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Results for "

Plasmodium falciparum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (2) Antibiotic (11) Apoptosis (10) Autophagy (1) Bacterial (15) Biochemical Assay Reagents (1) Cathepsin (3) CDK (1) CXCR (1) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (5) DNA Methyltransferase (3) DNA/RNA Synthesis (3) Endogenous Metabolite (2) Eukaryotic Initiation Factor (eIF) (1) Farnesyl Transferase (2) FKBP (1) Fungal (1) GLUT (2) GSK-3 (1) HCV (2) HDAC (5) HSV (1) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (1) Mitochondrial Metabolism (1) Na+/K+ ATPase (1) NF-κB (1) Parasite (148) Phosphodiesterase (PDE) (1) PI3K (1) PI4K (6) PKA (1) Potassium Channel (2) Proteasome (1) Reactive Oxygen Species (1) SARS-CoV (1) Virus Protease (1)
By Research Areas:	Cancer (23) Infection (156) Inflammation/Immunology (8) Metabolic Disease (4)

By Targets:

Aminoacyl-tRNA Synthetase (2)

Antibiotic (11)

Apoptosis (10)

Autophagy (1)

Bacterial (15)

Biochemical Assay Reagents (1)

Cathepsin (3)

CDK (1)

CXCR (1)

Dihydrofolate reductase (DHFR) (3)

Dihydroorotate Dehydrogenase (5)

DNA Methyltransferase (3)

DNA/RNA Synthesis (3)

Endogenous Metabolite (2)

Eukaryotic Initiation Factor (eIF) (1)

Farnesyl Transferase (2)

FKBP (1)

Fungal (1)

GLUT (2)

GSK-3 (1)

HCV (2)

HDAC (5)

HSV (1)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (1)

Mitochondrial Metabolism (1)

Na+/K+ ATPase (1)

NF-κB (1)

Parasite (148)

Phosphodiesterase (PDE) (1)

PI3K (1)

PI4K (6)

PKA (1)

Potassium Channel (2)

Proteasome (1)

Reactive Oxygen Species (1)

SARS-CoV (1)

Virus Protease (1)

By Research Areas:

Cancer (23)

Infection (156)

Inflammation/Immunology (8)

Metabolic Disease (4)

163

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9320

13,21-Dihydroeurycomanone	Parasite	Infection
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-161801

MMV006833 M-833	Parasite	Infection
MMV006833 is an inhibitor for Plasmodium falciparum. MMV006833 targets the lipid-transfer protein PfSTART1 and inhibits the development of Plasmodium falciparum at the ring stage .

HY-122385

Dabequin phosphate	Parasite	Infection
Dabequin phosphate is an antimalarial agent, that exhibits inhibitory activity against Plasmodium falciparum .

HY-173027

SPB07935	Parasite	Infection
SPB07935 inhibits the plasmepsin II in Plasmodium falciparum and can be used as an antimalarial agent. SPB07935 regulates the life cycle of P. falciparum, inhibits the growth of Plasmodium strains FcB1 and 3D7 with IC₅₀ of 8 μM and 4.7 μM .

HY-163997

Antimalarial agent 42	Parasite	Infection
Antimalarial agent 42 (Compound 2) is an antimalarial agent, that inhibits Plasmodium falciparum in the phase of asexual blood stages (IC₅₀ <0.5μM) and gametocytes (IC₅₀ is 0.14 μM) .

HY-163727

MMV1557817	Parasite	Infection
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites .

HY-162072

PfThrRS-IN-1	Parasite	Infection
PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC₅₀ value of 0.1 μM. PfThrRS-IN-1 is a potent antimalaria agent .

HY-N12700

Puberulic acid Ⅰ	Parasite	Infection
Puberulic acid Ⅰ possesses anti-malarial activity with an IC₅₀ value of 0.050 µM against Plasmodium falciparum K1 (chloroquine-resistant) .

HY-156105

8304-vs	Parasite Proteasome	Infection
8304-vs is a macrocyclic anti-Plasmodial agent that covalently and irreversibly targets the Plasmodium proteasome. 8304-vs effectively inhibits the growth of Plasmodium falciparum .

HY-163833

MMV1634566	Parasite	Infection Cancer
MMV1634566 is a potent antimalarial agent. MMV1634566 inhibits Plasmodium falciparum. MMV1634566 shows cytotoxicity .

HY-124078

NIC	Parasite	Infection
NIC is a host invasion inhibitor. NIC can suppress host invasion by interacting with the major invasion-related protein, merozoite surface protein 1 (MSP-1). NIC prevents the invasion of Plasmodium falciparum and Plasmodium vivax into the host .

HY-137646

Sp-2-Cl-cAMPS	PKA Parasite	Infection
Sp-2-Cl-cAMPS is an agonist for PKA with improved membrane permeability and stability to phosphodiesterase. Sp-2-Cl-cAMPS exhibits antimalarial activity, and inhibits the proliferation of Plasmodium falciparum with an EC₅₀ of 4 μM. Sp-2-Cl-cAMPS binds to purified P. falciparum* PfPKAr* (regulatory subunit of PfPKA) with a K_i of 1.3 µM .

HY-135619

DHODH-IN-4	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection Inflammation/Immunology
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC₅₀ values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity .

HY-N8383

Butyrolactone V	Parasite	Infection
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-N0352

Tuberostemonine	Parasite	Infection
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

HY-137126

Photosensitizer Pc 4 NSC-676418	Parasite	Infection
Photosensitizer Pc 4 (NSC-676418) is a photosensitizer, which inhibits Plasmodium falciparum in dark or under red light by disturbing the protein/DNA synthesis, with an IC₅₀ of 24 nM .

HY-125419

Amythiamicin B	Antibiotic Parasite Bacterial	Infection
Amythiamicin B is a trisubstituted pyridine thiopeptide with antibiotic properties against Gram-positive bacteria and activity against Plasmodium falciparum .

HY-149289

DNMT-IN-3	Parasite DNA Methyltransferase	Others
DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC₅₀ of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research .

HY-157840

Anti-infective agent 9	Parasite	Infection
Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor (IC₅₀=600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium. Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS) .

HY-135648

PfDHODH-IN-1	Parasite Lactate Dehydrogenase DNA/RNA Synthesis	Infection
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity .

HY-145912

RYL-552S	Parasite	Infection Inflammation/Immunology
RYL-552S kills drug-resistant strains of Plasmodium falciparum. RYL-552S can efficiently kill asexual blood-stage parasites in vitro .

HY-117897

CK-2-68	Parasite	Infection
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM .

HY-169099

Antiproliferative agent-56	Parasite	Infection
Antiproliferative agent-56 (Compound 31) is an antimalarial agent, that inhibits Plasmodium falciparum 3D7 (Pf3D7) with an IC₅₀ >12.5 (48h) and 0.03 μM (98h), and reveals a slow-acting property .

HY-155130

Antimalarial agent 31	Parasite	Infection
Antimalarial agent 31 (compound 7k) is an orally active Plasmodium falciparum aspartic protease plasmepsin X (PMX) inhibitor .

HY-159963

PfCLK3-IN-1	Parasite	Infection
PfCLK3-IN-1 (Compound 4) is a covalent inhibitor for Plasmodium falciparum CLK3 (Pf CLK3) under alkaline conditions with an pEC₅₀ of 7.1. PfCLK3-IN-1 reduces mature gametocytes in sexual stage parasites, and prevents transmission. PfCLK3-IN-1 inhibits P. falciparum Dd2-B2 clone with an IC₅₀ of 239.5 nM .

HY-153007

DHFR-IN-5	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity .

HY-153007A

DHFR-IN-5 hydrochloride	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-5 hydrochloride is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 hydrochloride shows anti-malaria activity .

HY-145327

Antimalarial agent 7	Na+/K+ ATPase Parasite	Infection
Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Parasite	Infection
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N8338

Pancixanthone A	Parasite	Infection
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N0352R

Tuberostemonine (Standard)	Parasite	Infection
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR) .

HY-12912

KDU691	PI4K Parasite	Infection
KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites .

HY-161079

TDI-8304	Parasite	Infection
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes .

HY-148315

GLUT1-IN-2	GLUT	Infection
GLUT1-IN-2 (compound 17) is a GLUT1 inhibitor with an IC₅₀ value of 12 μM. GLUT1-IN-2 shows inhibitory effect to Plasmodium falciparum hexose transporter PfHT with an IC₅₀ value of 13 μM. GLUT1-IN-2 can be used for the research of infection .

HY-121211

Digitolutein	Parasite	Infection
Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of **Plasmodium falciparum with an IC₅₀** value of 12.92 μg/mL. Digitolutein can be used for the research of infection .

HY-163765

Antimalarial agent 41	PI4K Potassium Channel	Infection
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC₅₀ of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC₅₀ of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC₅₀ of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .

HY-135666

DHODH-IN-8	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC₅₀s of 0.13 μM and 47.4 μM, and K_is of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity .

HY-N8374

Pheanthine	Parasite	Infection
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC₅₀ is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC₅₀ of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC₅₀ is 11.2 μM) and macrophages (PMM, IC₅₀ is 8 μM) .

HY-W078844

PfDHODH-IN-2	Dihydroorotate Dehydrogenase Parasite	Infection
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC₅₀ of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria .

HY-N5109

Cheilanthifoline	Parasite	Infection
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-147850

JMI-346	Parasite	Infection
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ ^S (3D7; IC₅₀=13 µM) and CQ ^R (RKL-9; IC₅₀=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .

HY-A0148

Halofantrine SKF-102886 free base; WR-171669	Parasite Potassium Channel	Infection Cancer
Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum . Halofantrine blocks HERG potassium channels .

HY-120104

Nitidanin (±)-Nitidanin	Parasite HCV	Infection
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection .

HY-106515

Tebuquine WR228258	Parasite	Infection
Tebuquine (WR228258), a 4-aminoquinoline, is a potent antimalarial agent. Tebuquine is active against the Chloroquine (HY-17589A) sensitive HB3 strain and the Chloroquine resistant K1 strain of Plasmodium falciparum with IC₅₀s of 0.9 nM and 20.8 nM, respectively .

HY-157892

Antimalarial agent 38	Parasite	Infection
Antimalarial agent 38 (Compound 1) exhibits activity against antiplasmodial, which inhibits Plasmodium falciparum D6 strain, chloroquine-sensitive Thai strain and chloroquine-resistant FcB1 strain and K1 strain, with IC₅₀s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC₅₀ >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .

HY-103397

Nanaomycin A 3 Publications Verification	Antibiotic DNA Methyltransferase Parasite	Infection Cancer
Nanaomycin A is the first selective DNMT3B inhibitor with an IC₅₀ of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells . Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC₈₀ value of 33.1 nM .

HY-N12232

Carbazomycin D	Parasite Bacterial	Infection Cancer
Carbazomycin D exhibits antituberculosis and antimalarial activities, that inhibits Plasmodium falciparum with an IC₅₀ > 10 μg/mL, inhibits Mycobacterium tuberculosis with MIC of 25 μg/mL. Carbazomycin D exhibits cytotoxicity in cell MCF-7, KB, NCI-H187 and Vero, with IC₅₀s of 21.3, 33.2, 12.9, and 34.3 μg/mL, respectively .

HY-120462

Genz-669178	Dihydroorotate Dehydrogenase Parasite	Infection
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC₅₀ of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC₅₀ of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED₅₀ of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice .

HY-103353A

SID 26681509 quarterhydrate 5 Publications Verification	Cathepsin Parasite	Infection Cancer
SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite **Plasmodium falciparum and inhibits Leishmania major with IC₅₀**s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G .

HY-147849

JMI-105	Parasite	Infection
JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQ ^S (3D7; IC₅₀=8.8 µM) and CQ ^R (RKL-9; IC₅₀=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent .

Cat. No.	Product Name	Type

HY-134421

2-Butenoyl coenzyme A lithium	Enzyme Substrates
2-Butenoyl coenzyme A (lithium), an active compound, can be used as a substrate for plasmodium falciparum enyl-ACP reductases and other enyl-CoA reductases. 2-Butenoyl coenzyme A lithium can be used as a substrate analogue to study the kinetics of β-hydroxyacyl-acyl-carrier protein (ACP) dehydratase (FabZ) .

Cat. No.	Product Name	Target	Research Area

HY-P5344

Dabcyl-LNKRLLHETQ-Edans Fluorigenic PEXEL peptide	Parasite	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9320

13,21-Dihydroeurycomanone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Eurycoma longifolia Jack Plants Disease Research Fields	Parasite
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-N0352

Tuberostemonine	Infection Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields	Parasite
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

HY-121211

Digitolutein	Morinda lucida Benth. Rubiaceae Plants	Parasite
Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of **Plasmodium falciparum with an IC₅₀** value of 12.92 μg/mL. Digitolutein can be used for the research of infection .

HY-N12700

Puberulic acid Ⅰ	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Parasite
Puberulic acid Ⅰ possesses anti-malarial activity with an IC₅₀ value of 0.050 µM against Plasmodium falciparum K1 (chloroquine-resistant) .

HY-N8383

Butyrolactone V	Infection Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Parasite
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-125419

Amythiamicin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Parasite Bacterial
Amythiamicin B is a trisubstituted pyridine thiopeptide with antibiotic properties against Gram-positive bacteria and activity against Plasmodium falciparum .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Structural Classification Flavonoids Xanthones Calophyllum caledonicum Vieill. ex Planch. & Triana Source classification Phenols Plants Calophyllaceae Other Flavonoids	Parasite
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N8338

Pancixanthone A	Structural Classification Flavonoids Source classification Guttiferae Garcinia vieillardii Pierre Plants Other Flavonoids	Parasite
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N0352R

Tuberostemonine (Standard)	Alkaloids Structural Classification other families Pyrrole Alkaloids Source classification Plants	Parasite
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR) .

HY-N8374

Pheanthine	Structural Classification Alkaloids Piperidine Alkaloids Triclisia gilletii (De Wild.) Staner Source classification Plants Menispermaceae	Parasite
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC₅₀ is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC₅₀ of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC₅₀ is 11.2 μM) and macrophages (PMM, IC₅₀ is 8 μM) .

HY-N5109

Cheilanthifoline	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Parasite
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-120104

Nitidanin (±)-Nitidanin	Structural Classification Buxaceae Source classification Lignans Phenylpropanoids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Parasite HCV
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection .

HY-N12232

Carbazomycin D	Structural Classification Natural Products Microorganisms Source classification	Parasite Bacterial
Carbazomycin D exhibits antituberculosis and antimalarial activities, that inhibits Plasmodium falciparum with an IC₅₀ > 10 μg/mL, inhibits Mycobacterium tuberculosis with MIC of 25 μg/mL. Carbazomycin D exhibits cytotoxicity in cell MCF-7, KB, NCI-H187 and Vero, with IC₅₀s of 21.3, 33.2, 12.9, and 34.3 μg/mL, respectively .

HY-134421

2-Butenoyl coenzyme A lithium	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Biochemical Assay Reagents
2-Butenoyl coenzyme A (lithium), an active compound, can be used as a substrate for plasmodium falciparum enyl-ACP reductases and other enyl-CoA reductases. 2-Butenoyl coenzyme A lithium can be used as a substrate analogue to study the kinetics of β-hydroxyacyl-acyl-carrier protein (ACP) dehydratase (FabZ) .

HY-126640

Phomoxanthone A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N8257

Dehydrobruceine A	Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields Brucea javanica (L.) Merr.	Parasite
Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .

HY-W779377

Erythromycin B	Structural Classification Microorganisms Antibiotics Source classification	Parasite
Erythromycin B has anti-malarial activity and effectively inhibits the asexual reproduction of Plasmodium falciparum .

HY-N10928

Lettowienolide	Quinones Structural Classification Stellaria media (L.) Villars Source classification Phenols Benzene Quinones Plants Caryophyllaceae	Parasite
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-118494

Ascaridole	Structural Classification Natural Products Source classification Plants Dysphania ambrosioides (Linnaeus) Mosyakin & Clemants Chenopodiaceae	Parasite
Ascaridole is an anthelmintic and also has antimalarial activity .

HY-N13885

Amythiamicin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Parasite
Amythiamicin A is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .

HY-N12538

trans-Cinnamic anhydride	Structural Classification Natural Products Source classification Cinnamomum verum J. Presl Plants Lauraceae	Parasite
trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-N13288

Cordysinin C/D	Structural Classification Alkaloids Animals Other Alkaloids Source classification	Parasite
Cordysinin C/D (compound 9) is a potential anti-plasmodial compound that can effectively inhibit Plasmodium falciparum 3D7 strain .

HY-N13881

Amythiamicin C	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Parasite
Amythiamicin C is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .

HY-N8513

Brevicompanine B	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Structural Classification Natural Products Source classification Rourea minor (Gaerth.) Leenh. Plants Connaraceae	Parasite
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-N11031

Z-Antiepilepsirine	Structural Classification Alkaloids Piperidine Alkaloids Piper capense Source classification Piperaceae Plants	Parasite
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-N10096

Epoxyazadiradione	Infection Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Parasite
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N12151

Chaparrinone	Structural Classification Natural Products Simaroubaceae Source classification Eurycoma harmandiana Pierre Plants	Parasite
Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively) .

HY-B0770

Artemotil 1 Publications Verification β-Arteether; (+)-Arteether; Arteether	Structural Classification Natural Products Classification of Application Fields Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	CXCR Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant **Plasmodium falciparum malaria with an IC₅₀** of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N10109A

Gallinamide A TFA	Structural Classification Natural Products Microorganisms Source classification	SARS-CoV Parasite Cathepsin
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC₅₀: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC₅₀: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC₅₀: 50 nM) .

HY-N8285

Sporogen AO-1	Structural Classification Natural Products Microorganisms Source classification	Parasite
Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC₅₀ value of 1.53 μM, and also has certain cytotoxicity .

HY-N5005

Guanfu base H Atisinium chloride	Infection Alkaloids Classification of Application Fields Source classification Ranunculaceae Quinoline Alkaloids Aconitum carmichaeli Debx. Plants Disease Research Fields	Parasite
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial **Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC₅₀** values of 4 μM and 3.6 μM, respectively .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-N6009

8-Deoxygartanin	Infection Structural Classification other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Parasite NF-κB
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-129476

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite **Plasmodium falciparum with an IC₅₀** of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-N7642

Oxysanguinarine Hydroxysanguinarine; 8-Oxosanguinarine	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Parasite
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with antimalarial activity .

HY-N7897

Myrrhone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	Parasite
Myrrhone is a terpenoid compound with antiplasmodial effects .

HY-N0941

beta-Mangostin 3 Publications Verification β-Mangostin	Infection Structural Classification Xanthones Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Garcinia mangostana Linn. Plants Disease Research Fields Cancer	Bacterial Parasite Apoptosis
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-126417

Methylenetanshinquinone	Structural Classification Natural Products Leguminosae Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	Parasite
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

HY-N9438R

Lactucin (Standard)	Iridoids Genista quadriflora Munby Source classification Plants Compositae	Apoptosis Parasite
Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities [4].

HY-N9438

Lactucin	Iridoids Genista quadriflora Munby Source classification Plants Compositae	Apoptosis Parasite
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities .

HY-N6742

Borrelidin 1 Publications Verification Treponemycin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Disease Research Fields	CDK Parasite Apoptosis Antibiotic
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC₅₀ of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC₅₀ of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC₅₀s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .

HY-N0941R

beta-Mangostin (Standard)	Structural Classification Xanthones Guttiferae Source classification Phenols Polyphenols Garcinia mangostana Linn. Plants	Bacterial Parasite Apoptosis
beta-Mangostin (Standard) is the analytical standard of beta-Mangostin. This product is intended for research and analytical applications. beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

Cat. No.	Product Name	Chemical Structure

HY-B0439S1

Sulfadoxine D3

Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

HY-B0148S

Risedronic acid-d4

Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148).Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

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