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Analgesic effects

" in MedChemExpress (MCE) Product Catalog:

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165

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1428

2-Ethoxybenzamide Ethenzamide	Epigenetic Reader Domain	Inflammation/Immunology Cancer
2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects . 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation .

HY-145628

CM398	Sigma Receptor	Neurological Disease Inflammation/Immunology
CM398 is a highly selective, orally active sigma-2 receptor ligand (K_i=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (K_i=32.90 nM) and serotonin transporters (K_i=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice .

HY-P1220A

Huwentoxin-IV TFA	Sodium Channel	Neurological Disease
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-129661

AH 7959	Opioid Receptor	Neurological Disease
AH 7959 is an orally active N-substituted cyclohexyl methyl benzamide compound that has analgesic effects, the oral and subcutaneous ED₅₀ of AH 7959 in mice is greater than 100 mg/kg .

HY-167865

O-1269	Cannabinoid Receptor	Neurological Disease
O-1269 is a partial agonist of cannabinoid receptor 1 (CB1R) with a K_i of 32 nM. O-1269 shows analgesic effects .

HY-W242735

4-Aminobenzimidamide Hydrochloride	Mas-related G-protein-coupled Receptor (MRGPR)	Neurological Disease
4-Aminobenzimidamide Hydrochloride (Compound 4a) is a MRGPRX1 agonist. 4-Aminobenzimidamide Hydrochloride can be used in the study of MRGPRX1-mediated analgesic effects .

HY-19876

PL37 Debio-0827	Opioid Receptor Aminopeptidase Neprilysin	Neurological Disease Metabolic Disease
PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating μ-opioid receptors (µ-opioid receptors), with an ED₅₀ value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain .

HY-155706

MOR agonist-2	Opioid Receptor Dopamine Receptor	Inflammation/Immunology
MOR agonist-2 (compound 46) is a antagonist of D3R and agonist of MOR (K_i: 7.26 nM and 564 nM, respectively). MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism .

HY-B1428R

2-Ethoxybenzamide (Standard) Ethenzamide (Standard)	Epigenetic Reader Domain	Inflammation/Immunology Cancer
2-Ethoxybenzamide (Standard) is the analytical standard of 2-Ethoxybenzamide (HY-B1428). 2-Ethoxybenzamide (Ethenzamide) Standard is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects . 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation .

HY-P1220

Huwentoxin-IV	Sodium Channel	Neurological Disease
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-172182

ONO-2920632 VU6011887	Potassium Channel	Neurological Disease
ONO-2920632 is an orally active and central nervous system (CNS)-penetrant TREK activator, with EC₅₀ values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK). ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.

HY-172149

Naltrindole 5′-isothiocyanate 5'-NTII	Opioid Receptor	Neurological Disease
Naltrindole 5′-isothiocyanate (5'-NTII) is a non-selective delta opioid receptor antagonist that can antagonize the analgesic effects induced by DSLET (HY-P1332) without affecting the analgesic effects induced by DPDPE (HY-P1334) .

HY-111473

Anti-inflammatory agent 82	Others	Inflammation/Immunology
Anti-inflammatory agent 82 has potential analgesic and anti-inflammatory effects .

HY-P1618

LY-281217	Opioid Receptor	Neurological Disease
LY-281217 is a potent mu-opioid agonist with analgesic effects .

HY-169844

D-19050	Drug Derivative	Neurological Disease
D-19050 is a derivative of triaminopyridine and is an analgesic with both central and peripheral effects .

HY-135735A

Levomedetomidine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Levomedetomidine hydrochloride is an isomer of Medetomidine (HY-17034), and a cardioprotective agent with sedative and analgesic effects .

HY-U00031A

Axomadol hydrochloride EN3324 hydrochloride	Endogenous Metabolite	Neurological Disease
Axomadol hydrochloride is a centrally active analgesic agent with opioid agonistic properties and inhibitory effects on the reuptake of monoamines .

HY-N11922

Ipalbidine	Others	Neurological Disease
Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects .

HY-163116

Anti-inflammatory agent 67	COX Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC₅₀s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII) .

HY-163117

Anti-inflammatory agent 68	COX Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Anti-inflammatory agent 68 (compound 7b) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), with anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 68 has IC₅₀s of 12.6 μM and 60 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 68 binding to different isoforms of carbonic anhydrase are 52.6 nM (CA I), 79.1 nM (CA II), 58.1 nM (CA IX), and 17.2 nM (CA XII) .

HY-U00031

Axomadol EN3324	Opioid Receptor	Neurological Disease
Axomadol (EN3324) is a centrally active analgesic agent with opioid agonistic properties and inhibitory effects on the reuptake of monoamines .

HY-105808

Furobufen	Others	Neurological Disease Inflammation/Immunology
Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue .

HY-105578A

Letimide hydrochloride MA 1143 hydrochloride	Endogenous Metabolite	Inflammation/Immunology
Letimide hydrochloride (MA 1143 hydrochloride) is an analgesic with potent analgesic activity. Letimide hydrochloride has shown cytogenetic effects on human lymphocytes in in vitro experiments. Letimide hydrochloride did not exhibit significant chromosomal aberrations or sister chromatid exchanges in in vivo studies in mouse bone marrow cells. Teratogenic studies conducted on mice with Letimide hydrochloride also did not show obvious effects on inducing congenital malformations .

HY-133588

4-Formylaminoantipyrine	Endogenous Metabolite	Metabolic Disease
4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-N0300

Tetrahydropalmatine 2 Publications Verification DL-Tetrahydropalmatine	Dopamine Receptor Apoptosis	Neurological Disease
Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-B1054

Famprofazone	COX	Inflammation/Immunology
Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the pyrazolone series, and it has analgesic, anti-inflammatory, and antipyretic effects.

HY-N15180

Corynantheidine (-)-Corynantheidine	Opioid Receptor	Neurological Disease
Corynantheidine ((-)-Corynantheidine) is a mu-opioid receptor (MOR) partial agonist that shows MOR-dependent analgesic effects in mice .

HY-117091

DDD-028	Opioid Receptor	Neurological Disease Inflammation/Immunology
DDD-028 is a potent non-opioid, non-cannabinoid analgesic which attenuates neuropathic and inflammatory pain without the possible side effects or abuse potential associated with opioid or cannabinoid activities. DDD-028 can be utilized in analgesic research .

HY-N0300A

Tetrahydropalmatine hydrochloride 2 Publications Verification DL-Tetrahydropalmatine hydrochloride	Dopamine Receptor	Neurological Disease
Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-101196

PG 9 maleate	Endogenous Metabolite	Neurological Disease
PG 9 maleate is a compound with analgesic and anti-memory loss activity. PG 9 maleate exerts analgesic effects by enhancing central cholinergic transmission. PG 9 maleate protects against memory loss caused by scopolamine or dicyclomine within a specific dose range. The affinity profile of PG 9 maleate indicates significant selectivity among the M4/M1 receptor subtypes, which may be the mechanism for its analgesic and anti-memory loss effects. PG 9 maleate can increase the release of acetylcholine, thereby improving its biological activity .

HY-N1469

Kaurenoic acid	Potassium Channel Bacterial	Infection Neurological Disease Inflammation/Immunology
Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects .

HY-B0163

Detomidine	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects .

HY-B0163A

Detomidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine hydrochloride, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine hydrochloride produces dose-dependent analgesic effects .

HY-117772

FSC231	iGluR	Metabolic Disease Inflammation/Immunology
FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects .

HY-157956

LASSBio-873	mAChR	Neurological Disease
LASSBio-873 is an orally active muscarinic cholinergic receptor (mAChR) agonist that crosses the blood-brain barrier. LASSBio-873 has potent analgesic effects on acute and inflammatory pain. The analgesic effect of LASSBio-873 can be inhibited by intrathecal injection of the M2 receptor antagonist methoctramine .

HY-108035

(-)-JM-1232 MR04A3	GABA Receptor	Neurological Disease
(-)-JM-1232 (MR04A3) targets GABA _A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA _A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI₅₀ values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia .

HY-B0972

Cinchophen 1 Publications Verification	Bacterial	Inflammation/Immunology
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases .

HY-N12180A

Hodgkinsine	Opioid Receptor Bacterial Fungal	Infection Neurological Disease
Hodgkinsine is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities .

HY-N0564

Notopterol 1 Publications Verification	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-N0436

Engeletin 3 Publications Verification	NF-κB	Infection Inflammation/Immunology
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-103386

FR122047	COX	Inflammation/Immunology
FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC₅₀ of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo .

HY-B1733

Phenyltoloxamine Bistrimin; Histionex	Histamine Receptor Sigma Receptor Cytochrome P450	Neurological Disease Inflammation/Immunology
Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (K_i: 160 nM) .

HY-168166

CHET3	Endogenous Metabolite	Neurological Disease
CHET3 is a sex-selective activator with potent analgesic activity. CHET3 was discovered to be a highly selective omnidirectional modulator of TASK-3-containing K2P channels, including TASK-3 homologues and TASK-3/TASK-1 heterologues. CHET3 exhibited significant analgesic effects in multiple acute and chronic pain models in mice, which could be abolished by pharmacological means or genetic knockout of TASK-3. CHET3 is able to functionally modulate the membrane excitability of specific small sensory neurons, which supports its analgesic effects on thermal hypersensitivity and mechanical hyperalgesia in chronic pain .

HY-167734

Pemedolac AY-30715	COX	Inflammation/Immunology
Pemedolac (AY-30715) is a potent analgesic with significant pain-relief efficacy against chemically induced and inflammatory pain in animal models. Pemedolac displays a notable separation between analgesic effects and anti-inflammatory activity, achieving effective pain relief at much lower doses than those required for anti-inflammatory or gastric irritant effects. Pemedolac also shows low ulcerogenic potential, indicating a safer profile compared to standard NSAIDs while being utilized for the treatment of neurological, skin, and musculoskeletal disorders.

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-N12180

Hodgkinsine B	Opioid Receptor Bacterial Fungal	Infection Neurological Disease
Hodgkinsine B is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities .

HY-124406

A-794282	mGluR	Neurological Disease
A-794282 is a compound with analgesic activity and is a selective mGlu1 receptor antagonist that significantly reduces pain behaviors in a postoperative pain model, but motor side effects may occur at higher doses.

HY-W040672

Ibufenac Dytransin	COX	Inflammation/Immunology
Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-137394

Nicotredole Tryptamide	Others	Inflammation/Immunology
Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity .

HY-14931

Naproxcinod AZD 3582; HCT 3012; Nitronaproxen	COX	Inflammation/Immunology
Naproxcinod (Nitronaproxen) is the first in class of cyclooxygenase (COX)-inhibiting nitric oxide donators (CINODs). Naproxcinod shows analgesic and anti-inflammatory effects, it can be used for the research of osteoarthritis and inflammation .

Cat. No.	Product Name

HY-L139

Pain-Related Compound Library

2,425 compounds

Pain is a kind of distressing feeling caused by the stimulation of tissue damage. According to the International Association for the Study of Pain (IASP), pain is defined as ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”.

Pain is usually classified according to its location, duration, underlying causes, and intensity. For example, acute and chronic pain, muscle pain, and nerve pain. Pain is the main symptom of most diseases, which seriously affects the quality of life and body function of patients. In the medical treatment of pain, anti-inflammatory drugs and opioid analgesic agents have traditionally been used, but the side effects are serious. In recent years, targeted drugs targeting the ERK/MAPK pathway or other targets have gradually become a research hotspot.

MCE supplies a unique collection of 2,425 compounds targeting key proteins in the pain system. MCE Pain-Related Compound Library is a useful tool for pain related research and anti-pain drug development.

Cat. No.	Product Name	Target	Research Area

HY-P1220A

Huwentoxin-IV TFA	Sodium Channel	Neurological Disease
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor p38 MAPK	Neurological Disease
Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC₅₀ of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects .

HY-107663A

MIF-1 TFA Pro-Leu-Gly-NH2 TFA; Melanostatin TFA	Dopamine Receptor	Neurological Disease
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .

HY-P1220

Huwentoxin-IV	Sodium Channel	Neurological Disease
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-P1618

LY-281217	Opioid Receptor	Neurological Disease
LY-281217 is a potent mu-opioid agonist with analgesic effects .

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B TFA inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA has analgesic and anxiolytic effects .

HY-P10555

(D-Arg2, Sar 4)-Dermorphin (1-4)	Opioid Receptor	Neurological Disease
(D-Arg2, Sar 4)-Dermorphin (1-4) is a tetrapeptide derivative of the peptide Dermorphin (HY-P0244) found in amphibian skin. (D-Arg2, Sar 4)-Dermorphin (1-4) has significant analgesic effects by binding to the μ-opioid receptor (MOR) in the body. (D-Arg2, Sar 4)-Dermorphin (1-4) can be used in the development of analgesic drugs .

HY-P5865

Tap1a Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a	Sodium Channel	Neurological Disease
Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC₅₀s of 80 nM and 301 nM against Na_v1.7 and Na_v1.1, respectively. Tap1a shows analgesic effects .

HY-P2544

[Lys8, Lys9]-Neurotensin (8-13) JMV438	Neurotensin Receptor	Neurological Disease
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with K_i values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P3206

Serum thymic factor Thymulin; Thymic factor	ERK	Neurological Disease Inflammation/Immunology Endocrinology
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .

HY-P3206A

Serum thymic factor acetate Thymulin acetate; Thymic factor acetate	ERK	Neurological Disease Inflammation/Immunology Endocrinology
Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .

HY-P1320A

[Nphe1]Nociceptin(1-13)NH2 TFA	Opioid Receptor	Inflammation/Immunology
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pK_i=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA₂=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent .

HY-P1320

[Nphe1]Nociceptin(1-13)NH2	Opioid Receptor	Inflammation/Immunology
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pK_i=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA₂=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-133588

4-Formylaminoantipyrine	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-N0300

Tetrahydropalmatine 2 Publications Verification DL-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor Apoptosis
Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-N0300A

Tetrahydropalmatine hydrochloride 2 Publications Verification DL-Tetrahydropalmatine hydrochloride	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor
Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-N1469

Kaurenoic acid	Structural Classification other families Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Senna siamea (Lamarck) H. S. Irwin & Barneby Plants Compositae Inflammation/Immunology Disease Research Fields	Potassium Channel Bacterial
Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects .

HY-N0564

Notopterol 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Coumarins Phenylpropanoids Kleinia odora (Forssk.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-N0436

Engeletin 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Flavanonols Flavonoids Microorganisms Liliaceae Phenols Polyphenols Smilacis Glabrae Rhizoma Inflammation/Immunology Disease Research Fields	NF-κB
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-N11922

Ipalbidine	Structural Classification Alkaloids Monophenols Other Alkaloids Source classification Phenols Plants Convolvulaceae Ipomoea alba Linnaeus	Others
Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects .

HY-N15180

Corynantheidine (-)-Corynantheidine	Structural Classification Alkaloids Source classification Rubiaceae Mitragyna speciosa Korth. Plants Indole Alkaloids	Opioid Receptor
Corynantheidine ((-)-Corynantheidine) is a mu-opioid receptor (MOR) partial agonist that shows MOR-dependent analgesic effects in mice .

HY-B0163

Detomidine	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects .

HY-N12180A

Hodgkinsine	Structural Classification Alkaloids Arecaceae Bercht. & J. Presl Source classification Rubiaceae Arecaceae Plants Indole Alkaloids	Opioid Receptor Bacterial Fungal
Hodgkinsine is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities .

HY-N12180

Hodgkinsine B	Structural Classification Alkaloids Arecaceae Bercht. & J. Presl Source classification Rubiaceae Arecaceae Plants Indole Alkaloids	Opioid Receptor Bacterial Fungal
Hodgkinsine B is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities .

HY-N0300R

Tetrahydropalmatine (Standard)	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor Apoptosis
Tetrahydropalmatine (Standard) is the analytical standard of Tetrahydropalmatine. This product is intended for research and analytical applications. Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-N1965

Gaultherin	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Gaultheria yunnanensis Ericaceae Plants Inflammation/Immunology Disease Research Fields	Others
Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin .

HY-N0212

Peimine 3 Publications Verification Verticine; Dihydroisoimperialine	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB
Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research .

HY-N1082

Visnagin	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Artemisia cana Pursh Source classification Umbelliferae Plants Disease Research Fields	Others
Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles .

HY-N9096

Gentiside B	Structural Classification Gentiana rigescens Franch. ex Hemsl. Source classification Gentianaceae Phenols Polyphenols Plants	Bacterial
Gentiside B has neuritogenic activity and induce neurite outgrowth. Gentiside B can be isolated from the root and rhizome of Gentiana rigescens. Gentiana has hepatoprotective, anti-inflammatory, analgesic, antiproliferative and antimicrobial effects .

HY-133588R

4-Formylaminoantipyrine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
4-Formylaminoantipyrine (Standard) is the analytical standard of 4-Formylaminoantipyrine. This product is intended for research and analytical applications. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-W017100

2-Hydroxy-6-methoxybenzoic acid 6-Methoxysalicylic acid	Monophenols Securidaca inappendiculata Hassk. Ketones, Aldehydes, Acids Source classification Polygalaceae Phenols Plants	Others
2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects .

HY-N3711

Dehydrocrenatine	Simaroubaceae Source classification Plants Indole Alkaloids Picrasma chinensis P. Y. Chen	JNK ERK Apoptosis
Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects .

HY-N12067

Columbianetin β-D-glucopyranoside	Structural Classification Source classification Plants Umbelliferae Seriphidium transiliense Saccharides Monosaccharides	Others
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity .

HY-N0436R

Engeletin (Standard)	Flavanonols Structural Classification Flavonoids Microorganisms Liliaceae Source classification Phenols Polyphenols Smilacis Glabrae Rhizoma Plants	NF-κB
Engeletin (Standard) is the analytical standard of Engeletin. This product is intended for research and analytical applications. Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-N7083

Citral 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Cymbopogon citratus Ketones, Aldehydes, Acids Gramineae Source classification Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Parasite
Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects ^[2][3].

HY-N0564R

Notopterol (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Kleinia odora (Forssk.) DC. Umbelliferae Plants	Apoptosis
Notopterol (Standard) is the analytical standard of Notopterol. This product is intended for research and analytical applications. Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-B0617A

S-Adenosyl-L-methionine tosylate Maximum Cited Publications 13 Publications Verification S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research .

HY-N1965R

Gaultherin (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Gaultheria yunnanensis Ericaceae Plants	Others
Gaultherin (Standard) is the analytical standard of Gaultherin. This product is intended for research and analytical applications. Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin .

HY-N9854

Icariside E4	Tabebuia roseoalba (Ridl.) Sandwith Structural Classification Natural Products Source classification Plants Bignoniaceae	Potassium Channel
Icariside E4 is an antinociceptive agent, and can be isolated from Tabebuia roseo-alba. Icariside E4 has peripheral analgesic activity by ATP-sensitive K ⁺ channel-dependent mechanisms. Icariside E4 also has anti-oxidant, anti-Alzheimer and anti-inflammatory effects .

HY-N7934

Trachelogenin (-)-Trachelogenin	Infection Monophenols Classification of Application Fields Source classification Lignans Phenols Rhaponticum carthamoides (Willd.) Iljin Phenylpropanoids Plants Compositae Disease Research Fields Inflammation/Immunology	HCV
Trachelogenin ((-)-Trachelogenin) is an HCV entry inhibitor without genotype specificity, and with low cytotoxicity. Trachelogenin inhibits HCVcc infection and HCVpp cell entry in a dose-dependent manner with an IC₅₀ of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. Trachelogenin exhibits effective antiviral, anti-inflammatory and analgesic effects .

HY-N0212R

Peimine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Source classification Plants	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB
Peimine (Standard) is the analytical standard of Peimine. This product is intended for research and analytical applications. Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research .

HY-116637

Tetrahydromagnolol Magnolignan	Structural Classification Classification of Application Fields Magnoliaceae Source classification Phenols Polyphenols Magnolia Liliflora Desr. Plants Inflammation/Immunology Disease Research Fields	Cannabinoid Receptor GPR55 Drug Metabolite
Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC₅₀ =170 nM) and GPR55 antagonist. The K_i of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects .

HY-N7083R

Citral (Standard)	Structural Classification Microorganisms Cymbopogon citratus Ketones, Aldehydes, Acids Gramineae Source classification Plants	Apoptosis Aldehyde Dehydrogenase (ALDH)
Citral (Standard) is the analytical standard of Citral. This product is intended for research and analytical applications. Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects .

HY-N0920

Dihydrokavain 7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin	Structural Classification Natural Products other families Source classification Plants	COX Cytochrome P450
Dihydrokavain is a natural compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects .

HY-122489A

(S)-Laudanosine	Structural Classification Alkaloids Microorganisms Source classification Isoquinoline Alkaloids	Opioid Receptor GABA Receptor
(S)-Laudanosine is an alkaloid that can be found in poppies and is the S-enantiomer of Laudanosine. Laudanosine acts on the central nervous system and cardiovascular system, inhibiting low-affinity GABA receptors with an IC₅₀ value of 10 μM, and can cause seizures, hypotension, and bradycardia. Additionally, Laudanosine exerts analgesic effects by competitively binding to the opioid Mu-1 receptor (K_i = 2.7 μM) .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Araliaceae	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-N15177

Δ9-THCB Δ9-Tetrahydrocannabutol	Structural Classification Monophenols Cannabis sativa L Source classification Phenols Plants Moraceae	Cannabinoid Receptor
Δ9-THCB (Δ9-Tetrahydrocannabutol) has a high affinity for human CB1 and CB2 receptors with the K_i values of 15 nM and 51 nM, respectively. Δ9-THCB (Δ9-Tetrahydrocannabutol) has analgesic and anti-inflammatory activities and plays partial agonistic effects on CB1 receptor in mice .

HY-B0617AR

S-Adenosyl-L-methionine (tosylate) (Standard) S-Adenosyl methionine (tosylate) (Standard); Ademetionine (tosylate) (Standard); AdoMet (tosylate) (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine tosylate (Standard) (S-Adenosyl methionine tosylate (Standard)) is the analytical standard of S-Adenosyl-L-methionine tosylate (HY-B0617A). This product is intended for research and analytical applications. S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

HY-N4225

Aaptamine 1 Publications Verification	Alkaloids Structural Classification Animals Classification of Application Fields Marine natural products Source classification Quinoline Alkaloids Sponge Disease Research Fields Endocrinology	Adrenergic Receptor Proteasome Cholinesterase (ChE) Bacterial Apoptosis AP-1 NF-κB
Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects .

HY-N0920R

Dihydrokavain (Standard) 7,8-Dihydrokawain (Standard); 7,8-Dihydrokavain (Standard); Marindinin (Standard)	Structural Classification Natural Products other families Source classification Plants	Others
Dihydrokavain (Standard) is the analytical standard of Dihydrokavain. This product is intended for research and analytical applications. Dihydrokavain is a natural compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects .

HY-107825

Flavonol	Flavonols Structural Classification Flavonoids Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial Cholinesterase (ChE)
Flavonol is a cholinesterase (ChE) inhibitor, with an IC₅₀ value of 120 μM and a K_i value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and COX-2 (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-78131AS

(S)-(+)-Ibuprofen D3
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

HY-B1279AS

Metamizole-d3 sodium
Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor .

HY-133588S

4-Formylaminoantipyrine-d3
4-Formylaminoantipyrine-d₃ is the deuterium labeled 4-Formylaminoantipyrine (HY-133588). 4-Formylaminoantipyrine is an excreted metabolite of Aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

HY-17034BS1

Medetomidine-13C,d3 hydrochloride
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-B0619S1

Zaltoprofen-13C,d3
Zaltoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

HY-B0653AS

Levobupivacaine-d9 hydrochloride

Levobupivacaine-d₉ ((S)-(–)-Bupivacaie-d₉) hydrochloride is deuterium labeled Levobupivacaine (hydrochloride). Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name		Classification

HY-159169

5-LOX/sEH-IN-1		Azide
5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC₅₀ values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC₅₀=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .

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