Search Result

Results for "

PDGFR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PDGFR (167) Akt (1) AMPK (1) Apoptosis (44) Aurora Kinase (3) Autophagy (51) Bcr-Abl (22) c-Fms (11) c-Kit (70) c-Met/HGFR (4) c-Myc (1) Casein Kinase (1) CDK (2) Checkpoint Kinase (Chk) (1) Discoidin Domain Receptor (2) DNA-PK (1) Dopamine Receptor (1) Drug Metabolite (13) EGFR (10) Endogenous Metabolite (1) Ephrin Receptor (2) ERK (2) FAK (2) Ferroptosis (5) FGFR (59) FLT3 (30) Haspin Kinase (1) IGF-1R (1) Influenza Virus (1) IRE1 (6) Isotope-Labeled Compounds (12) JAK (1) MEK (1) MELK (1) Mitophagy (6) mTOR (2) Necroptosis (2) PI3K (3) PROTACs (1) RAD51 (2) Raf (14) RET (21) RIP kinase (1) SARS-CoV (5) Src (21) TGF-β Receptor (1) Tie (5) Tyrosinase (1) VEGFR (119)
By Research Areas:	Cancer (188) Cardiovascular Disease (13) Infection (4) Inflammation/Immunology (8) Neurological Disease (2)
Oligonucleotides:	Aptamers (1)

215

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

PDGFR Tyrosine Kinase Inhibitor III PDGF Receptor Tyrosine Kinase Inhibitor III	PDGFR	Neurological Disease
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III), a multikinase inhibitor, inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGFR Tyrosine Kinase Inhibitor III can be used for the research of amyotrophic lateral sclerosis .

PDGFR-IN-1	PDGFR Apoptosis	Cancer
PDGFR-IN-1 (compound 7m) is a potent and orally active *PDGFR* (platelet-derived growth factor receptor) inhibitor, with IC₅₀ values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma .

740 Y-P 155+ Cited Publications 740YPDGFR; PDGFR 740Y-P	PI3K Autophagy	Cancer
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

PDGFRα kinase inhibitor 1	PDGFR	Cancer
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC₅₀s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively .

PDGFR Y1021 peptide (non-phosphorylation)	PDGFR	Others
PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response .

PDGFRα/β/VEGFR-2-IN-1	PDGFR VEGFR	Cancer
PDGFRα/β/VEGFR-2-IN-1 (6f), a multiple PDGFRα/ß and VEGFR-2 tyrosine kinase inhibitor, particularly targets PDGFRα, PDGFRβ, and VEGFR-2 kinases with Nano molar concentrations .

PDGFRα/FLT3-ITD-IN-2	PDGFR FLT3	Cancer
PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .

PDGFRα/FLT3-ITD-IN-3	PDGFR FLT3	Cancer
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of 0.153 and 0.004 μM, respectively. PDGFRα/FLT3-ITD-IN-3 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .

PDGFRα/FLT3-ITD-IN-1	PDGFR FLT3	Cancer
PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .

740 Y-P TFA 740YPDGFR TFA; PDGFR 740Y-P TFA	PI3K Autophagy	Cancer
740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

PDGFRα kinase inhibitor 2	Bcr-Abl c-Kit PDGFR	Cancer
PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC₅₀s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt .

AG 1295 3 Publications Verification	PDGFR	Cardiovascular Disease
AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR whereas not affects the autophosphorylation of the EGF receptor .

N-Desmethyl imatinib Norimatinib; Imatinib metabolite N-Desmethyl imatinib	Drug Metabolite	Others
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

N-Desmethyl imatinib mesylate Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate	Drug Metabolite	Others
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

N-Desmethyl imatinib-d4 Norimatinib-d₄; Imatinib metabolite N-Desmethyl imatinib-d₄	Isotope-Labeled Compounds	Others
N-Desmethyl imatinib-d₄ is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d₄ (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

PD168393 2 Publications Verification	EGFR Autophagy Apoptosis	Cancer
PD168393?is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC₅₀=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC .

Tyrphostin AG1112	Casein Kinase Tyrosinase	Cancer
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210 ^bcr-abl tyrosine kinase, with IC₅₀ values of 2, 15, 20 μM in p210 ^bcr-abl, EGFR and PDGFR cells, respectively .

KBP-7018	c-Kit RET PDGFR	Infection
KBP-7018 is a tyrosine kinase-selective inhibitor. KBP-7018 has potent inhibitory effects on c-KIT, PDGFR, and RET with IC₅₀ values of 10 nM, 7.6 nM and 25 nM, respectively. KBP-7018 can be used for the research of idiopathic pulmonary fibrosis .

KBP-7018 hydrochloride	c-Kit RET PDGFR	Infection
KBP-7018 hydrochloride is a tyrosine kinase-selective inhibitor. KBP-7018 hydrochloride has potent inhibitory effects on c-KIT, PDGFR, and RET with IC₅₀ values of 10 nM, 7.6 nM and 25 nM, respectively. KBP-7018 hydrochloride can be used for the research of idiopathic pulmonary fibrosis .

Ansornitinib ANG-3070	VEGFR PDGFR	Cardiovascular Disease Inflammation/Immunology
Ansornitinib is an orally active dual kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2). Ansornitinib can be used as an antifibrotic agent in lung, liver, kidney, and gastrointestinal fibrotic diseases .

Henatinib	VEGFR c-Kit PDGFR	Cancer
Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, *PDGFR* with IC₅₀ values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs) .

Multi-kinase-IN-3	VEGFR PDGFR	Cancer
Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC₅₀ values of 58.3 and 55 nM, respectively .

Vorolanib CM082; X-82	VEGFR PDGFR	Cardiovascular Disease Cancer
Vorolanib (CM082) is an orally active, potent multikinase *VEGFR/PDGFR* inhibitor. Vorolanib is a potent ATP-binding cassette (ABC) transporter inhibitor. Vorolanib is an angiogenesis inhibitor and has antitumor activity combined with ZD1839 (HY-50895) .

Tyrphostin AG1296 1 Publications Verification AG1296	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀ in the micromolar range .

CP-673451 10+ Cited Publications	PDGFR	Cancer
CP-673451 is a potent and selective inhibitor of *PDGFR* with IC₅₀s of 10 and 1 nM for PDGFRα and PDGFRβ, respectively.

Isosorbide mononitrate 4 Publications Verification Isosorbide-5-mononitrate	Autophagy Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

SU-4313	PDGFR EGFR IGF-1R	Cancer
SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC₅₀s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation .

Multi-kinase-IN-2	VEGFR PDGFR FGFR c-Kit Akt Src Apoptosis	Cancer
Multi-kinase-IN-2 (compound 7h) is an orally active and potent angiokinase inhibitor. Multi-kinase-IN-2 exhibits excellent inhibitory activity against angiokinases including VEGFR-1/2/3, PDGFRα/β, and FGFR-1, as well as LYN and c-KIT kinases. Multi-kinase-IN-2 significantly attenuates phosphorylation of AKT and ERK proteins. Multi-kinase-IN-2 induces cell apoptosis. Multi-kinase-IN-2 shows anticancer activity .

SU16f 1 Publications Verification	PDGFR	Cancer
SU16f is a potent and selective PDGFRβ inhibitor with IC₅₀s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively . Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration .

AC710	PDGFR c-Kit FLT3	Cancer
AC710 is a potent *PDGFR* inhibitor with K_ds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

AC710 Mesylate	PDGFR	Cancer
AC710 Mesylate is a potent *PDGFR* inhibitor with K_ds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

Tovetumab MEDI-575	PDGFR	Cancer
Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC) .

Cediranib maleate 5+ Cited Publications AZD-2171 maleate	VEGFR Autophagy PDGFR	Cancer
Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC₅₀s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.

Sch 13835	PDGFR	Cardiovascular Disease
Sch 13835 is a platelet-derived growth factor (PDGFR) inhibitor .

Cediranib 5+ Cited Publications AZD2171	VEGFR Autophagy PDGFR	Cancer
Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC₅₀s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.

N-Desethyl Sunitinib 5+ Cited Publications SU-12662	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

N-Desethyl Sunitinib hydrochloride 5+ Cited Publications SU-12662 hydrochloride	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

Seralutinib 1 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

WQ-C-401	PDGFR ERK	Cardiovascular Disease
WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking *PDGFR* autophosphorylation in a concentration-dependent manner, with EC₅₀ values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension .

Toceranib SU11654; PHA 291639E	PDGFR VEGFR c-Kit	Cancer
Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits *PDGFR, VEGFR, and Kit* with K_is of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors .

Toceranib phosphate SU11654 phosphate; PHA 291639E phosphate	PDGFR VEGFR c-Kit	Cancer
Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits *PDGFR, VEGFR, and Kit* with K_is of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors .

AGL 2043	PDGFR FLT3	Cancer
AGL 2043 is an effective inhibitor of *PDGFR* (IC₅₀=0.8 μM) and *TEL-PDGFR* kinases, as well as FLT3 and KIT kinases. AGL 2043 can effectively inhibit porcine cardiac smooth muscle cell proliferation and balloon-induced vascular stenosis, and is suitable for development as an anti-restenotic and anticancer agent .

Gint4.T aptamer sodium	PDGFR	Cancer
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .

Cediranib (Standard)	VEGFR Autophagy PDGFR	Cancer
Cediranib (Standard) is the analytical standard of Cediranib. This product is intended for research and analytical applications. Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC₅₀s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.

KN1022	PDGFR	Cardiovascular Disease
KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM .

N-Desethyl Sunitinib-d5	Isotope-Labeled Compounds Drug Metabolite	Cancer
N-Desethyl Sunitinib-d₅ is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].

Cat. No.	Product Name

HY-L016

Protein Tyrosine Kinase Compound Library

1,212 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,212 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L088

Angiogenesis-Related Compound Library

2,356 compounds

Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).

MCE offers a unique collection of 2,356 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

Cat. No.	Product Name	Type

HY-50751G

Linifanib (GMP)

ABT-869 (GMP); AL-39324 (GMP)

Fluorescent Dye

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells .

HY-10407G

SU 5402 (GMP)	Fluorescent Dye
SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC₅₀ of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively .

Cat. No.	Product Name	Type

HY-50751G

Linifanib (GMP)

ABT-869 (GMP); AL-39324 (GMP)

Biochemical Assay Reagents

HY-10407G

SU 5402 (GMP)	Biochemical Assay Reagents
SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC₅₀ of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P0175

740 Y-P 155+ Cited Publications 740YPDGFR; PDGFR 740Y-P	PI3K Autophagy	Cancer
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

HY-P10270

PDGFR Y1021 peptide (phosphorylation)	Peptides	Others
PDGFR Y1021 peptide (phosphorylation) is the phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (phosphorylation) supports association of PLCγ to PDGFR through PLCγSH2 domains, and thus promotes the production of inositol phosphates and mitogenic response .

HY-P10119

PDGFR Y1021 peptide (non-phosphorylation)	PDGFR	Others
PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response .

HY-P0175A

740 Y-P TFA 740YPDGFR TFA; PDGFR 740Y-P TFA	PI3K Autophagy	Cancer
740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

Cat. No.	Product Name	Target	Research Area

HY-P99223

Tovetumab MEDI-575	PDGFR	Cancer
Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC) .

HY-P9922

Olaratumab IMC-3G3; LY3012207	PDGFR	Cancer
Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity .

Recombinant Proteins Recommended:

PDGFR

Species:	Human (10) Rhesus Macaque (2) Rat (4) Mouse (2) Cynomolgus (1) Canine (1)
Tag:	His (14) Avi (5) Fc (6)
Source:	HEK293 (19) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P78194

	PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi) JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β	Human	HEK293
	PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P72494

	PDGF R beta Protein, Human (HEK293, His) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDGF R beta Protein, Human (HEK293, His) is 499 a.a., with molecular weight of 85-130 kDa.

HY-P77129

	PDGF R beta Protein, Rhesus Macaque (HEK293, His) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rhesus Macaque	HEK293
	PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Rhesus Macaque (HEK293, His) is 498 a.a., with molecular weight of ~80-96 KDa.

HY-P77123

	PDGF R beta Protein, Human (HEK293, C-His-Avi) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P700810

	PDGF R beta Protein, Canine (HEK293, His) JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β	Canine	HEK293
	PDGF R beta Protein is a tyrosine protein kinase that plays an important role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. PDGF R beta Protein, Canine (HEK293, His) is the recombinant canine-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Canine (HEK293, His) is 501 a.a., with molecular weight of 70-100 kDa.

HY-P77124

	PDGF R beta Protein, Human (HEK293, Fc) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, Fc) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PDGF R beta Protein, Human (HEK293, Fc) is 498 a.a., with molecular weight of ~82.8 KDa.

HY-P77127

	PDGF R beta Protein, Human (Biotinylated, HEK293, His) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Human (Biotinylated, HEK293, His) is 499 a.a., with molecular weight of ~57.6 KDa.

HY-P77128

	PDGF R beta Protein, Rhesus Macaque (HEK293, Fc) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rhesus Macaque	HEK293
	PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78506

	PDGF R alpha Protein, Human (HEK293, His-Avi) PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2	Human	HEK293
	PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, His-Avi) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78193

	PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2	Human	HEK293
	PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is 501 a.a., with molecular weight of 70-83 kDa.

HY-P73356

	PDGF R alpha Protein, Human (HEK293, Fc) Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA	Human	HEK293
	PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73721

	PDGF R alpha Protein, Rat (HEK293, His) Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA	Rat	HEK293
	PDGF R alpha protein is a tyrosine protein kinase receptor for PDGFA, PDGFB, and PDGFC that coordinates embryonic development, cell proliferation, survival, and chemotaxis. Their functions vary, promoting or inhibiting cell proliferation and migration depending on the situation. PDGF R alpha Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R alpha protein, expressed by HEK293 , with C-His labeled tag.

HY-P73722

	PDGF R alpha Protein, Rat (HEK293, Fc) Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA	Rat	HEK293
	PDGF R alpha protein is a tyrosine protein kinase receptor for PDGFA, PDGFB, and PDGFC that coordinates embryonic development, cell proliferation, survival, and chemotaxis. Their functions vary, promoting or inhibiting cell proliferation and migration depending on the situation. PDGF R alpha Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R alpha protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74645

	PDGF R alpha Protein, Mouse (HEK293, Fc) Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA	Mouse	HEK293
	PDGF R α is a tyrosine-protein kinase receptor with critical effects on embryonic development, cell proliferation, survival, and chemotaxis. Its effects on cell behavior vary depending on the environment and is critical for differentiation of bone marrow mesenchymal stem cells, normal skeletal development, embryonic skull closure, and gastrointestinal mucosal formation. PDGF R alpha Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PDGF R alpha protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700809

	PDGF R alpha Protein, Cynomolgus (501a.a, HEK293, His) PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2	Cynomolgus	HEK293
	PDGF R alpha Protein, a tyrosine-protein kinase receptor, crucially influences embryonic development, regulating cell proliferation, survival, and chemotaxis. Its effects on cell behavior vary contextually, either promoting or inhibiting proliferation and migration. Additionally, it plays a significant role in differentiating bone marrow-derived mesenchymal stem cells and is essential for normal skeletal development. PDGF R alpha Protein, Cynomolgus (501a.a, HEK293, His) is the recombinant cynomolgus-derived PDGF R alpha protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R alpha Protein, Cynomolgus (501a.a, HEK293, His) is 501 a.a., with molecular weight of 70-85 kDa.

HY-P702756

	PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) PDGFRB; platelet-derived growth factor receptor, beta polypeptide; PDGFR; platelet-derived growth factor receptor beta; CD140b; JTK12; PDGFR1; PDGFR-beta; PDGF-R-beta; CD140 antigen-like family member B; platelet-derived growth factor receptor 1; beta-type platelet-derived growth factor receptor; CD140B; PDGFR-1	Human	Sf9 insect cells
	PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) is the recombinant human-derived PDGF R beta, expressed by Sf9 insect cells , with Avi, His labeled tag. ,

HY-P72495

	PDGF R alpha Protein, Human (HEK293, His) Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-2; CD140a; PDGFRA	Human	HEK293
	PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, His) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72496

	PDGF R alpha Protein, Mouse (HEK293, His) Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-2; CD140a; PDGFRA	Mouse	HEK293
	PDGF R α is a tyrosine-protein kinase receptor with critical effects on embryonic development, cell proliferation, survival, and chemotaxis.Its effects on cell behavior vary depending on the environment and is critical for differentiation of bone marrow mesenchymal stem cells, normal skeletal development, embryonic skull closure, and gastrointestinal mucosal formation.PDGF R alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived PDGF R alpha protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73360

	PDGF R beta Protein, Rat (HEK293, His) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rat	HEK293
	PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P74644

	PDGF R beta Protein, Rat (HEK293, Fc) Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rat	HEK293
	PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.

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HY-P80510

	PDGFR alpha Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse
	PDGFR alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 123 kDa, targeting to PDGFR alpha. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P82180

	PDGFR beta Antibody (YA1925) PDGFRB; PDGFR; PDGFR1; PDGFRβ; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri	WB, IP	Human, Mouse, Rat
	PDGFR beta Antibody (YA1925) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1925), targeting PDGFR beta, with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). PDGFR beta Antibody (YA1925) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80278

	*Phospho-PDGFR* beta (Y740) Antibody**	WB, ICC/IF	Human, Rat
	Phospho-PDGFR beta (Y740) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 124 kDa, targeting to Phospho-PDGFR beta (Y740). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Rat.

HY-P83317

	*Phospho-PDGFR* beta (Tyr740) Antibody (YA3062)** PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri	WB, ICC/IF	Mouse, Rat
	Phospho-PDGFR beta (Tyr740) Antibody (YA3062) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3062), targeting Phospho-PDGFR beta (Tyr740), with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). Phospho-PDGFR beta (Tyr740) Antibody (YA3062) can be used for WB, ICC/IF experiment in mouse, rat background.

HY-P83737

	PDGF Receptor beta Antibody (YA3467) PDGFRB; PDGFR; PDGFR1; PDGFRβ; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PDGF Receptor beta Antibody (YA3467) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3467), targeting PDGFR beta, with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). PDGFR beta Antibody (YA3467) can be used for WB, IHC-P, IP, FC, IF-Tissue, IF-Cell, mIHC experiment in human, mouse, rat background.

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HY-160053

Gint4.T aptamer sodium		Aptamers
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .

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