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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

ADC Cytotoxin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (75) ADC Linker (9) Drug-Linker Conjugates for ADC (14) Antibiotic (6) Apoptosis (5) Autophagy (1) Bacterial (4) DNA Alkylator/Crosslinker (4) DNA Methyltransferase (1) DNA/RNA Synthesis (4) Drug Metabolite (1) EGFR (1) HSP (1) Isotope-Labeled Compounds (2) Microtubule/Tubulin (27) Mitochondrial Metabolism (1) Parasite (1) PD-1/PD-L1 (1) PI3K (1) TAM Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (16)
By Research Areas:	Cancer (140) Infection (6) Inflammation/Immunology (2) Neurological Disease (1)
Click Chemistry:	DBCO (1) Azide (1) BCN (1) Tetrazine (1) Alkynes (1)

141

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: ADC Cytotoxin ADC Antibody ADC Linker Drug-Linker Conjugates for ADC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144880

SC209	ADC Cytotoxin EGFR Drug Metabolite	Cancer
SC209, an **ADC cytotoxin extracted from patent WO2021247798, is used in synthesis of anti-EGFR** antibody-drug conjugate ADC. SC209 is the payload of STRO-002 .

HY-156513

7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)	ADC Cytotoxin	Cancer
7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) is a Camptothecin (HY-16560) analogue. 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) is a ADC cytotoxin that can be used for synthesis of ADCs, and for cancer research .

HY-145149

Duostatin 5	ADC Cytotoxin	Cancer
Duostatin 5 is a *cytotoxin* designed based on dolastatin, can meet the requirement of serving as an effective cytotoxin in *ADC*, but has the advantages of fewer synthesis steps, easy operation, less difficulty in quality control and more stable chemical synthesis process . Duostatin 5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-19791

N-Acetyl-Calicheamicin N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin	ADC Cytotoxin DNA/RNA Synthesis Antibiotic Bacterial	Infection Cancer
N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an **ADC cytotoxin*. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC* .

HY-131081

γ-Amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
γ-Amanitin an **ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀** of 163.1 ng/mL .

HY-126665A

DMEA-PNU-159682 dichloroacetate	ADC Cytotoxin	Cancer
DMEA-PNU-159682 (molecule D12) dichloroacetate is an **ADC cytotoxin** molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682 .

HY-400056

SC209 intermediate-2	ADC Cytotoxin	Cancer
SC209 intermediate-2 (Compound A9) is an intermediate of the ADC cytotoxin SC209 (HY-144880). SC209 intermediate-2 is an ADC Linker .

HY-156516A

10NH2-11F-Camptothecin TFA	ADC Cytotoxin Topoisomerase	Cancer
10NH2-11F-Camptothecin TFA is a Camptothecin (HY-16560) analogue that serves as an ADC cytotoxin for the synthesis of antibody-drug conjugates (ADCs). 10NH2-11F-Camptothecin TFA has anticancer effects (WO2022246576A1; compound 140) .

HY-19829

Sandramycin	ADC Cytotoxin Bacterial Antibiotic	Infection Cancer
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an **ADC cytotoxin. Sandramycin is active against Gram-positive bacteria** and has potent antitumor activity .

HY-130959

Tubulysin IM-2	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC *Cytotoxin) and an anti-microtubule toxin* (anti-microtubule toxins). Used for ADC synthesis.

HY-130960

Tubulysin IM-3	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC *Cytotoxin) and an anti-microtubule toxin* (anti-microtubule toxins). Used for ADC synthesis.

HY-130958

Tubulysin IM-1	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-1 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC *Cytotoxin) and an anti-microtubule toxin* (anti-microtubule toxins). Used for ADC synthesis .

HY-W190923

MMAF-methyl ester	ADC Cytotoxin	Cancer
MMAF-methyl ester is an ADC cytotoxin.

HY-126665

DMEA-PNU-159682	ADC Cytotoxin	Cancer
DMEA-PNU-159682 (molecule D12) is a **ADC cytotoxin** molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682 .

HY-79258

Dov-Val-Dil-OH	ADC Cytotoxin	Cancer
Dov-Val-Dil-OH is an ADC cytotoxin.

HY-129360A

Ala-Ala-Asn-PAB TFA	ADC Linker	Cancer
Ala-Ala-Asn-PAB TFA is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs) .

HY-129356

Seco-Duocarmycin SA	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
Seco-Duocarmycin SA is a DNA alkylator, and is used as an **ADC cytotoxin** .

HY-128896

Nitro-PDS-Tubulysin M	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
Nitro-PDS-Tubulysin M is a synthetic ADC drug-linker conjugate composed of the tubulin polymerization inhibitor Tubulysin M (an ADC Cytotoxin) and Nitro-PDS (an ADC linker).

HY-129355

Duocarmycin Analog	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and **ADC cytotoxin** .

HY-47858

Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc	ADC Cytotoxin	Cancer
Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is an ADC cytotoxin.

HY-13631M

Gly-Gly-Phe-Gly-NH-O-CO-Exatecan	ADC Cytotoxin	Cancer
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is an ADC cytotoxin.

HY-126687

Mal-PEG4-VC-PAB-DMEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for *ADC, consists the ADC* linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682 .

HY-126689

Mal-Phe-C4-VC-PAB-DMEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for *ADC, consists the ADC* linker Mal-Phe-C4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682 .

HY-148193

Tubulin polymerization-IN-38	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC *Cytotoxin) to synthesize ADCs* .

HY-135125

DC4	ADC Cytotoxin	Cancer
DC4, an ADC cytotoxin, can be used in the synthesis of antibody-drug conjugate (ADC). DC4 can be used for the targeted treatment of cancer .

HY-141594

Modified MMAF	Microtubule/Tubulin	Cancer
Modified MMAF, an ADC cytotoxin, can be used in the synthesis of Antibody-drug Conjugate (ADC). Modified MMAF can be used for the targeted research of cancer .

HY-148211

Tetrazine-PEG7-amine hydrochloride	ADC Linker	Cancer
Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-156687

GGFG-Eribulin	Drug-Linker Conjugates for ADC	Cancer
GGFG-Eribulin (Compound GGFG) is a Drug-Linker Conjugates for ADC. GGFG-Eribulin consists of the ADC Cytotoxin Eribulin (HY-13442) and a linker. GGFG-Eribulin can be used for synthesis of ADCs .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	ADC Cytotoxin	Cancer
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC *Cytotoxin) in antibody-drug conjugates (ADCs*) .

HY-78932A

Dap-NE hydrochloride	ADC Linker	Cancer
Dap-NE hydrochloride is a dipeptide hydrochloride and a cleavable ADC Linker.Dap-NE hydrochloride can be used to connect Antibody and toxin molecules (Cytotoxin) to synthesize Antibody-Drug Conjugates (ADCs) .

HY-W101718

Fmoc-N-(2-Boc-aminoethyl)-Gly-OH	Isotope-Labeled Compounds ADC Linker	Cancer
Fmoc-N-(2-Boc-aminoethyl)-Gly-OH is a Fmoc-protected glycine derivative that can be used in antibody agent coupling (ADC) synthesis. ADC consists of antibodies that are linked to ADC cytotoxins via ADC junctions[1].

HY-100861

C-11	ADC Cytotoxin Microtubule/Tubulin	Cancer
C-11 is a tubulin inhibitor and acts as an **ADC cytotoxin**, displays cytotoxicity for carcinoma cell lines .

HY-156617

Cyclopropaneacetamide-Exatecan	ADC Cytotoxin Topoisomerase	Cancer
Cyclopropaneacetamide-Exatecan (Compound 2-A) is an **ADC Cytotoxin and an Exatecan analogue. Cyclopropaneacetamide-Exatecan can be used in the synthesis of ADC** such as anti-B7H3 antibody-Exatecan analogue conjugate (compound ADC-2) .

HY-128914

Tubulysin	ADC Cytotoxin Antibiotic Microtubule/Tubulin	Cancer
The Tubulysin family of secondary metabolites was originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizers and anti-microtubule toxins (anti-microtubule toxins), with effective IC₅₀ concentrations against multidrug-resistant cancer cell lines. In the picomole range. Tubulysins are ideal candidates for incorporation into small active molecule conjugate (SMDC) delivery systems and are commonly used in ADC synthesis as ADC cytotoxins (ADC *Cytotoxin*) .

HY-126692

Mal-VC-PAB-ABAEP-Azonafide	Drug-Linker Conjugates for ADC	Cancer
Mal-VC-PAB-ABAEP-Azonafide is a agent-linker conjugate for ADC with with potent antitumor activity by using Azonafide (a cytotoxin), linked via the ADC linker Mal-VC-PAB .

HY-157407

Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a drug-linker conjugate for ADC (ADC Cytotoxin: Exatecan) .

HY-136313

MC-VC-PAB-Tubulysin M	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
MC-vc-PAB-Tubulysin M is a synthetic ADC drug-linker conjugate composed of the tubulin polymerization inhibitor Tubulysin M (an ADC Cytotoxin) (HY-N7053) and MC-vc-PAB (a cleavable ADC linker) .

HY-129356A

(S)-Seco-Duocarmycin SA	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a **ADC cytotoxin** for antibody-drug conjugates .

HY-131058

Muscotoxin A	ADC Cytotoxin	Cancer
Muscotoxin A is an ADC *cytotoxin*. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death .

HY-78738

MC-Val-Cit-PAB	ADC Linker	Cancer
MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-156849

Exatecan-methylacetamide-OH	ADC Cytotoxin Topoisomerase	Cancer
Exatecan-methylacetamide-OH (compound 6) is a Exatecan derivative with anticancer effects. Exatecan-methylacetamide-OH is an **ADC cytotoxin** that can be used to synthesize Antibody-Drug Conjugates (ADCs) (CN112125915A; compound 6) .

HY-153601

MC-VC-PAB-Cyclohexanediamine-Thailanstatin A	Drug-Linker Conjugates for ADC DNA/RNA Synthesis	Cancer
MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a Spliceostatin (HY-16466) analog, and a drug-linker conjugates for ADC, consisting of ADC Cytotoxin Thailanstatin A (HY-129589) and cleavable ADC linker (MC-vc-PAB). MC-VC-PAB-Cyclohexanediamine-Thailanstatin A can be used for ADC synthesis .

HY-15995

Tubulysin A 1 Publications Verification TubA	ADC Cytotoxin Antibiotic Microtubule/Tubulin	Cancer
Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC₅₀ values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as **ADC Cytotoxin** .

HY-78931

Boc-Dap-NE	ADC Linker	Cancer
Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-400684

Tubulysin A intermediate-1	Others	Cancer
Tubulysin A intermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A (HY-15995). Tubulysin A (TubA) is an antibiotic, anti-microtubule toxins, and apoptosis inducer isolated from myxobacteria. Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A arrests cells in the G2/M phase, effectively inhibits tubulin polymerization, and induces depolymerization of detached microtubules. Tubulysin A acts as an ADC cytotoxin (ADC *Cytotoxin) to synthesize ADC* .

HY-129379

DC0-NH2	ADC Cytotoxin	Cancer
DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component .

HY-147408

Rezetecán SHR9265	Topoisomerase ADC Cytotoxin	Cancer
Rezetecán (SHR9265) is a topoisomerase I inhibitor. In addition, Rezetecán can be used to synthesize Trastuzumab rezetecan, an antineoplastic agent. Rezetecán can be used as a cytotoxic payload (ADC *Cytotoxin) in antibody-drug conjugates (ADCs*) .

HY-161252

PBD-monoamide	ADC Cytotoxin	Cancer
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an **ADC Cytotoxin*. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC*). PBD-monoamide has DNA-binding activity and reduces cell viability .

HY-79490

Ac-Exatecan	ADC Cytotoxin Topoisomerase	Cancer
Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) .

HY-48878

Exatecan analog 36	ADC Cytotoxin Topoisomerase	Cancer
Exatecan analog 36 is a analog of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) .

Cat. No.	Product Name

HY-L023

Toxins for Antibody-Drug Conjugate Research Library

103 compounds

Antibody-Drug Conjugates (ADCs), a new class of treatment for cancer, are composed with a monoclonal antibody, a linker and a cytotoxic agent also referred to as a payload. To date, several ADCs have received market approval and more than 60 ADCs are currently in clinical trials. ADCs are one of the fastest growing classes of oncology drugs worldwide.

The payload or cytotoxic agent is the most important unit in the ADC. ADC has the capability to kill cancer cell depending on the potency of the payload. MCE provides 103 highly potent cytotoxins that contain auristatin derivatives, maytansinoids, calicheamicin, duocarmycin, pyrrolobenzodiazepines (PBDs), etc.

Cat. No.	Product Name	Type

HY-78738G

MC-Val-Cit-PAB (GMP)	Fluorescent Dye
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-78931G

Boc-Dap-NE (GMP)	Fluorescent Dye
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-16700G

PNU-159682 (GMP)	Fluorescent Dye
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Type

HY-78738G

MC-Val-Cit-PAB (GMP)	Biochemical Assay Reagents
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-78931G

Boc-Dap-NE (GMP)	Biochemical Assay Reagents
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-16700G

PNU-159682 (GMP)	Biochemical Assay Reagents
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Target	Research Area

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin .

Cat. No.	Product Name	Target	Research Area

HY-P99734

Mipasetamab uzoptirine ADCT-601	TAM Receptor	Cancer
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-131081

γ-Amanitin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	DNA/RNA Synthesis ADC Cytotoxin
γ-Amanitin an **ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀** of 163.1 ng/mL .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Structural Classification Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Cytotoxin
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC *Cytotoxin) in antibody-drug conjugates (ADCs*) .

HY-19829

Sandramycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics	ADC Cytotoxin Bacterial Antibiotic
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an **ADC cytotoxin. Sandramycin is active against Gram-positive bacteria** and has potent antitumor activity .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC *Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra* and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-12457

Rachelmycin CC-1065; NSC 298223	Structural Classification Classification of Application Fields Source classification Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Anticancer Disease Research Fields Cancer	Antibiotic DNA/RNA Synthesis
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .

HY-P99734

Mipasetamab uzoptirine ADCT-601	Classification of Application Fields Disease Research Fields Cancer	TAM Receptor
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers .

HY-106338

Polyketomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Naphthalene Quinones Disease Research Fields	Bacterial ADC Cytotoxin Parasite
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-114936

Piericidin A 1 Publications Verification AR-054	Structural Classification Neurological Disease Classification of Application Fields Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Anticancer Disease Research Fields	Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

Cat. No.	Product Name	Chemical Structure

HY-116852S

Thiocolchicine-d3

Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent *cytotoxin* in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

Cat. No.	Product Name		Classification