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Results for "

Acetylcholinesterase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (11) Antibiotic (2) Apoptosis (11) Autophagy (1) Bacterial (4) Beta-secretase (1) Biochemical Assay Reagents (2) Calcium Channel (1) Carbonic Anhydrase (2) CCR (1) Chemerin Receptor (1) Cholinesterase (ChE) (168) COX (2) Dopamine Receptor (1) Drug Metabolite (2) Endogenous Metabolite (5) Epoxide Hydrolase (2) Fungal (1) G-quadruplex (1) Glucosidase (1) HBV (2) Histamine Receptor (2) iGluR (4) Interleukin Related (3) Isotope-Labeled Compounds (5) JNK (1) Keap1-Nrf2 (2) mAChR (1) MMP (1) Monoamine Oxidase (7) nAChR (2) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (1) P-glycoprotein (3) Parasite (4) Phosphatase (3) PPAR (1) Reactive Oxygen Species (3) SARS-CoV (1) Ser/Thr Protease (2) Telomerase (1) Thrombopoietin Receptor (2) TNF Receptor (1) Topoisomerase (1) γ-secretase (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (3) Infection (24) Inflammation/Immunology (38) Metabolic Disease (16) Neurological Disease (130)

By Targets:

5-HT Receptor (3)

Aldehyde Dehydrogenase (ALDH) (1)

Amyloid-β (11)

Antibiotic (2)

Apoptosis (11)

Autophagy (1)

Bacterial (4)

Beta-secretase (1)

Biochemical Assay Reagents (2)

Calcium Channel (1)

Carbonic Anhydrase (2)

CCR (1)

Chemerin Receptor (1)

Cholinesterase (ChE) (168)

COX (2)

Dopamine Receptor (1)

Drug Metabolite (2)

Endogenous Metabolite (5)

Epoxide Hydrolase (2)

Fungal (1)

G-quadruplex (1)

Glucosidase (1)

HBV (2)

Histamine Receptor (2)

iGluR (4)

Interleukin Related (3)

Isotope-Labeled Compounds (5)

JNK (1)

Keap1-Nrf2 (2)

mAChR (1)

MMP (1)

Monoamine Oxidase (7)

nAChR (2)

NF-κB (1)

NO Synthase (2)

NOD-like Receptor (NLR) (1)

P-glycoprotein (3)

Parasite (4)

Phosphatase (3)

PPAR (1)

Reactive Oxygen Species (3)

SARS-CoV (1)

Ser/Thr Protease (2)

Telomerase (1)

Thrombopoietin Receptor (2)

TNF Receptor (1)

Topoisomerase (1)

γ-secretase (1)

By Research Areas:

Cancer (26)

Cardiovascular Disease (3)

Infection (24)

Inflammation/Immunology (38)

Metabolic Disease (16)

Neurological Disease (130)

186

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116792

Phenoxyacetone Phenoxy-2-propanone	Cholinesterase (ChE)	Others
Phenoxyacetone is a acetylcholinesterase (AChE) inhibitor .

HY-N12361

Osmanthuside B	Cholinesterase (ChE)	Neurological Disease
Osmanthuside B can be isolated from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb and has weak acetylcholinesterase inhibitory activity .

HY-B0882

Edrophonium chloride	Cholinesterase (ChE)	Neurological Disease
Edrophonium chloride is a reversible inhibitor of acetylcholinesterase.

HY-N0342

Scopoletin 2 Publications Verification Gelseminic acid; Chrysatropic acid	Cholinesterase (ChE) Apoptosis	Inflammation/Immunology
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-120479

Cythioate	Cholinesterase (ChE)	Neurological Disease
Cythioate is an organophosphorous insecticide and anthelmintic. Cythioate is an *acetylcholinesterase* inhibitor which interferes with neuromuscular transmission in ectoparastites .

HY-N8414

Dehydrogeijerin	Cholinesterase (ChE)	Neurological Disease
Dehydrogeijerin is an inhibitor of *acetylcholinesterase* with an IC₅₀ of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease .

HY-150728

AChE-IN-22	Cholinesterase (ChE)	Neurological Disease
AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC₅₀ values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease .

HY-155750

AChE-IN-37	Cholinesterase (ChE)	Neurological Disease
AChE-IN-37 (compound A2) is anacetylcholinesterase inhibitorswith an IC₅₀ of 0.23 μM. AChE-IN-37 effects ROS levels and gene expression of NRF2 .

HY-155749

AChE-IN-36	Cholinesterase (ChE)	Neurological Disease
AChE-IN-36 (compound A4) is anacetylcholinesterase inhibitorswith an IC₅₀ of 0.04 μM. AChE-IN-36 effects ROS levels and gene expression of NRF2 .

HY-B0882S

Edrophonium-d5 chloride	Cholinesterase (ChE)	Neurological Disease
Edrophonium-d₅ (chloride) is the deuterium labeled Edrophonium chloride. Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

HY-N10209

Paecilomide	Cholinesterase (ChE)	Others
Paecilomide is a pyridone alkaloid and *acetylcholinesterase* inhibitor .

HY-76299

Galanthamine Maximum Cited Publications 14 Publications Verification Galantamine	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-W782096

Salvianolic acid H	Cholinesterase (ChE)	Cardiovascular Disease
Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor .

HY-134006

Stemoninine	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC₅₀=5.52 μM) .

HY-B0884

Minaprine	Monoamine Oxidase	Neurological Disease
Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

HY-B0884A

Minaprine dihydrochloride	Monoamine Oxidase	Neurological Disease
Minaprine dihydrochloride is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

HY-P5797

Fasciculin-II Fas-2	Cholinesterase (ChE)	Neurological Disease
Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE) .

HY-B1206

Neostigmine methyl sulfate 1 Publications Verification	Cholinesterase (ChE)	Neurological Disease Cancer
Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.

HY-N0810

Timosaponin AIII	Cholinesterase (ChE)	Neurological Disease Cancer
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

HY-116026

3-Hydroxycarbofuran	Drug Metabolite Cholinesterase (ChE)	Neurological Disease
3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor .

HY-Y0504

Trimethylammonium chloride Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride	Endogenous Metabolite Cholinesterase (ChE)	Metabolic Disease
Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase .

HY-161243

AChE-IN-56	Cholinesterase (ChE)	Neurological Disease
AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy .

HY-105157

Icopezil CP-118,954	Cholinesterase (ChE)	Neurological Disease
Icopezil is a selective acetylcholinesterase (AchE) inhibitor. Icopezil can be used in Alzheimer's disease research .

HY-162916

AChE-IN-76	Cholinesterase (ChE)	Neurological Disease
AChE-IN-76 (compound 6) is an inhibitor of acetylcholinesterase with an IC₅₀ value of 7.6 nM .

HY-W004287

Methyl tridecanoate	Amyloid-β Cholinesterase (ChE)	Neurological Disease
Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE) .

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Cholinesterase (ChE)	Metabolic Disease
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective *acetylcholinesterase* (AChE) inhibitor with the IC₅₀ of 2.04 μM .

HY-N2034

Dehydrodicentrine	Cholinesterase (ChE)	Neurological Disease
Dehydrodicentrine is an alkaloid inhibitor of *acetylcholinesterase* (AChE) (IC₅₀=2.98 μM). Dehydrodicentrine .

HY-W165085

1,10-Bis(pyridinium)decane Decamethylenebispyridinium dibromide	Cholinesterase (ChE)	Neurological Disease
1,10-Bis(pyridinium)decane is an *acetylcholinesterase* (AchE) inhibitor, with an IC₅₀ of 25.8 nM .

HY-N4261

Dehydronuciferine	Cholinesterase (ChE)	Metabolic Disease
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-N1089

Vincosamide	Cholinesterase (ChE)	Inflammation/Immunology
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the *acetylcholinesterase* (AChE) activity with anti-inflammatory activity .

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Cholinesterase (ChE)	Others
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-B0832

Profenofos	Cholinesterase (ChE)	Neurological Disease
Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-B0882R

Edrophonium chloride (Standard)	Cholinesterase (ChE)	Neurological Disease
Edrophonium (chloride) (Standard) is the analytical standard of Edrophonium (chloride). This product is intended for research and analytical applications. Edrophonium chloride is a reversible inhibitor of acetylcholinesterase.

HY-N0342R

Scopoletin (Standard)	Cholinesterase (ChE) Apoptosis	Inflammation/Immunology
Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-B1093

Fenchlorphos	Parasite Cholinesterase (ChE)	Infection
Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction .

HY-N6619A

Lycoramine	Cholinesterase (ChE)	Neurological Disease
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-W077226

AChE-IN-23	Cholinesterase (ChE)	Neurological Disease
AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM .

HY-151927

AChE-IN-28	Cholinesterase (ChE)	Neurological Disease
AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of *acetylcholinesterase* with an IC₅₀ of 0.2 nM .

HY-162145

AChE-IN-54	Cholinesterase (ChE)	Inflammation/Immunology
AChE-IN-54 (compound 3c) is an inhibitor of acetylcholinesterase (AChE) and has anti-lipid oxidation activity .

HY-123887

Manumycin B	Antibiotic Cholinesterase (ChE)	Infection Cancer
Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC₅₀ of 15 mM .

HY-U00028

T 82	5-HT Receptor Cholinesterase (ChE)	Neurological Disease
T 82 is a potent 5-HT3 antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease.

HY-76299S1

Galanthamine-O-methyl-d3	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

HY-126765

Territrem B	Cholinesterase (ChE)	Infection Neurological Disease
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus .

HY-N6619

Lycoramine hydrobromide	Cholinesterase (ChE)	Neurological Disease
Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor .

HY-119592

Cyclophostin	Cholinesterase (ChE)	Neurological Disease
Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC₅₀ values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively .

HY-W795027

Anatoxin-a ATX-a	nAChR Cholinesterase (ChE)	Neurological Disease
Anatoxin-a (ATX-a) is a neurotoxic alkaloid. Anatoxin-a acts as both a *nicotinic acetylcholine* receptor (nAChR)** agonist and an Acetylcholinesterase (AChE) inhibitor .

HY-161058

AChE-IN-49	Cholinesterase (ChE)	Metabolic Disease
AChE-IN-49 (Compd (S)-7g) is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 0.0003 μM .

HY-76299R

Galanthamine (Standard)	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-164130

AChE-IN-65	Cholinesterase (ChE)	Neurological Disease
AChE-IN-65 (Compound DABA_1) is a mixed inhibitor for acetylcholinesterase (AChE), with a K_i of 556.4 μM for Electrophorus electricus AChE.

HY-N0825

Nodakenin	Cholinesterase (ChE)	Inflammation/Immunology
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

Cat. No.	Product Name	Type

HY-103373

PE154	Fluorescent Dyes/Probes
PE154 (Compound 13) is a potent fluorescent inhibitor of human *acetylcholinesterase* (AChE) and butyrylcholinesterase (BChE) (IC₅₀s=280 pM and 16 nM, respectively) . PE154 can label β-amyloid plaques in histochemical analysis .

Cat. No.	Product Name	Type

HY-21629

N-Boc-4-piperidinemethanol	Cell Assay Reagents
N-Boc-4-piperidinemethanol (compound 4) is an acetylcholinesterase (AChE) inhibitor. N-Boc-4-piperidinemethanol can used ti study Alzheimer’s Disease .

HY-W127493

1-Hexacosanol Ceryl Alcohol	Cell Assay Reagents
1-Hexacosanol is a compound in the bioactive fraction of plant extracts that mediates insecticidal activity. 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

HY-D0837

Imidazole

2 Publications Verification

Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Cell Assay Reagents

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-W127493R

1-Hexacosanol (Standard)

Cell Assay Reagents

1-Hexacosanol (Standard) is the analytical standard of 1-Hexacosanol. This product is intended for research and analytical applications. 1-Hexacosanol is a compound in the bioactive fraction of plant extracts that mediates insecticidal activity. 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

HY-D0837R

Imidazole (Standard)

Cell Assay Reagents

Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

Cat. No.	Product Name	Target	Research Area

HY-P5797

Fasciculin-II Fas-2	Cholinesterase (ChE)	Neurological Disease
Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE) .

HY-P5798

Fasciculin-I FAS-I	Cholinesterase (ChE)	Neurological Disease
Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting *acetylcholinesterase* (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12361

Osmanthuside B	Structural Classification Pseuderanthemum carruthersii (Seem.) Guillaumin Acanthaceae Source classification Phenols Polyphenols Plants	Cholinesterase (ChE)
Osmanthuside B can be isolated from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb and has weak acetylcholinesterase inhibitory activity .

HY-N0342

Scopoletin 2 Publications Verification Gelseminic acid; Chrysatropic acid	Structural Classification Classification of Application Fields Source classification Coumarins Plants Monophenols Leguminosae Rubiaceae Phenols Phenylpropanoids Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Hedyotis diffusa Willd.	Cholinesterase (ChE) Apoptosis
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-76299

Galanthamine Maximum Cited Publications 14 Publications Verification Galantamine	Alkaloids other families Source classification Plants	Cholinesterase (ChE) Apoptosis
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N0810

Timosaponin AIII	Structural Classification Liliaceae Neurological Disease Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids Cancer	Cholinesterase (ChE)
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC₅₀ of 35.4 μM.

HY-Y0504

Trimethylammonium chloride Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Cholinesterase (ChE)
Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase .

HY-W004287

Methyl tridecanoate	Natural Products other families Source classification Plants	Amyloid-β Cholinesterase (ChE)
Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE) .

HY-N8414

Dehydrogeijerin	Structural Classification Natural Products Euryops arabicus Steud. ex Jaub. & Spach Source classification Plants Umbelliferae	Cholinesterase (ChE)
Dehydrogeijerin is an inhibitor of *acetylcholinesterase* with an IC₅₀ of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease .

HY-N10209

Paecilomide	Alkaloids Microorganisms Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Disease Research Fields	Cholinesterase (ChE)
Paecilomide is a pyridone alkaloid and *acetylcholinesterase* inhibitor .

HY-W782096

Salvianolic acid H	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Cholinesterase (ChE)
Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor .

HY-134006

Stemoninine	Structural Classification Alkaloids Stichoneuron halabalensis Stemonaceae Other Alkaloids Source classification Plants	Cholinesterase (ChE)
Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC₅₀=5.52 μM) .

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Alkaloids Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Cholinesterase (ChE)
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective *acetylcholinesterase* (AChE) inhibitor with the IC₅₀ of 2.04 μM .

HY-N2034

Dehydrodicentrine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Cholinesterase (ChE)
Dehydrodicentrine is an alkaloid inhibitor of *acetylcholinesterase* (AChE) (IC₅₀=2.98 μM). Dehydrodicentrine .

HY-N4261

Dehydronuciferine	Alkaloids other families Classification of Application Fields Source classification Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Cholinesterase (ChE)
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-N1089

Vincosamide	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Source classification Rubiaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Cholinesterase (ChE)
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the *acetylcholinesterase* (AChE) activity with anti-inflammatory activity .

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Alkaloids other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Cholinesterase (ChE)
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-N0342R

Scopoletin (Standard)	Structural Classification Monophenols Leguminosae Source classification Rubiaceae Coumarins Phenols Phenylpropanoids Plants Glycyrrhiza uralensis Fisch. Hedyotis diffusa Willd.	Cholinesterase (ChE) Apoptosis
Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-N6619A

Lycoramine	Alkaloids Source classification Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Cholinesterase (ChE)
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-123887

Manumycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Cholinesterase (ChE)
Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC₅₀ of 15 mM .

HY-N6619

Lycoramine hydrobromide	Alkaloids other families Source classification Plants	Cholinesterase (ChE)
Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor .

HY-119592

Cyclophostin	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC₅₀ values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively .

HY-W795027

Anatoxin-a ATX-a	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	nAChR Cholinesterase (ChE)
Anatoxin-a (ATX-a) is a neurotoxic alkaloid. Anatoxin-a acts as both a *nicotinic acetylcholine* receptor (nAChR)** agonist and an Acetylcholinesterase (AChE) inhibitor .

HY-76299R

Galanthamine (Standard)	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	Cholinesterase (ChE) Apoptosis
Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N0825

Nodakenin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Bidens parviflora Willd.	Cholinesterase (ChE)
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-131413

O-Desmethyl Galanthamine Sanguinine	Alkaloids Monophenols Cornaceae Source classification Phenols Cornus sanguinea Walter Plants	Cholinesterase (ChE)
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM .

HY-N2192

Swertianolin	Structural Classification Xanthones Classification of Application Fields Source classification Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE) HBV Bacterial
Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity .

HY-124140

Heliosupine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Heliotropium indicum L. Other Diseases Plants Disease Research Fields Boraginaceae	Cholinesterase (ChE)
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-W017423

(-)-Carvone	Structural Classification Microorganisms Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Umbelliferae Plants	Cholinesterase (ChE)
(-)-Carvone is an insect neurotoxin and a irreversible *acetylcholinesterase* (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-N0826

Corynoline 5 Publications Verification	Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Cholinesterase (ChE) Keap1-Nrf2
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating Nrf2 .

HY-Y0504R

Trimethylammonium chloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Cholinesterase (ChE)
Trimethylammonium chloride (Standard) is the analytical standard of Trimethylammonium chloride. This product is intended for research and analytical applications. Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase .

HY-N6895

Violanthin	Structural Classification Classification of Application Fields Flavones Source classification Plants Dendrobium officinale Kimura et Migo Flavonoids other families Orchidaceae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE)
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 79.80 μM .

HY-N0793A

Protopine hydrochloride Corydinine hydrochloride	Structural Classification Alkaloids Other Alkaloids Source classification Rosaceae Pseudocydonia sinensis (Thouin) C. K. Schneid. Plants	Cholinesterase (ChE)
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of *acetylcholinesterase*. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N0793

Protopine Corydinine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Cholinesterase (ChE)
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of *acetylcholinesterase*. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N12423

Bis-(-)-8-demethylmaritidine	Crinum asiaticum L. Structural Classification Alkaloids Other Alkaloids Source classification Plants Amaryllidaceae	Cholinesterase (ChE)
Bis-(-)-8-demethylmaritidine, a natural alkaloid, is a potent acetylcholinesterase (AChE) inhibitor. Bis-(-)-8-demethylmaritidine can be used for Alzheimer's disease research .

HY-N7480A

Quinolactacin A1	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Neurological Disease Source classification Quinoline Alkaloids Disease Research Fields	Cholinesterase (ChE)
Quinolactacin A1 is a potent *acetylcholinesterase* (AChE) inhibitor from solid state fermentation of Penicillium citrinum 90648. Quinolactacin A1 can be used for the research of Alzheimer disease .

HY-17388

(±)-Huperzine A 1 Publications Verification	Structural Classification Terpenoids Huperziaceae Sesquiterpenes Source classification Huperzia serrata Plants	Cholinesterase (ChE)
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

HY-N2211

Picfeltarraenin IB	Infection Triterpenes Structural Classification Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Source classification Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE)
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation .

HY-N5076

Picfeltarraenin IV	Infection Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology	Cholinesterase (ChE)
Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation .

HY-N1474

Picfeltarraenin IA	Picria felterrae Lour. Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE)
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N2043

Huperzine B	Lycopodiaceae Alkaloids Piperidine Alkaloids Lycopodium serratum Thunb． Source classification Pyridine Alkaloids Plants	Cholinesterase (ChE)
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease .

HY-N6894

Pseudocoptisine acetate Isocoptisine acetate	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology	Cholinesterase (ChE)
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects .

HY-N6894A

Pseudocoptisine chloride Isocoptisine chloride	Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae Corydalis turtschaninovii Bess.	Cholinesterase (ChE)
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 12.8 μM. Anti-inflammatory and anti-amnestic effects .

HY-N6575

7β-Hydroxybufalin	Classification of Application Fields Animals Cardiacglycosides Source classification Metabolic Disease Disease Research Fields Steroids	Glucosidase Cholinesterase (ChE)
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and *acetylcholinesterase* .

HY-N4119

Neoeriocitrin	Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Cholinesterase (ChE)
Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor .

HY-N0825R

Nodakenin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Plants Bidens parviflora Willd.	Cholinesterase (ChE)
Nodakenin (Standard) is the analytical standard of Nodakenin. This product is intended for research and analytical applications. Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-W017423R

(-)-Carvone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Umbelliferae Plants	Cholinesterase (ChE)
(-)-Carvone (Standard) is the analytical standard of (-)-Carvone. This product is intended for research and analytical applications. (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-N2192R

Swertianolin (Standard)	Structural Classification Xanthones Source classification Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Phenols Polyphenols Plants	Cholinesterase (ChE) HBV Bacterial
Swertianolin (Standard) is the analytical standard of Swertianolin. This product is intended for research and analytical applications. Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity .

HY-124140R

Heliosupine (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Heliotropium indicum L. Source classification Plants Boraginaceae	Cholinesterase (ChE)
Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-N7010

(-)-Corynoxidine	Infection Alkaloids Classification of Application Fields Corydalis speciosa Maxim. Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Cholinesterase (ChE) Bacterial
(-)-Corynoxidine is an *acetylcholinesterase* inhibitor with an IC₅₀ value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa . (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees .

HY-N0826R

Corynoline (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids	Cholinesterase (ChE) Keap1-Nrf2
Corynoline (Standard) is the analytical standard of Corynoline. This product is intended for research and analytical applications. Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating Nrf2 .

HY-N0793R

Protopine (Standard)	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE)
Protopine (Standard) is the analytical standard of Protopine. This product is intended for research and analytical applications. Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

Cat. No.	Product Name	Chemical Structure

HY-76299S

Galanthamine-d6
Galanthamine-d₆ (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-B0882S

Edrophonium-d5 chloride
Edrophonium-d₅ (chloride) is the deuterium labeled Edrophonium chloride. Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

HY-76299S1

Galanthamine-O-methyl-d3
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

HY-W004287S

Methyl tridecanoate-d25
Methyl tridecanoate-d₂₅ is the deuterium labeled Methyl tridecanoate. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE)[1].

HY-B0732S

Itopride-d6 hydrochloride
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

HY-N6608S

Physostigmine-d3

Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

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