Src - SRC proto-oncogene, non-receptor tyrosine kinase Gene

Rattus norvegicus

Gene ID: 83805 | Gene type: protein coding

About Src

Primary_assembly 3: 146,091,841-146,139,476 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 261 orthologues, 32 paralogues and is associated with 42 phenotypes. Biased expression in Brain (RPKM 86.6), Lung (RPKM 78.5) and 9 other tissues.

Summary

Enables several functions, including Estrogen Receptor binding activity; Insulin Receptor binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to lipid; positive regulation of phosphorylation; and regulation of signal transduction. Located in caveola; neuron projection; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal Cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human Src (Src proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Src Products(1)

mRNA	Protein	Name
NM_031977.1	NP_114183.1	proto-oncogene tyrosine-protein kinase Src

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	19948503	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	15069201	RGD
enables insulin receptor binding	IPI IPI: Inferred from physical interaction	19952103	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	14751567	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8849729	RGD
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	14751567	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8849729	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12618293	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11478920	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	11834728	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	9227431	RGD
involved in adherens junction organization	IEP IEP: Inferred from expression pattern	15389520	RGD
involved in cell-cell adhesion	IEP IEP: Inferred from expression pattern	15591141	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	7586216	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	20149623	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	8807585	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20380727	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	19952103	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20149623	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	11417999	RGD
involved in cellular response to progesterone stimulus	IMP IMP: Inferred from mutant phenotype	21440892	RGD
involved in cellular response to prolactin	IEP IEP: Inferred from expression pattern	8584023	RGD
involved in epidermal growth factor receptor signaling pathway	IEP IEP: Inferred from expression pattern	15856020	RGD
involved in learning or memory	IEP IEP: Inferred from expression pattern	10884433	RGD
involved in myoblast proliferation	IEP IEP: Inferred from expression pattern	2425941	RGD
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	21440892	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16530387	RGD
involved in neurotrophin TRK receptor signaling pathway	IDA IDA: Inferred from direct assay	15546918	RGD
involved in peptidyl-tyrosine autophosphorylation	IMP IMP: Inferred from mutant phenotype	18583343	RGD
involved in platelet-derived growth factor receptor signaling pathway	IEP IEP: Inferred from expression pattern	16530387	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16530387	RGD
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	11941412	RGD
involved in positive regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	8626602	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15322113	RGD
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	8514886	RGD
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	15735685	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16530387	RGD
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19736311	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16530387	RGD
involved in positive regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	19230846	RGD
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	14985360	RGD
involved in positive regulation of intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	19713443	RGD
involved in positive regulation of male germ cell proliferation	IMP IMP: Inferred from mutant phenotype	18560731	RGD
involved in positive regulation of ovarian follicle development	IMP IMP: Inferred from mutant phenotype	22905678	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	9227431	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16530387	RGD
involved in positive regulation of protein transport	IMP IMP: Inferred from mutant phenotype	15007081	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	19736311	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	9227431	RGD
involved in primary ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	22905678	RGD
involved in progesterone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21440892	RGD
involved in response to acidic pH	IEP IEP: Inferred from expression pattern	12081562	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	20356829	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	19736311	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12226102	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15731459	RGD
involved in response to mineralocorticoid	IEP IEP: Inferred from expression pattern	16157790	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	20357031	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20149623	RGD
involved in skeletal muscle cell proliferation	IEP IEP: Inferred from expression pattern	2447874	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	7530000	RGD
involved in transcytosis	IDA IDA: Inferred from direct assay	15007081	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	20167931	RGD
located in dendritic filopodium	IDA IDA: Inferred from direct assay	2462872	RGD
located in dendritic growth cone	IDA IDA: Inferred from direct assay	2462872	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	9005855	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9005855	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	2462872	RGD
is active in postsynaptic specialization, intracellular component	IDA IDA: Inferred from direct assay	14529711	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	10884433	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Src Protein Structure

SH3_Src

SH2_Src_Src

PTKc_Src

0
100
200
300
400
500
542 a.a.

Protein Preferred Names

Protein Names

proto-oncogene tyrosine-protein kinase Src

Rous sarcoma oncogene	c-Src
p60-Src	pp60c-src
proto-oncogene c-Src	tyrosine protein kinase c-src
tyrosine protein kinase pp60-c-src	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Src Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Src	Q9WUD9	Cacna1c	Rattus norvegicus	P22002	Pull Down	16352297
Intra	Src	Q9WUD9	Cd63	Rattus norvegicus	P28648	Anti Bait CoIP	18211905
Intra	Src	Q9WUD9	Ptprr	Rattus norvegicus	O08617	Pull Down	12526090
Intra	Src	Q9WUD9	Ptprr	Rattus norvegicus	O08617	Anti Bait CoIP	12526090
Cross	Src	Q9WUD9	PTPN1	Homo sapiens	P18031	Pull Down	12023880

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10181	Dasatinib	Inhibitor	99.88%	Yes
HY-12047	Ponatinib	Inhibitor	99.67%	Yes
HY-10158	Bosutinib	Inhibitor	99.96%	Yes
HY-10209	Masitinib	Inhibitor	99.98%	Yes
HY-10181A	Dasatinib hydrochloride	Inhibitor	99.67%	Yes
HY-108766	Ponatinib hydrochloride	Inhibitor	99.55%	Yes
HY-10209A	Masitinib mesylate	Inhibitor	99.83%	Yes
HY-10181B	Dasatinib monohydrate	Inhibitor	98.48%	Yes
HY-10158A	Bosutinib hydrate	Inhibitor	99.87%	Yes

Clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10234	Saracatinib	Inhibitor	99.92%	Phase 3
HY-10340	Tirbanibulin	Inhibitor	99.56%	Phase 3
HY-10340B	Tirbanibulin Mesylate	Inhibitor	99.94%	Phase 3
HY-10340A	Tirbanibulin dihydrochloride	Inhibitor	99.59%	Phase 3
HY-13024	Rebastinib	Inhibitor	99.91%	Phase 2
HY-50868	Bafetinib	Inhibitor	99.77%	Phase 2
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Phase 2
HY-59047	Tolimidone	Activator	99.93%	Phase 2
HY-32718	Pelitinib	Inhibitor	98.80%	Phase 2
HY-111787	Elzovantinib	Inhibitor	99.93%	Phase 2
HY-10987A	ENMD-2076	Inhibitor	99.12%	Phase 2
HY-10987	ENMD-2076 Tartrate	Inhibitor	99.42%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-10032	PF 477736	Inhibitor	99.21%	Phase 1
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-112809	GSK2646264	Inhibitor	98.39%	Phase 1
HY-112314	AZD0424	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (141)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13805	PP2	Inhibitor	98.34%	Unkown
HY-12299	WH-4-023	Inhibitor	99.75%	Unkown
HY-B0789	SU6656	Inhibitor	98.30%	Unkown
HY-112096	eCF506	Inhibitor	99.77%	Unkown
HY-N0752	Scutellarein	Inhibitor	99.25%	Unkown
HY-12072	Lck Inhibitor	Inhibitor	99.45%	Unkown
HY-15764A	A 419259 trihydrochloride	Inhibitor	99.21%	Unkown
HY-101053	Src Inhibitor 1	Inhibitor	99.96%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-13942	1-NM-PP1	Inhibitor	99.17%	Unkown
HY-13804	PP1	Inhibitor	99.00%	Unkown
HY-135299	CH6953755	Inhibitor	99.45%	Unkown
HY-W062835	CGP77675	Inhibitor	99.00%	Unkown
HY-130254	CSK-IN-1	Inhibitor	98.61%	Unkown
HY-13941	1-Naphthyl PP1	Inhibitor	99.08%	Unkown
HY-11011	A-770041	Inhibitor	99.95%	Unkown
HY-15764	A 419259	Inhibitor	99.75%	Unkown
HY-112852	TL02-59	Inhibitor	99.84%	Unkown
HY-10395	PD173955	Inhibitor	99.12%	Unkown
HY-139147	iHCK-37	Inhibitor	99.52%	Unkown
HY-78263	MNS	Inhibitor	99.55%	Unkown
HY-108318	RK-24466	Inhibitor	98.53%	Unkown
HY-N0202	Atractylenolide II	Inhibitor	99.94%	Unkown
HY-18303	AMG-47a	Inhibitor	99.34%	Unkown
HY-10372	PP121	Inhibitor	98.67%	Unkown
HY-155657	BT424	Inhibitor	98.81%	Unkown
HY-112182	UM-164	Inhibitor	99.15%	Unkown
HY-P3279	EPQpYEEIPIYL	Activator	99.62%	Unkown
HY-13561	AZM475271	Inhibitor	99.85%	Unkown
HY-101963	AD80	Inhibitor	99.88%	Unkown
HY-122113	PD173952	Inhibitor	99.44%	Unkown
HY-18622	PP58	Inhibitor	99.75%	Unkown
HY-136605	DGY-06-116	Inhibitor	99.54%	Unkown
HY-163144	DAS-5-oCRBN	Degrader	98.75%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.81%	Unkown
HY-108485	Damnacanthal	Inhibitor	≥98.0%	Unkown
HY-120213	YH-306	Inhibitor	98.01%	Unkown
HY-107024	Osteogenic Growth Peptide (10-14)	Inhibitor	99.77%	Unkown
HY-P1377A	Caffeic acid-pYEEIE TFA		98.47%	Unkown
HY-108488	KB SRC 4	Inhibitor	99.66%	Unkown
HY-13941B	1-Naphthyl PP1 hydrochloride	Inhibitor	99.83%	Unkown
HY-N4127	3'-Demethylnobiletin		99.98%	Unkown
HY-127002	Squarunkin A	Inhibitor	99.34%	Unkown
HY-118144	PD166326	Inhibitor	99.99%	Unkown
HY-100434	PD-161570	Inhibitor	99.82%	Unkown
HY-103274	PD180970	Inhibitor	99.27%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-N4201	β-Hydroxyisovalerylshikonin	Inhibitor	99.83%	Unkown
HY-15805	KIN-8194	Inhibitor	98.01%	Unkown
HY-159480	AD1058	Inhibitor	/	Unkown
HY-120595	JNJ-49095397	Inhibitor	99.85%	Unkown
HY-132150A	HPK1-IN-2 dihydrochloride	Inhibitor	98.69%	Unkown
HY-10181S	Dasatinib-d8	Inhibitor	98.17%	Unkown
HY-112345	PD-089828	Inhibitor	98.07%	Unkown
HY-108016	Peruvoside	Inhibitor	99.32%	Unkown
HY-18237	KX1-004	Inhibitor	99.75%	Unkown
HY-W013857	Lavendustin C	Inhibitor	98.32%	Unkown
HY-125028	Hck-IN-1	Inhibitor	98.53%	Unkown
HY-123506	Fenlean	Inhibitor	99.56%	Unkown
HY-12047S	Ponatinib-d8	Inhibitor	99.91%	Unkown
HY-15764G	A 419259 (GMP)	Inhibitor	/	Unkown
HY-10234A	Saracatinib difumarate	Inhibitor	99.24%	Yes
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-18507	AD57	Inhibitor	98.08%	Unkown
HY-13342AS	Apatinib-d8 free base		92.56%	Unkown
HY-N6596	7-Hydroxy-4H-chromen-4-one	Inhibitor	99.94%	Unkown
HY-W744699	Larixol	Inhibitor	95.52%	Unkown
HY-111187	KX2-361	Inhibitor	99.55%	Unkown
HY-112291	SB 220025	Inhibitor	99.90%	Unkown
HY-138202	Lck-IN-1	Inhibitor	99.6%	Unkown
HY-15814	HG-7-85-01	Inhibitor	99.94%	Unkown
HY-10158S	Bosutinib-d8	Inhibitor	≥99.0%	Unkown
HY-16905	T338C Src-IN-1	Inhibitor	/	Unkown
HY-16906	T338C Src-IN-2	Inhibitor	/	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-157998	mG2N001		/	Unkown
HY-112852A	TL02-59 dihydrochloride	Inhibitor	/	Unkown
HY-W745090	Isomaltulose monohydrate	Inhibitor	/	Unkown
HY-P1111	Lyn peptide inhibitor	Inhibitor	/	Unkown
HY-102073	TG53	Inhibitor	/	Unkown
HY-157497	DA5-HTL	Inhibitor	/	Unkown
HY-10363	AP 24149	Inhibitor	/	Unkown
HY-P3743	p60c-src Substrate		/	Unkown
HY-112335	Lck Inhibitor III	Inhibitor	/	Unkown
HY-123298	Chrysotoxine	Inhibitor	/	Unkown
HY-121828	TX-1123	Inhibitor	/	Unkown
HY-P1377	Caffeic acid-pYEEIE		/	Unkown
HY-W062835A	CGP77675 hydrate	Inhibitor	/	Unkown
HY-162291	Lck-IN-3	Inhibitor	/	Unkown
HY-161687	Cisplatin/Dasatinib prodrug-1	Inhibitor	/	Unkown
HY-P0200	RR-SRC		/	Unkown
HY-146014	Multi-kinase-IN-1	Inhibitor	/	Unkown
HY-157290	HL403	Inhibitor	/	Unkown
HY-P1200A	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA	Inhibitor	/	Unkown
HY-115723	Antiallergic agent-1	Inhibitor	/	Unkown
HY-147314	HIV-IN-6		98.35%	Unkown
HY-110367A	LCB 03-0110	Inhibitor	/	Unkown
HY-P10665	pYEEI	Inhibitor	/	Unkown
HY-15268	PP487	Inhibitor	/	Unkown
HY-101447	SI-2	Inhibitor	/	Unkown
HY-112096S	eCF506-d5	Inhibitor	/	Unkown
HY-112393	TX-1918	Inhibitor	/	Unkown
HY-101268	CHMFL-ABL-053	Inhibitor	/	Unkown
HY-121849	KL-1156	Inhibitor	/	Unkown
HY-125387	TOP1210		/	Unkown
HY-162676	SJ45566	Degrader	/	Unkown
HY-P2547	Tyrosine Kinase Peptide 1		/	Unkown
HY-128397	CpCDPK1/TgCDPK1-IN-1	Inhibitor	/	Unkown
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	Unkown
HY-163469	SRC-3-IN-2	Inhibitor	/	Unkown
HY-P10527	CSK substrate		/	Unkown
HY-P10372	pFYN peptide		/	Unkown
HY-139890	DC-Srci-6649	Inhibitor	/	Unkown
HY-150026	Multi-kinase-IN-2	Inhibitor	/	Unkown
HY-163468	SRC-3-IN-1	Inhibitor	/	Unkown
HY-110367	LCB 03-0110 dihydrochloride	Inhibitor	/	Unkown
HY-163278	Lck-IN-2	Inhibitor	/	Unkown
HY-P1200	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH	Inhibitor	/	Unkown
HY-18507A	AD57 hydrochloride	Inhibitor	/	Unkown
HY-12847	CCT241161	Inhibitor	/	Unkown
HY-135216	Antiproliferative agent-54	Inhibitor	/	Unkown
HY-162879	FAK inhibitor 7	Inhibitor	/	Unkown
HY-162413	(R)-LW-Srci-8	Inhibitor	/	Unkown
HY-127002A	Squarunkin A hydrochloride	Inhibitor	/	Unkown
HY-P1111A	Lyn peptide inhibitor TFA	Inhibitor	/	Unkown
HY-100824	PP2 Analog	Inhibitor	/	Unkown
HY-168187	Src Inhibitor 3	Inhibitor	/	Unkown
HY-P3773	p60c-src substrate II		/	Unkown
HY-112291A	SB 220025 (tri(hydrochloride))	Inhibitor	/	Unkown
HY-160930	TOP1288	Inhibitor	/	Unkown
HY-N12166	2,3,4,6,8-Pentahydroxy-1-methylxanthone	Inhibitor	/	Unkown
HY-13314A	Tesevatinib tosylate	Inhibitor	/	Unkown
HY-125064	AP22408	Inhibitor	/	Unkown
HY-164530	SKLB646	Inhibitor	/	Unkown
HY-164527	Si306	Inhibitor	/	Unkown
HY-10234S	Saracatinib-d3	Inhibitor	/	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown
HY-122585	proMMP-9 inhibitor-3c	Inhibitor	/	Unkown
HY-N7160	2-Hydroxy-3-methylanthraquinone	Inhibitor	/	Unkown
HY-W700620	Hydroxymethyl dasatinib	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Src	NCBI	NCBI:6714
Mus musculus	Src	NCBI	NCBI:20779

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