2. Gene
  3. CREB3L1 - cAMP responsive element binding protein 3 like 1 Gene

CREB3L1 - cAMP responsive element binding protein 3 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OI16; OASIS

Gene ID: 90993 | Gene type: protein coding

About CREB3L1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,277,662-46,321,409 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 72 phenotypes. Broad expression in stomach (RPKM 29.2), colon (RPKM 23.7) and 16 other tissues.

Summary

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

CREB3L1 Products(1)

mRNA Protein Name
NM_052854.4 NP_443086.1 cyclic AMP-responsive element-binding protein 3-like protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
27121396 GOA
enables SMAD binding IPI
IPI: Inferred from physical interaction
25310401 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
27121396 GOA
involved in negative regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
27121396 GOA
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
27121396 GOA
involved in negative regulation of sprouting angiogenesis IGI
IGI: Inferred from genetic interaction
27121396 GOA
involved in positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
25310401 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
27121396 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16236796 GOA
located in membrane IDA
IDA: Inferred from direct assay
25310401 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25310401 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB3L1 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (288 - 350)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 1

BBF-2 homolog

CREB3L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CREB3L1 Q96BA8 TMEM218 Homo sapiens A2RU14
Y2H Array
29892012
Intra
CREB3L1 Q96BA8 TMEM218 Homo sapiens A2RU14
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 GPR25 Homo sapiens O00155
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 GPR25 Homo sapiens O00155
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 GPR25 Homo sapiens O00155
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 NRM Homo sapiens Q8IXM6
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 NRM Homo sapiens Q8IXM6
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 NRM Homo sapiens Q8IXM6
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 CCL4L1 Homo sapiens Q8NHW4
Y2H Array
32296183
Intra
CREB3L1 Q96BA8 SLC35B4 Homo sapiens Q969S0
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 SLC35B4 Homo sapiens Q969S0
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 MARCHF2 Homo sapiens Q9P0N8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 PRKAB2 Homo sapiens O43741
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 ADGRE2 Homo sapiens Q9UHX3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 MGST2 Homo sapiens Q99735
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TLCD1 Homo sapiens Q96CP7
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CFHR5 Homo sapiens Q9BXR6
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 ARV1 Homo sapiens Q9H2C2
Y2H Array
32296183
Intra
CREB3L1 Q96BA8 ARV1 Homo sapiens Q9H2C2
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 MAN2B2 Homo sapiens Q9Y2E5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SLC35A4 Homo sapiens Q96G79
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CNIH2 Homo sapiens Q6PI25
Y2H Array
32296183
Intra
CREB3L1 Q96BA8 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM208 Homo sapiens Q9BTX3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SLC52A1 Homo sapiens Q9NWF4
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SEMA4G Homo sapiens Q9NTN9-2
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 PLPPR2 Homo sapiens Q96GM1
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 FETUB Homo sapiens Q9UGM5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 C11orf24 Homo sapiens Q96F05
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 NAT8 Homo sapiens Q9UHE5
Y2H Array
32296183
Intra
CREB3L1 Q96BA8 FAM3C Homo sapiens Q92520
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 FAM3C Homo sapiens Q92520
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 TECR Homo sapiens Q9NZ01
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
CREB3L1 Q96BA8 SACM1L Homo sapiens Q9NTJ5
Complementation
32296183
Intra
CREB3L1 Q96BA8 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 MFSD5 Homo sapiens Q6N075
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 MFSD5 Homo sapiens Q6N075
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 MFSD5 Homo sapiens Q6N075
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 ALG8 Homo sapiens Q9BVK2
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 GOLT1B Homo sapiens Q9Y3E0
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 VKORC1 Homo sapiens Q9BQB6
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TSPO Homo sapiens P30536
Y2H Array
31515488
Intra
CREB3L1 Q96BA8 TSPO Homo sapiens P30536
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 AGPAT5 Homo sapiens Q9NUQ2
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 NEU1 Homo sapiens Q99519
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CMTM3 Homo sapiens Q96MX0
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CIAO2A Homo sapiens Q9H5X1
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 CREB3L3 Homo sapiens Q68CJ9
FRET
23661758
Intra
CREB3L1 Q96BA8 C5 Homo sapiens P01031
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 C5 Homo sapiens P01031
Y2H Array
25416956
Intra
CREB3L1 Q96BA8 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 TMEM234 Homo sapiens Q8WY98
Y2H Prey Pooling
25416956
Intra
CREB3L1 Q96BA8 TMEM234 Homo sapiens Q8WY98
Validated Y2H
25416956
Intra
CREB3L1 Q96BA8 DOLK Homo sapiens Q9UPQ8
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra
CREB3L1 Q96BA8 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CREB3L1 Proteins

Cat. No. Product Name Accession Purity
HY-P76284 CREB3L1 Protein, Human (HEK293, His) Q96BA8-1 (E396-S519) ≥95%

Related Diseases

Diseases Alias
Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16

OI16

Oi, Type Xvi

Osteogenesis Imperfecta Type Xvi

Chromosome 11p11.2 Deletion Syndrome 91.3-Kb

Osteogenesis Imperfecta 16

Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb
Myxofibrosarcoma

Fibromyxosarcoma

Fibromyxoid Sarcoma

Myxoid Malignant Fibrous Histiocytoma

Dermatofibrosarcoma Protuberans, Myxoid
Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness
Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii

OI3

Oi, Type Iii

Osteogenesis Imperfecta Type 3

Oi Type Iii

Oi Type 3

Progressive Deforming Osteogenesis Imperfecta

Severe Osteogenesis Imperfecta

Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

Progressively Deforming Oi

Osteogenesis Imperfecta 3

Oi-Iii

Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney
Dentinogenesis Imperfecta

Hereditary Opalescent Dentin

Dentinogenesis Imperfecta Without Osteogenesis Imperfecta

Dgi

Capdepont Teeth

Dgi Without Oi

Di

Non-Syndromic Dgi

Non-Syndromic Dentinogenesis Imperfecta

Opalescent Teeth Without Oi

Opalescent Teeth Without Osteogenesis Imperfecta

Opalescent Dentin
Small Cell Osteogenic Sarcoma

Small Cell Osteosarcoma

Round Cell Osteosarcoma

Osteosarcoma Small Cell
Osteogenesis Imperfecta, Type Xix

OI19

Osteogenesis Imperfecta Type 19

Osteogenesis Imperfecta Type Xix

Osteogenesis Imperfecta, Type 19

Osteogenesis Imperfecta 19
Keratosis Follicularis Spinulosa Decalvans

Kfsd

Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi

Keratosis Follicularis Spinulosa Decalvans, X-Linked

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Keratosis Pilaris Atrophicans

KPA

Burnett Schwartz Berberian Syndrome
Cole-Carpenter Syndrome

Cole Carpenter Syndrome

Bone Fragility Craniosynostosis Proptosis Hydrocephalus

Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features

Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome
Sarcomatosis
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T

PLSDT

Platyspondylic Dysplasia, Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

Thanatophoric Dysplasia, Torrance Variant

Platyspondylic Skeletal Dysplasia, Torrance Type

Torrance Type Platyspondylic Dysplasia

Platyspondylic Dysplasia, Torrance-Luton Type

Platyspondylic Lethal Skeletal Dysplasia Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

Thanatophoric Dysplasia Torrance Variant

Platyspondylic Chondrodysplasia, Torrance-Luton Type

Plsd-Tl

Dysplasia, Skeletal, Platyspondylic, Torrance Type
Conventional Osteosarcoma

Intracortical Osteosarcoma

Conventional Central Osteosarcoma

Intracortical Osteogenic Sarcoma

Medullary Osteosarcoma
Spindle Cell Liposarcoma
Pseudosarcomatous Fibromatosis

Nodular Fasciitis

Pseudosarcomatous Fasciitis

Fasciitis - Nodular

Fasciitis Nodular
Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm
Adult Fibrosarcoma
Osteogenesis Imperfecta, Type Xiv

Osteogenesis Imperfecta Type 14

OI14

Osteogenesis Imperfecta Type Xiv

Oi, Type Xiv

Osteogenesis Imperfecta 14

Oi Type Xiv

Oi-Xiv
Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone
Bruck Syndrome

Osteogenesis Imperfecta With Congenital Joint Contractures

Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome
Spondyloepiphyseal Dysplasia Congenita

SEDC

Sed Congenita

Spondyloepiphyseal Dysplasia, Congenital Type

Late Spondyloepiphyseal Dysplasia

Sed, Congenital Type

Congenital Spondyloepiphyseal Dysplasia

Spranger-Wiedemann Disease

Spondyloepiphyseal Dysplasia Congenital Type

Dysplasia, Spondyloepiphyseal, Congenita

Spondyloepiphyseal Dysplasia, Congenita

Spondyloepiphyseal Dysplasia Tarda, X-Linked
Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma
Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I

OI1

Oi, Type I

Osteogenesis Imperfecta Tarda

Osteogenesis Imperfecta With Blue Sclerae

Osteogenesis Imperfecta Type 1

Adair-Dighton Syndrome

Mild Osteogenesis Imperfecta

Non-Deforming Osteogenesis Imperfecta

Oi Type 1

Van Der Hoeve Syndrome

Classic Non-Deforming Oi With Blue Sclerae

Osteogenesis Imperfecta 1

Oi-I

Osteopenic Non-Fracture Syndrome

Osteogenesis Imperfecta, Mild

Osteogenesis Imperfecta

Lobstein'S Disease
Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv
Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03150 CREB3L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CREB3L1 MGD MGI:1347062
Bos taurus CREB3L1 VGNC VGNC:27694
Felis catus CREB3L1 VGNC VGNC:61166
Rattus norvegicus CREB3L1 RGD RGD:1359613
Canis familiaris CREB3L1 VGNC VGNC:39597
Macaca mulatta CREB3L1 VGNC VGNC:71438
Others CREB3L1 NCBI