MAP1LC3B	Q9GZQ8	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	MAP1LC3B	Q9GZQ8	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956
Intra	MAP1LC3B	Q9GZQ8	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	MAP1LC3B	Q9GZQ8	KXD1	Homo sapiens	Q9BQD3	Y2H Prey Pooling	25416956
Intra	MAP1LC3B	Q9GZQ8	KXD1	Homo sapiens	Q9BQD3	Y2H Array	25416956
Intra	MAP1LC3B	Q9GZQ8	TBC1D5	Homo sapiens	Q92609	BioID	34524948
Intra	MAP1LC3B	Q9GZQ8	TBC1D5	Homo sapiens	Q92609	Phage Display	35044719
Intra	MAP1LC3B	Q9GZQ8	NBR1	Homo sapiens	Q14596	Pull Down	19250911
Intra	MAP1LC3B	Q9GZQ8	NBR1	Homo sapiens	Q14596	Pull Down	24879152
Intra	MAP1LC3B	Q9GZQ8	NBR1	Homo sapiens	Q14596	Confocal	19250911
Intra	MAP1LC3B	Q9GZQ8	UBA5	Homo sapiens	Q9GZZ9	Pull Down	20562859
Intra	MAP1LC3B	Q9GZQ8	BUB1	Homo sapiens	O43683	FPS	39009827
Intra	MAP1LC3B	Q9GZQ8	BUB1	Homo sapiens	O43683	Anti Tag CoIP	39009827
Intra	MAP1LC3B	Q9GZQ8	BRCA2	Homo sapiens	P51587	FPS	39009827
Intra	MAP1LC3B	Q9GZQ8	BRCA2	Homo sapiens	P51587	ITC	39009827
Intra	MAP1LC3B	Q9GZQ8	NCOA7	Homo sapiens	Q8NI08	BioID	34524948
Intra	MAP1LC3B	Q9GZQ8	ULK1	Homo sapiens	O75385	Pull Down	24290141
Intra	MAP1LC3B	Q9GZQ8	LMNB1	Homo sapiens	P20700	BiFC	26524528
Intra	MAP1LC3B	Q9GZQ8	LMNB1	Homo sapiens	P20700	Anti Tag CoIP	26524528
Intra	MAP1LC3B	Q9GZQ8	LMNB1	Homo sapiens	P20700	Pull Down	26524528
Intra	MAP1LC3B	Q9GZQ8	LMNB1	Homo sapiens	P20700	Anti Bait CoIP	26524528
Intra	MAP1LC3B	Q9GZQ8	ATG7	Homo sapiens	O95352	Anti Tag CoIP	18083104
Intra	MAP1LC3B	Q9GZQ8	ATG7	Homo sapiens	O95352	Comig Non-Denat Gel	16303767
Intra	MAP1LC3B	Q9GZQ8	ATG7	Homo sapiens	O95352	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	18083104
Intra	MAP1LC3B	Q9GZQ8	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	35271311
Intra	MAP1LC3B	Q9GZQ8	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	20562859
Intra	MAP1LC3B	Q9GZQ8	STK3	Homo sapiens	Q13188	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP1LC3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70909	MAP1LC3B Protein, Human	Q9GZQ8 (M1-V125)	≥95%

MAP1LC3B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80741	LC3A/B Antibody	WB	Human, Mouse, Rat
HY-P80742	LC3B Antibody	WB, ICC/IF, IHC-F, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08029	MAP1LC3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08030	MAP1LC3B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP1LC3B	RGD	RGD:621315
Mus musculus	MAP1LC3B	MGD	MGI:1914693

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