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Results for "

Raw 264.7

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (30) Cardiovascular Disease (14) Endocrinology (3) Infection (24) Inflammation/Immunology (164) Metabolic Disease (21) Neurological Disease (15)
Click Chemistry:	Azide (1)
Oligonucleotides:	CpG ODNs (2)

202

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Natural
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Isotope-Labeled Compounds

Click Chemistry

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2620

Rutaevin	Reactive Oxygen Species	Inflammation/Immunology
Rutaevin is isolated from the fruits of Euodia rutaecarpa. Rutaevin inhibits NO production in LPS-induced RAW 264.7 macrophages .

HY-125531

Dactylorhin A	Others	Others
Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .

HY-N1494

(+)-14-Deoxy-ε-caesalpin 14-Deoxy-ε-caesalpin	NO Synthase	Inflammation/Immunology
(+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS) .

HY-N10297

Curindolizine	Others	Inflammation/Immunology
Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC₅₀ value of 5.31 μM .

HY-N3646

Cudratricusxanthone A	Others	Others Neurological Disease Inflammation/Immunology Cancer
Cudratricusxanthone A is isolated from Cudrania tricuspidata, and has anti-inflammatory, hepatoprotective, and anti-proliferative activities. Cudratricusxanthone A inhibits osteoclast differentiation and function in RAW 264.7 cells and mouse bone marrow monocytes .

HY-149650

TLR4 agonist-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells .

HY-N1186

Tachioside	Glucosidase	Metabolic Disease
Tachioside inhibits nitric oxide production in lipopolysaccharide (HY-D1056)-stimulated RAW 264.7 cells with IC₅₀ value of 12.14 μM. Tachioside has anti-obesity, antioxidant and α-glucosidase inhibitory activities .

HY-149650A

TLR4 agonist-1 TEA	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (TEA) (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells .

HY-N9891

12-Dehydrogingerdione 12-DHGD	NO Synthase Interleukin Related	Inflammation/Immunology
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-114730

CGA-JK3	IKK	Inflammation/Immunology
CGA-JK3 is CGA-JK3 is an ATP-competitive inhibitor of IKKβ-catalyzed kinase activity. CGA-JK3 inhibits IκBα phosphorylation in LPS (HY-D1056) - induced RAW 264.7 cells .

HY-162425

Anti-inflammatory agent 78	PGE synthase COX	Inflammation/Immunology Cancer
Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line .

HY-164361

2′-Hydroxy-2,3-dimethoxychalcone	NO Synthase	Inflammation/Immunology
α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells .

HY-N0569

Madecassic acid 1 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-156431

Anti-inflammatory agent 61	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces TNF-α expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells .

HY-N8719

Pratol 7-Hydroxy-4'-methoxyflavone	NF-κB	Inflammation/Immunology
Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .

HY-126211

KBH-A42	HDAC	Inflammation/Immunology
KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC₅₀ values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells .

HY-N10120

Methylsyringin	Others	Inflammation/Immunology
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-W573700

Methyl everninate	Others	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-N8160

Dehydrocurdione	Keap1-Nrf2 Reactive Oxygen Species	Inflammation/Immunology
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-N13175

Panaxcerol B	NO Synthase	Cancer
Panaxcerol B is a monogalactosyl monoacylglyceride, with an IC₅₀ of 59.4 μM for NO production in LPS-stimulated RAW264.7 cells .

HY-163355

COX-2/15-LOX-IN-5	COX Lipoxygenase NF-κB	Inflammation/Immunology
COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .

HY-N4207

Cnidicin	Others	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N3392

Lethedoside A	NO Synthase	Inflammation/Immunology
Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells .

HY-N10111

Siegesbeckialide I	IKK	Inflammation/Immunology
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.

HY-N2838

Alismol	NO Synthase	Inflammation/Immunology
Alismol is a natural sesquiterpene. Alismol shows promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells .

HY-N10062

Amakusamine	RANKL/RANK	Others
Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

HY-130787

Apterin	NO Synthase	Inflammation/Immunology
Apterin is a natural compound with anti-inflammatory activity. Apterin shows significantly inhibitory activity on NO production in RAW264.7 cells with an IC₅₀ value of 41.8 μM .

HY-N10114

Hyperectumine	Others	Inflammation/Immunology
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	NO Synthase	Inflammation/Immunology
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-161043

ECDD-S16	Pyroptosis	Inflammation/Immunology
ECDD-S16 is a potent inhibitor of pyroptosis. ECDD-S16 inhibits surface and endosomal TLR ligands activated pyroptosis in Raw264.7 cells .

HY-N11544

Inflexuside B	NO Synthase	Inflammation/Immunology
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .

HY-N11548

Inflexuside A	NO Synthase	Inflammation/Immunology
Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .

HY-149647

HD-2a	Others	Inflammation/Immunology
HA-2a can inhibit the JAK2/STAT3 pathway via downregulates circDcbld2 expression in RAW264.7 cells .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N2939

Bis-5,5-Nortrachelogenin	Others	Others
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC₅₀ value of 48.6 mM .

HY-129151

Ganoderic acid C1	Others	Inflammation/Immunology
Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .

HY-139844

Anti-inflammatory agent 7	p38 MAPK NF-κB	Inflammation/Immunology
Anti-inflammatory agent 7 inhibits proinflammatory cytokines by blocking the NF-κB/MAPK signaling pathway in LPS-treated RAW 264.7 cells as well as mice.

HY-N9896

Anhydronotoptol	NO Synthase	Inflammation/Immunology
Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC₅₀ value of 36.6 μM .

HY-N12283

NF-κB-IN-13	NF-κB	Inflammation/Immunology
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-N1695

Demethylregelin Regelin acid	NO Synthase	Inflammation/Immunology
Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of iNOS protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .

HY-N13184

Giraldoid B	TNF Receptor	Inflammation/Immunology
Giraldoid B is an active ingredient that can be isolated from Girald Daphne Bark. Giraldoid B can inhibit LPS induced NO and b>TNF-α production in RAW264.7 and has anti-inflammatory activity .

HY-149671

Anti-inflammatory agent 63	Others	Inflammation/Immunology
Anti-inflammatory agent 63 is an anti-inflammatory agent that shows optimal inhibitory activity (EC₅₀ = 5.33±0.57 μM) against the production of nitric oxide (NO) induced by lipopolysaccharide (LPS) in RAW264.7 cells .

HY-125495

Telmesteine	Others	Inflammation/Immunology
Telmesteine is an amucolitic agent. Telmesteine has anti-protease activity. Telmesteine inhibits LPS-induced NO production in RAW264.7 cells. Telmesteine can be used for research of inflammation, such as acute and chronic bronchitis and obstructive airways disease .

HY-N13138

Angulasaponin B	NO Synthase	Inflammation/Immunology
Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC₅₀ values ranging from 13 μM to 24 μM .

HY-N10865

Chloranthalactone E	NO Synthase	Inflammation/Immunology
Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages .

HY-N1080

Vitexdoin A	Others	Inflammation/Immunology
Vitexdoin A is a nitric oxide scavenging lignin. Vitexdoin A inhibits NO production with an IC₅₀ of 0.38 μM in LPS (HY-D1056)-stimulated RAW 264.7 cells .

HY-N4207R

Cnidicin (Standard)	Others	Others
Cnidicin (Standard) is the analytical standard of Cnidicin. This product is intended for research and analytical applications. Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N12494

Diplacol	NO Synthase	Inflammation/Immunology
Diplacol is a geranylated flavanone that can be isolated from paulownia trees (Paulownia coreana UYEKI). Diplacol has anti-inflammatory activity. Diplacol inhibits NO production in LPS-stimulated Raw264.7 cells with an IC₅₀ value of 4.53 μM .

HY-N11570

Phaeocaulisin E	Others	Inflammation/Immunology
Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 10.3 μM .

HY-134467

Phylloflavan	Parasite	Infection
Phylloflavan is an antileishmanial agent with an intracellular EC₅₀ of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL) .

Cat. No.	Product Name	Type

HY-W013435

1,2-Diaminoanthraquinone	Fluorescent Dyes/Probes
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .

Cat. No.	Product Name	Type

HY-W042416

N,N-Dimethylacetamide 1 Publications Verification DMAc	Co-solvents
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .

HY-W042416R

N,N-Dimethylacetamide (Standard)

Co-solvents

N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P10329

KK14(R)	Fungal	Infection
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2620

Rutaevin	Other Terpenoids Classification of Application Fields Terpenoids Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
Rutaevin is isolated from the fruits of Euodia rutaecarpa. Rutaevin inhibits NO production in LPS-induced RAW 264.7 macrophages .

HY-125531

Dactylorhin A	Bletilla striata (Thunb. ex Murray) Rchb. f. Classification of Application Fields Ketones, Aldehydes, Acids Orchidaceae Source classification Other Diseases Plants Disease Research Fields	Others
Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .

HY-N0569

Madecassic acid 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	NO Synthase COX TNF Receptor Interleukin Related
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-N10120

Methylsyringin	Classification of Application Fields Simple Phenylpropanols Carthamus tinctorius L. Source classification Phenylpropanoids Plants Compositae Disease Research Fields Inflammation/Immunology	Others
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-N10297

Curindolizine	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Others
Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC₅₀ value of 5.31 μM .

HY-N3646

Cudratricusxanthone A	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Other Flavonoids	Others
Cudratricusxanthone A is isolated from Cudrania tricuspidata, and has anti-inflammatory, hepatoprotective, and anti-proliferative activities. Cudratricusxanthone A inhibits osteoclast differentiation and function in RAW 264.7 cells and mouse bone marrow monocytes .

HY-N1186

Tachioside	Structural Classification Monophenols Agrostidoideae Source classification Phenols Plants Triticum aestivum L.	Glucosidase
Tachioside inhibits nitric oxide production in lipopolysaccharide (HY-D1056)-stimulated RAW 264.7 cells with IC₅₀ value of 12.14 μM. Tachioside has anti-obesity, antioxidant and α-glucosidase inhibitory activities .

HY-N9891

12-Dehydrogingerdione 12-DHGD	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	NO Synthase Interleukin Related
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-N8719

Pratol 7-Hydroxy-4'-methoxyflavone	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Trifolium pratense Linn.	NF-κB
Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .

HY-W573700

Methyl everninate	Structural Classification other families Source classification Plagiochila bifaria (Sw.) Lindenb. Phenols Plants	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-N8160

Dehydrocurdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Zingiberaceae	Keap1-Nrf2 Reactive Oxygen Species
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-N13175

Panaxcerol B	Panax ginseng C. A. Meyer Structural Classification Source classification Plants Saccharides Araliaceae Monosaccharides	NO Synthase
Panaxcerol B is a monogalactosyl monoacylglyceride, with an IC₅₀ of 59.4 μM for NO production in LPS-stimulated RAW264.7 cells .

HY-N4207

Cnidicin	Structural Classification Classification of Application Fields Source classification Other Diseases Coumarins Phenylpropanoids Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC.	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N3392

Lethedoside A	Structural Classification Flavonoids Flavones Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	NO Synthase
Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells .

HY-N10111

Siegesbeckialide I	Classification of Application Fields Terpenoids Pterocarpus macrocarpus Kurz Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	IKK
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.

HY-N2838

Alismol	Structural Classification Animals Terpenoids Sesquiterpenes Source classification	NO Synthase
Alismol is a natural sesquiterpene. Alismol shows promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells .

HY-N10062

Amakusamine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	RANKL/RANK
Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

HY-130787

Apterin	Structural Classification Carpesium divaricatum Siebold & Zucc. Source classification Plants Umbelliferae Saccharides Monosaccharides	NO Synthase
Apterin is a natural compound with anti-inflammatory activity. Apterin shows significantly inhibitory activity on NO production in RAW264.7 cells with an IC₅₀ value of 41.8 μM .

HY-N10114

Hyperectumine	Alkaloids Classification of Application Fields Source classification Hypecoum erectum L. Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae	Others
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Inflammation/Immunology	NO Synthase
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-N11544

Inflexuside B	Structural Classification Natural Products Labiatae Source classification Artemisia tanacetifolia L. Plants	NO Synthase
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .

HY-N11548

Inflexuside A	Structural Classification Terpenoids Labiatae Source classification Artemisia tanacetifolia L. Diterpenoids Plants	NO Synthase
Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .

HY-N1912

Andropanolide	Structural Classification Natural Products Andrographis paniculata (Burm. F.) Nees Acanthaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Others
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N2939

Bis-5,5-Nortrachelogenin	Structural Classification Thymelaeaceae Source classification Lignans Phenylpropanoids Plants Wikstroemia indica	Others
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC₅₀ value of 48.6 mM .

HY-129151

Ganoderic acid C1	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Inflammation/Immunology	Others
Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .

HY-N9896

Anhydronotoptol	Structural Classification Natural Products Source classification Plants Umbelliferae Kleinia odora (Forssk.) DC.	NO Synthase
Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC₅₀ value of 36.6 μM .

HY-N12283

NF-κB-IN-13	Structural Classification Natural Products Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	NF-κB
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-N1695

Demethylregelin Regelin acid	Structural Classification Terpenoids Source classification Celastraceae Plants Pentacyclic Triterpenoids Euonymus alatus (Thunb.) Sieb.	NO Synthase
Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of iNOS protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .

HY-N13184

Giraldoid B	Structural Classification Thymelaeaceae Source classification Daphne giraldii Nitsche Coumarins Phenylpropanoids Plants	TNF Receptor
Giraldoid B is an active ingredient that can be isolated from Girald Daphne Bark. Giraldoid B can inhibit LPS induced NO and b>TNF-α production in RAW264.7 and has anti-inflammatory activity .

HY-N13138

Angulasaponin B	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Vigna angularis (Willd.) Ohwi et Ohashi Plants	NO Synthase
Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC₅₀ values ranging from 13 μM to 24 μM .

HY-N10865

Chloranthalactone E	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	NO Synthase
Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages .

HY-N1080

Vitexdoin A	Structural Classification Verbenaceae Source classification Lignans Phenylpropanoids Plants Vitex negundo Linn.	Others
Vitexdoin A is a nitric oxide scavenging lignin. Vitexdoin A inhibits NO production with an IC₅₀ of 0.38 μM in LPS (HY-D1056)-stimulated RAW 264.7 cells .

HY-N4207R

Cnidicin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Plants Echinacea angustifolia DC.	Others
Cnidicin (Standard) is the analytical standard of Cnidicin. This product is intended for research and analytical applications. Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N12494

Diplacol	Structural Classification other families Source classification Paulownia coreana UYEKI Phenols Polyphenols Plants	NO Synthase
Diplacol is a geranylated flavanone that can be isolated from paulownia trees (Paulownia coreana UYEKI). Diplacol has anti-inflammatory activity. Diplacol inhibits NO production in LPS-stimulated Raw264.7 cells with an IC₅₀ value of 4.53 μM .

HY-N11570

Phaeocaulisin E	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Zingiberaceae	Others
Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 10.3 μM .

HY-134467

Phylloflavan	Structural Classification other families Phyllocladus alpinus Source classification Phenols Polyphenols Plants	Parasite
Phylloflavan is an antileishmanial agent with an intracellular EC₅₀ of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL) .

HY-N2794

9-Hydroxy-α-lapachone α-Dihydrocaryopterone	Quinones Structural Classification Catalpa ovata G. Don Monophenols Source classification Phenols Plants Bignoniaceae Naphthalene Quinones	NO Synthase
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC₅₀ of 4.64 µM on LPS-induced NO production in RAW 264.7 cells .

HY-N3211

N-cis-Feruloyl tyramine cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-Feruloyltyramine	Structural Classification Annona cherimola Mill. Source classification Phenols Polyphenols Plants Annonaceae	NO Synthase
N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells .

HY-N9000

Loganic acid 6′-O-β-D-glucoside	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields Gentiana rhodantha Franch. ex Hemsl.	TNF Receptor
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

HY-N3383

Ligustroside Ligstroside	Monophenols Iridoids Oleaceae Ligustrum japonicum Thunb. Terpenoids Source classification Phenols Plants	Mitochondrial Metabolism
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .

HY-N6893

Ergolide 2 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Compositae Inflammation/Immunology Disease Research Fields Piptanthus nepalensis (Hook.) D. Don	NF-κB
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .

HY-N12429

Marstenacisside F1	Structural Classification Polysaccharides Source classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Saccharides	Others
Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.

HY-N11058

Damnacanthol	Quinones Structural Classification Monophenols Anthraquinones Source classification Rubiaceae Phenols Plants Damnacanthus major Sieb. et Zucc.	Lipoxygenase NO Synthase
Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .

HY-N11657

Sanggenon A Sanggenone A	Structural Classification Flavonoids Source classification Morus alba L. Plants Moraceae Other Flavonoids	NF-κB Keap1-Nrf2
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .

HY-N0223

Epibetulinic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Endocrinology	NO Synthase Prostaglandin Receptor
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC₅₀s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity .

HY-124508

Lambertellin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal p38 MAPK NF-κB
Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways .

HY-N0634

Cimifugin 1 Publications Verification Cimitin	Structural Classification Classification of Application Fields Ranunculaceae Coumarins Phenylpropanoids Plants Cimicifuga racemosa (L.) Nutt. Inflammation/Immunology Disease Research Fields	NF-κB
Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions . Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS .

HY-N12235

Sarglaroids F	Structural Classification Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

HY-N12042

Taxamairin B	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	TNF Receptor PI3K Reactive Oxygen Species Interleukin Related
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-N3548

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

Cat. No.	Product Name	Chemical Structure

HY-128922S

Dexamethasone palmitate-d31
Dexamethasone palmitate-d31 is the deuterium labeled Dexamethasone palmitate(HY-128922).Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation .

Cat. No.	Product Name		Classification

HY-159564

iNOS/COX-2-IN-3		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

Cat. No.	Product Name		Classification

HY-146245C

ODN 1826 sodium 2 Publications Verification CpG 1826 sodium		CpG ODNs
ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) that is a TLR9 agonist. ODN 1826 sodium is an immunostimulatory agent that induces NO and iNOS production in mouse models. ODN 1826 sodium also enhances apoptosis (apoptosis) and may promote atherosclerosis. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’ .

HY-146245

ODN 1826 CpG 1826		CpG ODNs
ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’ .

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