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Results for "

Iron

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ferroportin (4) Akt (4) Androgen Receptor (2) Antibiotic (8) Apoptosis (16) Autophagy (8) Bacterial (24) Biochemical Assay Reagents (32) Cathepsin (2) Cholinesterase (ChE) (2) COX (2) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (3) EBV (1) Endogenous Metabolite (19) Ferroptosis (31) Fluorescent Dye (11) Fungal (5) G-quadruplex (1) Glucosidase (1) Glutathione Peroxidase (1) Guanylate Cyclase (1) HCV (3) HDAC (1) HIF/HIF Prolyl-Hydroxylase (13) HSV (1) Isotope-Labeled Compounds (6) JAK (1) Lipoxygenase (2) MDM-2/p53 (1) Mitochondrial Metabolism (1) Mitophagy (1) MMP (2) Monoamine Oxidase (2) Necroptosis (1) NF-κB (1) NO Synthase (1) Oxidative Phosphorylation (1) Parasite (3) Potassium Channel (7) PROTACs (1) Reactive Oxygen Species (11) RIP kinase (1) ROS Kinase (1) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (2) Telomerase (1) TGF-beta/Smad (1) Transferrin Receptor (4) VDAC (1) Xanthine Oxidase (4) α-synuclein (2)
By Research Areas:	Cancer (61) Cardiovascular Disease (11) Endocrinology (2) Infection (38) Inflammation/Immunology (35) Metabolic Disease (29) Neurological Disease (18)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Nucleotides and their Analogs (2) siRNAs (2) pH Modifiers (1)

194

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Ferroportin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2068

Iron sucrose Iron saccharate	Reactive Oxygen Species	Metabolic Disease Cancer
Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment .

HY-N1428C

Ferric citrate 1 Publications Verification Iron(III) citrate; Zerenex	Reactive Oxygen Species Antibiotic	Metabolic Disease
Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .

HY-B1651

Iron(II) fumarate Ferrous fumarate	Others	Metabolic Disease
Iron (II) fumarate is an orally effective active dietary supplement. Iron (II) fumarate can alleviate metabolic damage and damage to silkworms caused by cypermethrin (HY-123178). Iron (II) fumarate can be used for research on iron deficiency anemia .

HY-107928

Iron dextran Fe dextran	Others	Metabolic Disease Cancer
Iron dextran (Fe dextran) can be used in the study of iron-deficiency anemia in animals .

HY-B1651R

Iron(II) fumarate (Standard) Ferrous fumarate (Standard)	Others	Metabolic Disease Cancer
Iron(II) fumarate (Standard) is the analytical standard of Iron(II) fumarate. This product is intended for research and analytical applications. Iron(II) fumarate (Ferrous fumarate) is the iron(II) salt of fumaric acid. Iron(II) fumarate is an orally active dietary supplement and has the potential for iron deficiency anemia treatment .

HY-W127813

Iron(III) octaethylporphine chloride Chloro(octaethylporphyrinato)Iron	Biochemical Assay Reagents	Others
Iron(III) octaethylporphine chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W698286

Iron(II) gluconate	Biochemical Assay Reagents
Iron(II) gluconate is a kind of biochemical reagent.

HY-130765

Ferbam Iron(III) dimethyldithiocarbamate	Fungal	Infection
Ferbam (Iron(III) dimethyldithiocarbamate) is a potent fungicide .

HY-107928A

Iron–Dextran(Fe 25-35% w/w)	Biochemical Assay Reagents	Others
Iron-Dextran is an injectable complex of iron and dextran, a complex carbohydrate. It is often used to improve iron deficiency anemia, a condition characterized by low levels of iron in the blood due to insufficient dietary intake or malabsorption. Iron-glucan works by providing a source of supplemental iron that the body can use to produce hemoglobin, the protein responsible for carrying oxygen in the blood. However, caution should be exercised when taking iron dextran because it may cause hypersensitivity reactions, including anaphylaxis, and may also increase the risk of infection or other adverse reactions. Therefore, it should only be administered under the supervision of a qualified healthcare provider in a clinical setting.

HY-W105875

Iron(II) D-gluconate dihydrate, 98% D-Gluconic acid Iron(II) salt dihydrate, 98%	Biochemical Assay Reagents	Others
Iron(II) D-gluconate dihydrate, 98% is used for blood coagulation.

HY-Y0945B

Iron (III) sulfate hydrate,for plant cell culture	Biochemical Assay Reagents	Others
Iron (III) sulfate hydrate,for plant cell culture is a biochemical assay reagent.

HY-107928B

Iron–Dextran(Fe 35-40% w/w)	Biochemical Assay Reagents	Others
Iron–Dextran(Fe 35-40% w/w) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y1103A

Iron(Ⅱ) sulfate heptahydrate, for cell culture, 99% Ferrous sulfate heptahydrate, for cell culture, 99%	Biochemical Assay Reagents	Others
Iron(Ⅱ) sulfate heptahydrate, for cell culture, 99% is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-Y1103

Iron(II) sulfate heptahydrate, 99% Ferrous sulfate heptahydrate, 99%	Biochemical Assay Reagents	Others
Iron(II) sulfate heptahydrate, 99% is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W075707

FeTCPP 1 Publications Verification Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride	Biochemical Assay Reagents	Others
FeTCPP (Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride) is a metallic porphyrin compound formed by the coordination of a central iron ion (Fe ³⁺) with four 4-carboxyphenylporphyrins (TCPP). FeTCPP can be used as a catalyst for catalytic, electrochemical, photochemical and biomedical research. FeTCPP has high photocatalytic performance for p-nitrophenol under visible light. FeTCPP also has peroxisase-like activity, which is used in bionic catalysis research .

HY-Y0329G

Iron(III) nitrate nonahydrate, for cell culture Ferric nitrate nonahydrate, for cell culture	Biochemical Assay Reagents	Others
Iron(III) nitrate nonahydrate, for cell culture, is used for cell culture.

HY-106594A

Prussian blue insoluble Iron(III) ferrocyanide; Milori blue	Bacterial	Infection Cancer
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .

HY-B1645

*Ammonium iron(III) citrate* 15+ Cited Publications Ammonium ferric citrate; FAC	Ferroptosis	Cancer
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis . Ammonium iron(III) citrate can enhance protein production .

HY-131926

*EDTA iron* sodium** Ethylenediaminetetraacetic acid Iron sodium	Biochemical Assay Reagents	Others
EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127835

*EDTA iron* sodium hydrate** Ethylenediaminetetraacetic acid Iron sodium hydrate	Biochemical Assay Reagents	Others
EDTA iron sodium hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127779

*Deferasirox iron* complex**	Biochemical Assay Reagents	Others
Deferasirox iron complex is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W019927

*Ammonium iron(Ⅲ) sulfate dodecahydrate, 99%* Ammonium ferric sulfate dodecahydrate, 99%	Biochemical Assay Reagents	Others
Ammonium iron(Ⅲ) sulfate dodecahydrate, 99% is a biochemical reagent. Ammonium iron(Ⅲ) sulfate dodecahydrate, 99% is often used as a source material for the reagent solution or the standard solution of iron(III) .

HY-114837

HBED	Ferroptosis	Cancer
HBED is a potent iron chelator. HBED can be used to study transfusional iron overload .

HY-130078

Ferrous bisglycinate	Others	Metabolic Disease Inflammation/Immunology
Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia .

HY-17359

Deferasirox 5+ Cited Publications ICL 670	Bacterial Ferroptosis	Cancer
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

HY-108260

Deferitrin GT-56-252	Others	Cardiovascular Disease
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major .

HY-101672

Deferitazole FBS 0701	Ferroptosis Parasite	Infection
Deferitazole (FBS 0701) is an orally active iron chelator. Deferitazole shows antimalarial activity and Can be used for study of malaria .

HY-136861

Antibacterial agent 192	Bacterial	Infection
Antibacterial agent 192 is an antibacterial agent that can disrupt iron homeostasis in E. coli .

HY-147379

Hepcidin antagonist-1	Others	Metabolic Disease
Hepcidin antagonist-1 (example 104) is a potent hepcidin (hepcidine) antagonist with an IC₅₀<50 μM. Hepcidin antagonist-1 can be used for researching iron metabolism disorders, such as anemias .

HY-145965

Ferroportin-IN-1	Ferroportin	Metabolic Disease
Ferroportin-IN-1 is a ferroportin inhibitor extracted from patent WO2020123850A1 compound 23. Ferroportin-IN-1 can be used for the research of diseases caused by a lack of hepcidin or iron metabolism disorders .

HY-137805

Ferrozine	Fluorescent Dye	Others
Ferrozine is a spectrophotometric reagent for iron, can react with divalent Fe to form a stable magenta complex species. The complex has an absorption peak at 562 nm .Ferrozine-based colorimetric assays can quantify iron in cells

HY-NP011

Human transferrin (suitable for cell culture) TRF	Transferrin Receptor	Others
Human transferrin (suitable for cell culture) is a glycoprotein with a branched sugar chain that mediates the transport of iron from plasma to cells .

HY-131060

CN128 hydrochloride CN328	Others	Others
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia .

HY-D0221

2,4,6-Tri-2-pyridinyl-1,3,5-triazine NSC 112125; 2,4,6-Tipyidyl-s-tiazie	Fluorescent Dye	Others
2,4,6-Tri-2-pyridinyl-1,3,5-triazine (NSC 112125) is a commonly used fluorescent dye for detecting iron. 2,4,6-Tri-2-pyridinyl-1,3,5-triazine forms a complex with Fe (II) and can be quantified as a measure of iron concentration by colorimetric detection at 594 nm .

HY-120475

PBT434 ATH434	α-synuclein	Neurological Disease
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .

HY-120475A

PBT434 mesylate ATH434 mesylate	α-synuclein	Neurological Disease
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .

HY-P3267

Transferrins 1 Publications Verification	Transferrin Receptor	Others
Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

HY-112220

VIT-2763 1 Publications Verification	Ferroportin	Metabolic Disease
VIT-2763, an oral ferroportin inhibitor, inhibits hepcidin binding to ferroportin and blocks iron efflux. VIT-2763 has the potential in the treatment of β-thalassemia .

HY-P1997

*Ferrichrome Iron-free* Desferrichrome; DFC; N-Desferriferrichrome	Biochemical Assay Reagents	Others
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

HY-P4373A

Hepcidin-1 (mouse) (TFA)	Cathepsin MMP	Inflammation/Immunology
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation .

HY-N10473

Pulcherriminic acid	Bacterial Fungal	Infection
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe ³⁺, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .

HY-126164

LK 614	Biochemical Assay Reagents	Others
LK 614 is a membrane permeable iron chelator that can be used to study the protective effects against L-Histidine (HY-N0832)-induced cell damage .

HY-153629

FSEN1	Ferroptosis	Cancer
FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC₅₀ value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer .

HY-129457

FINO2 2 Publications Verification	Ferroptosis	Cancer
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .

HY-153435

RIP1 kinase inhibitor 5	RIP kinase Necroptosis	Cancer
RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity . RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity .

HY-120303

LY269415	Lipoxygenase	Inflammation/Immunology
LY269415, is an anti-oxidant agent, is a potent and orally active iron dependent lipid peroxidation and 5-lipoxygenase enzyme inhibitor. LY269415 has anti-inflammatory effects .

HY-156439

Antibiofilm agent-2	Bacterial	Infection
Antibiofilm agent-2 (compound 4T) is a potent biofilm inhibitor with an IC₅₀ of 3.6 μM. Antibiofilm agent-2 inhibits the quorum sensing system and iron homeostasis as antibacterial synergists against Pseudomonas aeruginosa .

HY-148204

Gallichrome	Bacterial	Infection
Gallichrome is an active peptide. Gallichrome can interact directly with the hydroxamate moieties of the siderophore. Gallichrome can be used for the research of the uptake of iron in many gram-positive and gramnegative bacteria .

HY-108017

Ferric maltol	Others	Metabolic Disease
Ferric maltol is an orally active complex of a single ferric ion (Fe ³⁺). Ferric maltol has tha potential for iron deficiency anemia treatment in inflammatory bowel disease .

HY-126302

DMT1 blocker 2 2 Publications Verification	Others	Metabolic Disease
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC₅₀ of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1645

*Ammonium iron(III) citrate* 15+ Cited Publications Ammonium ferric citrate; FAC	Ketones, Aldehydes, Acids Source classification Rutaceae Plants Disease Research Fields Citrus reticulata Blanco Cancer	Ferroptosis
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis . Ammonium iron(III) citrate can enhance protein production .

HY-N10473

Pulcherriminic acid	Structural Classification Microorganisms Cyclopeptides	Bacterial Fungal
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe ³⁺, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .

HY-101193

Zinc Protoporphyrin Maximum Cited Publications 35 Publications Verification Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Reactive Oxygen Species Endogenous Metabolite Apoptosis
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂ . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-113133

Kojibiose	Microorganisms Source classification	Glucosidase
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .

HY-128525

Enterobactin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Bacterial
Enterobactin is a bacterial siderophore that promotes iron absorption and can be used to study inflammation. Enterobactin also disrupts macrophage (MΦs) iron homeostasis and M1/M2 polarization to protect intracellular bacteria from host antimicrobial effects .

HY-19424

Hemin 25+ Cited Publications Hemin chloride	Cardiovascular Disease Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Autophagy Mitophagy Ferroptosis
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.

HY-123648

Rhizoferrin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Rhizoferrin is a siderophore, which can be isolated from Rhizopus microsporus. Rhizoferrin binds iron ions with high affinity, and can be used as an effective iron source .

HY-126650

Mycobactin P	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Mycobactin P is a derivative of Mycobactin. The Mycobactin biosynthesis pathway exists only in Mycolata actinomycetes, such as Mycobacterium tuberculosis. Under the iron stress conditions of host macrophages, Mycobactin synthesizes peptides with salicylic acid groups to meet the pathogen's demand for iron.

HY-121858

Nicotianamine	Structural Classification Nicotiana tabacum L. Ketones, Aldehydes, Acids Source classification Solanaceae Plants	Others
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

HY-125605

Nannochelin A	Structural Classification Natural Products Microorganisms Source classification	Others
Nannochelin A is an iron-chelating compound that can be isolated from Nannocystis exedens .

HY-111914A

Ferroheme	Alkaloids Human Gut Microbiota Metabolites Microorganisms Pyrrole Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Others
Ferroheme, a complex of ferrous iron and a porphyrin, is an isosteric inhibitor of fatty acid binding to rat liver fatty acid binding protein .

HY-135024

Phenylacetyl CoA Phenylacetyl Coenzyme A	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica .

HY-135024A

Phenylacetyl CoA lithium Phenylacetyl Coenzyme A lithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenylacetyl CoA lithium (Phenylacetyl Coenzyme A lithium) is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica .

HY-N13022

Humic acid	Structural Classification Natural Products Source classification Plants	Others
Humic acid is an important component of organic matter in soil and water. Humic acid enhances pyrene degradation. Humic acid inhibits extracellular polysaccharides (EPS) secretion under high levels of iron conditions and ultimately inhibits colony formation of Microcystis .

HY-N0928

Mimosine	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-N12196

Terretonin	Structural Classification Other Monoterpenes Microorganisms Terpenoids Source classification	Others
Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin .

HY-N5134

5'-Guanylic acid 1 Publications Verification 5'-GMP; 5'-guanosine monophosphate	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway. 5'-Guanylic acid can form a supramolecular catalyst with iron(III)-hemoglobin that has peroxidase activity .

HY-N0814B

Phytic acid hexasodium Inositol hexaphosphate hexasodium; SNF472	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Endogenous Metabolite
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-N0814

Phytic acid 1 Publications Verification Inositol hexaphosphate; SNF472 free acid	Structural Classification Neurological Disease Classification of Application Fields Food Preservation Research Source classification Plants Endogenous metabolite Agricultural Research Microorganisms other families Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields	Xanthine Oxidase Endogenous Metabolite
Phytic acid (Inositol hexaphosphate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects .

HY-N8707

Homobutein	Classification of Application Fields Source classification Plants Compositae Infection Chalcones Flavonoids Millettia pachyloba Drake Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Parasite HDAC NF-κB
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

HY-142125

Broussochalcone A	Structural Classification Chalcones Flavonoids Source classification Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat	Xanthine Oxidase Reactive Oxygen Species Apoptosis
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC₅₀=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways .

HY-N0814A

Phytic acid dodecasodium hydrate 1 Publications Verification Inositol hexaphosphate dodecasodium hydrate; SNF472 dodecasodium hydrate	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	Xanthine Oxidase Endogenous Metabolite
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects .

HY-113066

Guanosine 5'-diphosphate GDP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-N0814R

Phytic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	Xanthine Oxidase Endogenous Metabolite
Phytic acid (Standard) is the analytical standard of Phytic acid. This product is intended for research and analytical applications. Phytic acid (Inositol hexaphosphate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects .

HY-113066C

Guanosine 5'-diphosphate (sodium), 96% (HPLC) 2 Publications Verification GDP (sodium), Type I, 96% (HPLC)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (sodium), 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium, Type I, 96% (HPLC) is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate (sodium), 96% (HPLC) can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-131300

Colchicoside	Colchicaceae Source classification Gloriosa superbaL. Plants	Parasite
Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .

HY-N7432

DIMBOA	Infection Structural Classification Zea mays L. Classification of Application Fields Antibiotics Gramineae Source classification Antibacterial Disease Research Plants Disease Research Fields Other Antibiotics	Antibiotic Bacterial Fungal
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

HY-N0123

Aloin 5+ Cited Publications Aloin-A; Barbaloin-A	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Cancer	Others
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-N0123R

Aloin (Standard)	Quinones Structural Classification Liliaceae Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants	Others
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-113066A

Guanosine 5'-diphosphate disodium salt 2 Publications Verification GDP disodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K ⁺ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI) .

Cat. No.	Product Name	Chemical Structure

HY-13426S

Roxadustat-d5
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].

HY-101193S

Zinc Protoporphyrin-d2,15N2

Zinc Protoporphyrin-d₂, ¹⁵N₂ is ¹⁵N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂ . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-B0568S

Deferiprone-d3
Deferiprone-d₃ is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating agent to be used therapeutically in conditions of transfusional iron overload[1][2].

HY-17359S

Deferasirox-d4
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium

Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

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