Search Result
Results for "
Asp-Lys
" in MedChemExpress (MCE) Product Catalog:
3
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P0266B
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Ac-SDKP acetate
|
Angiotensin-converting Enzyme (ACE)
|
Inflammation/Immunology
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N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .
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-
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- HY-P2660
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GD4K-na
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Enteropeptidase
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Others
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Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (Km: 0.16 mM) .
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-
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- HY-P3823
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Influenza Virus
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Infection
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Asp-Asp-Asp-Asp-Asp-Asp is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.
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-
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- HY-P3217
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Oxytocin Receptor
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Endocrinology
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[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg 2+. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .
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-
-
- HY-P3217A
-
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Oxytocin Receptor
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Endocrinology
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[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg 2+. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .
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-
-
- HY-P0266
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-
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- HY-P0266A
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-
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- HY-P3823A
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Influenza Virus
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Infection
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Asp-Asp-Asp-Asp-Asp-Asp TFA is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.
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-
-
- HY-152210
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Cathepsin
|
Cancer
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ASPER-29 is Asperphenamate HY-129578 analog. ASPER-29 also is a dual cathepsin L and S inhibitor with IC50 value of 6.03 μM and 5.02 μM, respectively. ASPER-29 can be used for the research of the migration and invasion of cancer .
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-
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- HY-P4386
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GLP Receptor
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Metabolic Disease
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(Asp28)-Exenatide is a degradation product of exenatide (HY-13443). (Asp28)-Exenatide can be used as a GLP-1R agonist .
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-
- HY-D1630
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Fluorescent Dye
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Others
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4-Di-10-ASP is a fluorescent lipophilic tracer (Excitation 485 nm; Emission 620 nm). 4-Di-10-ASP can be used to stain phospholipid membranes in a specific manner .
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-
-
- HY-D0060
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Fluorescent Dye
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Others
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4-Di-2-ASP, a styryl pyridinium fluorescent dye, is a vital mitochondrial marker. 4-Di-2-ASP shows reliable and specific labelling of pulmonary NEBs (neuroepithelial bodies) .
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-
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- HY-P2631
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Folate Receptor (FR)
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Others
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EC119 consists of Pteroic acid-gGlu-Asp-Arg-Asp-Asp-Cys, which is the folate–peptide moiety found within both the EC140 and EC145 structures .
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-
-
- HY-P3950
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Fluorescent Dye
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Others
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Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond .
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-
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- HY-W013291A
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Amino Acid Derivatives
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Others
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H-D-Asp(OtBu)-OtBu·HCl is the isomer of H-Asp(OtBu)-OtBu.HCl (HY-W013291), and can be used as an experimental control. H-Asp(OtBu)-OtBu.HCl is an aspartic acid derivative .
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-
-
- HY-162249
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Ras
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Cancer
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ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity .
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-
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- HY-W338079
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Caspase
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Others
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Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .
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- HY-P10450
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D2R; (D)2-Rhodamine 110
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Caspase
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Others
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(Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .
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-
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- HY-163991
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-
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- HY-133876
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DiA
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Fluorescent Dye
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Others
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4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .
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- HY-135009
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DAspI
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G-quadruplex
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Others
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2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .
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- HY-U00289
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-
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- HY-E70196
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Asp-N
|
MMP
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Others
|
Endoproteinase Asp-N (Asp-N) is a metalloprotease that can specifically cleave the N-terminal side of aspartyl and cysteic acid residues .
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- HY-160888
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mAChR
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Others
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ASP8302 is a positive allosteric modulator of muscarinic M3 Receptor. ASP8302 improves voiding efficiency and reduced residual urine volume in two voiding dysfunction models. ASP8302 can be used for research of underactive bladder .
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- HY-W094758A
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Fluorescent Dye
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Cancer
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4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λex /λem = 475/606 nm) .
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- HY-P4389
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GLP Receptor
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Metabolic Disease
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(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .
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- HY-W130364
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Pro-Asp
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Biochemical Assay Reagents
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Others
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H-Pro-Asp-OH (Pro-asp) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-P10147
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Caspase
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Cancer
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Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
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-
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- HY-124428
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FK881
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COX
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Cardiovascular Disease
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ASP6537 is a potent and selective rhCOX-1 inhibitor with an IC50 of 0.703 nM. ASP6537 has the potential for cardiovascular disease research .
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-
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- HY-167874
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-
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- HY-19903
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17β-HSD
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Cancer
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ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.
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- HY-Y1169S1
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Isotope-Labeled Compounds
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Others
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Fmoc-Asp(OtBu)-OH- 13C4, 15N is the 13C and 15N labeled Fmoc-Asp(OtBu)-OH[1]. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis[2].
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- HY-W142117
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Fluorescent Dye
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Others
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H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
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- HY-101907
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ASP7663
1 Publications Verification
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TRP Channel
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Neurological Disease
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ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions .
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-
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- HY-13326
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ASP3026
5 Publications Verification
|
Anaplastic lymphoma kinase (ALK)
Apoptosis
ROS Kinase
Caspase
PARP
IGF-1R
STAT
Akt
JNK
|
Cancer
|
ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC50 value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research .
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- HY-P1613
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Cyclo(RGDfV); C(RGDfV)
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Integrin
Apoptosis
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Cancer
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Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .
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- HY-P4391
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-
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- HY-P4453
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Caspase
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Cancer
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Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .
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-
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- HY-Y1169S2
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4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-Aspartate-d3; Fmoc-L-Asp(OtBu)-OH-d3
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Isotope-Labeled Compounds
Amino Acid Derivatives
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Others
|
Fmoc-Asp(OtBu)-OH-d3 (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate-d3) is deuterium labeled Fmoc-Asp(OtBu)-OH. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
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- HY-P4603
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-
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- HY-P1613A
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Cyclo(RGDfV) TFA; C(RGDfV) TFA
|
Integrin
Apoptosis
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Cancer
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Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .
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- HY-136447
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ASP4132
1 Publications Verification
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AMPK
|
Cancer
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ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models .
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- HY-167677
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5-HT Receptor
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Neurological Disease
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ASP-2205 is a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM). ASP-2205 enhances the pudendal nerve-mediated urethral closure reflex through the 5-HT2C receptor, thereby preventing urinary incontinence .
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- HY-W010959
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- HY-42065
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- HY-W008360
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-
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- HY-W105884
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-
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- HY-W017499
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-
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- HY-W008685
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-
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- HY-W011703
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- HY-W018741
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- HY-W041982
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- HY-W009328
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- HY-132966
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ASP2453
1 Publications Verification
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Ras
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Cancer
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ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
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- HY-134563
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Caspase
Apoptosis
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Cancer
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Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK is an inhibitor for caspase-3, and inhibits Dihydroartemisinin (HY-N0176) and Dictamnine (HY-N0849) co-induced apoptosis .
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- HY-P5737
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Bacterial
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Infection
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ASP-1 is a strong antistaphylococcal peptide with minimum inhibitory concentrations (MICs) of the purified peptide against S. aureus and methicillin-resistant S. aureus (MRSA) ranged from 2 μg/mL to 64 μg/mL .
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- HY-137950
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- HY-W041996
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- HY-W008787
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- HY-W013659
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- HY-W002326
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- HY-W024554
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- HY-W011553
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- HY-W007108
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- HY-P2376
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- HY-W013145
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- HY-W007399
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- HY-Y0029
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- HY-W009840
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- HY-W018489
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- HY-W011126
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- HY-77757
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- HY-30231
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- HY-W008075
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- HY-W129833
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- HY-W142115
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- HY-W011278
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- HY-W013291
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- HY-P4487
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Biochemical Assay Reagents
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Others
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H-Pro-Pro-Asp-NH2 is a potent and selective catalyst for asymmetric aldol reactions. H-Pro-Pro-Asp-NH2 catalyzes aldol reactions between acetone and several aldehydes .
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- HY-110176
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GlyT
|
Neurological Disease
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ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease .
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- HY-P2016
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Proteasome
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Others
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Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
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- HY-N3331
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Others
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Others
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Magnolignan A is a natural lignan found in the heartwood of Streblus asper .
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- HY-W011279
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-
- HY-W013719
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- HY-W004083
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- HY-W015233
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- HY-W013144
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- HY-W142120
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- HY-W041999
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- HY-W142111
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- HY-P0319
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Biochemical Assay Reagents
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Others
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3X FLAG peptides are FLAG-tagged peptides containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide can be used for protein separation and purification, and competitive elution with target proteins.
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- HY-P3726
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Integrin
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Inflammation/Immunology
Cancer
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Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .
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- HY-122015
-
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Potassium Channel
|
Neurological Disease
|
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities .
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- HY-Y1169
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4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-Aspartate; Fmoc-L-Asp(OtBu)-OH
|
Amino Acid Derivatives
|
Others
|
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
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- HY-W141911
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-
- HY-P3351
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-
- HY-46859
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-
- HY-W663527
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-
- HY-W013740
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-
- HY-111021
-
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LPL Receptor
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Inflammation/Immunology
|
ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile .
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- HY-111021A
-
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LPL Receptor
|
Inflammation/Immunology
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ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile .
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- HY-P2300A
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Cyclo(RGDfC) TFA
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Integrin
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Cancer
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Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors .
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- HY-125881
-
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LPL Receptor
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Inflammation/Immunology
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ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile .
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- HY-P2300
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Cyclo(RGDfC)
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Integrin
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Cancer
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Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
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- HY-N2238
-
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Others
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Metabolic Disease
|
Dipsanoside A is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .
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- HY-P2403
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-
- HY-N9352
-
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Others
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Others
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Cantleyoside is a natiural iridoid glycoside that could be found in the Roots of Dipsacus asper .
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- HY-P2404
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-
- HY-19983
-
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FGFR
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Cancer
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ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity .
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- HY-N2236
-
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Others
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Infection
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Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .
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- HY-123171
-
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Dipeptidyl Peptidase
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Metabolic Disease
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ASP8497 is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor that reduces blood glucose levels and increases plasma active GLP-1 and insulin levels without causing hypoglycemia in fasted normal mice. ASP8497 can be utilized for antihyperglycemic research .
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- HY-W650842
-
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Caspase
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Cancer
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Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .
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- HY-120833
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Caspase
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Others
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Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
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- HY-P5021
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c(RGDfE)
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Biochemical Assay Reagents
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Cancer
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Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) (c(RGDfE)) is a cyclic RGD peptide that serves as a conjugated multifunctional nanodrug delivery system to target Gemcitabine to pancreatic cancer cells. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) can be used in cancer research .
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- HY-W016749
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- HY-P0295
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GRGDS
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Integrin
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Others
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Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ~5 and ~6.5 μM
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- HY-12290
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RGDS peptide; Fibronectin tetrapeptide
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Integrin
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Inflammation/Immunology
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Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
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- HY-P4419
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Fluorescent Dye
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Others
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Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). The excitation and emission wavelengths are 351 nm and 430 nm, respectively .
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- HY-P0295A
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GRGDS TFA
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Integrin
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Inflammation/Immunology
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Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM .
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- HY-112415
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-
- HY-120496
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-
- HY-P4900
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Caspase
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Others
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Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .
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- HY-P10004
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-
- HY-W554764
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-
- HY-P4901
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-
- HY-P4419A
-
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Fluorescent Dye
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Others
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Boc-Asp(OBzl)-Pro-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC acetate undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-136733
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Ac-Asp-Asn-Leu-Asp-CHO
|
Caspase
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Infection
Neurological Disease
|
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Ki app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .
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-
- HY-12290A
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RGDS peptide TFA; Fibronectin tetrapeptide TFA
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Integrin
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Inflammation/Immunology
|
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .
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-
- HY-P5974
-
Z-Tyr-Val-Ala-Asp-pNA
|
Caspase
|
Others
|
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate .
|
-
- HY-P5023
-
-
- HY-135418
-
|
ADC Linker
|
Cancer
|
Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-P4232
-
-
- HY-N0240
-
|
Ornithine decarboxylase (ODC)
|
Cancer
|
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .
|
-
- HY-B1349
-
|
Biochemical Assay Reagents
|
Others
|
Mepiroxol can form various interactions with key residues of specific proteins. It establishes salt bridges with Arg-153 and Arg-74, and forms two hydrogen bonds with Asp-50 and Gly-96 through its terminal hydroxyl group, these interactions help enhance its binding affinity and lead to a higher docking score .
|
-
- HY-N3557
-
Leontoside A
|
Fungal
|
Infection
|
Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity .
|
-
- HY-P4724
-
-
- HY-112860
-
-
- HY-P4431
-
|
Amino Acid Derivatives
|
Others
|
H-Met-Asp-OH is a dipeptide containing methionine and aspartic acid, which can be used for the synthesis of polypeptides .
|
-
- HY-P4403
-
(Z-Asp-Glu-Val-Asp)₂-Rhodamine 110
|
Fluorescent Dye
Apoptosis
Caspase
|
Others
|
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .
|
-
- HY-124744
-
|
FAAH
|
Neurological Disease
|
ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research .
|
-
- HY-P5038
-
c(GRGDSP)
|
Integrin
|
Cancer
|
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .
|
-
- HY-W015824
-
DL-Asp-OH
|
Biochemical Assay Reagents
|
Others
|
DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-P4288
-
|
Amino Acid Derivatives
|
Others
|
Beta-Asp-His is a dipeptide containing aspartic acid and histidine, which can form amino acid derivatives by complexing with Zinc .
|
-
- HY-P5023A
-
-
- HY-P4547
-
AC-WEHD-AMC
|
Caspase
|
Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
-
- HY-P4022
-
-
- HY-P0309
-
|
Integrin
|
Cancer
|
Arg-Gly-Glu-Ser is a polypeptide related to RGD and is a negative control for Arg-Gly-Asp-Ser (HY-12290) .
|
-
- HY-P4535
-
-
- HY-P3227
-
XJ735
|
Integrin
|
Inflammation/Immunology
|
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension
Research .
|
-
- HY-142031
-
|
Bacterial
|
Infection
|
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent .
|
-
- HY-P4813
-
-
- HY-P0309A
-
-
- HY-P3523
-
|
Integrin
|
Others
|
KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .
|
-
- HY-136727
-
|
Caspase
|
Cancer
|
Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
|
-
- HY-N0240R
-
|
Others
|
Cancer
|
Herbacetin (Standard) is the analytical standard of Herbacetin. This product is intended for research and analytical applications. Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .
|
-
- HY-19803
-
Asp8273 mesylate
|
EGFR
|
Cancer
|
Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR.
|
-
- HY-19729
-
Asp8273
|
EGFR
|
Cancer
|
Naquotinib (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR.
|
-
- HY-14894S2
-
Asp1941-13C6
|
Isotope-Labeled Compounds
SGLT
|
Metabolic Disease
|
Pragliflozin- 13C6 (ASP1941- 13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
- HY-113953
-
|
Caspase
Apoptosis
|
Inflammation/Immunology
|
Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development .
|
-
- HY-120598
-
-
- HY-12432A
-
Asp2215 hemifumarate
|
FLT3
TAM Receptor
|
Cancer
|
Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
|
-
- HY-P3236
-
Ac-IEPD-pNA
|
Fluorescent Dye
|
Cancer
|
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .
|
-
- HY-12432
-
Asp2215
|
FLT3
TAM Receptor
|
Cancer
|
Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
|
-
- HY-P4410
-
|
Drug Derivative
|
Metabolic Disease
|
(D-Asp28)-Exenatide is an Exenatide (HY-13443) impurity. Exenatide is a long-acting glucagon-like peptide-1 receptor agonist .
|
-
- HY-P1008A
-
Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK
|
Caspase
|
Cancer
|
Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .
|
-
- HY-P10303
-
Cyclo[RGDfK(Azide)]
|
Biochemical Assay Reagents
|
Others
|
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
-
- HY-120478
-
|
LPL Receptor
|
Infection
|
ASP6432 is a potent and selective type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC50s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively .
|
-
- HY-W011254
-
Ac-Val-Ala-Asp-CHO
|
Caspase
|
Cancer
|
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .
|
-
- HY-P10001
-
Z-Ile-Glu-Thr-Asp-pNA
|
Caspase
|
Cancer
|
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .
|
-
- HY-P5996
-
|
Fluorescent Dye
|
Others
|
MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .
|
-
- HY-P0110
-
(Iso)-Z-Val-Ala-Asp(OMe)-FMK
|
Caspase
|
Cancer
|
(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and UCHL1 inhibitor Z-VAD(OMe)-FMK (HY-16658) .
|
-
- HY-103348
-
Boc-Asp(OMe)-FMK
|
Caspase
|
Inflammation/Immunology
|
Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8 .
|
-
- HY-P3761
-
|
Caspase
|
Others
|
Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .
|
-
- HY-W590561
-
|
Biochemical Assay Reagents
|
Others
|
Fmoc-Asp(biotinyl-PEG)-OH is a biotinylation reagent with a Fmoc-protected amino group. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations.
|
-
- HY-112535
-
-
- HY-P5025
-
Azido-c(RGDyK)
|
Drug Intermediate
|
Others
|
Cyclo(Arg-Gly-Asp-D-Tyr-ε-azido-Nle) (Azido-c(RGDyK)) is a polypeptide composed of arginine, glycine, aspartic acid, and tyrosine that can be used for Synthesis of [ 18F]FPyKYNE-c(RGDyK) .
|
-
- HY-W015824R
-
|
Biochemical Assay Reagents
|
Others
|
DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-103248R
-
|
IRE1
Fungal
Antibiotic
Apoptosis
CDK
|
Infection
Cancer
|
DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-P4787
-
|
Cathepsin
|
Others
|
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .
|
-
- HY-19568B
-
Asp015K hydrochloride; JNJ-54781532 hydrochloride
|
JAK
|
Inflammation/Immunology
|
Peficitinib (ASP015K) hydrochloride is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively .
|
-
- HY-19568
-
Asp015K; JNJ-54781532
|
JAK
|
Inflammation/Immunology
|
Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively .
|
-
- HY-12432S1
-
Asp2215-d8
|
FLT3
TAM Receptor
|
Cancer
|
Gilteritinib-d8 is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
|
-
- HY-19568A
-
Asp015K hydrobromide; JNJ-54781532 hydrobromide
|
JAK
|
Inflammation/Immunology
|
Peficitinib (ASP015K) hydrobromide is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively .
|
-
- HY-108767
-
B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14
|
Insulin Receptor
|
Metabolic Disease
|
Insulin aspart (B28Asp) is a fast-acting analog of human insulin. Insulin aspart provides more rapid absorption than regular human insulin after subcutaneous administration. Insulin aspart can be used for researching diabetes .
|
-
- HY-P0322
-
EMD 56574
|
Integrin
|
Cardiovascular Disease
Metabolic Disease
|
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .
|
-
- HY-P3234
-
|
Casein Kinase
|
Others
|
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
|
-
- HY-P3497
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Cys-Asp10 is a non-releasable oligopeptide linker, involves in the synthesis of releasable oligopeptide linker. Releasable oligopeptide linker can be used to deliver agent to a bone fracture-homing oligopeptide and reduces fractured femur healing times .
|
-
- HY-P4896
-
|
Integrin
|
Cancer
|
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an integrin inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .
|
-
- HY-12432R
-
|
FLT3
TAM Receptor
|
Cancer
|
Gilteritinib (Standard) is the analytical standard of Gilteritinib. This product is intended for research and analytical applications. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
|
-
- HY-P3858
-
|
Amyloid-β
|
Neurological Disease
|
(D-Asp1)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .
|
-
- HY-P0322A
-
EMD 56574 TFA
|
Integrin
|
Cardiovascular Disease
Metabolic Disease
|
GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption .
|
-
- HY-P3497A
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker, involves in the synthesis of releasable oligopeptide linker. Releasable oligopeptide linker can be used to deliver agent to a bone fracture-homing oligopeptide and reduces fractured femur healing times .
|
-
- HY-Y0313S
-
-
- HY-10423
-
Asp7486
|
mTOR
Autophagy
|
Cancer
|
OSI-027 (ASP7486) is a potent, selective, orally active and ATP-competitive mTOR kinase activity inhibitor with an IC50 of 4 nM. OSI-027 targets both mTORC1 and mTORC2 with IC50s of 22 nM and 65 nM, respectively .
|
-
- HY-Y0313S1
-
-
- HY-P1816
-
|
Integrin
|
Cancer
|
The connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. Fibronectin CS1 Peptide lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models .
|
-
- HY-136980
-
Asp-Glu
|
Endogenous Metabolite
|
Neurological Disease
|
Aspartylglutamate (Asp-Glu) is a dipeptide that exhibits excitatory activity, as it has been shown to depolarize CA1 pyramidal neurons and increase conductance in response to stimulation. Aspartylglutamate selectively binds to certain glutamate receptors and demonstrates potent effects in specific regions of the hippocampus, particularly in the stratum radiatum where it enhances excitatory neurotransmission.
|
-
- HY-P4320
-
|
Integrin
|
Cancer
|
Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10), a decapeptide containing a cyclic RGD active sequence, is an Integrin αIIbβ3 antagonist that inhibits platelet and Adhesion of proMMP-13 .
|
-
- HY-111770
-
2-Bromopalmitic acid; 2-Bromopalmitate
|
Pyroptosis
|
Infection
Inflammation/Immunology
Cancer
|
2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis .
|
-
- HY-19568R
-
|
JAK
|
Inflammation/Immunology
|
Peficitinib (Standard) is the analytical standard of Peficitinib. This product is intended for research and analytical applications. Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively .
|
-
- HY-P4307
-
|
SARS-CoV
|
Infection
|
Antioxidant agent-9 is a peptide with the sequence Asp-Trp. Antioxidant agent-9 shows antioxidant activity. Antioxidant agent-9 also is potential as SARS-CoV-2 antiviral, with an affinity strength equal to Chloroquine (HY-17589A) and Favipiravir (HY-14768) .
|
-
- HY-14894
-
Asp1941
|
SGLT
|
Metabolic Disease
|
Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
- HY-P10215
-
|
Parasite
|
Infection
|
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
|
-
- HY-16658
-
Z-VAD(OMe)-FMK
Maximum Cited Publications
172 Publications Verification
Z-Val-Ala-Asp(OMe)-FMK
|
Caspase
|
Cancer
|
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .
|
-
- HY-P99413
-
Asp1650
|
HCV
|
Cancer
|
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 + ovarian and testicular cancer cell lines .
|
-
- HY-150044
-
|
DNA/RNA Synthesis
Topoisomerase
Bacterial
|
Infection
|
Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC50: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC50: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area .
|
-
- HY-P0178
-
|
Integrin
|
Inflammation/Immunology
|
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .
|
-
- HY-P0178A
-
|
Integrin
|
Inflammation/Immunology
|
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .
|
-
- HY-14894R
-
|
SGLT
|
Metabolic Disease
|
Ipragliflozin (Standard) is the analytical standard of Ipragliflozin. This product is intended for research and analytical applications. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
- HY-152086
-
|
Dynamin
|
Cardiovascular Disease
|
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .
|
-
- HY-152086A
-
|
Dynamin
|
Cardiovascular Disease
|
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .
|
-
- HY-126402
-
|
Integrin
|
Cancer
|
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.
|
-
- HY-P3732
-
|
Integrin
|
Cancer
|
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .
|
-
- HY-123201
-
|
FLT3
|
Cancer
|
KRN383 analog is an analog of KRN383. KRN383 is an orally active Flt3 inhibitor that inhibits the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr (D835Y) point mutation with IC50 values of < or =5.9 and 43 nM, respectively. KRN383 also inhibits the proliferation of the ITD-positive cell lines with IC50 values of < or =2.9 nM. KRN383 can be used for the research of acute myeloid leukemia .
|
-
- HY-N0265
-
-
- HY-P991084
-
|
PD-1/PD-L1
|
Cancer
|
TQB-2858 is a bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor. TQB-2858 has a high affinity for PD-L1, TGF-β1, and TGF-β3 and exhibited high PD-L1 target occupancy. TQB-2858 can be used for the study of osteosarcoma and alveolar soft part sarcoma (ASPS) .
|
-
- HY-P4919
-
|
Beta-secretase
|
Others
|
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
|
-
- HY-N0265R
-
|
Caspase
Apoptosis
PERK
Akt
p38 MAPK
HIF/HIF Prolyl-Hydroxylase
PPAR
|
Cardiovascular Disease
Neurological Disease
|
Asperosaponin VI (Standard) is the analytical standard of Asperosaponin VI. This product is intended for research and analytical applications. Asperosaponin VI is a saponin component from Dipsacus asper. Asperosaponin VI induces osteoblast differentiation through the BMP-2/p38 and ERK1/2 signaling pathways. Asperosaponin VI protects against hypoxia-induced cardiomyocyte apoptosis by activating the PI3K/Akt and CREB pathways. Additionally, Asperosaponin VI also has antidepressant and wound-healing-promoting activities .
|
-
- HY-P2875
-
|
Endogenous Metabolite
|
Others
|
Hemicellulase is a hemicellulose-targeting hydrolase that breaks down the binding of glucose and polymers to water molecules present in plant fibers. Hemicellulase specifically degrades hemicellulose (such as xylan and mannan) in plant cell walls by hydrolyzing β-1,4-xylosidic bonds and ester bonds (such as acetyl and ferulic acid ester bonds). Hemicellulase relies on the synergistic action of the glycoside hydrolase (GH) and carbohydrate esterase (CE) families to achieve efficient hydrolysis through acid-base catalysis (such as Glu/Asp residues) and substrate binding pockets. Hemicellulase can be used in the food industry (such as improving bread texture), biofuel production (lignocellulose pretreatment) and paper industry (biobleaching) .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D1630
-
|
Fluorescent Dyes/Probes
|
4-Di-10-ASP is a fluorescent lipophilic tracer (Excitation 485 nm; Emission 620 nm). 4-Di-10-ASP can be used to stain phospholipid membranes in a specific manner .
|
-
- HY-D0060
-
|
Fluorescent Dyes/Probes
|
4-Di-2-ASP, a styryl pyridinium fluorescent dye, is a vital mitochondrial marker. 4-Di-2-ASP shows reliable and specific labelling of pulmonary NEBs (neuroepithelial bodies) .
|
-
- HY-133876
-
DiA
|
Fluorescent Dyes/Probes
|
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .
|
-
- HY-135009
-
DAspI
|
Fluorescent Dyes/Probes
|
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .
|
-
- HY-W094758A
-
|
Fluorescent Dyes/Probes
|
4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λex /λem = 475/606 nm) .
|
-
- HY-W142117
-
-
- HY-P3236
-
Ac-IEPD-pNA
|
Fluorescent Dyes/Probes
|
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .
|
-
- HY-W338079
-
Cat. No. |
Product Name |
Type |
-
- HY-W015824
-
DL-Asp-OH
|
Microbial Culture
|
DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-163991
-
-
- HY-W015824R
-
|
Microbial Culture
|
DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P0266B
-
Ac-SDKP acetate
|
Angiotensin-converting Enzyme (ACE)
|
Inflammation/Immunology
|
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .
|
-
- HY-P2660
-
GD4K-na
|
Enteropeptidase
|
Others
|
Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (Km: 0.16 mM) .
|
-
- HY-P3823
-
|
Influenza Virus
|
Infection
|
Asp-Asp-Asp-Asp-Asp-Asp is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.
|
-
- HY-P3217
-
|
Oxytocin Receptor
|
Endocrinology
|
[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg 2+. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .
|
-
- HY-P3217A
-
|
Oxytocin Receptor
|
Endocrinology
|
[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg 2+. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .
|
-
- HY-P4305
-
|
Peptides
|
Others
|
Asp-Lys is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
-
- HY-P0266
-
-
- HY-P0266A
-
-
- HY-P0321
-
-
- HY-P3823A
-
|
Influenza Virus
|
Infection
|
Asp-Asp-Asp-Asp-Asp-Asp TFA is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.
|
-
- HY-P5029
-
-
- HY-P4386
-
|
GLP Receptor
|
Metabolic Disease
|
(Asp28)-Exenatide is a degradation product of exenatide (HY-13443). (Asp28)-Exenatide can be used as a GLP-1R agonist .
|
-
- HY-P2631
-
|
Folate Receptor (FR)
|
Others
|
EC119 consists of Pteroic acid-gGlu-Asp-Arg-Asp-Asp-Cys, which is the folate–peptide moiety found within both the EC140 and EC145 structures .
|
-
- HY-P3950
-
|
Fluorescent Dye
|
Others
|
Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond .
|
-
- HY-P4313
-
|
Peptides
|
Others
|
Asp-Val is a dipeptide formed from L-alpha-aspartyl and L-valine residues. Asp-Val has a role as a metabolite. Asp-Val can be isolated from an enzymatic hydrolysate of food proteins .
|
-
- HY-P10450
-
D2R; (D)2-Rhodamine 110
|
Caspase
|
Others
|
(Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .
|
-
- HY-P4389
-
|
GLP Receptor
|
Metabolic Disease
|
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .
|
-
- HY-P10147
-
|
Caspase
|
Cancer
|
Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
|
-
- HY-W142117
-
|
Fluorescent Dye
|
Others
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
|
-
- HY-P1613
-
Cyclo(RGDfV); C(RGDfV)
|
Integrin
Apoptosis
|
Cancer
|
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .
|
-
- HY-P4391
-
-
- HY-P4453
-
|
Caspase
|
Cancer
|
Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .
|
-
- HY-P0314A
-
|
Peptides
|
Cardiovascular Disease
|
Arg-Gly-Asp-Cys TFA is the binding motif of fibronectin to cell adhesion molecules. Arg-Gly-Asp-Cys TFA can inhibit platelet aggregation and fibrinogen binding .
|
-
- HY-P4529
-
-
- HY-P4601
-
-
- HY-P4603
-
-
- HY-P4598
-
-
- HY-P1613A
-
Cyclo(RGDfV) TFA; C(RGDfV) TFA
|
Integrin
Apoptosis
|
Cancer
|
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .
|
-
- HY-P4233
-
|
Peptides
|
Cancer
|
Gly-Arg-Gly-Asp-Ser-NH2 is a pentapeptide with no N-terminal modification. Gly-Arg-Gly-Asp-Ser-NH2 can be coupled to carrriers .
|
-
- HY-W010959
-
-
- HY-42065
-
-
- HY-P4601A
-
-
- HY-W008360
-
-
- HY-W105884
-
-
- HY-W017499
-
-
- HY-W008685
-
-
- HY-W011703
-
-
- HY-W018741
-
-
- HY-W041982
-
-
- HY-W009328
-
-
- HY-P5737
-
|
Bacterial
|
Infection
|
ASP-1 is a strong antistaphylococcal peptide with minimum inhibitory concentrations (MICs) of the purified peptide against S. aureus and methicillin-resistant S. aureus (MRSA) ranged from 2 μg/mL to 64 μg/mL .
|
-
- HY-137950
-
-
- HY-W041996
-
-
- HY-W008787
-
-
- HY-W013659
-
-
- HY-W002326
-
-
- HY-W024554
-
-
- HY-W011553
-
-
- HY-W007108
-
-
- HY-P2376
-
- HY-W013145
-
- HY-W007399
-
- HY-Y0029
-
- HY-W009840
-
- HY-W018489
-
- HY-W011126
-
- HY-77757
-
- HY-30231
-
- HY-W008075
-
- HY-W142115
-
- HY-W011278
-
- HY-W013291
-
- HY-P4487
-
|
Biochemical Assay Reagents
|
Others
|
H-Pro-Pro-Asp-NH2 is a potent and selective catalyst for asymmetric aldol reactions. H-Pro-Pro-Asp-NH2 catalyzes aldol reactions between acetone and several aldehydes .
|
- HY-P2016
-
|
Proteasome
|
Others
|
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
|
- HY-W011279
-
- HY-W013719
-
- HY-W004083
-
- HY-W015233
-
- HY-W013144
-
- HY-W142120
-
- HY-W041999
-
- HY-W142111
-
- HY-P0319
-
|
Biochemical Assay Reagents
|
Others
|
3X FLAG peptides are FLAG-tagged peptides containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide can be used for protein separation and purification, and competitive elution with target proteins.
|
- HY-P3726
-
|
Integrin
|
Inflammation/Immunology
Cancer
|
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .
|
- HY-Y1169
-
4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-Aspartate; Fmoc-L-Asp(OtBu)-OH
|
Amino Acid Derivatives
|
Others
|
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
|
- HY-W141911
-
- HY-P3351
-
- HY-W013740
-
- HY-P0319A
-
|
Peptides
|
Others
|
3X FLAG peptide TFA is a FLAG-tagged peptide containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide TFA can be used for protein separation and purification, and competitive elution with target proteins.
|
- HY-P2300A
-
Cyclo(RGDfC) TFA
|
Integrin
|
Cancer
|
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors .
|
- HY-P2300
-
Cyclo(RGDfC)
|
Integrin
|
Cancer
|
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
|
- HY-P2403
-
- HY-P2404
-
- HY-P10461
-
|
Peptides
|
Others
|
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM -1s -1), and can be used for detection of proteinase 3 (PR3) activity .
|
- HY-P3746
-
|
Peptides
|
Inflammation/Immunology
|
Pentigetide is a sythsis pepetide (Asp-Ser-Asp-Pro-Arg or D-S-D-P-R), also know as “HEPP” for “Human IgE Pentapeptide”. Pentigetide can not produce IgE inhibition in several different systems, due to the aspartic acids in HEPP changed into an asparagine .
|
- HY-W650842
-
|
Caspase
|
Cancer
|
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .
|
- HY-120833
-
|
Caspase
|
Others
|
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
|
- HY-P5021
-
c(RGDfE)
|
Biochemical Assay Reagents
|
Cancer
|
Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) (c(RGDfE)) is a cyclic RGD peptide that serves as a conjugated multifunctional nanodrug delivery system to target Gemcitabine to pancreatic cancer cells. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) can be used in cancer research .
|
- HY-W016749
-
- HY-P0295
-
GRGDS
|
Integrin
|
Others
|
Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ~5 and ~6.5 μM
|
- HY-12290
-
RGDS peptide; Fibronectin tetrapeptide
|
Integrin
|
Inflammation/Immunology
|
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
|
- HY-P4419
-
|
Fluorescent Dye
|
Others
|
Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). The excitation and emission wavelengths are 351 nm and 430 nm, respectively .
|
- HY-P0295A
-
GRGDS TFA
|
Integrin
|
Inflammation/Immunology
|
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM .
|
- HY-P4940
-
|
Peptides
|
Others
|
Abz-Val-Asn-Leu-Asp-Ala-Glu-EDDnp is a quenched fluorometric substrate .
|
- HY-P4395
-
|
Peptides
|
Others
|
(Asp76)-pTH (39-84) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4900
-
|
Caspase
|
Others
|
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .
|
- HY-P10004
-
- HY-P4901
-
- HY-P4419A
-
|
Fluorescent Dye
|
Others
|
Boc-Asp(OBzl)-Pro-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC acetate undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
- HY-136733
-
Ac-Asp-Asn-Leu-Asp-CHO
|
Caspase
|
Infection
Neurological Disease
|
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Ki app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .
|
- HY-12290A
-
RGDS peptide TFA; Fibronectin tetrapeptide TFA
|
Integrin
|
Inflammation/Immunology
|
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .
|
- HY-P5974
-
Z-Tyr-Val-Ala-Asp-pNA
|
Caspase
|
Others
|
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate .
|
- HY-P5023
-
- HY-P3520
-
|
Peptides
|
Others
|
SDGR is a Ser-Asp-Gly-Arg tetrapeptide sequence that effectively inhibits fibronectin-mediated cell attachment
|
- HY-P4232
-
- HY-P4727
-
DSIP-isoD
|
Peptides
|
Others
|
(β-Asp5)-Delta-Sleep Inducing Peptide (DSIP-isoD) is a synthetic polypeptide that can be partially hydrolyzed by NaOH or SDS. (β-Asp5)-Delta-Sleep Inducing Peptide can be used to study the catalytic activity of mitochondrial protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) .
|
- HY-P4724
-
- HY-P4431
-
|
Amino Acid Derivatives
|
Others
|
H-Met-Asp-OH is a dipeptide containing methionine and aspartic acid, which can be used for the synthesis of polypeptides .
|
- HY-P4403
-
(Z-Asp-Glu-Val-Asp)₂-Rhodamine 110
|
Fluorescent Dye
Apoptosis
Caspase
|
Others
|
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .
|
- HY-P5038
-
c(GRGDSP)
|
Integrin
|
Cancer
|
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .
|
- HY-P4288
-
|
Amino Acid Derivatives
|
Others
|
Beta-Asp-His is a dipeptide containing aspartic acid and histidine, which can form amino acid derivatives by complexing with Zinc .
|
- HY-P5023A
-
- HY-P0314
-
|
Peptides
|
Others
|
Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding.
|
- HY-P4547
-
AC-WEHD-AMC
|
Caspase
|
Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
- HY-P4022
-
- HY-P0309
-
|
Integrin
|
Cancer
|
Arg-Gly-Glu-Ser is a polypeptide related to RGD and is a negative control for Arg-Gly-Asp-Ser (HY-12290) .
|
- HY-P4535
-
- HY-P3227
-
XJ735
|
Integrin
|
Inflammation/Immunology
|
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension
Research .
|
- HY-P4813
-
- HY-P0309A
-
- HY-P3523
-
|
Integrin
|
Others
|
KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .
|
- HY-136727
-
|
Caspase
|
Cancer
|
Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
|
- HY-P3236
-
Ac-IEPD-pNA
|
Fluorescent Dye
|
Cancer
|
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .
|
- HY-P5394
-
|
Peptides
|
Others
|
Dby HY Peptide (608-622), mouse is a biological active peptide. (Dby HY Peptide, NAGFNSNRANSSRSS, is a HYAb epitope belonging to a well-conserved family of genes coding for known or putative RNA helicases and containing a core sequence with a DEAD (Asp-Glu-Ala-Asp) box peptide motif, hence the name Dby (Dead box RNA helicase Y). The single Phenylalanine in the sequence serves as the anchor point while FNSNRANSS most likely is the “core” sequence of this HYAb epitope.)
|
- HY-P4410
-
|
Drug Derivative
|
Metabolic Disease
|
(D-Asp28)-Exenatide is an Exenatide (HY-13443) impurity. Exenatide is a long-acting glucagon-like peptide-1 receptor agonist .
|
- HY-P10303
-
Cyclo[RGDfK(Azide)]
|
Biochemical Assay Reagents
|
Others
|
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
- HY-W011254
-
Ac-Val-Ala-Asp-CHO
|
Caspase
|
Cancer
|
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .
|
- HY-P10001
-
Z-Ile-Glu-Thr-Asp-pNA
|
Caspase
|
Cancer
|
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .
|
- HY-P5996
-
|
Fluorescent Dye
|
Others
|
MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .
|
- HY-P0110
-
(Iso)-Z-Val-Ala-Asp(OMe)-FMK
|
Caspase
|
Cancer
|
(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and UCHL1 inhibitor Z-VAD(OMe)-FMK (HY-16658) .
|
- HY-P3788
-
|
Peptides
|
Others
|
Ac-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2 is a peptide, can be used to synthesise tyrosine kinase inhibitor for hair growth reduction .
|
- HY-P3761
-
|
Caspase
|
Others
|
Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .
|
- HY-P5025
-
Azido-c(RGDyK)
|
Drug Intermediate
|
Others
|
Cyclo(Arg-Gly-Asp-D-Tyr-ε-azido-Nle) (Azido-c(RGDyK)) is a polypeptide composed of arginine, glycine, aspartic acid, and tyrosine that can be used for Synthesis of [ 18F]FPyKYNE-c(RGDyK) .
|
- HY-P4787
-
|
Cathepsin
|
Others
|
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .
|
- HY-108767
-
B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14
|
Insulin Receptor
|
Metabolic Disease
|
Insulin aspart (B28Asp) is a fast-acting analog of human insulin. Insulin aspart provides more rapid absorption than regular human insulin after subcutaneous administration. Insulin aspart can be used for researching diabetes .
|
- HY-P0322
-
EMD 56574
|
Integrin
|
Cardiovascular Disease
Metabolic Disease
|
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .
|
- HY-P3234
-
|
Casein Kinase
|
Others
|
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
|
- HY-P4324
-
|
Peptides
|
Cardiovascular Disease
|
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 is a linear peptide from laminin B1 chain that interferes with tumor cell attachment and invasion into basement membrane and has anti-angiogenic effects .
|
- HY-P3497
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Cys-Asp10 is a non-releasable oligopeptide linker, involves in the synthesis of releasable oligopeptide linker. Releasable oligopeptide linker can be used to deliver agent to a bone fracture-homing oligopeptide and reduces fractured femur healing times .
|
- HY-P4896
-
|
Integrin
|
Cancer
|
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an integrin inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .
|
- HY-P4026
-
|
Peptides
|
Others
|
K(biotinyl)-KEDVV-Abu-CS-Abu-SYKK-NH2 is a peptide that the primary structure is: Lys(biotinyl)-Lys-Glu-Asp-Val-Val-Abu-Cys-Ser-Abu-Ser-Tyr-Lys-Lys-NH2.
|
- HY-P3858
-
|
Amyloid-β
|
Neurological Disease
|
(D-Asp1)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .
|
- HY-P0322A
-
EMD 56574 TFA
|
Integrin
|
Cardiovascular Disease
Metabolic Disease
|
GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption .
|
- HY-P3497A
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker, involves in the synthesis of releasable oligopeptide linker. Releasable oligopeptide linker can be used to deliver agent to a bone fracture-homing oligopeptide and reduces fractured femur healing times .
|
- HY-P4412
-
|
Peptides
|
Others
|
H-Lys-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4539
-
|
Peptides
|
Others
|
H-Thr-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P3787
-
|
Peptides
|
Metabolic Disease
|
Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2 is the SH2 domain ligand. SH2 domains participate in protein tyrosine kinase (PTK)-mediated cellular signal .
|
- HY-P4377
-
|
Peptides
|
Others
|
H-Leu-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4501
-
|
Peptides
|
Others
|
H-Ser-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4472
-
|
Peptides
|
Others
|
H-Phe-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4660
-
|
Peptides
|
Others
|
H-Val-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4234
-
|
Peptides
|
Others
|
H-Gly-Asp-Gly-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4258
-
|
Peptides
|
Others
|
Arg-Gly-Asp-Ser-Pro is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P1816
-
|
Integrin
|
Cancer
|
The connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. Fibronectin CS1 Peptide lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models .
|
- HY-P4945
-
|
Peptides
|
Others
|
Biotinyl-(εAhx)-Gly-Arg-Gly-Asp-Ser is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P5510
-
HCV NS3 protease substrate
|
Peptides
|
Others
|
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 355/500 nm.)
|
- HY-P4320
-
|
Integrin
|
Cancer
|
Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10), a decapeptide containing a cyclic RGD active sequence, is an Integrin αIIbβ3 antagonist that inhibits platelet and Adhesion of proMMP-13 .
|
- HY-P4730
-
|
Peptides
|
Others
|
(β-D-Asp28)-Exenatide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4307
-
|
SARS-CoV
|
Infection
|
Antioxidant agent-9 is a peptide with the sequence Asp-Trp. Antioxidant agent-9 shows antioxidant activity. Antioxidant agent-9 also is potential as SARS-CoV-2 antiviral, with an affinity strength equal to Chloroquine (HY-17589A) and Favipiravir (HY-14768) .
|
- HY-P5000
-
H-Asp-Tyr-OH
|
Peptides
|
Others
|
Cholecystokinin Octapeptide (1-2) (desulfated) (H-Asp-Tyr-OH) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P10215
-
|
Parasite
|
Infection
|
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
|
- HY-P0178
-
|
Integrin
|
Inflammation/Immunology
|
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .
|
- HY-P0178A
-
|
Integrin
|
Inflammation/Immunology
|
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .
|
- HY-P3732
-
|
Integrin
|
Cancer
|
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .
|
- HY-P4919
-
|
Beta-secretase
|
Others
|
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
|
- HY-P5365
-
|
Peptides
|
Others
|
[Asn23] β-Amyloid (1-40), Iowa mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.)
|
- HY-P5331
-
|
Peptides
|
Others
|
[Asn23]-beta-Amyloid (1-42), iowa mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.)
|
-
- HY-KE7022
-
|
MCE Kpn I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Asp718 I, Acc65 I.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99413
-
Asp1650
|
HCV
|
Cancer
|
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 + ovarian and testicular cancer cell lines .
|
-
- HY-P991084
-
|
PD-1/PD-L1
|
Cancer
|
TQB-2858 is a bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor. TQB-2858 has a high affinity for PD-L1, TGF-β1, and TGF-β3 and exhibited high PD-L1 target occupancy. TQB-2858 can be used for the study of osteosarcoma and alveolar soft part sarcoma (ASPS) .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-12432S1
-
|
Gilteritinib-d8 is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
|
-
-
- HY-Y0313S
-
|
p-Hydroxybenzaldehyde-d4 is the deuterium labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
|
-
-
- HY-Y1169S1
-
|
Fmoc-Asp(OtBu)-OH- 13C4, 15N is the 13C and 15N labeled Fmoc-Asp(OtBu)-OH[1]. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis[2].
|
-
-
- HY-Y1169S2
-
|
Fmoc-Asp(OtBu)-OH-d3 (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate-d3) is deuterium labeled Fmoc-Asp(OtBu)-OH. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
|
-
-
- HY-14894S2
-
|
Pragliflozin- 13C6 (ASP1941- 13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
-
- HY-Y0313S1
-
|
p-Hydroxybenzaldehyde- 13C is the 13C-labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-P10303
-
Cyclo[RGDfK(Azide)]
|
|
Azide
|
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
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