MAP1LC3B - microtubule associated protein 1 light chain 3 beta Gene

Homo sapiens

Also known as LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3

Gene ID: 81631 | Gene type: protein coding

About MAP1LC3B

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:87,392,336-87,404,774 (from NCBI)

This gene has 6 transcripts (splice variants), 173 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 94.3), brain (RPKM 58.8) and 25 other tissues.

Summary

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in Autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

MAP1LC3B Products(1)

mRNA	Protein	Name
NM_022818.5	NP_073729.1	microtubule-associated proteins 1A/1B light chain 3B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide binding	IDA IDA: Inferred from direct assay	22922758	GOA
enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	15355958	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15187094	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	37943659	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	28223137	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	23629966	GOA
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	28223137	GOA
involved in macroautophagy	IDA IDA: Inferred from direct assay	28223137	GOA
involved in mitophagy	IDA IDA: Inferred from direct assay	28017329	GOA
involved in mitophagy	IGI IGI: Inferred from genetic interaction	19279012	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	22948227	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	33499712	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	30420355	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25215947	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP1LC3B Protein Structure

Atg8

0
100
125 a.a.

Protein Preferred Names

Protein Names

microtubule-associated proteins 1A/1B light chain 3B

MAP1 light chain 3-like protein 2

Recombinant MAP1LC3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70909	MAP1LC3B Protein, Human	Q9GZQ8 (M1-V125)	≥95%

Related Diseases

Diseases

Alias

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08029	MAP1LC3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08030	MAP1LC3B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP1LC3B	RGD	RGD:621315
Mus musculus	MAP1LC3B	MGD	MGI:1914693

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