Search Result

Results for "

Second-generation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adenylate Cyclase (1) Amyloid-β (1) Androgen Receptor (1) Antibiotic (20) Apoptosis (32) AUTACs (1) Autophagy (12) Bacterial (30) Bcl-2 Family (1) Bcr-Abl (2) Beta-lactamase (3) Btk (3) Calcium Channel (3) CDK (3) Checkpoint Kinase (Chk) (6) CRM1 (1) DNA Methyltransferase (2) DNA/RNA Synthesis (2) Drug Metabolite (7) EGFR (1) Endogenous Metabolite (4) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (8) Factor VIII (1) FLT3 (3) Fluorescent Dye (1) Fungal (9) GHR (2) Glucocorticoid Receptor (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (30) HIV (5) HIV Protease (1) HSP (3) Huntingtin (3) IAP (1) Influenza Virus (4) Integrin (2) Interleukin Related (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (15) Kallikrein (2) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (3) MMP (1) Molecular Glues (2) mTOR (1) NOD-like Receptor (NLR) (1) Parasite (3) Pim (1) Potassium Channel (2) Prostaglandin Receptor (2) PROTACs (2) Proteasome (1) Proton Pump (9) RANKL/RANK (4) RAR/RXR (3) Ras (1) Reactive Oxygen Species (2) Reverse Transcriptase (1) Salt-inducible Kinase (SIK) (2) SARS-CoV (5) Ser/Thr Protease (1) SGLT (1) Small Interfering RNA (siRNA) (2) Smo (1) TNF Receptor (1) Toll-like Receptor (TLR) (4) Trk Receptor (1) Virus Protease (1) Wnt (4) β-catenin (4)
By Research Areas:	Cancer (84) Cardiovascular Disease (5) Endocrinology (28) Infection (45) Inflammation/Immunology (57) Metabolic Disease (8) Neurological Disease (11)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Antisense Oligonucleotides (7) siRNAs (2)

183

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1682A

Loracarbef hydrate	Antibiotic Bacterial	Infection
Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class .

HY-13675

ME-143 NV-143	Endogenous Metabolite	Cancer
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .

HY-B1128A

Cefamandole sodium Cephamandole sodium	Bacterial Antibiotic	Infection
Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.

HY-B0458

Cefprozil monohydrate	Bacterial Antibiotic	Infection
Cefprozil monohydrate (Cefzil) is a second-generation cephalosporin type antibiotic .

HY-109127A

Berotralstat dihydrochloride 1 Publications Verification BCX7353 dihydrochloride	Kallikrein	Others
Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .

HY-111186

Flocoumafen WL 108366	Glucocorticoid Receptor MMP	Others
Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects .

HY-B1166

Cefamandole nafate Cefamandole formate sodium	Bacterial Antibiotic	Infection Inflammation/Immunology
Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic .

HY-B1682

Loracarbef	Antibiotic Bacterial	Infection
Loracarbef, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class .

HY-B1128

Cefamandole Cephamandole	Bacterial Antibiotic	Infection
Cefamandole is a second-generation broad-spectrum cephalosporin antibiotic.

HY-B0458A

Cefprozil	Antibiotic Bacterial	Infection Inflammation/Immunology
Cefprozil (Cefzil) is a second-generation cephalosporin type antibiotic .

HY-153481

ATL 1102 ISIS-107248	Integrin	Others
ATL 1102 is a novel second-generation antisense oligonucleotide to CD49d mRNA

HY-153481A

ATL 1102 sodium ISIS-107248 sodium	Integrin	Others
ATL 1102 sodium is a novel second-generation antisense oligonucleotide to CD49d mRNA

HY-14463

Onalespib 5+ Cited Publications AT13387	HSP	Cancer
Onalespib (AT13387) is a long-acting second-generation Hsp90 inhibitor with a K_d of 0.71 nM.

HY-B0797

Etretinate 1 Publications Verification Ro 10-9359	Apoptosis	Others
Etretinate(Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis treatment.

HY-112865

Octocog alfa	Factor VIII	Others
Octocog alfa is a second-generation full-length recombinant factor VIII, as a antihemophilic factor .

HY-15835

CUDC-427 3 Publications Verification GDC-0917	IAP	Cancer
CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

HY-164419

Atesidorsen COR-004; ATL1103; ISIS 227452	GHR	Others
Atesidorsen is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA

HY-164419A

Atesidorsen sodium COR-004 sodium; ATL1103 sodium; ISIS 227452 sodium	GHR	Others
Atesidorsen sodium is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA

HY-109127R

Berotralstat (Standard)	Ser/Thr Protease	Others
Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .

HY-18636

LEQ506 NVP-LEQ506	Smo	Cancer
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

HY-163127

AUTAC2-2G	AUTACs Autophagy	Cancer
AUTAC2-2G is a second-generation AUTAC with a 100-fold increase in activity .

HY-B0458AS

Cefprozil-d4	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Cefprozil-d4 is the deuterium labeled Cefprozil. Cefprozil monohydrate (Cefzil) is a second-generation cephalosporin type antibiotic .

HY-13301

MPC-3100	HSP	Cancer
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity .

HY-101126

TP-3654 3 Publications Verification	Pim	Cancer
TP-3654 is a second-generation Pim kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

HY-B0458R

Cefprozil monohydrate (Standard)	Bacterial Antibiotic	Infection
Cefprozil (monohydrate) (Standard) is the analytical standard of Cefprozil (monohydrate). This product is intended for research and analytical applications. Cefprozil monohydrate (Cefzil) is a second-generation cephalosporin type antibiotic .

HY-U00116

GP531	Adenosine Receptor	Cardiovascular Disease
GP531 is a potent, second-generation adenosine regulating agent, is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.

HY-15229

Guadecitabine sodium 5+ Cited Publications SGI-110 sodium; S-110 sodium	DNA Methyltransferase	Cancer
Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) .

HY-B0797S

Etretinate-d3	Apoptosis	Others
Etretinate-d₃ is the deuterium labeled Etretinate. Etretinate (Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis research.

HY-13542

Guadecitabine SGI-110	DNA Methyltransferase	Cancer
Guadecitabine (SGI-110) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) .

HY-107833

A40926	Bacterial	Infection
A40926, the precursor of Dalbavancin, is a second-generation glycopeptide antibiotic. A40926 inhibits gram-positive bacteria, and is very active against Neisseria gonorrhoeae .

HY-16488

Temoporfin 5+ Cited Publications m-THPC; KW2345	Reactive Oxygen Species	Cancer
Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers .

HY-115568

BETd-246 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
BETd-246 is a second-generation and PROTAC-based BET bromodomain (BRD) inhibitor connected by ligands for Cereblon and BET, exhibiting superior selectivity, potency and antitumor activity .

HY-17404

Cilnidipine 1 Publications Verification FRC-8653	Calcium Channel	Cardiovascular Disease
Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-G0014A

Quetiapine sulfoxide dihydrochloride Quetiapine S-oxide dihydrochloride	Drug Metabolite	Neurological Disease
Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic . Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist .

HY-G0014B

Quetiapine sulfoxide hydrochloride Quetiapine S-oxide hydrochloride	Drug Metabolite	Neurological Disease
Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic . Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist .

HY-G0014

Quetiapine sulfoxide Quetiapine S-oxide	Drug Metabolite	Neurological Disease
Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic . Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist .

HY-131579

Deschloro Cetirizine dihydrochloride	Drug Metabolite	Inflammation/Immunology
Deschloro Cetirizine Dihydrochloride is a Cetirizine impurity. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist.

HY-106758

Cefuzonam sodium	Others	Infection
Cefuzonam sodium is a second-generation cephalosporin antibiotic with activity against Staphylococcus aureus, which is resistant to most third-generation cephalosporins. Cefuzonam sodium is effective for preventing infection after cesarean delivery .

HY-B0107

Acitretin 3 Publications Verification Ro 10-1670	RAR/RXR Autophagy Apoptosis	Inflammation/Immunology Cancer
Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease .

HY-B0107A

Acitretin sodium Ro 10-1670 sodium	RAR/RXR Autophagy	Inflammation/Immunology Cancer
Acitretin (Ro 10-1670) sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin sodium also can be used for the research of Alzheimer’s disease .

HY-B0674

Ebastine 2 Publications Verification LAS-W 090; RP64305	Histamine Receptor	Inflammation/Immunology Endocrinology
Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research .

HY-B1256

Cefuroxime sodium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-B1256A

Cefuroxime 5+ Cited Publications Kefurox	Beta-lactamase Bacterial Antibiotic	Infection Cancer
Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-101212

Fadraciclib 5 Publications Verification CYC065	CDK	Cancer
Fadraciclib (CYC065) is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC₅₀s of 5 and 26 nM, respectively .

HY-131256

Cetirizine Impurity C	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-131256A

Cetirizine Impurity C dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-P99625

Frexalimab SAR441344; INX-021	TNF Receptor	Inflammation/Immunology
Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sjögren’s syndrome and type I diabetes research .

HY-12966

Cetirizine methyl ester	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine methyl ester is an impurity of Cetirizine (HY-17042). Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist .

HY-B1825

Cefoxitin 4 Publications Verification	Antibiotic Bacterial	Infection Cancer
Cefoxitin, a β-lactam antibiotic, is a broad-spectrum, second-generation cephalosporin. Cefoxitin has a broad spectrum antibacterial activity which includes anaerobic as well as Gram-positive and Gram-negative aerobic bacteria .

HY-151798

TDI-11861	Adenylate Cyclase	Others
TDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor with slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC₅₀ value of 5.5 nM .

Cat. No.	Product Name	Type

HY-19948

Leucomethylene blue mesylate 5+ Cited Publications TRx0237 mesylate; Methylene blue leuco base mesylate	Chromogenic Assays
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (K_i of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .

HY-150236

FITC-labeled Tominersen sodium	Dyes
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-D1353

LipidGreen 2	Fluorescent Dyes/Probes
LipidGreen 2 is a second generation small molecule probe for lipid imaging. LipidGreen 2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish .

Cat. No.	Product Name	Target	Research Area

HY-P99625

Frexalimab SAR441344; INX-021	TNF Receptor	Inflammation/Immunology
Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sjögren’s syndrome and type I diabetes research .

HY-P99934

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13675

ME-143 NV-143	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .

HY-B1256A

Cefuroxime 5+ Cited Publications Kefurox	Classification of Application Fields Disease Research Fields Cancer	Beta-lactamase Bacterial Antibiotic
Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-17042

Cetirizine 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Histamine Receptor
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-76200

Voriconazole 5+ Cited Publications UK-109496	Microorganisms Source classification	Fungal Bacterial
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .

HY-P99934

Eftozanermin alfa ABBV-621	Classification of Application Fields Disease Research Fields Cancer	Apoptosis
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

HY-10985

Marizomib Maximum Cited Publications 10 Publications Verification Salinosporamide A; NPI-0052	Marine natural products Source classification Marine microorganism	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-17042R

Cetirizine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Histamine Receptor
Cetirizine (Standard) is the analytical standard of Cetirizine. This product is intended for research and analytical applications. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-76200R

Voriconazole (Standard) UK-109496 (Standard)	Microorganisms Source classification	Fungal Bacterial
Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .

HY-B0157AR

Ketotifen fumarate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-13738A

Raloxifene hydrochloride Maximum Cited Publications 10 Publications Verification Keoxifene hydrochloride; LY156758; LY139481 hydrochloride	Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Plants Disease Research Fields Tetradium ruticarpum (A. Jussieu) T. G. Hartley Endocrinology Cancer	Estrogen Receptor/ERR Autophagy
Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-13738AR

Raloxifene hydrochloride (Standard) Maximum Cited Publications 10 Publications Verification Keoxifene (hydrochloride)(Standard); LY156758(Standard); LY139481 hydrochloride (Standard)	Structural Classification Alkaloids Classification of Application Fields Source classification Rutaceae Phenols Plants Disease Research Fields Tetradium ruticarpum (A. Jussieu) T. G. Hartley Endocrinology Cancer	Estrogen Receptor/ERR Autophagy
Raloxifene (hydrochloride) (Standard) is the analytical standard of Raloxifene (hydrochloride). This product is intended for research and analytical applications. Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

Cat. No.	Product Name	Chemical Structure

HY-B0157AS

Ketotifen-d3 fumarate
Ketotifen-d₃ (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks[1][2].

HY-B0458AS

Cefprozil-d4
Cefprozil-d4 is the deuterium labeled Cefprozil. Cefprozil monohydrate (Cefzil) is a second-generation cephalosporin type antibiotic .

HY-B0797S

Etretinate-d3
Etretinate-d₃ is the deuterium labeled Etretinate. Etretinate (Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis research.

HY-B1256S

Cefuroxime-d3
Cefuroxime-d₃ is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1].

HY-B0674S

Ebastine-d5
Ebastine-d₅ is the deuterium labeled Ebastine. Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1][2].

HY-17404S

Cilnidipine-d7
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel[1][2][3][4]. Antihypertensive effects[5].

HY-G0014S

Quetiapine Sulfoxide-d8
Quetiapine Sulfoxide-d₈ is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].

HY-B0674S1

Ebastine-d6
Ebastine-d₆ is deuterated labeled Ebastine (HY-B0674). Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research .

HY-129240S

13-cis Acitretin-d3
13-cis Acitretin-d₃ is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis[1][2].

HY-17042AS

Cetirizine-d4 dihydrochloride
Cetirizine-d₄ (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042AS1

Cetirizine-d8 dihydrochloride
Cetirizine-d₈ (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042S

Cetirizine-d4
Cetirizine-d₄ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042S1

Cetirizine-d8
Cetirizine-d₈ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-B0005AS

Toremifene-d6
Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-76200S

Voriconazole-d3
Voriconazole-d₃ is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

HY-B0005S1

Toremifene-d6 hydrochloride
Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively .

HY-B0005S

Toremifene-d6 citrate
Toremifene-d₆ (citrate) is the deuterium labeled Toremifene citrate. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-17600S

Acalabrutinib-d4
Acalabrutinib-d₄ is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0656S

Rabeprazole-d4
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-B0656AS

Rabeprazole-d4 sodium

Rabeprazole-d₄ (sodium) is the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-B0656AS1

Rabeprazole-d3 sodium

Rabeprazole-d₃ (sodium)mis the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-W757743

Acalabrutinib-d3
Acalabrutinib-d₃ (ACP-196-d₃) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

HY-B0656AS2

Rabeprazole-d4 potassium

Rabeprazole-d₄ potassium is deuterated labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-B0656S1

Rabeprazole-13C,d3

Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-17373S

Posaconazole-d5
Posaconazole-d₅ is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].

HY-17373S1

Posaconazole-d4
Posaconazole-d₄ is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].

Cat. No.	Product Name		Classification

HY-130252

YQ128 1 Publications Verification		Alkynes
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC₅₀ of 0.30 μM. YQ128 significantly and selectively suppresses the production of IL-1β, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity . YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HTTRx sodium		Antisense Oligonucleotides
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-150236

FITC-labeled Tominersen sodium		Antisense Oligonucleotides
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-132604A

Fazirsiran sodium ARO-AAT sodium		siRNAs
Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes . Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease.