1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  3. HSP

HSP

HSP

Heat shock proteins

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10213
    SNX-5422
    99.11%
    SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM.
    SNX-5422
  • HY-N0830BS1
    Palmitic acid-13C16 sodium
    Activator ≥98.0%
    Palmitic acid-13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-<sup>13</sup>C<sub>16</sub> sodium
  • HY-124805
    MAL3-101
    Inhibitor 98.22%
    MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC).
    MAL3-101
  • HY-145722
    Apatorsen sodium
    Inhibitor 98.54%
    Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
    Apatorsen sodium
  • HY-30270
    Mequinol
    Activator 99.98%
    Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity.
    Mequinol
  • HY-139301
    DDO-5936
    Inhibitor 99.20%
    DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer.
    DDO-5936
  • HY-137441
    Icapamespib
    Inhibitor 99.52%
    Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5 nM. Icapamespib is able to cross blood-brain barrier.
    Icapamespib
  • HY-N0830S7
    Palmitic acid-d4
    Activator 98.13%
    Palmitic acid-d4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
    Palmitic acid-d<sub>4</sub>
  • HY-148877
    AT-533
    Inhibitor 98.86%
    AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including Akt/mTOR/p70S6K, Erk1/2 and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).
    AT-533
  • HY-N0830S3
    Palmitic acid-1-13C
    Activator ≥98.0%
    Palmitic acid-1-13C is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
    Palmitic acid-1-<sup>13</sup>C
  • HY-145102
    NCT-58
    Inhibitor 99.82%
    NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.
    NCT-58
  • HY-P10072A
    MK2-IN-5 acetate
    98.46%
    MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation.
    MK2-IN-5 acetate
  • HY-N6790
    Nonactin
    Inhibitor ≥99.0%
    Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity.
    Nonactin
  • HY-18399
    YM-1
    Inhibitor 99.25%
    YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins.
    YM-1
  • HY-152153
    GRP78-IN-3
    Inhibitor 99.98%
    GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM).
    GRP78-IN-3
  • HY-P1750A
    Shepherdin (79-87) (TFA)
    Antagonist 98.65%
    Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.
    Shepherdin (79-87) (TFA)
  • HY-120909
    YK5
    Inhibitor 99.66%
    YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes.
    YK5
  • HY-119046
    SNX-0723
    Inhibitor 99.12%
    SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM.
    SNX-0723
  • HY-125759
    3-Phenyltoxoflavin
    Inhibitor 99.76%
    3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity.
    3-Phenyltoxoflavin
  • HY-12622
    HSP70-IN-1
    Inhibitor 98.07%
    HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
    HSP70-IN-1
Cat. No. Product Name / Synonyms Application Reactivity

HSP40

HSP70

HSP90

HSP105

HSF1

HSP

HSPA5

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Please try each isoform separately.

HSP Pre-designed Setss, Inducers, Inhibitors, Antagonists & Activators
Product NameHSP40HSP70HSP90HSP105HSF1HSPHSPA5Purity    
Tamoxifen  
HSP90
    99.92%
Polyinosinic-polycytidylic acid 
HSP70
     99.40%
Tanespimycin  
HSP90, IC50: 5 nM
    99.01%
VER-155008 
HSP70, IC50: 0.5 μM
HSC70, IC50: 2.6 μM
Grp78, IC50: 2.6 μM
     99.91%
Rosolutamide    
HSF1
  99.03%
2-Methoxyhydroquinone  
HSP90
    
CH5015765  
HSP90
    98.01%
Geldanamycin  
HSP90, Kd: 1.2 μM
    99.78%
Tamoxifen Citrate  
HSP90
    99.93%
Ganetespib  
HSP90
    99.94%
Luminespib  
HSP90α, IC50: 7.8 nM
HSP90β, IC50: 21 nM
GRP94, IC50: 535 nM
    99.81%
Gamitrinib TPP hexafluorophosphate  
HSP90
    99.68%
Rocaglamide    
HSF1, IC50: 50 nM
  99.34%
Novobiocin sodium  
HSP90
    99.12%
Pifithrin-μ 
HSP70
     99.66%
Onalespib  
HSP90, Kd: 0.71 nM
    99.92%
Apoptozole 
HSP70, Kd: 0.14 μM
HSC70, Kd: 0.21 μM
     99.42%
Pimitespib  
HSP90α, Ki: 34.7 nM
HSP90β, Ki: 21.3 nM
    98.79%
HSF1A    
HSF1
  99.94%
Alvespimycin hydrochloride  
HSP90, EC50: 62 nM
GRP94, EC50: 65 nM
    98.80%
Tamoxifen (Standard)  
HSP90
    99.76%
Col003
HSP47, IC50: 1.8 μM
      99.87%
KRIBB11    
HSF1, IC50: 1.2 μM
  99.54%
MKT-077 
HSP70
     98.05%
BIIB021  
HSP90, Ki: 1.7 nM
HSP90, EC50: 38 nM
    99.19%
ML346 
HSP70, EC50: 4.6 μM (HeLa cells)
     98.71%
Arimoclomol maleate     
HSP
 99.96%
NXP800    
HSF1
  99.86%
Teprenone     
HSP
 99.58%
Alvespimycin  
HSP90, EC50: 62 nM
GRP94, EC50: 65 nM
    99.59%
Zelavespib  
HSP90, IC50: 51 nM (MDA-MB-468 cells)
    99.93%
NVP-HSP990  
HSP90α, IC50: 0.6 nM
HSP90β, IC50: 0.8 nM
GRP94, IC50: 8.5 nM
    99.49%
Grp94 Inhibitor-1  
GRP94, IC50: 2 nM
    98.72%
AMP-PCP disodium  
HSP90, Kd: 3.8 μM
    99.29%
Retaspimycin Hydrochloride  
HSP90, EC50: 119 nM
GRP94, EC50: 119 nM
    
KNK437
HSP40
HSP70
 
HSP105
   99.04%
PU-WS13  
GRP94, EC50: 0.22 μM
HSP90α, EC50: 27.3 μM
HSP90β, EC50: 41.8 μM
    99.82%
SNX-2112 
TRAP-1, IC50: 862 nM
HSP90α, IC50: 30 nM
HSP90β, IC50: 30 nM
GRP94, IC50: 4275 nM
    99.49%
XL888  
HSP90, IC50: 24 nM
    99.27%
Novobiocin  
HSP90
    
Radicicol  
HSP90, IC50: 1 μM
    99.63%
Smurf1-IN-A01  
HSP90β
    99.81%
HM03      
HSPA5
99.34%
TRC051384 
HSP70
     99.79%
CCT251236 
HSP72, IC50: 19 nM (SK-OV-3 cells)
     98.82%
VER-82576  
HSP90β, IC50: 58 nM
GRP94, IC50: 4.1 μM
    98.76%
CCT018159  
human Hsp90β, IC50: 3.2 μM
yeast Hsp90, IC50: 6.6 μM
    99.94%
Debio 0932  
HSP90α, IC50: 100 nM
HSP90β, IC50: 103 nM
    99.97%
Eupalinolide A    
HSF1
  99.92%
KW-2478  
HSP90α, IC50: 3.8 nM
    99.53%
VER-49009  
HSP90, IC50: 25 nM
    99.45%
Chetomin  
HSP90
    ≥99.0%
NMS-E973  
HSP90α, DC50: 10 nM
    98.57%
Geldanamycin-FITC  
HSP90
    98.43%
PROTAC HSP90 degrader BP3  
HSP90
    99.54%
Cucurbitacin D  
HSP90
    99.91%
Dihydroberberine  
HSP90
    98.44%
JG-231 
HSP70
     98.81%
VER-50589  
HSP90, IC50: 21 nM
    99.76%
Ethoxyquin  
HSP90
    98.32%
MAL3-101 
HSP70
     98.22%
AT-533  
HSP90
    98.86%
NCT-58  
HSP90
    99.82%
GRP78-IN-3      
HSPA5, IC50: 0.59 μM
99.98%
YK5 
HSP70
HSP90
    99.66%
3-Phenyltoxoflavin  
HSP90, Kd: 585 nM
    99.76%
HSP70-IN-1 
HSP70
     98.07%
CH5138303  
HSP90α, Kd: 0.52 nM
    99.05%
Zelavespib hydrochloride  
HSP90, IC50: 51 nM (MDA-MB-468 cells)
    98.89%
Bimoclomol     
HSP
 99.29%
YZ129  
HSP90
    99.85%
Tamoxifen-d5  
HSP90
    99.99%
Arimoclomol citrate     
HSP
 99.76%
SW02 
TRAP1 ATPase, EC50: 150 ± 21 μM
     98.30%
HS-27  
HSP90
    98.48%
Gedunin  
HSP90
    ≥98.0%
Gamitrinib TPP  
HSP90
    
Aminohexylgeldanamycin  
HSP90
    99.56%
SNX-5422 mesylate  
HSP90, Kd: 41 nM
    
DN401  
HSP90, IC50: 698 nM
    ≥99.0%
Conglobatin  
HSP90
    
Zelavespib formic  
HSP90, IC50: 51 nM
    
Arimoclomol     
HSP
 
HSP90/mTOR-IN-1  
HSP90, IC50: 69 nM
    
Onalespib lactate  
HSP90, Kd: 0.71 nM
    
Cemdomespib  
HSP90
    
Shepherdin (79-87)  
HSP90
    
Gamendazole  
HSP90AB1
    
BX-2819  
HSP90, IC50: 41 nM
    
EZH2/HSP90-IN-29  
HSP90, IC50: 60.1 nM
    
Macbecin  
HSP90, IC50: 2 μM
HSP90, Kd: 0.24 μM
    
EV206 
HSP70
     
HSP90/LSD1-IN-1  
HSP90
    
AP-4-139B 
HSP70, IC50: 180 nM
     98.87%
HSP90-IN-20  
HSP90, IC50: ≤10 μM
    
Colletofragarone A2  
HSP90
    
HEMTAC WEE1 degrader-1  
HSP90, IC50: 16.76 nM
    
Aminohexylgeldanamycin hydrochloride  
HSP90
    
YM-08 
HSP70
     
DMT003096 
HSP70
     
Hsp90-IN-15  
HSP90
    
Hsp90-IN-38  
HSP90, Kd: 68 nM
    
HSP70-IN-6 
HSP70
     
HSP90-IN-33  
HSP90α, EC50: ≥200 μM
HSP90β, EC50: 7.3 μM
    
HSP90-IN-13  
HSP90, IC50: 25.07 nM
    
Tasiamide B  
HSP90
    
KU-177  
HSP90
    
HSP90-IN-9  
HSP90
    
Antitumor agent-174  
HSP90
    
MAO A/HSP90-IN-2  
HSP90, IC50: 0.016 μM
    
HDAC/HSP90-IN-3  
HSP90, IC50: 0.83 μM (fungal Hsp90)
HSP90, IC50: 19.52 μM (human Hsp90)
    
17-AEP-GA  
HSP90
    
GRP78-IN-1 
Grp78
     
HDAC6/HSP90-IN-1  
HSP90, IC50: 46.8 nM
    
Grp94 Inhibitor-2  
GRP94, Kd: 0.48 nM
HSP90α, Kd: 0.65 nM
    
HSP70/SIRT2-IN-1 
HSP70
     
17-GMB-APA-GA  
HSP90
    
HSP90-IN-14  
HSP90β, Kd: 0.26 ± 0.0 μM
    
HSP70-IN-4 
HSP70, IC50: 3.2 μM
     
AMP-PCP  
HSP90, Kd: 3.8 μM
    
PU24FCl  
HSP90
    
MPC-0767  
HSP90
    
MAO A/HSP90-IN-1  
HSP90, IC50: 0.019 μM
    
HSP90-IN-29  
HSP90, IC50: 30 nM
    
HSP90-IN-35  
HSP90, IC50: 0.05-0.5 μM
    
CYP51/Hsp90-IN-1  
HSP90
    
Retaspimycin  
HSP90, EC50: 119 nM
GRP94, EC50: 119 nM