2. Gene
  3. Hdac8 - histone deacetylase 8 Gene

Hdac8 - histone deacetylase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2610007D20Rik

Gene ID: 70315 | Gene type: protein coding

About Hdac8

Chromosome X: 101,328,245-101,548,965 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 202 orthologues, 10 paralogues and is associated with 18 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.) and 28 other tissues.

Summary

Predicted to enable chromatin binding activity; heat shock protein binding activity; and histone deacetylase activity. Predicted to be involved in several processes, including histone deacetylation; negative regulation of macromolecule metabolic process; and regulation of chromosome organization. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including 2-cell stage embryo; brain; embryo ectoderm; foregut; and retina. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]

Hdac8 Products(2)

mRNA Protein Name
NM_027382.4 NP_081658.1 histone deacetylase 8 isoform 1
NM_001313742.1 NP_001300671.1 histone deacetylase 8 isoform 2

Hdac8 Protein Structure

HDAC8

HDAC8: cd10000 (15 - 376)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

histone deacetylase 8

HD8

protein deacetylase HDAC8

protein decrotonylase HDAC8

Recombinant Hdac8 Proteins

Cat. No. Product Name Accession Purity
HY-P75144 HDAC8 Protein, Mouse (sf9, His) Q8VH37-1 (M1-V377) ≥95%

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.70% Unkown
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-138799 KA2507 Inhibitor 99.24% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
Bioactive Molecules (110)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13271A Tubastatin A Inhibitor 98.37% Unkown
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13428 Tubacin Inhibitor 99.54% Unkown
HY-15224 PCI-34051 Inhibitor 99.75% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.19% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-16699 Nexturastat A Inhibitor 98.28% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-111342 HDAC8-IN-1 Inhibitor 99.82% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-18976 UF010 99.84% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.11% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-13267 Droxinostat Inhibitor 98.91% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-117348 NCC-149 Inhibitor 99.14% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-100384 NKL 22 Inhibitor 97.27% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-114483 AES-135 Inhibitor 98.21% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-164233 YX968 Inhibitor / Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-124782 HDAC8-IN-8 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-152147 SZUH280 Degrader / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-126829 Coumarin-SAHA / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-151366 HDAC8/BRPF1-IN-1 Inhibitor / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-150694 HDAC6-IN-11 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-157314 HDAC6-IN-27 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-10226 JNJ-16241199 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-163846 HDAC8-IN-10 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-119550 J1075 Inhibitor / Unkown
HY-139795 ZYJ-25e Inhibitor / Unkown
HY-139815 ZYJ-34c Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac8 NCBI NCBI:55869