Search Result

Results for "

Sphingosine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SphK (30) Acyltransferase (2) Akt (2) Apoptosis (16) Autophagy (5) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (6) Ceramidase (3) Drug Metabolite (5) Endogenous Metabolite (14) ERK (1) Estrogen Receptor/ERR (2) Filovirus (1) Fluorescent Dye (5) HCV (1) Isotope-Labeled Compounds (13) Leukotriene Receptor (2) Liposome (1) LPL Receptor (67) mTOR (1) p38 MAPK (1) PAK (6) Parasite (2) Phosphatase (3) PI3K (1) PKC (8) RAR/RXR (1) Sialyltransferase (1) Smo (1) TRP Channel (1) Wnt (1)
By Research Areas:	Cancer (59) Cardiovascular Disease (8) Endocrinology (2) Infection (12) Inflammation/Immunology (55) Metabolic Disease (26) Neurological Disease (23)
Click Chemistry:	Alkynes (2)

166

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: SphK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141630

Sphingosine-1-phosphate (d17:1) D-erythro-Sphingosine-C17-1-phosphate	Others	Cancer
Sphingosine-1-phosphate d17:1 (D-erythro-Sphingosine-C17-1-phosphate) is a derivative of ceramide. Sphingosine-1-phosphate d17:1 can be used for the research of cancer .

HY-141579

Sphingosine (d17:1)	Others	Others
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin. Sphingosine (d17:1) can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. Sphingosine C-17 was used as an internal standard for spectral analysis of sphingoid compounds .

HY-108496

Sphingosine-1-phosphate 5+ Cited Publications S1P	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-108496S

Sphingosine-1-phosphate-d7 S1P-d₇	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	PKC	Cancer
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-15425

PF-543 5+ Cited Publications Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

HY-15425A

PF-543 Citrate 5+ Cited Publications Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy .

HY-165550

*Sphingosine* C22-D-erythro-Sphingosine	Others	Metabolic Disease
Sphingosine (C22-D-erythro-Sphingosine) is an ester product.

HY-D2284

SGPL1 fluorogenic substrate Sphingosine-1-phosphate lyase fluorogenic substrate	Fluorescent Dye	Cancer
SGPL1 fluorogenic substrate is the fluorogenic substrate of sphingosine-1-phosphate lyase (SGPL1) that can be used to measure the activity of SGPL1 .

HY-15425B

PF-543 hydrochloride Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy .

HY-130433

NBD Sphingosine	Fluorescent Dye	Others
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-139097

C12-Sphingosine	Others	Others
C12-Sphingosine is a short-chain Sphingosine homologue. C12-Sphingosine inhibits serine palmitoyltransferase activity in primary cultured cerebellar cells .

HY-117152

L-threo-Sphingosine L-threo-Sphingosine C-18	p38 MAPK Apoptosis	Cancer
L-threo-Sphingosine is a potent MAPK inhibitor. L-threo-Sphingosine induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine shows anticancer effect .

HY-W344461

N-Butyroyl-D-sphingosine N-Butyryl-D-erythro-Sphingosine	Others	Metabolic Disease
N-Butyroyl-D-sphingosine (N-Butyryl-D-erythro-sphingosine) is an ester product.

HY-148292

*C16-Sphingosine-1-phosphate*	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and also an endogenous ligand for the EDG/S1P receptor. C16-Sphingosine-1-phosphate can be used in the research of angiogenesis, inflammation, and cardiovascular diseases .

HY-134104

C20-Sphingosine D-erythro-Sphingosine-C20	Others	Neurological Disease
C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development .

HY-W019781

Biotinylated sphingosine Biotinyl-Sph	SphK	Metabolic Disease
Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 .

HY-131701S

*Lactosyl-C18-sphingosine-d7*	Isotope-Labeled Compounds	Others
Lactosyl-C18-sphingosine-d₇ is deuterium labeled Lactosyl-C18-sphingosine.

HY-131701

Lactosyl-C18-sphingosine C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine; Lyso-Lactosylceramide (synthetic)	Endogenous Metabolite	Metabolic Disease
Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.

HY-W749873

*D-Sphingosine* sulfate**	Others	Metabolic Disease
D-Sphingosine sulfate is an ester product.

HY-W089922

*D-erythro-Sphingosine* hydrochloride** 3 Publications Verification ErythroSphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	TRP Channel	Neurological Disease
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

HY-165818

Octadecanoyl-L-erythro-sphingosine	Others	Metabolic Disease
Octadecanoyl-L-erythro-sphingosine is an ester product.

HY-113775

Octadecanoyl-L-threo-sphingosine	Others	Metabolic Disease
Octadecanoyl-L-threo-sphingosine is an ester product.

HY-139286

Photoclick sphingosine Pacsph; PacSphingosine (d18:1)	Biochemical Assay Reagents	Others
Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .

HY-166863

*L-erythro-Sphingosine(synthetic)*	Biochemical Assay Reagents	Others
L-erythro-Sphingosine(synthetic) is a biochemical assay reagent.

HY-101047

D-erythro-Sphingosine 3 Publications Verification ErythroSphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-146908S

*N-Pentadecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
N-Pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled N-Pentadecanoyl-D-erythro-sphingosine.

HY-166310

C12-NBD-L-Threo-sphingosine	Others	Metabolic Disease
C12-NBD-L-Threo-sphingosine is an ester product.

HY-101047S

*D-erythro-Sphingosine-d7* ErythroSphingosine-d₇; erythro-C18-Sphingosine-d₇; trans-4-Sphingenine-d₇	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-166089

*N,N-dimethyl sphingosine* (d17:1)**	Others	Metabolic Disease
N,N-dimethyl sphingosine (d17:1) is an ester product.

HY-150513

SLP9101555	SphK	Cancer
SLP9101555 (compound 14c) is a potent and selective SphK2 (sphingosine kinase 2) inhibitor (K_i=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels .

HY-W739800

N-Boc-1-pivaloyl-D-erythro-sphingosine	Biochemical Assay Reagents
N-Boc-1-pivaloyl-D-erythro-sphingosine is a kind of biochemical reagent.

HY-N10238

Mycestericin G	Endogenous Metabolite	Inflammation/Immunology
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-W127354

*N-Tetracosanoyl-D-sphingosine* 1-benzoate**	Biochemical Assay Reagents	Others
N-Tetracosanoyl-D-sphingosine 1-benzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-19542A

N-Hexanoyl-L-erythro-sphingosine L-Ceramide-C6	Others	Metabolic Disease
N-Hexanoyl-L-erythro-sphingosine (L-Ceramide-C6) is an ester product.

HY-116535B

DL-threo-PPMP	Parasite	Infection
DL-threo-PPMP is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP inhibits the activity of sphingosine synthetase by mimicking the substrate sphingosine. This inhibition leads to a rapid decrease in the activity of sensitive sphingosine synthetase, selectively destroying the interconnected tubular network of TVMs in the host cell cytoplasm, and this inhibition also blocks the proliferation of Plasmodium falciparum. DL-threo-PPMP can be used for the study of Plasmodium biology and the search for new antimalarial strategies .

HY-116535A

DL-threo-PPMP hydrochloride	Parasite	Infection
DL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies .

HY-146922S

*D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146923S

*D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146764S

*D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.

HY-146766S

*D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146920S

*3-O-Sulfo-galactosyl(β)sphingosine* (d18:1)-d7 ammonium**	Isotope-Labeled Compounds	Others
3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).

HY-N10636

D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine	Others	Others
D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine is a neutral glycolipid .

HY-158638

NBD-FTY720 phenoxy hydrochloride	Fluorescent Dye	Others
NBD-FTY720 phenoxy hydrochloride is a fluorescently-labeled analog of FTY720. FTY720 (HY-12005) is a potent sphingosine 1-phosphate (S1P) receptors modulator .

HY-116147

Ceranib-2	LPL Receptor Apoptosis	Cancer
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC₅₀ of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .

HY-165761

D-Threo-sphingosine (E)-2-Aminooctadec-4-ene-1,3-diol	Others	Metabolic Disease
D-Threo-sphingosine ((E)-2-Aminooctadec-4-ene-1,3-diol) is an ester product.

HY-101047S1

*D-erythro-Sphingosine-13C2,d2* ErythroSphingosine-¹³C₂,d₂; erythro-C18-Sphingosine-¹³C₂,d₂; trans-4-Sphingenine-¹³C₂,d₂	Isotope-Labeled Compounds PKC Endogenous Metabolite Phosphatase	Cancer
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-115703

C17 Ceramide (d18:1/17:0) N-Heptadecanoyl-D-erythro-Sphingosine	Others	Metabolic Disease
C17 Ceramide (d18:1/17:0) (N-Heptadecanoyl-D-erythro-sphingosine) is an ester product.

HY-120268

SLM6031434	SphK	Inflammation/Immunology Cancer
SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with K_is of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 has the potential for renal fibrosis research .

HY-146761S

*3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7*	Isotope-Labeled Compounds	Others
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.

Cat. No.	Product Name	Type

HY-130433

NBD Sphingosine	Dyes
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-D2284

SGPL1 fluorogenic substrate Sphingosine-1-phosphate lyase fluorogenic substrate	Fluorescent Dyes/Probes
SGPL1 fluorogenic substrate is the fluorogenic substrate of sphingosine-1-phosphate lyase (SGPL1) that can be used to measure the activity of SGPL1 .

HY-D2257

BDP TR ceramide	Fluorescent Dyes/Probes
BDP TR ceramide is a red fluorescent dye with a terminal sphingosine group. BDP TR ceramide can be used to study lipids microscopically .

HY-D2255

BDP FL ceramide	Fluorescent Dyes/Probes
BDP FL ceramide, a highly fluorescent lipid, is a conjugate of green-emitting BDP FL fluorophore with sphingosine. BDP FL ceramide can be used for the visualization of the Golgi apparatus via fluorescence microscopy.The excitation wavelength is 503 nm and the emission wavelength is 509 nm .

Cat. No.	Product Name	Type

HY-134427

Palmitoyl coenzyme A lithium Palmitoyl CoA lithium	Drug Delivery
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-154831

C22-Ceramide N-Behenoyl-D-erythro-Sphingosine; Cer d18:1/22:0	Drug Delivery
C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

HY-166863

*L-erythro-Sphingosine(synthetic)*	Drug Delivery
L-erythro-Sphingosine(synthetic) is a biochemical assay reagent.

HY-W739800

N-Boc-1-pivaloyl-D-erythro-sphingosine	Drug Delivery
N-Boc-1-pivaloyl-D-erythro-sphingosine is a kind of biochemical reagent.

HY-W127354

*N-Tetracosanoyl-D-sphingosine* 1-benzoate**	Drug Delivery
N-Tetracosanoyl-D-sphingosine 1-benzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Enzyme Substrates
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-141579

Sphingosine (d17:1)	Animals Source classification	Others
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin. Sphingosine (d17:1) can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. Sphingosine C-17 was used as an internal standard for spectral analysis of sphingoid compounds .

HY-108496

Sphingosine-1-phosphate Maximum Cited Publications 8 Publications Verification S1P	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	Natural Products Animals Classification of Application Fields Source classification Disease Research Fields Cancer	PKC
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-134104

C20-Sphingosine D-erythro-Sphingosine-C20	Structural Classification Natural Products Source classification Endogenous metabolite	Others
C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development .

HY-W089922

*D-erythro-Sphingosine* hydrochloride** 3 Publications Verification ErythroSphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	Animals Source classification	TRP Channel
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

HY-101047

D-erythro-Sphingosine 3 Publications Verification ErythroSphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-N10238

Mycestericin G	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-154922

Palmitoyl coenzyme A Palmitoyl CoA	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Palmitoyl coenzyme A is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A can also be used as a substrate for sphingosine biosynthesis .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-112016

C20 Ceramide N-Arachidoyl-D-Sphingosine	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain .

HY-N6723

Fumonisin B2	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .

HY-N6719

Fumonisin B1 5 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702765

	*SPHK1/Sphingosine* Kinase 1 Protein, Human (sf9, 363a.a)** SK1; Sphingosine kinase 1; SPHK1; SPK 1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a) is the recombinant human-derived SPHK1/Sphingosine Kinase 1, expressed by Sf9 insect cells , with tag Free labeled tag. ,

HY-P73631

	*SPHK1/Sphingosine* Kinase 1 Protein, Human (sf9, His-GST)** Sphingosine kinase 1; SPK 1; SPHK1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) is the recombinant human-derived SPHK1/Sphingosine Kinase 1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) is 384 a.a., with molecular weight of ~64 kDa.

HY-P702913

	SPHK2 Protein, Human (sf9, His) SK2; Sphingosine kinase 2	Human	Sf9 insect cells
	SPHK2 Protein, Human (sf9, His) is the recombinant human-derived SPHK2, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-101047S

*D-erythro-Sphingosine-d7*
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-131701S

*Lactosyl-C18-sphingosine-d7*
Lactosyl-C18-sphingosine-d₇ is deuterium labeled Lactosyl-C18-sphingosine.

HY-146908S

*N-Pentadecanoyl-D-erythro-sphingosine-d7*
N-Pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled N-Pentadecanoyl-D-erythro-sphingosine.

HY-146922S

*D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*
D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146923S

*D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7*
D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.

HY-146764S

*D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7*
D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.

HY-146766S

*D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7*
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146920S

*3-O-Sulfo-galactosyl(β)sphingosine* (d18:1)-d7 ammonium**
3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).

HY-101047S1

*D-erythro-Sphingosine-13C2,d2*
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-146761S

*3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7*
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146921S

*3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d7 ammonium*
3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d₇ (ammonium) is deuterium labeled 3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine (ammonium).

HY-12355S

Siponimod-d11
Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

HY-11063S1

Fingolimod-d4 hydrochloride
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-N6723S

Fumonisin B2-13C34
Fumonisin B2- ¹³C₃₄ is the ¹³C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .

HY-N6719S

Fumonisin B1-13C34
Fumonisin B1- ¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82614

	EDG3 Antibody (YA2359) S1PR3; EDG3; Sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3	WB	Human, Mouse, Rat
	EDG3 Antibody (YA2359) is a biotin-conjugated non-conjugated IgG antibody, targeting EDG3, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). EDG3 Antibody (YA2359) can be used for WB experiment in human, mouse, rat background.