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Results for "

iNOS expression

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (2) Apoptosis (15) Arginase (1) Autophagy (6) Bacterial (9) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcium Channel (2) Caspase (2) CFTR (3) Chloride Channel (3) Cholinesterase (ChE) (3) COX (57) Cytochrome P450 (2) Dengue Virus (1) Drug Metabolite (1) Endogenous Metabolite (16) ERK (6) Ferroptosis (4) Flavivirus (1) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) Glucocorticoid Receptor (2) Glutathione Peroxidase (3) Glycosidase (1) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (1) IFNAR (2) IKK (3) Interleukin Related (28) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (5) JAK (2) JNK (3) Lipoxygenase (1) MDM-2/p53 (1) MEK (4) Microtubule/Tubulin (1) MMP (4) Monoamine Oxidase (1) nAChR (2) NADPH Oxidase (1) NF-κB (37) NO Synthase (72) NOD-like Receptor (NLR) (1) p38 MAPK (8) PGE synthase (2) Phosphodiesterase (PDE) (4) PI3K (3) PKC (1) Potassium Channel (1) PTEN (1) Pyruvate Kinase (2) RAR/RXR (1) Reactive Oxygen Species (ROS) (11) Reference Standards (24) RGS Protein (1) STAT (4) Syk (2) Tau Protein (1) TGF-beta/Smad (4) TGF-β Receptor (1) TNF Receptor (23) Toll-like Receptor (TLR) (6) Topoisomerase (1) TREM receptor (1) TRP Channel (1)
By Research Areas:	Cancer (38) Cardiovascular Disease (12) Endocrinology (4) Infection (7) Inflammation/Immunology (111) Metabolic Disease (11) Neurological Disease (14)
Click Chemistry:	Azide (1) Alkynes (1)

142

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145846

iNOs-IN-1 1 Publications Verification	NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .

HY-119692

Curvulin	Microtubule/Tubulin	Others
Curvulin is a phytotoxin . Curvularin inhibits microtubule assembly and inhibits iNOS expression.

HY-N5015

Rosmanol 1 Publications Verification	COX	Inflammation/Immunology Cancer
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-126241

RV01	Aldehyde Dehydrogenase (ALDH)	Inflammation/Immunology
RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity . RV01 decreases *iNOS* expression, with anti-neuroinflammatory activity .

HY-N6878

Cauloside D	NO Synthase	Inflammation/Immunology
Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines .

HY-171251

RGS10 modulator-1	RGS Protein	Cancer
RGS10 modulator-1 (compound 15) is a potent RGS10 modulator. RGS10 modulator-1 significantly reverses IFNγ-induced RGS10 protein and mRNA expression. RGS10 modulator-1 reverse the IFNγ-induced COX-2 mRNA and iNOS expression .

HY-118160

PPM-18 NSC 73233	NO Synthase	Inflammation/Immunology Cancer
PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter . PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways .

HY-173410

iNOs-IN-6	NF-κB p38 MAPK NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-6 is an anti-inflammatory agent. iNOs-IN-6 inhibits NF-κB, *iNOS, and MAPK* expression(IC₅₀: 0.2-0.62 μM). iNOs-IN-6 reduces IL-6, TNF-α, and IL-1β pro-inflammatory mediators levels (IC₅₀: 0.4-0.69 μM) .

HY-133098

Juncutol	NO Synthase	Inflammation/Immunology
Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-168096

iNOs-IN-5	NO Synthase Apoptosis	Cardiovascular Disease Neurological Disease
iNOs-IN-5 (Compound BN-4) is an inhibitor for *iNOS* with an IC₅₀ of 0.1707 μM, and reduces NO levels in LPS (HT-D1056)-induced RAW264.7 cells. iNOs-IN-5 reduces the hypoxic injury stimulated ROS and lactate dehydrogenase expression, and exhibits anti-necrosis and anti-apoptosis efficacy. iNOs-IN-5 exhibits anti-cerebral ischemia and neuroprotective activities in SD rat models. iNOs-IN-5 is blood-brain barrier penetrable .

HY-N6919

Cauloside C	NO Synthase	Inflammation/Immunology
Cauloside C is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside C exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines .

HY-159564

iNOS/COX-2-IN-3	COX NO Synthase	Inflammation/Immunology
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of *iNOS* and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on *iNOS* and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

HY-N7688

Regaloside B	NO Synthase COX	Inflammation/Immunology
Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B can inhibit the expression of *iNOS* and COX-2. Regaloside B has anti-inflammatory activity .

HY-N0635

Prim-O-glucosylcimifugin 4 Publications Verification	TNF Receptor NO Synthase COX	Inflammation/Immunology
Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of *iNOS* and COX-2 expression by through regulating JAK2/STAT3 signaling.

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	NO Synthase	Inflammation/Immunology
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-P10710A

BMP-4 acetate	IFNAR Interleukin Related COX	Inflammation/Immunology
BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. BMP-4 acetate regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as *iNOS, COX2, IFN, and IL6*, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages .

HY-P10710

BMP-4	IFNAR Interleukin Related COX	Inflammation/Immunology
BMP-4 is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. In murine chondrocytes and macrophages, BMP-4 regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as *iNOS, COX2, IFN, and IL6* in a dose-dependent manner, effectively suppressing inflammation and alleviating various arthritis symptoms .

HY-W010270A

Aurothiomalate disodium	TRP Channel NF-κB NO Synthase TREM receptor Arginase	Metabolic Disease Inflammation/Immunology
Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and *iNOS* expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis .

HY-N0158

Oxymatrine 15+ Cited Publications	TGF-beta/Smad Apoptosis	Infection Inflammation/Immunology Cancer
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the *iNOS* expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-N15305

Ferolin	FXR	Inflammation/Immunology
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

HY-N6968

α-Humulene Humulene; α-Caryophyllene	NO Synthase COX	Inflammation/Immunology
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 μg/mL). α-Humulene inhibits COX-2 and *iNOS* expression .

HY-136341

7,8-Dihydroneopterin	Apoptosis NO Synthase Endogenous Metabolite	Neurological Disease Inflammation/Immunology
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Others	Inflammation/Immunology
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .

HY-153832

MSU-42011	RAR/RXR NO Synthase	Cancer
MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the *iNOS* activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .

HY-N1695

Demethylregelin Regelin acid	NO Synthase	Inflammation/Immunology
Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of *iNOS* protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .

HY-N5015R

Rosmanol (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Rosmanol (Standard) is the analytical standard of Rosmanol. This product is intended for research and analytical applications. Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N0001

(-)-Epicatechin 5 Publications Verification (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0158R

Oxymatrine (Standard)	Reference Standards TGF-beta/Smad Apoptosis	Infection Inflammation/Immunology Cancer
Oxymatrine (Standard) is the analytical standard of Oxymatrine. This product is intended for research and analytical applications. Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of *iNOS* and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-162805

iNOS/TopoI-IN-1	NO Synthase Topoisomerase Apoptosis NF-κB	Inflammation/Immunology Cancer
iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC₅₀ of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (K_i=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of *iNOS* by inhibiting the activation of NF-kB (K_i=1.49 μM) .

HY-146161

COX-2/NO-IN-1	COX NO Synthase	Inflammation/Immunology
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC₅₀ of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects .

HY-N0698

Crocin II	NO Synthase COX Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of *iNOS* and COX-2 .

HY-137957

Longiferone B	NO Synthase COX	Inflammation/Immunology
Longiferone B is a daucane sesquiterpene, that can be isolated from Boesenbergia longiflora rhizomes. Longiferone B shows anti-inflammatory activity against NO release with an IC₅₀ of 21.0 μM. Longiferone B also suppresses the iNOS and COX-2 mRNA expression .

HY-N0506

Rosarin	Interleukin Related	Neurological Disease
Rosarin is a cinnamyl alcohol?glycoside isolated from?Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1?β, and TNF- α in the kidney and prefrontal cortex of brain in mice? .

HY-163888

NO-IN-1	NO Synthase NF-κB COX	Inflammation/Immunology
NO-IN-1 (Compound 7a) inhibits the production of NO (IC₅₀ = 3.13 μΜ). NO-IN-1 has anti-inflammatory effects. NO-IN-1 downregulates the expression of COX-2 and iNOS by inhibiting the NF-κB signaling pathway .

HY-161255

3,4-DAA	NO Synthase	Inflammation/Immunology
3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 ⁺CD25 ⁺ T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .

HY-N0774

Isofraxidin 4 Publications Verification	ERK COX MMP Toll-like Receptor (TLR)	Inflammation/Immunology
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of *iNOS* and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-W750902

Oxymatrine-d3	Isotope-Labeled Compounds TGF-beta/Smad Apoptosis	Infection Inflammation/Immunology Cancer
Oxymatrine-d₃ is the deuterium labeled Oxymatrine (HY-N0158). Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the *iNOS* expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-125827

13-Methylberberine chloride 13-Methylberberinium chloride	Interleukin Related	Metabolic Disease Cancer
13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS .

HY-N0613

Sauchinone 1 Publications Verification	NF-κB	Inflammation/Immunology
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-P3168

Martentoxin	Potassium Channel NO Synthase	Cardiovascular Disease Inflammation/Immunology
Martentoxin, a 4,046 Da polypeptide toxin, is a large-conductance Ca ²⁺-activated K ⁺ (BK_Ca) channel inhibitor. Martentoxin attenuates NO release, inhibits *iNOS* activation and upregulates eNOS mRNA expression in HUVECs induced by TNF-α. Martentoxin can be used for vascular diseases research .

HY-N0577

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	NO Synthase	Inflammation/Immunology
Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC₅₀ = 0.08 mg/mL) in-vitro and iNOS expression (IC₅₀ = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

HY-W011849

Phenyl β-D-glucopyranoside	NF-κB COX	Cancer
Phenyl β-D-glucopyranoside has anti-cancer and anti-inflammatory activities. Phenyl β-D-glucopyranoside inhibits nitric oxide (NO) production, and the expression of iNOS and COX-2. Phenyl β-D-glucopyranoside also inhibits the nuclear translocation of NF-κB .

HY-N0635R

Prim-O-glucosylcimifugin (Standard)	TNF Receptor Reference Standards NO Synthase COX	Inflammation/Immunology
Prim-O-glucosylcimifugin (Standard) is the analytical standard of Prim-O-glucosylcimifugin. This product is intended for research and analytical applications. Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by through regulating JAK2/STAT3 signaling.

HY-N15226

Butyrolactone Ia	NO Synthase Interleukin Related Autophagy	Inflammation/Immunology
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N0722

Neochlorogenic acid 1 Publications Verification trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N15651

Asperflavin	NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Asperflavin is an anti-inflammatory compound that can be produced by the marine fungus Eurotium amstelodami. Asperflavin inhibits the production of NO, PGE₂, and proinflammatory cytokines, as well as the expression of inducible NOS (iNOS) in RAW 264.7 cells treated with LPS (HY-D1056). Asperflavin can be used in the study of inflammatory diseases .

HY-B1197

Amcinonide CL-34699	Glucocorticoid Receptor NO Synthase Interleukin Related TNF Receptor	Inflammation/Immunology Endocrinology
Amcinonide is an inhibitor of NO release (IC₅₀ = 3.38 nM). Amcinonide inhibits NNC-induced expression of the proinflammatory genes *iNOS, TNF-α, and IL-1β* in glial cells. Amcinonide reduces the numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. Amcinonide induces a selective reduction in expression of Ia antigens. Amcinonide can also be studied in research for eczematous dermatitis .

HY-129113R

α-?Chaconine (Standard)	Reference Standards COX	Inflammation/Immunology
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

Cat. No.	Product Name	Type

HY-W251598C

Sodium bicarbonate, for cell culture

Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture

Buffer Reagents

Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W040074

Glycylglycine hydrochloride hydrate

Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)

Buffer Reagents

Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

HY-W251598I

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Buffer Reagents

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W251598B

Sodium bicarbonate, for molecular biology

Sodium hydrogen carbonate for molecular biology; Soda bicarbonate for molecular biology

Buffer Reagents

Sodium bicarbonate, for molecular biology (Sodium hydrogen carbonate for molecular biolog; Soda bicarbonate for molecular biolog) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

Cat. No.	Product Name	Target	Research Area

HY-P10710A

BMP-4 acetate	IFNAR Interleukin Related COX	Inflammation/Immunology
BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. BMP-4 acetate regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as *iNOS, COX2, IFN, and IL6*, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages .

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-D0889

Glycylglycine 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Glycylglycine is a non-selective glycylglycine dipeptidase substrate and *iNOS* inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

HY-D0889R

Glycylglycine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and *iNOS* inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

HY-P10710

BMP-4	IFNAR Interleukin Related COX	Inflammation/Immunology
BMP-4 is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. In murine chondrocytes and macrophages, BMP-4 regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as *iNOS, COX2, IFN, and IL6* in a dose-dependent manner, effectively suppressing inflammation and alleviating various arthritis symptoms .

HY-P3168

Martentoxin	Potassium Channel NO Synthase	Cardiovascular Disease Inflammation/Immunology
Martentoxin, a 4,046 Da polypeptide toxin, is a large-conductance Ca ²⁺-activated K ⁺ (BK_Ca) channel inhibitor. Martentoxin attenuates NO release, inhibits *iNOS* activation and upregulates eNOS mRNA expression in HUVECs induced by TNF-α. Martentoxin can be used for vascular diseases research .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

Cat. No.	Product Name	Target	Research Area

HY-P991316

KD014 DX-2400; DX-2410	MMP TGF-β Receptor TGF-beta/Smad NO Synthase	Cancer
KD014 (DX-2400) is a human monoclonal antibody (mAb) targeting MMP14 (K_i: 0.9 nM). KD014 inhibits TGFβ and SMAD2/3 activity, increases macrophage numbers and *iNOS* expression, and shifts macrophage phenotype toward anti-tumor M1-like. KD014 has anti-tumor activity in three different tumor models (MDA-MB-231, MDA-MB-435, and PC3). KD014 can be used in breast cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5015

Rosmanol 1 Publications Verification	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	COX
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N6878

Cauloside D	Triterpenes Structural Classification Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Caulophyllum robustum Maxim. Source classification Plants Berberidaceae Inflammation/Immunology Disease Research Fields Araliaceae	NO Synthase
Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines .

HY-N6919

Cauloside C	Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Caulophyllum robustum Maxim. Source classification Plants Berberidaceae Inflammation/Immunology Disease Research Fields Araliaceae	NO Synthase
Cauloside C is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside C exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines .

HY-N7688

Regaloside B	Monophenols Liliaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Lilium brownie var. viridulum	NO Synthase COX
Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B can inhibit the expression of *iNOS* and COX-2. Regaloside B has anti-inflammatory activity .

HY-N0635

Prim-O-glucosylcimifugin 4 Publications Verification	Structural Classification Natural Products Ophryosporus axilliflorus Hieron. Classification of Application Fields Source classification Umbelliferae Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NO Synthase COX
Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of *iNOS* and COX-2 expression by through regulating JAK2/STAT3 signaling.

HY-N0158

Oxymatrine 15+ Cited Publications	Infection Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields	TGF-beta/Smad Apoptosis
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the *iNOS* expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-N6968

α-Humulene Humulene; α-Caryophyllene	Structural Classification Classification of Application Fields Source classification Myristicaceae Plants Endogenous metabolite Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Terpenoids Myristica fragrans Houtt. Inflammation/Immunology Disease Research Fields	NO Synthase COX
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 μg/mL). α-Humulene inhibits COX-2 and *iNOS* expression .

HY-133098

Juncutol	Juncaceae Source classification Plants Juncus acutus L.	NO Synthase
Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Inflammation/Immunology	NO Synthase
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-N15305

Ferolin	Other Terpenoids Structural Classification Terpenoids Apiaceae Source classification Plants Ferula lapidosa Korovin	FXR
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

HY-136341

7,8-Dihydroneopterin	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Apoptosis NO Synthase Endogenous Metabolite
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Structural Classification Source classification Coumarins Ageratina altissima (L.) R.M.King & H.Rob. Phenylpropanoids Umbelliferae Plants	Others
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .

HY-N1695

Demethylregelin Regelin acid	Structural Classification Terpenoids Source classification Celastraceae Plants Pentacyclic Triterpenoids Euonymus alatus (Thunb.) Sieb.	NO Synthase
Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of *iNOS* protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .

HY-N5015R

Rosmanol (Standard)	Structural Classification Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Source classification Phenols Polyphenols Plants	Reference Standards COX
Rosmanol (Standard) is the analytical standard of Rosmanol. This product is intended for research and analytical applications. Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N0001

(-)-Epicatechin 5 Publications Verification (-)-Epicatechol; Epicatechin; epi-Catechin	Structural Classification Classification of Application Fields Anti-aging Source classification Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Theaceae Cancer	COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0158R

Oxymatrine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Source classification Sophora flavescens Aiton Plants	Reference Standards TGF-beta/Smad Apoptosis
Oxymatrine (Standard) is the analytical standard of Oxymatrine. This product is intended for research and analytical applications. Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields	COX
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of *iNOS* and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0698

Crocin II	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Rubiaceae Diterpenoids Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NO Synthase COX Endogenous Metabolite
Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of *iNOS* and COX-2 .

HY-137957

Longiferone B	Structural Classification Terpenoids Sesquiterpenes Source classification Boesenbergia longiflora (Wallich) Kuntze Plants Zingiberaceae	NO Synthase COX
Longiferone B is a daucane sesquiterpene, that can be isolated from Boesenbergia longiflora rhizomes. Longiferone B shows anti-inflammatory activity against NO release with an IC₅₀ of 21.0 μM. Longiferone B also suppresses the iNOS and COX-2 mRNA expression .

HY-N0506

Rosarin	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	Interleukin Related
Rosarin is a cinnamyl alcohol?glycoside isolated from?Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1?β, and TNF- α in the kidney and prefrontal cortex of brain in mice? .

HY-N0774

Isofraxidin 4 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of *iNOS* and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-125827

13-Methylberberine chloride 13-Methylberberinium chloride	Alkaloids Structural Classification Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Interleukin Related
13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS .

HY-N0613

Sauchinone 1 Publications Verification	Structural Classification Saururaceae Classification of Application Fields Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N0577

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray Inflammation/Immunology Disease Research Fields	NO Synthase
Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC₅₀ = 0.08 mg/mL) in-vitro and iNOS expression (IC₅₀ = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

HY-W011849

Phenyl β-D-glucopyranoside	Crassulaceae Source classification Rhodiola imbricata Edgew. Plants	NF-κB COX
Phenyl β-D-glucopyranoside has anti-cancer and anti-inflammatory activities. Phenyl β-D-glucopyranoside inhibits nitric oxide (NO) production, and the expression of iNOS and COX-2. Phenyl β-D-glucopyranoside also inhibits the nuclear translocation of NF-κB .

HY-N0635R

Prim-O-glucosylcimifugin (Standard)	Structural Classification Natural Products Ophryosporus axilliflorus Hieron. Source classification Umbelliferae Plants	TNF Receptor Reference Standards NO Synthase COX
Prim-O-glucosylcimifugin (Standard) is the analytical standard of Prim-O-glucosylcimifugin. This product is intended for research and analytical applications. Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by through regulating JAK2/STAT3 signaling.

HY-N15226

Butyrolactone Ia	Structural Classification Microorganisms Source classification Phenols	NO Synthase Interleukin Related Autophagy
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N0722

Neochlorogenic acid 1 Publications Verification trans-5-O-Caffeoylquinic acid	Structural Classification Caprifoliaceae Classification of Application Fields Simple Phenylpropanols Lonicera japonica Thunb. Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	NF-κB Interleukin Related TNF Receptor COX
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N15651

Asperflavin	Structural Classification Natural Products Microorganisms Source classification	NO Synthase TNF Receptor Interleukin Related
Asperflavin is an anti-inflammatory compound that can be produced by the marine fungus Eurotium amstelodami. Asperflavin inhibits the production of NO, PGE₂, and proinflammatory cytokines, as well as the expression of inducible NOS (iNOS) in RAW 264.7 cells treated with LPS (HY-D1056). Asperflavin can be used in the study of inflammatory diseases .

HY-129113R

α-?Chaconine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Gramineae Source classification Plants	Reference Standards COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N2106R

Dehydroevodiamine (Standard)	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Indole Alkaloids	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N2106

Dehydroevodiamine 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced *iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression* in murine macrophage cells .

HY-N0001R

(-)-Epicatechin (Standard) 5 Publications Verification (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Phenols Cosmetic Research Inflammation/Immunology Disease Research Fields Theaceae Cancer	Reference Standards COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N9955

Isonardosinone	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	NF-κB p38 MAPK NO Synthase COX
Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of *iNOS* and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056)-induced BV2 microglia, exhibits anti-inflammatory activity .

HY-N2008

Luteolin 5-O-glucoside	Structural Classification Flavonoids Classification of Application Fields Flavones Vigna angularis (Willd.) Ohwi et Ohashi Plants Compositae Inflammation/Immunology Disease Research Fields	NO Synthase Reactive Oxygen Species (ROS)
Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS generation. Luteolin 5-O-glucoside suppresses the expression of iNOS and COX-2 in macrophages .

HY-N8413

Chlojaponilactone B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Toll-like Receptor (TLR) Reactive Oxygen Species (ROS) NF-κB
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

HY-N12224

1-Heptadecanoyl-rac-glycerol MG(17:0/0:0/0:0); 1-Heptadecanoin	Apocynaceae Structural Classification Natural Products Source classification Plants Trachelospermum jasminoides (Lindl.) Lem.	NO Synthase
1-Heptadecanoyl-rac-glycerol (1-Heptadecanoin) is a glyceride compound with anti-inflammatory activity. 1-Heptadecanoyl-rac-glycerol inhibits the occurrence of inflammation by suppressing the expression of inducible nitric oxide synthase (iNOS) related to inflammation. 1-Heptadecanoyl-rac-glycerol can be used for research on diseases related to inflammation .

HY-N6968R

α-Humulene (Standard) Humulene (Standard); α-Caryophyllene (Standard)	Other Terpenoids Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Source classification Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite	Reference Standards NO Synthase COX
α-Humulene (Standard) is the analytical standard of α-Humulene. This product is intended for research and analytical applications. α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression .

HY-N0506R

Rosarin (Standard)	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	Reference Standards Interleukin Related
Rosarin (Standard) is the analytical standard of Rosarin. This product is intended for research and analytical applications. Rosarin is a cinnamyl alcohol glycoside isolated from Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .

HY-N0774R

Isofraxidin (Standard)	Structural Classification Monophenols Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	ERK Reference Standards COX MMP Toll-like Receptor (TLR)
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N3548

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-N0698R

Crocin II (Standard)	Structural Classification Terpenoids Source classification Rubiaceae Diterpenoids Plants Gardenia jasminoides Ellis	Reference Standards NO Synthase COX Endogenous Metabolite
Crocin II (Standard) is the analytical standard of Crocin II. This product is intended for research and analytical applications. Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2 .

HY-N8371

Shizukaol B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits **iNOS and COX-2, and suppresses NO production, TNF-α, and *IL-1β expression* .****

HY-N15272

Artocarpesin	Structural Classification Flavanonols Flavonoids Source classification Plants Moraceae	Bacterial COX NO Synthase Reactive Oxygen Species (ROS) p38 MAPK
Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE₂ and ROS by inhibiting COX-2 and *iNOS* expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases .

HY-N0577R

Apiin (Standard) Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray	Reference Standards NO Synthase
Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

HY-111954

(+)-Erinacin A Erinacine A	Structural Classification Microorganisms Terpenoids Diterpenoids	Apoptosis JNK NF-κB Histone Acetyltransferase NO Synthase Bcl-2 Family p38 MAPK Caspase
(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage .

HY-N0613R

Sauchinone (Standard)	Structural Classification Saururaceae Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants	Reference Standards NF-κB
Sauchinone (Standard) is the analytical standard of Sauchinone. This product is intended for research and analytical applications. Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N0936R

Coixol (Standard) 6-Methoxy-2-benzoxazolinone (Standard); 6-MBOA (Standard)	Structural Classification Ketones, Aldehydes, Acids Gramineae Marine natural products Source classification Coix lacryma-jobi Linn. Plants	Others
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level .

HY-N0722R

Neochlorogenic acid (Standard) trans-5-O-Caffeoylquinic acid (Standard)	Structural Classification Caprifoliaceae Simple Phenylpropanols Lonicera japonica Thunb. Source classification Phenols Polyphenols Phenylpropanoids Plants	Reference Standards NF-κB Interleukin Related TNF Receptor COX
Neochlorogenic acid (Standard) is the analytical standard of Neochlorogenic acid. This product is intended for research and analytical applications. Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-13518

Piceatannol Maximum Cited Publications 21 Publications Verification Astringenin; trans-Piceatannol	Structural Classification Microorganisms Stilbenes Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Plants Disease Research Fields Cancer	Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

Cat. No.	Product Name	Chemical Structure

HY-W251598S

Bicarbonate-13C sodium

Bicarbonate- ¹³C sodium is the ¹³C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W750902

Oxymatrine-d3

Oxymatrine-d₃ is the deuterium labeled Oxymatrine (HY-N0158). Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-N0001S2

(-)-Epicatechin-13C3
(-)-Epicatechin- ¹³C₃ ((-)-Epicatechol- ¹³C₃) is ¹³C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N0001S

(±)-Epicatechin-13C3
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB .

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .

Cat. No.	Product Name		Classification

HY-159564

iNOS/COX-2-IN-3		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of *iNOS* and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on *iNOS* and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

HY-172451

MC4762		Alkynes
MC4762 is an inhibitor of NOX2 and MAOB, with IC₅₀ values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines *iNOS, IL-1β, and IL-6* .

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