HSP

Heat shock proteins

HSP

HSP Isoform Specific Products:

HSP Isoform Comparison

HSP Related Products (328)
Antibodies (47)
HSP Isoform Comparison

By Effects:	Pre-designed Sets (1) Inhibitors (218) Agonist (1) Degraders (4) Antagonists (6) Activators (64) Modulators (3) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0830BS1

Palmitic acid-¹³C₁₆ sodium	Activator	99.0%
Palmitic acid-¹³C₁₆ sodium is the ¹³C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.

HY-10213

SNX-5422		99.11%
SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a K_d of 41 nM, and also induces Her-2 degradation, with an IC₅₀ of 37 nM.

HY-137441

Icapamespib	Inhibitor	99.52%
Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC₅₀ of 5 nM. Icapamespib is able to cross blood-brain barrier.

HY-124805

MAL3-101	Inhibitor	98.22%
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC).

HY-30270

Mequinol	Activator	99.98%
Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity.

HY-139301

DDO-5936	Inhibitor	99.20%
DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer.

HY-148877

AT-533	Inhibitor	98.86%
AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including Akt/mTOR/p70S6K, Erk1/2 and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).

HY-145722

Apatorsen sodium	Inhibitor	98.54%
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.

HY-N2468

Xylobiose	Activator	≥98.0%
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome.

HY-N0830S7

Palmitic acid-d₄	Activator	98.13%
Palmitic acid-d₄ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S3

Palmitic acid-1-¹³C	Activator	≥98.0%
Palmitic acid-1-¹³C is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-145102

NCT-58	Inhibitor	99.82%
NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.

HY-18399

YM-1	Inhibitor	99.25%
YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins.

HY-P10072A

MK2-IN-5 acetate		98.46%
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation.

HY-N6790

Nonactin	Inhibitor	≥99.0%
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K⁺, and NH₄⁺, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity.

HY-152153

GRP78-IN-3	Inhibitor	99.98%
GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC₅₀ of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC₅₀ of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC₅₀ of 13.9 μM).

HY-P1750A

Shepherdin (79-87) (TFA)	Antagonist	98.65%
Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.

HY-120909

YK5	Inhibitor	99.66%
YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes.

HY-119046

SNX-0723	Inhibitor	99.12%
SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with K_is of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC₅₀ of 3.3 μM.

HY-125759

3-Phenyltoxoflavin	Inhibitor	99.76%
3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a K_d of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity.

Tamoxifen			HSP90					99.92%
Polyinosinic-polycytidylic acid		HSP70						99.40%
Tanespimycin			HSP90, IC₅₀: 5 nM					99.01%
VER-155008		HSP70, IC₅₀: 0.5 μM HSC70, IC₅₀: 2.6 μM Grp78, IC₅₀: 2.6 μM						99.91%
2-Methoxyhydroquinone			HSP90
CH5015765			HSP90					98.01%
Geldanamycin			HSP90, Kd: 1.2 μM					99.78%
Tamoxifen Citrate			HSP90					99.93%
Ganetespib			HSP90					99.94%
Luminespib			HSP90α, IC₅₀: 7.8 nM HSP90β, IC₅₀: 21 nM GRP94, IC₅₀: 535 nM					99.81%
Gamitrinib TPP hexafluorophosphate			HSP90					99.68%
Rocaglamide					HSF1, IC₅₀: 50 nM			99.34%
Novobiocin sodium			HSP90					99.12%
Pifithrin-μ		HSP70						99.66%
Onalespib			HSP90, Kd: 0.71 nM					99.92%
Pimitespib			HSP90α, Ki: 34.7 nM HSP90β, Ki: 21.3 nM					98.79%
Apoptozole		HSP70, Kd: 0.14 μM HSC70, Kd: 0.21 μM						99.42%
HSF1A					HSF1			99.94%
Alvespimycin hydrochloride			HSP90, EC₅₀: 62 nM GRP94, EC₅₀: 65 nM					98.80%
Tamoxifen (Standard)			HSP90					99.76%
KRIBB11					HSF1, IC₅₀: 1.2 μM			99.54%
Col003	HSP47, IC₅₀: 1.8 μM							99.87%
MKT-077		HSP70						98.05%
BIIB021			HSP90, Ki: 1.7 nM HSP90, EC₅₀: 38 nM					99.19%
ML346		HSP70, EC₅₀: 4.6 μM (HeLa cells)						98.25%
Arimoclomol maleate						HSP		99.96%
NXP800					HSF1			99.86%
Teprenone						HSP		99.58%
Alvespimycin			HSP90, EC₅₀: 62 nM GRP94, EC₅₀: 65 nM					99.59%
Zelavespib			HSP90, IC₅₀: 51 nM (MDA-MB-468 cells)					99.93%
Grp94 Inhibitor-1			GRP94, IC₅₀: 2 nM					98.72%
NVP-HSP990			HSP90α, IC₅₀: 0.6 nM HSP90β, IC₅₀: 0.8 nM GRP94, IC₅₀: 8.5 nM					99.49%
AMP-PCP disodium			HSP90, Kd: 3.8 μM					99.29%
Retaspimycin Hydrochloride			HSP90, EC₅₀: 119 nM GRP94, EC₅₀: 119 nM
KNK437	HSP40	HSP70		HSP105				99.04%
PU-WS13			GRP94, EC₅₀: 0.22 μM HSP90α, EC₅₀: 27.3 μM HSP90β, EC₅₀: 41.8 μM					99.82%
SNX-2112		TRAP-1, IC₅₀: 862 nM	HSP90α, IC₅₀: 30 nM HSP90β, IC₅₀: 30 nM GRP94, IC₅₀: 4275 nM					99.49%
Novobiocin			HSP90
XL888			HSP90, IC₅₀: 24 nM					99.27%
Radicicol			HSP90, IC₅₀: 1 μM					99.63%
HM03							HSPA5	99.34%
Smurf1-IN-A01			HSP90β					99.81%
TRC051384		HSP70						99.79%
CCT251236		HSP72, IC₅₀: 19 nM (SK-OV-3 cells)						98.82%
VER-82576			HSP90β, IC₅₀: 58 nM GRP94, IC₅₀: 4.1 μM					98.76%
CCT018159			human Hsp90β, IC₅₀: 3.2 μM yeast Hsp90, IC₅₀: 6.6 μM					99.94%
Eupalinolide A					HSF1			99.92%
Debio 0932			HSP90α, IC₅₀: 100 nM HSP90β, IC₅₀: 103 nM					99.97%
KW-2478			HSP90α, IC₅₀: 3.8 nM					99.53%
VER-49009			HSP90, IC₅₀: 25 nM					99.45%
Chetomin			HSP90					≥99.0%
NMS-E973			HSP90α, DC₅₀: 10 nM					98.57%
Geldanamycin-FITC			HSP90					98.43%
Dihydroberberine			HSP90					98.44%
JG-231		HSP70						98.81%
PROTAC HSP90 degrader BP3			HSP90					99.54%
Cucurbitacin D			HSP90					99.91%
Ethoxyquin			HSP90					98.32%
VER-50589			HSP90, IC₅₀: 21 nM					99.76%
MAL3-101		HSP70						98.22%
AT-533			HSP90					98.86%
NCT-58			HSP90					99.82%
GRP78-IN-3							HSPA5, IC₅₀: 0.59 μM	99.98%
YK5		HSP70	HSP90					99.66%
3-Phenyltoxoflavin			HSP90, Kd: 585 nM					99.76%
HSP70-IN-1		HSP70						98.07%
CH5138303			HSP90α, Kd: 0.52 nM					99.05%
Rosolutamide					HSF1			99.03%
Zelavespib hydrochloride			HSP90, IC₅₀: 51 nM (MDA-MB-468 cells)					98.89%
Bimoclomol						HSP		99.29%
YZ129			HSP90					99.85%
SW02		TRAP1 ATPase, EC₅₀: 150 ± 21 μM						98.30%
Tamoxifen-d₅			HSP90					99.99%
Arimoclomol citrate						HSP		99.76%
HS-27			HSP90					98.48%
Gedunin			HSP90					≥98.0%
Gamitrinib TPP			HSP90
Aminohexylgeldanamycin			HSP90					99.56%
SNX-5422 mesylate			HSP90, Kd: 41 nM
DN401			HSP90, IC₅₀: 698 nM					≥99.0%
Conglobatin			HSP90
Zelavespib formic			HSP90, IC₅₀: 51 nM
Arimoclomol						HSP
HSP90/mTOR-IN-1			HSP90, IC₅₀: 69 nM
Onalespib lactate			HSP90, Kd: 0.71 nM
Cemdomespib			HSP90
Shepherdin (79-87)			HSP90
Gamendazole			HSP90AB1					99.44%
BX-2819			HSP90, IC₅₀: 41 nM
EZH2/HSP90-IN-29			HSP90, IC₅₀: 60.1 nM
Macbecin			HSP90, IC₅₀: 2 μM HSP90, Kd: 0.24 μM
EV206		HSP70
HSP90/LSD1-IN-1			HSP90
AP-4-139B		HSP70, IC₅₀: 180 nM						98.87%
HSP90-IN-20			HSP90, IC₅₀: ≤10 μM
Colletofragarone A2			HSP90
HSP90α-IN-1			HSP90α, IC₅₀: 111 nM
HEMTAC WEE1 degrader-1			HSP90, IC₅₀: 16.76 nM
Aminohexylgeldanamycin hydrochloride			HSP90
YM-08		HSP70
DMT003096		HSP70
Hsp90-IN-15			HSP90
Hsp90-IN-38			HSP90, Kd: 68 nM
HSP70-IN-6		HSP70
HSP90-IN-33			HSP90α, EC₅₀: ≥200 μM HSP90β, EC₅₀: 7.3 μM
HSP90-IN-13			HSP90, IC₅₀: 25.07 nM
Tasiamide B			HSP90
KU-177			HSP90
HSP90-IN-9			HSP90
Antitumor agent-174			HSP90
MAO A/HSP90-IN-2			HSP90, IC₅₀: 0.016 μM
HDAC/HSP90-IN-3			HSP90, IC₅₀: 0.83 μM (fungal Hsp90) HSP90, IC₅₀: 19.52 μM (human Hsp90)
17-AEP-GA			HSP90
GRP78-IN-1		Grp78
HDAC6/HSP90-IN-1			HSP90, IC₅₀: 46.8 nM
Grp94 Inhibitor-2			GRP94, Kd: 0.48 nM HSP90α, Kd: 0.65 nM
HSP70/SIRT2-IN-1		HSP70
17-GMB-APA-GA			HSP90
HSP90-IN-14			HSP90β, Kd: 0.26 ± 0.0 μM
HSP70-IN-4		HSP70, IC₅₀: 3.2 μM
AMP-PCP			HSP90, Kd: 3.8 μM
PU24FCl			HSP90
MPC-0767			HSP90
MAO A/HSP90-IN-1			HSP90, IC₅₀: 0.019 μM
HSP90-IN-29			HSP90, IC₅₀: 30 nM
HSP90-IN-35			HSP90, IC₅₀: 0.05-0.5 μM
CYP51/Hsp90-IN-1			HSP90
Retaspimycin			HSP90, EC₅₀: 119 nM GRP94, EC₅₀: 119 nM

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HSP

HSP

HSP Isoform Specific Products:

HSP Isoform Specific Products:

HSP Related Products (328)

Antibodies (47)

HSP Isoform Comparison

HSP Related Products (328):