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Results for "

AM ester

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Akt (1) Amyloid-β (1) Antibiotic (16) Apelin Receptor (APJ) (2) Apoptosis (5) Autophagy (2) Bacterial (19) BCRP (1) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (5) c-Met/HGFR (1) Cannabinoid Receptor (11) Caspase (1) Cathepsin (1) CGRP Receptor (3) Cholinesterase (ChE) (1) COX (1) Dopamine Receptor (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (3) E1/E2/E3 Enzyme (1) EAAT (1) Endogenous Metabolite (1) FAAH (5) FAP (1) FLAP (5) Fluorescent Dye (42) Free Fatty Acid Receptor (3) Fungal (4) Glucokinase (1) GPR55 (1) HBV (2) Histone Acetyltransferase (1) Influenza Virus (2) Insulin Receptor (1) Integrin (1) Isotope-Labeled Compounds (3) JNK (1) Leukotriene Receptor (2) Liposome (1) LPL Receptor (6) MAGL (1) MDM-2/p53 (3) MicroRNA (8) Microtubule/Tubulin (2) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) PI3K (2) PKA (4) PKC (2) PKG (2) Potassium Channel (4) PPAR (1) Prostaglandin Receptor (2) PROTAC Linkers (1) Proteasome (1) RAR/RXR (4) Ras (2) Reactive Oxygen Species (1) Sodium Channel (1) STING (3) Thyroid Hormone Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (10) TRP Channel (3) VEGFR (1)
By Research Areas:	Cancer (37) Cardiovascular Disease (17) Endocrinology (3) Infection (28) Inflammation/Immunology (28) Metabolic Disease (16) Neurological Disease (27)
Click Chemistry:	Azide (1) Tetrazine (1) Alkynes (1)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) Aptamers (2) Emulsifiers (1) miRNA inhibitors (2) Solubilizing Agents (1) Cationic Lipids (1)

188

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: CETP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131131

5-CFDA-AM	Fluorescent Dye	Others
5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .

HY-125967

AM 374	FAAH	Neurological Disease
AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC₅₀ value of 13 nM. AM 374 can be used for the research of neurological disease .

HY-100221

AM-2394	Glucokinase	Metabolic Disease
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC₅₀ of 60 nM.

HY-D1441

Zinquin AM ester	Fluorescent Dye	Others
Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn ²⁺ status .

HY-139486

AM-8123	Apelin Receptor (APJ)	Cardiovascular Disease
AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease .

HY-165524

AM 92016	Potassium Channel	Cardiovascular Disease
AM 92016 is a potassium channel blocker. AM 92016 can increase the duration of action potentials in isolated ventricular cells from guinea pigs and rabbits. AM 92016 has proarrhythmic activity in guinea pigs and pigs .

HY-135495

AM-0466	Others	Inflammation/Immunology
AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing .

HY-12941

AM-7209	MDM-2/p53	Cancer
AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a K_d of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC₅₀ of 1.6 nM. AM-7209 shows antitumor activities .

HY-16619

AM-5262	Free Fatty Acid Receptor	Metabolic Disease
AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .

HY-18052

AM-8553	MDM-2/p53	Cancer
AM-8553 is a MDM2/p53 inhibitor (K_D: 0.4 nM for MDM2). AM-8553 has anti-tumor activity

HY-101253

AM-92016 hydrochloride 1 Publications Verification	Potassium Channel	Cardiovascular Disease
AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse .

HY-126133

AM-001	Ras	Cardiovascular Disease Others
AM-001 is a non-competitive inhibitor of Epac1 that blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells. AM-001 can be used in heart disease-related research .

HY-12734

AM-8735	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
AM-8735 is a potent and selective MDM2 inhibitor with an IC₅₀ of 25 nM.

HY-120423

AM-6538	Cannabinoid Receptor	Neurological Disease
AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may be useful in future studies that require temporary reductions in cannabinoid receptor availability . AM-6538 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-110206

AM6545	Cannabinoid Receptor	Metabolic Disease
AM6545 is a peripherally active, cannabinoid receptor antagonist with limited brain penetration. AM6545 binds to CB1 and CB2 receptors with K_is of 1.7 nM and 523 nM, respectively. AM6545 is a neutral antagonist. AM6545 can be used for the research of obesity and its complications .

HY-137103

BTC-AM	Fluorescent Dye	Others
BTC-AM is a low affinity calcium indicator. BTC-AM has substantial calcium-independent fluorescence at all excitation wavelengths. BTC-AM is readily loaded into neurons and is rapidly hydrolysed .

HY-149933

AM841	Cannabinoid Receptor	Neurological Disease
AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility .

HY-110128

Sulfidefluor 7-AM SF7-AM	Fluorescent Dye	Others
Sulfidefluor 7-AM is a stable hydrogen sulphide (H₂S) fluorescent probe . Sulfidefluor 7-AM is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-144894

AM-5308	Microtubule/Tubulin	Cancer
AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13) .

HY-126831

SBFI-AM 2 Publications Verification	Fluorescent Dye	Others
SBFI-AM is a Na ⁺ selective fluorescent indicator. SBFI-AM shows selectivity for Na ⁺ over K ⁺ .

HY-162110

AM-9022	Microtubule/Tubulin	Cancer
AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer .

HY-118374

AM-9635	PI3K Akt	Inflammation/Immunology
AM-9635 is a selective PI3Kδ inhibitor with oral bioavailability, good in vitro and in vivo activity and pharmacodynamic properties. AM-9635 inhibits PI3Kδ-dependent B cell receptor-mediated AKT phosphorylation and suppresses the production of specific IgG and IgM antibodies in rats immunized with Aplysia leocyanin (KLH).

HY-129683

AM3102	PPAR	Metabolic Disease
AM3102 is an oleoylethanolamide (OEA) analog. AM3102 is an endogenous high-affinity PPAR-alpha agonist. AM3102 resists enzymatic hydrolysis, activates PPAR-alpha with high potency in vitro, and persistently reduces feeding when administered in vivo either parenterally or orally .

HY-120471

AM-0687	PI3K	Inflammation/Immunology
AM-0687 is a selective inhibitor for PI3Kδ with an IC₅₀ of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC₅₀=0.8 nM) and the phosphorylation of AKT (IC₅₀=0.7 nM), and exhibits anti-inflammatory efficacy .

HY-D1776

FFP-18-AM	Fluorescent Dye	Others
FFP-18-AM is a cell-permeable fluorescent indicator for measurement of near-membrane calcium.

HY-13467

AM-1638 2 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC₅₀ of 0.16 μM.

HY-13505

AM281	Cannabinoid Receptor	Neurological Disease
AM281 is a selective CB1 receptor antagonist with an IC₅₀ of 9.91 nM. AM281 inhibits CB2 receptor with an IC₅₀ of 13000 nM .

HY-163291

AM4085	Bacterial	Infection
AM4085 is an orally active Antagonist for FmlH with an IC₅₀ of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma .

HY-128774

AM-6494	Beta-secretase	Neurological Disease
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM) . AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144827

AM8936	Cannabinoid Receptor	Neurological Disease Metabolic Disease
AM8936 acts as a balanced and potent cannabinoid receptor type-1 (CB1) agonist in functional assays (EC₅₀s of 8.6 and 1.4 nM for rCB1 and hCB1, respectively). AM8936 exhibits high affinity for rat CB1 (rCB1) with K_i of 0.55 nM. AM8936 is a potent and efficacious CB1 agonist in vivo. AM8936 can be used for the research of CNS and metabolic disorders, pain, glaucoma, etc .

HY-100727

AM-2099	Sodium Channel	Neurological Disease
AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC₅₀ of 0.16 μM for human Nav1.7.

HY-147367

AM-1488	Others	Neurological Disease
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC₅₀=0.45 μM) .

HY-19367

MD-39-AM	Others	Cardiovascular Disease
MD-39-AM exhibits antihypertensive, diuretic and saliuretic activities with good in vivo pharmacokinetic characters .

HY-109561

Pegaptanib sodium EYE001; NX1838	VEGFR	Metabolic Disease Inflammation/Immunology
Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

HY-108329

AM-0902	TRP Channel	Neurological Disease Inflammation/Immunology
AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC₅₀s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.

HY-D1681

Rhod-590 AM Ester	Fluorescent Dye	Others
Rhod-590 AM Ester is a fluorescent dye. Rhod-590 AM Ester can be used as a fluorescent indicator for calcium determination .

HY-D1700

Mag-indo-1/AM	Fluorescent Dye	Others
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg ²⁺ and also for Ca ²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg ²⁺ and Ca ²⁺ concentrations .

HY-D1629

Calcium Orange AM	Fluorescent Dye	Others
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles .

HY-15443

AM251 15+ Cited Publications	Cannabinoid Receptor	Neurological Disease
AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC₅₀ of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC₅₀ of 39 nM .

HY-126558

GA3-AM	Others	Others
GA3-AM is a cell permeable analog of the plant hormone gibberellic acid that acts as a chemical dimerizer or chemical inducer of dimerization .

HY-161091

AM-2-19	Fungal	Infection
AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists .

HY-D1502

FURA-PE3/AM	Fluorescent Dye	Others
FURA-PE3/AM is a leak-resistant fluorescent calcium indicator dye .

HY-W010756

FMOC-AM	Others	Others
FMOC-AM is a protein cross-linking agent.

HY-155466

Boc-MIF-1-Am	Dopamine Receptor	Neurological Disease
Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC₅₀=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells .

HY-N8430

Poricoic acid AM	Others	Cancer
Poricoic acid AM is a triterpenoid with ant-tumor activities .

HY-14162

AM103 free acid	FLAP	Inflammation/Immunology
AM103 (free acid) is a selective FLAP inhibitor that can block the first step of the LT pathway, which is 5-LO activation. AM103 (free acid) can inhibit the production of LTB₄ and cysteinyl leukotrienes (CysLT). AM103 (free acid) has anti-inflammatory activity in a mouse model of chronic lung inflammation and can extend the survival time of mice injected with platelet-activating factor. AM103 (free acid) can be used for research on respiratory diseases such as asthma .

HY-D1755

Fluo-3FF AM	Fluorescent Dye	Others
Fluo-3FF AM is a low affinity (Kd = 42 μM) fluorescent Ca ²⁺ sensitive indicator (Abs/Em = 462 nm/526 nm). Fluo-3FF AM is Mg ²⁺ insensitive and relatively photostable. Fluo-3FF AM is an analog of Fluo-3FF AM. Fluo-3FF AM is essentially non-fluorescent, but exhibits a strong fluorescence enhancement upon entry into cells and binding to calcium.

HY-120288

AM4299B	Cathepsin	Infection Metabolic Disease
AM4299B is an inhibitor for thiol protease. AM4299B inhibits bovine spleen cathepsin B, human kidney cathepsin L and papain with IC₅₀s of 0.7, 0.5 and 20 μM, respectively. AM4299B can be used in research in osteoporosis, and has potential to be used as an antiparasitic agent .

HY-104058

Oregon-BAPTA Green 1AM Oregon Green 488 BAPTA 1AM	Fluorescent Dye	Others
Oregon-BAPTA Green 1AM (Oregon Green 488 BAPTA 1AM) is a fluorescent Ca ²⁺ indicator that consists of a green fluorescent probe OG 488 and a cell-permeable Ca ²⁺ chelator BAPTA AM.

HY-D1903

Fura Red AM	Fluorescent Dye	Others
Fura Red AM is a fluorescent probe that can be used to visualize [Ca(2+)] distribution in the cytoplasm of undifferentiated cells. Fura Red AM operates at an excitation wavelength of 488 nm .

Cat. No.	Product Name	Type

HY-131131

5-CFDA-AM

Fluorescent Dyes/Probes

5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .

HY-126831

SBFI-AM 2 Publications Verification	Fluorescent Dyes/Probes
SBFI-AM is a Na ⁺ selective fluorescent indicator. SBFI-AM shows selectivity for Na ⁺ over K ⁺ .

HY-104058

Oregon-BAPTA Green 1AM Oregon Green 488 BAPTA 1AM	Fluorescent Dyes/Probes
Oregon-BAPTA Green 1AM (Oregon Green 488 BAPTA 1AM) is a fluorescent Ca ²⁺ indicator that consists of a green fluorescent probe OG 488 and a cell-permeable Ca ²⁺ chelator BAPTA AM.

HY-D1903

Fura Red AM	Dyes
Fura Red AM is a fluorescent probe that can be used to visualize [Ca(2+)] distribution in the cytoplasm of undifferentiated cells. Fura Red AM operates at an excitation wavelength of 488 nm .

HY-137103

BTC-AM	Fluorescent Dyes/Probes
BTC-AM is a low affinity calcium indicator. BTC-AM has substantial calcium-independent fluorescence at all excitation wavelengths. BTC-AM is readily loaded into neurons and is rapidly hydrolysed .

HY-D1776

FFP-18-AM	Fluorescent Dyes/Probes
FFP-18-AM is a cell-permeable fluorescent indicator for measurement of near-membrane calcium.

HY-D1700

Mag-indo-1/AM	Fluorescent Dyes/Probes
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg ²⁺ and also for Ca ²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg ²⁺ and Ca ²⁺ concentrations .

HY-D1629

Calcium Orange AM	Fluorescent Dyes/Probes
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles .

HY-D1502

FURA-PE3/AM	Fluorescent Dyes/Probes
FURA-PE3/AM is a leak-resistant fluorescent calcium indicator dye .

HY-D1755

Fluo-3FF AM	Fluorescent Dyes/Probes
Fluo-3FF AM is a low affinity (Kd = 42 μM) fluorescent Ca ²⁺ sensitive indicator (Abs/Em = 462 nm/526 nm). Fluo-3FF AM is Mg ²⁺ insensitive and relatively photostable. Fluo-3FF AM is an analog of Fluo-3FF AM. Fluo-3FF AM is essentially non-fluorescent, but exhibits a strong fluorescence enhancement upon entry into cells and binding to calcium.

HY-128536

KMG-104AM	Fluorescent Dyes/Probes
KMG-104AM, a selective fluorescein-derived magnesium fluorescent membrane-permeable probe, successfully incorporates into PC12 cells and is used to Intracellular 3D Mg ²⁺ Imaging .

HY-101902

Quin-2AM Quin-2 acetoxymethyl ester	Fluorescent Dyes/Probes
Quin-2AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-D1746

EDTA-AM

EDTA acetoxymethyl ester; EthylenediAMinetetraacetic acid acetoxymethyl ester

Fluorescent Dyes/Probes

EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .

HY-101883

BCECF-AM 3 Publications Verification	Fluorescent Dyes/Probes
BCECF-AM is a cell membrane permeable compound widely used as a fluorescent indicator for intracellular pH.

HY-D1176

Calcium Green 1AM	Fluorescent Dyes/Probes
Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .

HY-101896

Fluo-4 AM 20+ Cited Publications	Fluorescent Dyes/Probes
Fluo-4 AM is a cell-permeable Ca ²⁺ indicator .

HY-D1498

Mag-Fluo-4 AM 1 Publications Verification	Fluorescent Dyes/Probes
Mag-Fluo-4 AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-D1701

Mag-Fura-2 AM

Fluorescent Dyes/Probes

Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

HY-15141G

Staurosporine (GMP) Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Fluorescent Dye
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

HY-D1561

FG 488 BAPTA-2 AM	Dyes
FG 488 BAPTA-2 AM is a calcium-specific reporter dye. FG 488 BAPTA-2 AM can be used to detect calcium concentration.

HY-D1628

Calcium Green BAPTA-2 AM	Fluorescent Dyes/Probes
Calcium Green BAPTA-2 AM is a fluorescent calcium indicator.

HY-D0716

Fluo-3AM 5+ Cited Publications Fluo-3-pentaacetoxymethyl ester	Fluorescent Dyes/Probes
Fluo-3 AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-130575

Fura-FF AM	Fluorescent Dyes/Probes
Fura-FF AM is a cell-permeable acetoxymethyl ester of fura-FF, a dluorescent calcium indicator. Fura-FF AM is hydrolyzed by intracellular esterases to release fura-FF in cells. Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Compared to fura-2, fura-FF has a low affinity for calcium and is suitable for studying compartments with high concentrations of calcium.

HY-W127775

Demethyl Rhod-2 AM	Fluorescent Dyes/Probes
Demethyl Rhod-2 AM is a fluorescent mitochondrial probe (λex=552 nm, λem=581 nm).

HY-D1631

Calcium Green-5N AM	Fluorescent Dyes/Probes
Calcium Green-5N AM is a novel Ca ²⁺-sensitive fluorescent probe. Calcium Green-5N AM shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-101898

Indo-1 AM

Indo-1 Acetoxymethyl ester

Fluorescent Dyes/Probes

HY-D0041

Calcein-AM

Maximum Cited Publications

47 Publications Verification

Calcein acetoxymethyl ester

Fluorescent Dyes/Probes

Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .

HY-D1758

Fura-5F AM	Fluorescent Dyes/Probes
Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.

HY-D1759

Fura-4F AM	Fluorescent Dyes/Probes
Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.

HY-101897

Fura-2 AM 5 Publications Verification Fura-2 Acetoxymethyl ester	Fluorescent Dyes/Probes
Fura-2 AM is a high affinity, intracellular, UV light-excitable and ratiometric fluorescent Ca ²⁺ indicator.

HY-158741

IPG-2 AM APG-2 Acetoxymethyl ester	Fluorescent Dyes/Probes
IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeable K ⁺ fluorescent indicator .

HY-10475G

AM580 (GMP) CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Fluorescent Dye
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-130013

HKYellow-AM (6/12-mixture)	Fluorescent Dyes/Probes
HKYellow-AM (6/12-mixture) is a yellow fluorescent probe that can detect ONOO- in living cells and tissues with high selectivity and sensitivity without cytotoxicity .

HY-D1768

Fluo-4FF AM	Fluorescent Dyes/Probes
Fluo-4FF AM is a cell-permeant fluorescent calcium indicator. Fluo-4FF is an analog of Fluo-4 with a lower affinity for calcium, which is suitable for investigation of relatively high level of intracellular calcium.

HY-D0989

Rhod-2 AM

10+ Cited Publications

Fluorescent Dyes/Probes

Rhod-2 is a high-affinity visible light excitation wavelength Ca ²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm .

HY-158746

Fluo-2 AM Fluo-2 acetoxymethyl ester; Fluo-2 ha; Fluo-2 high affinity	Fluorescent Dyes/Probes
Fluo-2 AM (Fluo-2 acetoxymethyl ester) is a fluorescent dye, that can be used for detection of intracellular calcium ion concentration .

HY-126821

Fluo-3	Fluorescent Dyes/Probes
Fluo-3 and related molecule Fluo3/AM are used as a fluorescence indicator of intracellular calcium (Ca ²⁺). Fluo-3 may be use for flow cytometry and confocal laser scanning microscopy using visible light excitation (compatible with argon laser sources operating at 488 nm). Fluorescence intensity increases about 40-fold after calcium binding.

Cat. No.	Product Name	Type

HY-D0973

EGTA-AM 4 Publications Verification EGTA Acetoxymethyl ester	Chelators
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca ²⁺ chelator with slow chelating dynamics.

HY-100545

BAPTA-AM Maximum Cited Publications 60 Publications Verification	Chelators
BAPTA-AM is a well-known membrane permeable Ca ²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .

HY-15141G

Staurosporine (GMP) Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Biochemical Assay Reagents
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

HY-10475G

AM580 (GMP) CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Biochemical Assay Reagents
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-D1005

Poloxamer 407 (F127) 2 Publications Verification PEG-PPG-PEG, 12600 (Average Mn)	Co-solvents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8? AM and Quest Rhod-4? AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .

HY-W127775

Demethyl Rhod-2 AM	Fluorescent Dyes/Probes
Demethyl Rhod-2 AM is a fluorescent mitochondrial probe (λex=552 nm, λem=581 nm).

Cat. No.	Product Name	Target	Research Area

HY-P0069

D-JNKI-1 Maximum Cited Publications 7 Publications Verification AM-111; XG-102	JNK	Others
D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

HY-P1457

Adrenomedullin (AM) (13-52), human	Peptides	Cardiovascular Disease
Adrenomedullin (AM) (13-52), human is a 40 amino acid peptide, which acts as an endothelium-dependent vasodilator agent.

HY-P1455A

Adrenomedullin (AM) (1-52), human TFA Human adrenomedullin-(1-52)-NH2 TFA	Peptides	Cancer
Adrenomedullin (AM) (1-52), human (TFA) affects cell proliferation and angiogenesis in cancer.

HY-P1471

Adrenomedullin (AM) (22-52), human 1 Publications Verification 22-52-Adrenomedullin (human)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .

HY-P1471A

Adrenomedullin (AM) (22-52), human TFA 22-52-Adrenomedullin (human) (TFA)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH₂ terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .

HY-P1455

Adrenomedullin (AM) (1-52), human Human adrenomedullin-(1-52)-NH2	Peptides	Cancer
Adrenomedullin (AM) (1-52), human is a 52-amino acid peptide, which affects cell proliferation and angiogenesis in cancer.

HY-P2424

Cholecystokinin-J CCK-J	Peptides	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8430

Poricoic acid AM	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Cancer	Others
Poricoic acid AM is a triterpenoid with ant-tumor activities .

HY-15141

Staurosporine 110+ Cited Publications Antibiotic AM-2282; STS; AM-2282	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Marine natural products Source classification Marine microorganism Disease Research Fields Indole Alkaloids	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-N7697

Chitotetraose tetrahydrochloride	Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitotetraose tetrahydrochloride is an arbuscular mycorrhizal (AM) fungal short-chain chitin oligomer. Chitotetraose tetrahydrochloride activates the AM fungal-dependent conserved symbiosis signaling pathway (CSSP) in actinorhizal plant species .

HY-129148

Ganoderic acid AM1 GAAM1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-129291

Reductiomycin AM 6201	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal
Reductiomycin is an antibiotic, which exhibits antimicrobial activity against gram positive bacteria and fungi. Reductiomycin exhibits antitumor activity .

HY-123379

Relomycin Tylosin D; LL-AM 684B	Structural Classification Microorganisms Antibiotics Source classification	Others
Relomycin is an active compound.

HY-N11472

Rhamnocitrin 3-glucoside RhAMnocitrin-3-O-β-D-glucopyranoside	Structural Classification Flavonoids Flavones Leguminosae Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Others
Rhamnocitrin 3-glucoside (Rhamnocitrin-3-O-β-D-glucopyranoside) is a natural product that can be isolated from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (AM) .

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Compare	Product Name	Species	Source

HY-P74426

	Adrenomedullin/ADM Protein, Human (HEK293, Fc) Pro-adrenomedullin; ADM; Adrenomedullin; AM; PAMP	Human	HEK293
	Adrenomedullin (ADM) and PAMP serve as potent hypotensive and vasodilatory agents, mainly influencing fluid and electrolyte homeostasis. In the kidney, ADM demonstrates diuretic and natriuretic effects, while both ADM and PAMP directly inhibit aldosterone secretion in the adrenal glands. In the pituitary gland, both peptides suppress basal ACTH secretion at physiologically relevant doses. Additionally, ADM and PAMP act in the brain and pituitary gland, promoting plasma volume loss, complementing their hypotensive effects. These multifaceted actions highlight ADM's role in regulating cardiovascular and hormonal processes related to fluid and electrolyte balance. Adrenomedullin/ADM Protein, Human (HEK293, Fc) is the recombinant human-derived Adrenomedullin/ADM protein, expressed by HEK293, with N-hFc labeled tag. The total length of Adrenomedullin/ADM Protein, Human (HEK293, Fc) is 52 a.a., with molecular weight of ~39 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-10581AS1

Gatifloxacin-d4 hydrochloride
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-W700069

Gatifloxacin-d4
Gatifloxacin-d4 is the deuterium labeled Gatifloxacin .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83216

	GPR182 Antibody (YA2961) AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gAMrh; hrhAMR	WB	Human, Mouse, Rat
	GPR182 Antibody (YA2961) is a biotin-conjugated non-conjugated IgG antibody, targeting GPR182, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). GPR182 Antibody (YA2961) can be used for WB experiment in human, mouse, rat background.

HY-P83587

	Hydroxyl-Histone H2A Antibody (YA3332) H2A.1; H2A/c; H2A1; H2AFC:; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone cluster 1; H2ai; Histone H2A type 1; Histone H2A/p	WB, IHC-P	Human, Mouse
	Hydroxyl-Histone H2A Antibody (YA3332) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3332), targeting Hydroxyl-Histone H2A, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). Hydroxyl-Histone H2A Antibody (YA3332) can be used for WB, IHC-P experiment in human, mouse background.

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Cat. No.	Product Name		Classification

HY-110128

Sulfidefluor 7-AM SF7-AM		Azide
Sulfidefluor 7-AM is a stable hydrogen sulphide (H₂S) fluorescent probe . Sulfidefluor 7-AM is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128774

AM-6494		Alkynes
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM) . AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160258

GDP-Fucose-Tz GDP-Fucose-AM-Tz		Tetrazine
GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. GDP-fucose-Am-Tz and TCO-ssDNA were reacted at a ratio of 1:1 to obtain the final product GDP-fucose-ssDNA .

Cat. No.	Product Name		Classification

HY-109561

Pegaptanib sodium EYE001; NX1838		Aptamers
Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

HY-147079

Egaptivon pegol ARC 1779		Aptamers
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-R01647

hsa-miR-548am-3p mimic		MicroRNAs miRNA mimics
hsa-miR-548am-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01648

hsa-miR-548am-5p mimic		MicroRNAs miRNA mimics
hsa-miR-548am-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01647

hsa-miR-548am-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-548am-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01648

hsa-miR-548am-5p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-548am-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R01647A

hsa-miR-548am-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-548am-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01648A

hsa-miR-548am-5p agomir		MicroRNAs miRNA agomirs
hsa-miR-548am-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01647A

hsa-miR-548am-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-548am-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01648A

hsa-miR-548am-5p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-548am-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-D1005

Poloxamer 407 (F127) 2 Publications Verification PEG-PPG-PEG, 12600 (Average Mn)		Emulsifiers Solubilizing Agents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8? AM and Quest Rhod-4? AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .

HY-154974

LNP Lipid-8		Cationic Lipids
LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .

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