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Results for "

transient

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TRP Channel (74) Adrenergic Receptor (4) Akt (4) Amyloid-β (1) Apoptosis (2) Bacterial (5) Bcl-2 Family (2) Biochemical Assay Reagents (2) Calcium Channel (5) Cannabinoid Receptor (1) Caspase (2) CaSR (2) CDK (1) CGRP Receptor (1) Cholinesterase (ChE) (1) COX (1) Cytochrome P450 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Dopamine Receptor (5) EAAT (1) Endogenous Metabolite (7) ERK (4) FAAH (1) Filovirus (1) Fluorescent Dye (1) GABA Receptor (3) GLP Receptor (1) GlyT (1) GPR119 (1) Histamine Receptor (2) HIV (4) HIV Protease (1) iGluR (5) Insulin Receptor (1) Isotope-Labeled Compounds (1) Liposome (2) Phospholipase (1) PI3K (2) Potassium Channel (5) Pyroptosis (1) Reactive Oxygen Species (3) Sigma Receptor (1) Small Interfering RNA (siRNA) (1) Sodium Channel (2) SphK (1) Toll-like Receptor (TLR) (1) Trk Receptor (1) Tryptophan Hydroxylase (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (15) Endocrinology (1) Infection (5) Inflammation/Immunology (24) Metabolic Disease (25) Neurological Disease (54)
Oligonucleotides:	Liposomal Film-forming Agents (1) Flavoring Agents (1) Emulsifiers (1) Cationic Lipids (1) Phospholipids (1) siRNAs (2)

128

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: TRP Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128205

BTD	TRP Channel	Neurological Disease
BTD is a selective transient receptor potential canonical 5 (TRPC5) activator. BTD can be used for the research of neurological disease .

HY-121539

Supercinnamaldehyde	TRP Channel	Neurological Disease
Supercinnamaldehyde is a potent transient receptor potential ankyrin 1 (TRPA1) activator with an EC₅₀ value of 0.8 μM. Supercinnamaldehyde activates TRPA1 ion channels through covalent modification of cysteines .

HY-19608

GSK1016790A Maximum Cited Publications 21 Publications Verification	TRP Channel Calcium Channel	Cardiovascular Disease Metabolic Disease
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca ²⁺ influx and elevate intracellular Ca ²⁺ in HEK cells .

HY-11062

Icilin 1 Publications Verification AG-3-5	TRP Channel	Neurological Disease Inflammation/Immunology
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC₅₀=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response .

HY-N12605

hTRPA1-IN-1	TRP Channel	Neurological Disease
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM .

HY-D2321

Lyso Flipper-TR 29	Fluorescent Dye	Others
Lyso Flipper-TR 29 is a Flipper probe that can label lysosomes. Lyso Flipper-TR 29 enters lysosomes and late endosomes by transient deprotonation to cross their membranes in neutral form .

HY-N3230

Murpanicin Murraxocin	TRP Channel	Inflammation/Immunology
Murpanicin (murraxocin) is a coumarin that is a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. Murpanicin has significant anti-inflammatory and insecticidal effects.

HY-N10756

Hyp9	TRP Channel	Neurological Disease
Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI) .

HY-19589

JTS-653	TRP Channel	Neurological Disease Inflammation/Immunology
JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents .

HY-P5157

BmP02	Potassium Channel	Neurological Disease
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC₅₀ value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells .

HY-U00330

TRPV antagonist 1	TRP Channel	Inflammation/Immunology
TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC₅₀ of < 250 nM.

HY-149999

Xeniafaraunol A	TRP Channel	Cancer
Xeniafaraunol A (compound 31) is a potent transient receptor potential melastatin 7 (TRPM7) inhibitor .

HY-12777

Asivatrep PAC-14028	TRP Channel	Inflammation/Immunology
Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.

HY-16162

D-3263	TRP Channel	Cancer
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

HY-104059

AMG2850	TRP Channel	Inflammation/Immunology
AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist .

HY-119211

LY 97241	Potassium Channel	Neurological Disease
LY 97241 accelerates the apparent rate of inactivation of transient outward K current. LY 97241 is an antiarrhythmic drug .

HY-19960

BCTC 3 Publications Verification	TRP Channel Insulin Receptor CGRP Receptor	Neurological Disease Metabolic Disease Cancer
BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects .

HY-16162A

D-3263 hydrochloride 1 Publications Verification	TRP Channel	Cancer
D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

HY-P10654

RhTx	TRP Channel	Neurological Disease
RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception .

HY-B0545

Probenecid 15+ Cited Publications	TRP Channel Bacterial HIV	Metabolic Disease Cancer
Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.

HY-112088

AZD4573 5+ Cited Publications	CDK	Cancer
AZD4573 is a potent and highly selective CDK9 inhibitor (IC₅₀ of <4 nM) that enables transient target engagement for the treatment of hematologic malignancies .

HY-101547

TRPC6-IN-1 1 Publications Verification	TRP Channel	Cancer
TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC₅₀ of 4.66 μM.

HY-W092533

6-Fluorotryptophan	Tryptophan Hydroxylase	Neurological Disease
6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes .

HY-112202

GSK3395879	TRP Channel	Cardiovascular Disease
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC₅₀ of 1 nM for hTRPV4 .

HY-101323

Olvanil NE-19550; N-Vanillyloleamide	TRP Channel	Neurological Disease
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC₅₀ of 0.7 nM .

HY-132596A

Tivanisiran sodium SYL1001 sodium	TRP Channel	Neurological Disease
Tivanisiran sodium is a siRNA used for the study of dry eye disease. Tivanisiran sodium was designed to silence transient receptor potential vanilloid 1 (TRPV1) mRNA .

HY-10633

SB-705498 5+ Cited Publications	TRP Channel	Neurological Disease
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC₅₀ of 7.1.

HY-132596

Tivanisiran SYL1001	Small Interfering RNA (siRNA) TRP Channel	Neurological Disease
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) .

HY-112754A

DOTAP chloride 4 Publications Verification 1,2-Dioleoyl-3-trimethylammonium-propane chloride	Liposome	Cancer
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-12195

ABT-239 2 Publications Verification	Histamine Receptor TRP Channel	Neurological Disease Endocrinology
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

HY-108465

Pyr3 5+ Cited Publications	TRP Channel	Others
Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC₅₀ of 700 nM for TRPC3-mediated Ca ²⁺ influx.

HY-114400A

TRPV4 agonist-1	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

HY-120962

N-Arachidonoyl Taurine	TRP Channel	Metabolic Disease
N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid TRPV1 and TRPV4, with EC₅₀s value of 28 μM and 21 μM, respectively .

HY-126426

CBHcy	DNA Methyltransferase	Cardiovascular Disease
CBHcy is an inhibitor for betaine-homocysteine S-methyltransferase (BGMT), with an IC₅₀ of 0.09 μM. CBHcy upregulates the plasma total homocysteine and causes transient hyperhomocysteinemia in mice model .

HY-108329

AM-0902	TRP Channel	Neurological Disease Inflammation/Immunology
AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC₅₀s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.

HY-114400

TRPV4 agonist-1 free base	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC₅₀ of 60 nM in the hTRPV4 Ca ²⁺ assay .

HY-108461

TRPM8-IN-1	TRP Channel	Neurological Disease
TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC₅₀<5 μM .

HY-15620

Methylproamine 1 Publications Verification	DNA/RNA Synthesis	Others
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .

HY-110270A

RN-9893 hydrochloride	TRP Channel	Inflammation/Immunology
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC₅₀ values of 0.42 and 0.66 μM, for humans and rats, respectively .

HY-139006

N-Oleoyl glutamine	TRP Channel	Neurological Disease
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist .

HY-137704

2′-Deoxy-ADPR	TRP Channel	Others
2′-Deoxy-ADPR is an agonist for transient receptor potential melastatin 2 channel (TRPM2 channel). 2′-Deoxy-ADPR may acts as the signaling molecule in Jurkat T-lymphocytes .

HY-B0545S

Probenecid-d14	TRP Channel Bacterial HIV	Metabolic Disease
Probenecid-d₁₄ is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

HY-101366

A-61603	Adrenergic Receptor	Cardiovascular Disease
A-61603 is a selective α_1A-adrenergic receptor agonist . A-61603 increases the frequency of spontaneous Ca ²⁺ transients in rat ventricular myocytes in vitro .

HY-B0545R

Probenecid (Standard) 15+ Cited Publications	TRP Channel Bacterial HIV	Metabolic Disease Cancer
Probenecid (Standard) is the analytical standard of Probenecid. This product is intended for research and analytical applications. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.

HY-162164

Neuroprotective agent 3	Others	Neurological Disease
Neuroprotective agent 3 (Compound 21a) is an antioxidant that exhibits neuroprotective effects. Neuroprotective agent 3 significantly increases neuronal viability and induces neuroprotection, as well as improves neurological deficit scores in an in vivo model of transient cerebral ischemia .

HY-75161

(-)-Menthol 1 Publications Verification	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-112754A1

DOTAP chloride (Excipient) 1,2-Dioleoyl-3-trimethylammonium-propane chloride (Excipient)	Biochemical Assay Reagents	Others
DOTAP chloride Excipient is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride Excipient can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .

HY-111036

AMG0347	TRP Channel	Others
AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC₅₀ = 0.2 nm), protons (IC₅₀= 0.8 nm), or capsaicin (IC₅₀ = 0.7 nm) .

HY-114826

Prostaglandin E2-1-glyceryl ester PGE2-1-glyceyl ester	Cannabinoid Receptor	Metabolic Disease Cancer
Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB₁ receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca ²⁺ .

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	TRP Channel Endogenous Metabolite	Neurological Disease
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

Cat. No.	Product Name	Type

HY-D2321

Lyso Flipper-TR 29	Fluorescent Dyes/Probes
Lyso Flipper-TR 29 is a Flipper probe that can label lysosomes. Lyso Flipper-TR 29 enters lysosomes and late endosomes by transient deprotonation to cross their membranes in neutral form .

Cat. No.	Product Name	Type

HY-112754A

DOTAP chloride 4 Publications Verification 1,2-Dioleoyl-3-trimethylammonium-propane chloride	Drug Delivery
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-15620

Methylproamine 1 Publications Verification	Gene Sequencing and Synthesis
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .

Cat. No.	Product Name	Target	Research Area

HY-P1651B

SOR-C13 acetate	TRP Channel	Cancer
SOR-C13 acetate is the acetate salt form of SOR-C13 (HY-P1651). SOR-C13 acetate is an antagonist for transient receptor potential vanilloid 6 (TRPV 6), with an IC₅₀ of 14 nM. SOR-C13 acetate inhibits tumor growth in SKOV-3 xenograft mouse model .

HY-P5157

BmP02	Potassium Channel	Neurological Disease
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC₅₀ value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells .

HY-P10654

RhTx	TRP Channel	Neurological Disease
RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception .

HY-139006

N-Oleoyl glutamine	TRP Channel	Neurological Disease
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist .

HY-P10465

TRPV1-Tat	TRP Channel	Inflammation/Immunology
TRPV1-Tat is an antagonistic peptide that fuses the TRPV1 (transient receptor potential vanilla subtype 1) of the cell-penetrating peptide Tat. TRPV1-Tat blocks this phosphorylation process by competitively binding to the AKAP79 binding site of TRPV1, thereby inhibiting the sensitization of TRPV1. TRPV1-Tat can be used in the study of inflammatory pain .

HY-P10716

Exendin-P5	GLP Receptor	Metabolic Disease
Exendin-P5 is a selective agonist that targets the GLP-1R. Exendin-P5 promotes rapid activation of G proteins by transient interactions with the transmembrane domain of GLP-1R, enhancing its potency in G protein-mediated signaling and accelerating cAMP production. This mechanism suggests the potential application of Exendin-P5 in the study of metabolic diseases .

HY-P5906

Citrullinated amyloid-β (1-40) peptide (human) Citrullinated Aβ (1-40); Citrullinated Aβ40	Amyloid-β	Neurological Disease
Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40)) is a modified form of β-Amyloid (1-40) (HY-P0265) with a citrullination at the Arg5 site. Citrullinated amyloid-β (1-40) peptide (human) exhibits increased transient formation of soluble oligomers and insoluble aggregates composed of distorted parallel β-sheets compared with unmodified β-Amyloid (1-40) .

HY-P2110

RS-18286	Peptides	Others
RS-18286 is a potent LHRH antagonist studied for its effects on pituitary hormone secretion in sexually active rams. Injection of RS-18286 resulted in an immediate suppression of pulsatile LH secretion, accompanied by a decrease in testosterone levels, while FSH and PRL levels remained unchanged. The duration of LH suppression was dose-related, lasting approximately 4.3 to 31.8 hours for low to high doses, respectively. During the recovery phase, a compensatory increase in LH pulse frequency was observed, suggesting a response to diminished testosterone feedback. Even at the lowest dose, RS-18286 transiently reduced testosterone levels, demonstrating an effect on acute hypothalamic sensitivity to changes in hormonal feedback .

Cat. No.	Product Name	Target	Research Area

HY-P990034

Pateclizumab MLTA3698A; RG7415; PRO283698	Inhibitory Antibodies	Inflammation/Immunology
Pateclizumab (MLTA3698A) is a humanized antibody against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-75161

(-)-Menthol 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite Disease Research Fields Cancer	TRP Channel Endogenous Metabolite
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-D0887

Disodium 5'-inosinate 1 Publications Verification IMP disodium salt; Disodium inosinate	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Disease Research Fields Food Research	Biochemical Assay Reagents
Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice .

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	Cardiovascular Disease Euphorbia resinifera O. Berg Classification of Application Fields Source classification Euphorbiaceae Plants Disease Research Fields	TRP Channel
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-W011121

2-Oleoylglycerol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	GPR119
2-Oleoylglycerol is a dietary naturally occurring lipid. 2-Oleoylglycerol is a GPR119 agonist, with an EC₅₀ of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo .

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-N12605

hTRPA1-IN-1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	TRP Channel
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM .

HY-N3230

Murpanicin Murraxocin	Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants Murraya alata Drake	TRP Channel
Murpanicin (murraxocin) is a coumarin that is a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. Murpanicin has significant anti-inflammatory and insecticidal effects.

HY-149999

Xeniafaraunol A	Structural Classification Animals Terpenoids Source classification Diterpenoids	TRP Channel
Xeniafaraunol A (compound 31) is a potent transient receptor potential melastatin 7 (TRPM7) inhibitor .

HY-75161R

(-)-Menthol (Standard)	Structural Classification Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-123245

Scalaradial	Structural Classification Animals Terpenoids Sesquiterpenes Source classification	TRP Channel Phospholipase ERK Akt
Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC₅₀ of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage .

HY-N6962

α-Spinasterol	Structural Classification Natural Products Plants Caryophyllaceae Melandrium firmum (S. et Z . ) Rohrb.	TRP Channel COX Bacterial
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice .

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Microorganisms Source classification	Bacterial Reactive Oxygen Species
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	Structural Classification Natural Products Guttiferae Source classification Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-116330

Hyperforin	Structural Classification Anti-inflammation/Immunoregulatory Antibiotics Guttiferae Source classification Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-116330AR

Hyperforin dicyclohexylammonium salt (Standard)	Structural Classification Natural Products Guttiferae Source classification Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin (dicyclohexylammonium salt) (Standard) is the analytical standard of Hyperforin (dicyclohexylammonium salt). This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

Species:	Human (4) Mouse (1)
Tag:	His (4) Strep (1) MBP (1) Flag (2)
Source:	HEK293 (4) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74223

	Contactin-2/CNTN2 Protein, Mouse (HEK293, His) Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; transient axonal glycoprotein 1; CNTN2; AXT; TAG1; TAX1	Mouse	HEK293
	Contactin-2/CNTN2 Protein collaborates with transmembrane protein CNTNAP2, crucially organizing axonal domains at nodes of Ranvier.This partnership maintains voltage-gated potassium channels at the juxtaparanodal region, emphasizing Contactin-2's pivotal role in the intricate molecular architecture essential for efficient nerve impulse propagation along myelinated axons.Contactin-2/CNTN2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Contactin-2/CNTN2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702374

	MCOLN1 Protein, Human (Cell-Free, His) Mucolipin-1; MG-2; Mucolipidin; transient receptor potential channel mucolipin 1; TRPML1	Human	E. coli Cell-free
	The TRPML1 protein is a nonselective cation channel that regulates membrane trafficking and metal homeostasis. It promotes the release of Ca(2+) in late endosomes and lysosomes, affecting organelle fusion, exocytosis and autophagy. MCOLN1 Protein, Human (Cell-Free, His) is the recombinant human-derived MCOLN1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of MCOLN1 Protein, Human (Cell-Free, His) is 580 a.a., with molecular weight of 66.5 kDa.

HY-P701383

	TRPML1 Protein, Human (HEK293, Strep, FLAG) MCOLN1 (ML4, TRPML1); Mucolipin-1; MG-2; Mucolipidin; transient receptor potential channel mucolipin 1 (TRPML1)	Human	HEK293
	The TRPML1 protein is a nonselective cation channel that regulates membrane trafficking and metal homeostasis. It promotes the release of Ca(2+) in late endosomes and lysosomes, affecting organelle fusion, exocytosis and autophagy. TRPML1 Protein, Human (HEK293, Strep, FLAG) is the recombinant human-derived TRPML1 protein, expressed by HEK293 , with N-Strep, C-Flag labeled tag. The total length of TRPML1 Protein, Human (HEK293, Strep, FLAG) is 580 a.a., .

HY-P70054

	Contactin-2/CNTN2 Protein, Human (HEK293, His) rHuContactin-2/CNTN2, His ; Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; transient axonal glycoprotein 1; CNTN2; AXT; TAG1; TAX1	Human	HEK293
	The Contactin-2/CNTN2 protein, together with CNTNAP2, organizes axonal domains at the nodes of Ranvier and maintains voltage-gated potassium channels in the proximal paranodal region. This partnership ensures axonal signaling integrity and function. Contactin-2/CNTN2 Protein, Human (HEK293, His) is the recombinant human-derived Contactin-2/CNTN2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Contactin-2/CNTN2 Protein, Human (HEK293, His) is 982 a.a., with molecular weight of 110-140 kDa.

HY-P701382

	TRPA1 Protein, Human (HEK293, His, MBP, FLAG) TRPA1; transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor	Human	HEK293
	The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag. The total length of TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is 1118 a.a. .

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Cat. No.	Product Name	Chemical Structure

HY-B0545S

Probenecid-d14
Probenecid-d₁₄ is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

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HY-P81864

	TRPM8 Antibody (YA1609) LTrpC6; MGC2849; transient receptor potential p8; Trp p8; Trpm8; TRPP8	WB, ICC/IF	Human, Mouse
	TRPM8 Antibody (YA1609) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1609), targeting TRPM8, with a predicted molecular weight of 128 kDa (observed band size: 128 kDa). TRPM8 Antibody (YA1609) can be used for WB, ICC/IF experiment in human, mouse background.

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HY-132596A

Tivanisiran sodium SYL1001 sodium		siRNAs
Tivanisiran sodium is a siRNA used for the study of dry eye disease. Tivanisiran sodium was designed to silence transient receptor potential vanilloid 1 (TRPV1) mRNA .

HY-112754A

DOTAP chloride 4 Publications Verification 1,2-Dioleoyl-3-trimethylammonium-propane chloride		Cationic Lipids
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-75161

(-)-Menthol 1 Publications Verification		Flavoring Agents
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-132596

Tivanisiran SYL1001		siRNAs
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) .

HY-112754A1

DOTAP chloride (Excipient) 1,2-Dioleoyl-3-trimethylammonium-propane chloride (Excipient)		Emulsifiers Liposomal Film-forming Agents
DOTAP chloride Excipient is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride Excipient can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .

HY-145547

1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine 14:0 Lyso PE; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine		Phospholipids
1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells . Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls .

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