2. Gene
  3. HDAC8 - histone deacetylase 8 Gene

HDAC8 - histone deacetylase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as HD8; RGD1562895

Gene ID: 363481 | Gene type: protein coding

About HDAC8

Primary_assembly X: 67,385,289-67,592,923 reverse strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 202 orthologues, 12 paralogues and is associated with 19 phenotypes. Biased expression in Thymus (RPKM 26.7), Brain (RPKM 23.8) and 9 other tissues.

Summary

Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of macromolecule metabolic process; and negative regulation of osteoblast differentiation. Located in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]

HDAC8 Products(1)

mRNA Protein Name
NM_001126373.2 NP_001119845.2 histone deacetylase 8
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
28559304 RGD
enables deacetylase activity IDA
IDA: Inferred from direct assay
23868068 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to forskolin IDA
IDA: Inferred from direct assay
28559304 RGD
involved in cellular response to trichostatin A IDA
IDA: Inferred from direct assay
26391271 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28559304 RGD
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
25019367 RGD
involved in negative regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
25019367 RGD
involved in response to 11-deoxycorticosterone IDA
IDA: Inferred from direct assay
23868068 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC8 Protein Structure

HDAC8

HDAC8: cd10000 (15 - 334)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

histone deacetylase 8

protein deacetylase HDAC8

protein decrotonylase HDAC8

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.70% Unkown
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-138799 KA2507 Inhibitor 99.24% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
Bioactive Molecules (110)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13271A Tubastatin A Inhibitor 98.37% Unkown
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13428 Tubacin Inhibitor 99.54% Unkown
HY-15224 PCI-34051 Inhibitor 99.75% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.19% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-16699 Nexturastat A Inhibitor 98.28% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-111342 HDAC8-IN-1 Inhibitor 99.82% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-18976 UF010 99.84% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.11% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-13267 Droxinostat Inhibitor 98.91% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-117348 NCC-149 Inhibitor 99.14% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-100384 NKL 22 Inhibitor 97.27% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-114483 AES-135 Inhibitor 98.21% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-164233 YX968 Inhibitor / Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-124782 HDAC8-IN-8 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-152147 SZUH280 Degrader / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-126829 Coumarin-SAHA / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-151366 HDAC8/BRPF1-IN-1 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-150694 HDAC6-IN-11 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-157314 HDAC6-IN-27 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-10226 JNJ-16241199 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-163846 HDAC8-IN-10 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-119550 J1075 Inhibitor / Unkown
HY-139795 ZYJ-25e Inhibitor / Unkown
HY-139815 ZYJ-34c Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HDAC8 NCBI NCBI:55869
Mus musculus HDAC8 NCBI NCBI:70315