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Results for "

cascade

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (2) AP-1 (1) Apoptosis (25) Autophagy (6) Bacterial (1) Biochemical Assay Reagents (2) Btk (1) Cannabinoid Receptor (2) Caspase (5) CDK (1) Complement System (2) COX (13) Drug Derivative (1) Drug Isomer (1) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (15) ERK (5) FAAH (2) Factor XI (1) FAK (3) FKBP (1) Fluorescent Dye (1) GnRH Receptor (2) HIV (1) IKK (1) Interleukin Related (1) Isotope-Labeled Compounds (5) JAK (2) JNK (4) Keap1-Nrf2 (2) LPL Receptor (1) MDM-2/p53 (1) MEK (3) Microtubule/Tubulin (2) Molecular Glues (1) Monoamine Oxidase (1) mTOR (2) NF-κB (6) Notch (1) p38 MAPK (6) PAI-1 (1) Parasite (2) PDGFR (1) PERK (1) Phosphatase (2) Phospholipase (1) PI3K (3) PKC (3) Prostaglandin Receptor (2) Protease Activated Receptor (PAR) (1) Protein Arginine Deiminase (1) Pyroptosis (1) RABV (1) Raf (1) Ras (3) Reactive Oxygen Species (3) Ser/Thr Protease (1) Sirtuin (2) Src (1) STAT (5) STING (8) Thrombin (1) Thrombopoietin Receptor (2) TNF Receptor (1) Toll-like Receptor (TLR) (3) Topoisomerase (3) Wnt (1) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (11) Endocrinology (2) Infection (5) Inflammation/Immunology (43) Metabolic Disease (11) Neurological Disease (9)
Oligonucleotides:	Nucleosides and their Analogs (1) Aptamers (1) CpG ODNs (2)

104

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99515

Xeligekimab GR 1501	Interleukin Related	Inflammation/Immunology
Xeligekimab (GR 1501) is an anti-human interleukin 17A (IL-17A) humanized monoclonal antibody. Xeligekimab inhibits the pro-inflammatory cascade .

HY-N8481

3,6-Dihydroxyflavone 1 Publications Verification 3,6-DHF	Apoptosis	Cancer
3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation .

HY-15036

Diclofenac 15+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15038

Diclofenac potassium 15+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036A

Diclofenac diethylamine 15+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15037

Diclofenac Sodium 15+ Cited Publications GP 45840	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-120894

16(R)-HETE	Endogenous Metabolite	Others
16(R)-HETE, a metabolite of the cytochrome P450 branch of the arachidonate cascade, is a vasodilator .

HY-15036R

Diclofenac (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15038R

Diclofenac (potassium) (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036AR

Diclofenac (diethylamine) (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-116553

FzM1	Wnt β-catenin	Cancer
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC_50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade .

HY-P3496

Pep19-2.5	Pyroptosis	Inflammation/Immunology
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .

HY-W041308R

DCOIT (Standard) Kathon 930 (Standard)	GnRH Receptor	Endocrinology
DCOIT (Standard) is the analytical standard of DCOIT. This product is intended for research and analytical applications. DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca2+ signaling cascades[1].

HY-125046

CYM50374	LPL Receptor	Others
CYM50374 is a potent antagonist sphingosine-1-phosphate 4 (S1P4) antagonists, with the IC₅₀ of 34 nM .

HY-111789

Subasumstat 15+ Cited Publications TAK-981	E1/E2/E3 Enzyme	Inflammation/Immunology Cancer
Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .

HY-E70544

Human Factor X	Biochemical Assay Reagents	Cardiovascular Disease
Human Factor X is a coagulation factor naturally present in human plasma. Human Factor X can be converted to factor Xa in the coagulation cascade .

HY-149918

Antiproliferative agent-23	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .

HY-N0341

Scopolin	Sirtuin	Metabolic Disease
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .

HY-15037S1

Diclofenac-d4 sodium	COX Apoptosis	Inflammation/Immunology
Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-167709

Azacosterol 20.25-Diazacholesterol	Xanthine Oxidase	Neurological Disease
Azacosterol (20.25-Diazacholesterol), also known as Diazasterol, acts as a DHCR24 inhibitor and initiates a cascade of reactions in cortical neurons after being administered orally or via intraperitoneal injection.

HY-111789A

(S)-Subasumstat (S)-TAK-981	Drug Isomer	Inflammation/Immunology Cancer
(S)-Subasumstat is the isomer of Subasumstat (HY-111789). Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .

HY-P2893A

Creatinase (Recombinant) Creatine amidinohydrolase	Endogenous Metabolite	Metabolic Disease
Creatinase (Recombinant) is a hydrolase responsible for catalyzing the hydrolysis of creatine (HY-W010388) into sarcosine (HY-101037) and urea (HY-Y0271). Creatinase (Recombinant) can be used in conjunction with creatinine deiminase (HY-P2838) and sarcosine oxidase (HY-P2861) in an enzyme cascade reaction to measure creatinine (HY-B0504) levels in blood and urine. Creatinase (Recombinant) is the rate-limiting enzyme in this enzymatic cascade, and the enzymatic quantification of creatinine is an important method for evaluating kidney function .

HY-15037S

Diclofenac-13C6 sodium heminonahydrate	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-101021

Ascochlorin Ilicicolin D	STAT Apoptosis Antibiotic	Inflammation/Immunology Cancer
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity .

HY-P2319

OVA-E1 peptide	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-P2319A

OVA-E1 peptide TFA	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-13992

AP20187 Maximum Cited Publications 33 Publications Verification B/B Homodimerizer	FKBP	Metabolic Disease
AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

HY-W041308

DCOIT Kathon 930	GnRH Receptor	Endocrinology
DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca ²⁺ signaling cascades .

HY-148511A

Vidutolimod sodium CMP-001 sodium	Toll-like Receptor (TLR)	Cancer
Vidutolimod sodium is a CpG-A oligodeoxynucleotide. Vidutolimod sodium is a Toll-like receptor 9 (TLR9) agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects.

HY-P991124

Cenvacibart	Factor XI	Cardiovascular Disease
Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases .

HY-E70393I

Bovine Factor IXa Beta	Others	Others
Bovine Factor IXa Beta is an inactive and highly specific enzyme, with a minimal extended substrate recognition site and a preference for particular amino acid residues at specific subsites. Bovine Factor IXa Beta plays a role in the blood coagulation cascade .

HY-122464A

Jasmonic acid (-)-Jasmonic acid	Molecular Glues	Others
Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of α-Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules .

HY-106591A

4-Vinylcyclohexene dioxide Vinylcyclohexene diepoxide	Apoptosis	Cardiovascular Disease
4-Vinylcyclohexene dioxide is a metabolite of 4-vinylcyclohexene that can specifically destroy oocytes in primordial and primary follicles of rats and mice. 4-Vinylcyclohexene dioxide induces apoptosis in rat cells is associated with activation of a caspase-mediated cascade .

HY-113632

Debromohymenialdisine 10Z-Debromohymenialdisine	Raf MEK	Cancer
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation .

HY-148511

Vidutolimod CMP-001	Toll-like Receptor (TLR)	Cancer
Vidutolimod (CMP-001) is a CpG-A oligodeoxynucleotide. Vidutolimod is a Toll-like receptor 9 (TLR9) agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects.

HY-N12526

Isolappaol A	Others	Others
Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .

HY-N0341R

Scopolin (Standard)	Sirtuin	Metabolic Disease
Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .

HY-108904

Urokinase, Human urine Urokinase-type plasminogen activator; Uronase; Win 22005; Win-Kinase	Ser/Thr Protease	Cardiovascular Disease Cancer
Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research .

HY-B0143A

Niacin hydrochloride Nicotinic acid hydrochloride; Vitamin B3 hydrochloride	Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases .

HY-N6857

Armepavine	NF-κB	Inflammation/Immunology
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades .

HY-109110

Avasopasem manganese GC-4419; M-40419	Reactive Oxygen Species	Inflammation/Immunology Cancer
Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O₂ ^- to hydrogen peroxide (H₂O₂), arresting the initiation of this cascade*. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer .

HY-12512

cGAMP 10+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-164410

MO-I-1100	Notch	Cancer
MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC .

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Biochemical Assay Reagents	Cancer
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

HY-157159

BTK-IN-28	Btk	Cancer
BTK-IN-28 (compound PID-4) is a potent BTK inhibitor with anticancer activity. BTK-IN-28 has inhibitory effects on BTK and downstream signaling cascades and selectively inhibits Burkitt lymphoma RAMOS proliferation. BTK-IN-28 has no significant cytotoxicity towards non-tumor cells .

HY-110385

cGAMP disodium 10+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385A

cGAMP diammonium 10+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-N0809

Sesamolin 2 Publications Verification	p38 MAPK JNK Caspase Reactive Oxygen Species NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology
Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active .

HY-14756

Totrombopag	Thrombopoietin Receptor	Others
Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

705 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 705 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

HY-L069

Anti-Alzheimer's Disease Compound Library

1,662 compounds

Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc.

MCE offers a unique collection of 1,662 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

HY-L165

Dopamine Receptor Compound Library

228 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 228 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Type

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Indicators
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

Cat. No.	Product Name	Target	Research Area

HY-P3496

Pep19-2.5	Pyroptosis	Inflammation/Immunology
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .

HY-P2319A

OVA-E1 peptide TFA	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-P2230

Angstrom6 A6 Peptide	PAI-1	Cancer
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .

HY-P2265A

SAH-SOS1A TFA	Ras	Cancer
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .

HY-P2319

OVA-E1 peptide	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-P2265

SAH-SOS1A	Ras	Cancer
SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .

Cat. No.	Product Name	Target	Research Area

HY-P99515

Xeligekimab GR 1501	Interleukin Related	Inflammation/Immunology
Xeligekimab (GR 1501) is an anti-human interleukin 17A (IL-17A) humanized monoclonal antibody. Xeligekimab inhibits the pro-inflammatory cascade .

HY-P991124

Cenvacibart	Factor XI	Cardiovascular Disease
Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases .

HY-P991076

Entolimod CBLB-502	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Entolimod (CBLB-502), a recombinant protein is a toll-like receptor 5 (TLR5) agonist. Entolimod induces a cascade of TLR5-NF-κB signaling resulting in mobilization to the liver of various components of innate and adaptive immunity, followed by suppression of liver metastases and development of long-term antitumor immune memory .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0341

Scopolin	Structural Classification Classification of Application Fields Anisodus tanguticus (Maxinowicz) Pascher Source classification Coumarins Metabolic Disease Arabidopsis thaliana Phenylpropanoids Solanaceae Plants Brassicaceae Disease Research Fields	Sirtuin
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .

HY-N6857

Armepavine	Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Nymphaeaceae	NF-κB
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades .

HY-110385

cGAMP disodium Maximum Cited Publications 14 Publications Verification Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-120894

16(R)-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
16(R)-HETE, a metabolite of the cytochrome P450 branch of the arachidonate cascade, is a vasodilator .

HY-101021

Ascochlorin Ilicicolin D	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Disease Research Plants Other Antibiotics Microorganisms other families Antibiotics Phenols Polyphenols Anticancer Inflammation/Immunology Disease Research Fields	STAT Apoptosis Antibiotic
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity .

HY-122464A

Jasmonic acid (-)-Jasmonic acid	Structural Classification Leguminosae Ketones, Aldehydes, Acids Source classification Plants Vicia faba L.	Molecular Glues
Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of α-Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules .

HY-113632

Debromohymenialdisine 10Z-Debromohymenialdisine	Structural Classification Natural Products Classification of Application Fields Marine natural products Sponge Disease Research Fields Cancer	Raf MEK
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation .

HY-N12526

Isolappaol A	Structural Classification Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc.	Others
Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .

HY-N0341R

Scopolin (Standard)	Structural Classification Anisodus tanguticus (Maxinowicz) Pascher Source classification Coumarins Arabidopsis thaliana Phenylpropanoids Solanaceae Plants Brassicaceae	Sirtuin
Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .

HY-B0143A

Niacin hydrochloride Nicotinic acid hydrochloride; Vitamin B3 hydrochloride	Structural Classification Alkaloids Classification of Application Fields Ketones, Aldehydes, Acids Source classification Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases .

HY-110385A

cGAMP diammonium Maximum Cited Publications 14 Publications Verification Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-N0809

Sesamolin 2 Publications Verification	Structural Classification Sesamum indicum Linn. Source classification Other Phenylpropanoids Phenylpropanoids Pedaliaceae Plants	p38 MAPK JNK Caspase Reactive Oxygen Species NF-κB
Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active .

HY-B0143

Niacin 5+ Cited Publications Nicotinic acid; Vitamin B3	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Autophagy Endogenous Metabolite
Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases .

HY-N10018

Cimiside E 25-Anhydrocimigenol xyloside	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga racemosa (L.) Nutt.	Caspase
Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC₅₀ value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways .

HY-N6857R

Armepavine (Standard)	Alkaloids Structural Classification Monophenols other families Source classification Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae	NF-κB
Armepavine (Standard) is the analytical standard of Armepavine. This product is intended for research and analytical applications. Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades .

HY-N2409

Delphinidin chloride	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Anthocyans Flavonoids Microorganisms other families Solanum melongena L. Phenols Polyphenols Solanaceae Disease Research Fields Cancer	Apoptosis EGFR JAK STAT
Delphinidin chloride is an anthocyanin isolated from berries and red wine. Delphinidin chloride exhibits endothelium-dependent vasodilation and anticancer activity. Delphinidin chloride also modulates JAK/STAT3 and MAPK signaling, thereby inducing apoptosis in HCT116 cells. Delphinidin chloride is also a potent inhibitor of EGFR (IC₅₀: 1.3 μM), shutting down downstream signaling cascades .

HY-126232

Verproside	Plantaginaceae Infection Structural Classification Iridoids Veronica officinalis L. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	NF-κB TNF Receptor IKK
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

HY-N0809R

Sesamolin (Standard)	Structural Classification Sesamum indicum Linn. Source classification Other Phenylpropanoids Phenylpropanoids Pedaliaceae Plants	p38 MAPK JNK Caspase
Sesamolin (Standard) is the analytical standard of Sesamolin. This product is intended for research and analytical applications. Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesamolin potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression .

HY-N15340

1-Oleoyl-2-linoleoyl-sn-glycerol	Structural Classification Natural Products Source classification Endogenous metabolite	PKC
1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DG). 1-Oleoyl-2-linoleoyl-sn-glycerol can activate protein kinase C (PKC), thus triggering downstream signaling cascades and promoting tumor growth. 1-Oleoyl-2-linoleoyl-sn-glycerol is promising for research of breast cancer .

HY-B0143R

Niacin (standard) 5+ Cited Publications Nicotinic acid (standard); Vitamin B3 (standard)	Structural Classification Alkaloids Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite	Autophagy Endogenous Metabolite
Niacin (Standard) is the analytical standard of Niacin. This product is intended for research and analytical applications. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases .

HY-W011527

Xanthosine 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research .

HY-N2409R

Delphinidin chloride (Standard)	Structural Classification Anthocyans Flavonoids Microorganisms other families Solanum melongena L. Source classification Phenols Polyphenols Solanaceae Plants	Apoptosis EGFR JAK STAT
Delphinidin (chloride) (Standard) is the analytical standard of Delphinidin (chloride). This product is intended for research and analytical applications. Delphinidin chloride is an anthocyanin isolated from berries and red wine. Delphinidin chloride exhibits endothelium-dependent vasodilation and anticancer activity. Delphinidin chloride also modulates JAK/STAT3 and MAPK signaling, thereby inducing apoptosis in HCT116 cells. Delphinidin chloride is also a potent inhibitor of EGFR (IC50: 1.3 μM), shutting down downstream signaling cascades .

HY-N2484

Methylnissolin Astrapterocarpan	Cardiovascular Disease Monophenols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields	PDGFR ERK
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .

HY-N0498

Nitidine chloride 3 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-W011527R

Xanthosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Xanthosine (Standard) is the analytical standard of Xanthosine. This product is intended for research and analytical applications. Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research .

HY-N0498R

Nitidine chloride (Standard)	Alkaloids Structural Classification Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-18980

Rottlerin 10+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-N5072

Desmethylglycitein 1 Publications Verification 4',6,7-Trihydroxyisoflavone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-113469R

Cyclic GMP (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	STING Endogenous Metabolite
Cyclic GMP (Standard) is the analytical standard of Cyclic GMP. This product is intended for research and analytical applications. Cyclic GMP is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of Cyclic GMP, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases.

HY-113469A

Cyclic GMP sodium 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .

HY-113469

Cyclic GMP 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	STING Endogenous Metabolite
Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases .

Cat. No.	Product Name	Chemical Structure

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-W654000

Cyclic GMP-13C,15N2
Cyclic GMP- ¹³C, ¹⁵N₂ is ¹³C and ¹⁵N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-B0143S4

Niacin-15N,13C3
Niacin- ¹⁵N, ¹³C₃ is the ¹³C and ¹⁵N labeled Niacin[1]. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[2][3].

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

Cat. No.	Product Name		Classification