2. Gene
  3. GABARAPL2 - GABA type A receptor associated protein like 2 Gene

GABARAPL2 - GABA type A receptor associated protein like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16

Gene ID: 11345 | Gene type: protein coding

About GABARAPL2

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,566,379-75,577,881 (from NCBI)

This gene has 5 transcripts (splice variants), 268 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 110.1), heart (RPKM 86.3) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in negative regulation of proteasomal protein catabolic process and protein localization to endoplasmic reticulum. Located in Golgi membrane and autophagosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

GABARAPL2 Products(1)

mRNA Protein Name
NM_007285.7 NP_009216.1 gamma-aminobutyric acid receptor-associated protein-like 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylethanolamine binding IDA
IDA: Inferred from direct assay
15169837 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11096062 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25127057 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
21669198 GOA
involved in protein localization to endoplasmic reticulum IDA
IDA: Inferred from direct assay
30990354 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
21669198 GOA
located in autophagosome IDA
IDA: Inferred from direct assay
19056683 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
15169837 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21669198 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABARAPL2 Protein Structure

Atg8

Atg8: Autophagy protein Atg8 ubiquitin like (13 - 116)

  • 0
  • 100
  • 117 a.a.
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor-associated protein-like 2

GABA(A) receptor-associated protein-like 2

Recombinant GABARAPL2 Proteins

Cat. No. Product Name Accession Purity
HY-P76353 GABARAPL2/GATE-16 Protein, Human (His) P60520 (M1-F117) ≥95%

Related Diseases

Diseases Alias
Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba
Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3
Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05203 GABARAPL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GABARAPL2 MGD MGI:1890602
Rattus norvegicus GABARAPL2 RGD RGD:620510
Canis familiaris GABARAPL2 VGNC VGNC:41047
Felis catus GABARAPL2 VGNC VGNC:62415
Macaca mulatta GABARAPL2 VGNC VGNC:104727
Bos taurus GABARAPL2 VGNC VGNC:29186
Others GABARAPL2 NCBI