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HIV-1 Reverse Transcriptase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (125) HIV Integrase (2) HIV Protease (3) Reverse Transcriptase (81) Antibiotic (1) Apoptosis (6) Autophagy (12) Cytochrome P450 (2) DNA/RNA Synthesis (4) Drug Metabolite (1) Endogenous Metabolite (4) HBV (2) HCV (2) Isotope-Labeled Compounds (9) MMP (1) NOD-like Receptor (NLR) (4) Nucleoside Antimetabolite/Analog (7) Parasite (5) PKC (1) Potassium Channel (1) SARS-CoV (1)
By Research Areas:	Cancer (11) Infection (131) Inflammation/Immunology (11) Neurological Disease (1)
Click Chemistry:	Azide (5) Alkynes (5)
Oligonucleotides:	Nucleosides and their Analogs (3)

139

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Reverse Transcriptase HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130241

Reverse transcriptase-IN-1	HIV	Infection
Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active **HIV-1 nonnucleoside reverse transcriptase** inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC₅₀ values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 III_B, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC₅₀of 13.7 nM against HIV-1 reverse transcriptase enzyme .

HY-15379

Atevirdine	HIV	Infection
Atevirdine is a potent non-nucleoside **HIV-1 reverse transcriptase** inhibitor. Atevirdine inhibits non-nucleoside reverse transcriptase that leads to viral multiplication .

HY-132291

HIV-1 inhibitor-8	HIV	Infection
HIV-1 inhibitor-8 is an orally active, low-toxicity and potent *HIV‑1* non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC₅₀=4.44~54.5 nM) against various *HIV‑1* strains. The IC₅₀ of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM .

HY-118632

BILR 355	Reverse Transcriptase HIV	Infection
BILR 355 is a second-generation nonnucleoside **reverse transcriptase** inhibitor (NNRTI). BILR 355 is highly specific toward **HIV-1 reverse transcriptase** (RT). BILR 355 can be used for HIV infections research .

HY-14294

Capravirine S-1153	Reverse Transcriptase	Infection
Capravirine is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. Capravirine inhibits replication of HIV-1 strains that are resistant to nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4 .

HY-107001

DPC 961 (S)-DPC 961; DMP 961	HIV Reverse Transcriptase	Infection
DPC 961 (DMP 961) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). DPC 961 is a potent and specific inhibitor of **HIV-1 reverse transcriptase*, which inhibits* the activity of **HIV-1 reverse transcriptase** in a non-competitive manner, thereby preventing viral replication. DPC 961 can be used for research on AIDS .

HY-152200

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

HY-151938

Reverse transcriptase-IN-3	HIV	Infection
Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of *HIV-1. Reverse* transcriptase-IN-3 shows potent activity against the *HIV-1* wild-type and mutant strains .

HY-106958

Talviraline HBY 097	HIV Reverse Transcriptase	Infection
Talviraline is a non-nucleoside reverse transcriptase (NNRT) inhibitor that is primarily used to inhibit the replication of human immunodeficiency virus type 1 (HIV-1). Talviraline inhibits the viral replication process by binding to a specific site of HIV-1 reverse transcriptase (RT). Talviraline can be used to study the potential countermeasures and safety of HIV-1 infection .

HY-152160

HIV-1 inhibitor-50	HIV Reverse Transcriptase	Infection
HIV-1 invistor-50 is a non-nucleoside **reverse transcriptase** inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC₅₀=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC₅₀s of 2.22-53.3nM against HIV-1 IIIB and its mutant strains .

HY-120737

L-702007	HIV	Infection
L-702007 is a potent **HIV-1 reverse transcriptase** inhibitor .

HY-15355

Loviride R 89439	Reverse Transcriptase HIV	Infection
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC₅₀ of 0.3 μM for **reverse transcriptase from HIV-1*. Loviride (R 89439) inhibits* HIV-1, HIV-2 and SIV replication in MT-4 cells .

HY-162461

HIV-1 inhibitor-66	Reverse Transcriptase HIV	Infection
HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type **HIV-1 reverse transcriptase with an IC₅₀** of 40 nM .

HY-100260

beta-L-D4A 2'3'-didehydro-2'3'-dideoxyadenosine	HIV	Infection
beta-L-D4A is a nucleoside **HIV-1 reverse transcriptase** inhibitor.

HY-109056

Elsulfavirine R-1206	HIV	Infection
Elsulfavirine is a reverse transcriptase inhibitors for *HIV-1* infection and is a new anti-HIV agent .

HY-146031

A3N19	HIV	Infection
A3N19 is a potent **HIV-1 non-nucleoside reverse transcriptase** inhibitor, with an EC₅₀ of 3.28 nM against HIV-1 IIIB .

HY-111079

HIV-1 inhibitor-70	Others	Others
HIV-1 inhibitor-70 (compound 20) is a bifunctional inhibitor that inhibits both wild-type (WT) and K103N mutant reverse transcriptases (RTs) of HIV-1.

HY-100079

9-Propenyladenine Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2	HIV	Infection
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

HY-150697

HIV-1 inhibitor-44	HIV	Others
HIV-1 inhibitor-44 (compound 11l) is a HIV-1 reverse transcriptase inhibitor. HIV-1 inhibitor-44 shows inhibitory activity against wild-type HIV-1 strain with an EC₅₀ value of 0.209 μM .

HY-10891

HIV-1 inhibitor-61	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-61 (2c) is a **HIV-1 reverse transcriptase** inhibitor, with an EC₅₀ of 0.07 nM in NL4-3 wt MT-4 cells .

HY-163110

NNRT-IN-2	HIV Reverse Transcriptase	Infection
NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type *HIV-1* and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC₅₀ of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics .

HY-150769

ZLM-66	HIV	Inflammation/Immunology
ZLM-66 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTIs) with an IC₅₀ of 41 nM for wild-type (WT) *HIV-1* reverse transcriptase and an EC₅₀ value of 13 nM for wild-type HIV-1. ZLM-66 is a Doravirine (HY-16767) analogs. ZLM-66 can be used for the research of AIDS .

HY-153225

PYR01	HIV	Infection
PYR01 is a potent *HIV-1* nonnucleoside reverse transcriptase inhibitor. PYR01 is an also targeted activator of cell kill molecules eliminate cells expressing HIV-1 .

HY-147370

HIV-1 inhibitor-46	HIV	Infection
HIV-1 inhibitor-46 (compound 13d) is a potent *HIV-1* non-nucleoside reverse transcriptase inhibitor with an EC₅₀ value of 1.425 μM. HIV-1 inhibitor-46 can be used for the research of AIDS .

HY-100079A

(Z)-9-Propenyladenine (Z)-Mutagenic Impurity of Tenofovir Disoproxil	HIV	Infection
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

HY-10570

Nevirapine 4 Publications Verification BI-RG 587; NSC 641530; NVP	HIV Reverse Transcriptase Parasite	Infection Cancer
Nevirapine is a non-nucleoside inhibitor of *HIV-1* reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-15232

Tenofovir alafenamide 5+ Cited Publications GS-7340	HIV Reverse Transcriptase	Infection
Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor.

HY-15232A

Tenofovir alafenamide fumarate 5+ Cited Publications GS-7340 fumarate	HIV Reverse Transcriptase	Infection
Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor.

HY-163362

HIV-1 inhibitor-65	Reverse Transcriptase PKC HIV	Infection
HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC₅₀: 2.9 nM) and an activator of protein kinase C (PKC). HIV-1 inhibitor-65 inhibits syncytium formation (EC₅₀: 7.0 nM) and inhibits HIV-1 entry and HIV-1 reverse transcriptase .

HY-10572

Efavirenz 5+ Cited Publications DMP 266; EFV; L-743726	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite	Infection Cancer
Efavirenz (DMP 266) is a potent inhibitor of the wild-type **HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity .

HY-15232B

Tenofovir alafenamide hemifumarate 5+ Cited Publications GS-7340 hemifumarate	HIV Reverse Transcriptase	Infection
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor.

HY-149991

HIV-1 inhibitor-56	HIV	Infection
HIV-1 inhibitor-56 (compound 12126065) is a potent **HIV-1 non-nucleoside reverse transcriptase** inhibitor. HIV-1 inhibitor-56 has antiviral activity against wild-type HIV-1 in TZM cells with an EC₅₀ value of 0.24 nM. HIV-1 inhibitor-56 penetrates the blood-brain barrier .

HY-146308

HIV-1 inhibitor-26	HIV	Infection
HIV-1 inhibitor-26 (compound 9a) is a potent HIV-1 reverse transcriptase (RT) inhibitor with an IC₅₀ value of 1.4 μM. HIV-1 inhibitor-26 has low cytotoxicity with a CC₅₀ of 1486 μM in PBMCs. HIV-1 inhibitor-26 can be used for researching AIDS .

HY-149338

NNRT-IN-3	HIV Protease	Infection
NNRT-IN-3 (compound 8) is an *HIV-1* non-nucleoside reverse transcriptase inhibitor (EC₅₀=0.01 μM) .

HY-19111

R-82150 TIBO-R 82150	HIV Reverse Transcriptase	Infection
R-82150 (TIBO-R 82150) is an **HIV-1 reverse transcriptase** inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses .

HY-144112

HIV-1 inhibitor-13	HIV	Infection
HIV-1 inhibitor-13 (compound 16c) is a orally active and potent *HIV-1* non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC₅₀ of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of *HIV-1* resistant strains, with EC₅₀ values of 2.85-18.0 nM .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-10571A

Delavirdine mesylate 3 Publications Verification U 90152 mesylate; BHAP-U 90152 mesylate	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26?μM) over DNA polymerase?α?(IC₅₀=440 μM) and polymerase?δ (IC₅₀>550?μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-105249

RDEA 806	HIV Reverse Transcriptase	Infection
RDEA 806 is an orally active non-nucleoside **reverse transcriptase** inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type *HIV-1* (EC₅₀ of 3.05 nM) and NNRTI-resistant *HIV-1* .

HY-B1408

Salicylanilide 2 Publications Verification 2-Hydroxybenzanilide	HIV Integrase HIV	Infection
Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or **reverse transcriptase**.

HY-136548

Tenofovir diphosphate TFV-DP	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) **reverse transcriptase** (RT) .

HY-129667

BM 21.1298	Reverse Transcriptase	Infection
BM 21.1298 is a selective and high specific nonnucleoside immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) inhibitor with antiviral activity .

HY-19143

L-697639	HIV	Infection
L-697639 is an inhibitor for **HIV-1 reverse transcriptase (HIV-1 RT) with IC₅₀** of 20-400 nM (in a template-primer-dependent manner). L-697639 exhibits antiviral activity, that inhibits 95% HIV-1 infection at concentrations of 12-200 nM in human T lymphocyte cultures .

HY-14266

Dapivirine 2 Publications Verification TMC120; R147681	HIV Reverse Transcriptase Apoptosis Autophagy	Infection
Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and *nonnucleoside reverse* transcriptase inhibitor (NRTI)*. Dapivirine (TMC120) binds directly to HIV-1* reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-16767

Doravirine 5+ Cited Publications MK-1439	HIV Reverse Transcriptase	Infection
Doravirine (MK-1439) is a highly specific **HIV-1 nonnucleoside reverse transcriptase** inhibitor with IC₅₀s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C **reverse transcriptase** mutants, respectively .

HY-147723

HIV-1 inhibitor-39	HIV	Infection
HIV-1 inhibitor-39 (compound 3c) is a potent *HIV-1* inhibitor with an EC₅₀ of >112.88 µM. HIV-1 inhibitor-39 shows anti-RT (HIV-1 reverse transcriptase) activities with an IC₅₀ of 15.75 µM. HIV-1 inhibitor-39 shows cytotoxicity for MT-4 cells with an CC₅₀ of 112.9 µM .

HY-151933

HIV-1 inhibitor-49	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-49 is an orally active *HIV-1* inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside **reverse transcriptase inhibitory activity (IC₅₀*=30 nM). HIV-1* inhibitor-49 exerts potential safety without acute toxicity in mouse model .

HY-144113

HIV-1 inhibitor-14	HIV	Infection
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum *HIV-1* non-nucleoside reverse transcriptase (RT) inhibitor with an EC₅₀ of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC₅₀s of 5.79 ~ 28.3 nM .

HY-147841

HIV-1 inhibitor-41	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside **HIV-1 reverse transcriptase** inhibitor with EC₅₀ values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10572

Efavirenz Maximum Cited Publications 7 Publications Verification DMP 266; EFV; L-743726	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (DMP 266) is a potent inhibitor of the wild-type **HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-N0365

Sennoside A 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Source classification Folium Sennae Cassia angustifolia Vahl Cassia acutifolia Del. Plants Disease Research Fields	HIV
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an *HIV-1* inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

HY-122935

Nigranoic acid	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	HIV Reverse Transcriptase
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits **HIV-1 reverse transcriptase**. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-N11288

Methyl salvionolate A	Structural Classification Labiatae Source classification Phenols Polyphenols Salvia yunnanensis C. H. Wright Plants	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits* P24 antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-N2571

Corydine	Infection Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Reverse Transcriptase HIV
Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting **reverse transcriptase (RT) activity with an IC₅₀ of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV** potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine .

HY-10572R

Efavirenz (Standard) DMP 266 (Standard); EFV (Standard); L-743726 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type **HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-142074

Inophyllum B (+)-Inophyllum B	Structural Classification Source classification Rosaceae Coumarins Phenylpropanoids Plants Photinia serratifolia (Desf.) Kalkman	Reverse Transcriptase HIV
Inophyllum B ((+)-Inophyllum B) is a potent HIV **Reverse Transcriptase** inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits *HIV-1* (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

Cat. No.	Product Name	Chemical Structure

HY-10570S

Nevirapine-d4
Nevirapine-d₄ is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

HY-10572S1

Efavirenz-13C6
Efavirenz- ¹³C₆ is the ¹³C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].

HY-14266S

Dapivirine-d11
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2].

HY-10570S1

Nevirapine-d3
Nevirapine-d₃ (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

HY-16767S1

Doravirine-13C,d3
Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific **HIV-1 nonnucleoside reverse transcriptase** inhibitor with IC₅₀s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C **reverse transcriptase** mutants, respectively .

HY-10572BS

(Rac)-Efavirenz-d4

(Rac)-Efavirenz-d₄ is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1]. (Rac)-Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10572S

Efavirenz-d5

Efavirenz-d₅ (DMP 266-d5) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1]. Efavirenz-d5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

HY-132508S

Etravirine-d8
Etravirine-d₈ is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV[1][2].

HY-10574S

Rilpivirine-d6
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV[1][2].

Cat. No.	Product Name		Classification

HY-105268

AzddMeC CS-92		Azide
AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active **HIV-1 reverse transcriptase** and HIV-1 replication inhibitor. In *HIV-1*-infected human PBM cells and *HIV-1*-infected human macrophages, the EC₅₀ values of AzddMeC are 9 nM and 6 nM, respectively . AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-16776

Censavudine Festinavir; BMS-986001; OBP-601		Alkynes
Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC₅₀ ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and *HIV-1*, respectively . Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19314A

Azvudine hydrochloride 1 Publications Verification RO-0622 hydrochloride; FNC hydrochloride		Azide
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains . Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-19314

Azvudine 1 Publications Verification RO-0622; FNC		Azide
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains . Azvudine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111640

3'-Azido-3'-deoxy-5-methylcytidine		Azide
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC₅₀ of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits **HIV-1 reverse transcriptase with an EC₅₀** of 0.06 μM in peripheral blood mononuclear (PBM) cells . 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152233

Reverse transcriptase-IN-4		Azide
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC₅₀ value of 0.053 μM for wild-type HIV-1 and an EC₅₀ value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-138561

EFdA-TP		Alkynes
EFdA-TP is a potent *nucleoside reverse* transcriptase (RT)** inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits *HIV-1* RT with multiple mechanisms .

HY-138561A

EFdA-TP tetraammonium		Alkynes
EFdA-TP tetraammonium is a potent *nucleoside reverse* transcriptase (RT)** inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits *HIV-1* RT with multiple mechanisms . EFdA-TP (tetraammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138561B

EFdA-TP tetrasodium		Alkynes
EFdA-TP tetrasodium is a potent *nucleoside reverse* transcriptase (RT)** inhibitor. EFdA-TP tetrasodium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetrasodium inhibits *HIV-1* RT with multiple mechanisms . EFdA-TP (tetrasodium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-125810

4'-Ethynyl-2'-deoxyadenosine		Alkynes
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-B0249

Didanosine 1 Publications Verification 2',3'-Dideoxyinosine; ddI		Nucleosides and their Analogs
Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV .