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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

Cereblon ligand-linker Conjugate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (240) Apoptosis (120) Autophagy (122) Ligands for E3 Ligase (2)
By Research Areas:	Cancer (233) Inflammation/Immunology (2)
Click Chemistry:	PROTAC Synthesis (2) Azide (15) Alkynes (2)

241

Inhibitors & Agonists

Click Chemistry

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates ADC Linker PROTAC-Linker Conjugates for PAC Drug-Linker Conjugates for ADC PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129608

Lenalidomide-acetylene-C5-COOH Cereblon ligand-linker Conjugate	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC . Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103613

Thalidomide-O-amido-C4-NH2 TFA Cereblon ligand-linker Conjugates 6 TFA; E3 ligase ligand-linker Conjugates 19 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Others
Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-112618A

Thalidomide-O-amido-C6-NH2 TFA Cereblon ligand-linker Conjugates 11 TFA; E3 Ligase ligand-linker Conjugates 25 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-130521

Pomalidomide-amido-PEG3-C2-NH2 Cereblon ligand-linker Conjugates 22; E3 ligase ligand-linker Conjugates 55	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology .

HY-103614

Thalidomide-O-amido-C8-NH2 TFA 1 Publications Verification Cereblon ligand -linker Conjugates 2 TFA; E3 Ligase ligand-linker Conjugates 20 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Others
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-107439

Thalidomide-O-amido-C8-NH2 Cereblon ligand-linker Conjugates 2; E3 Ligase ligand-linker Conjugates 20	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-107438

Thalidomide-O-amido-C4-NH2 Cereblon ligand-linker Conjugates 6; E3 Ligase ligand-linker Conjugates 19	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-112618

Thalidomide-O-amido-C6-NH2 Cereblon ligand-linker Conjugates 11; E3 Ligase ligand-linker Conjugates 25	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-128716B

Pomalidomide-PEG3-C2-NH2 hydrochloride Cereblon ligand-linker Conjugates 5 hydrochloride; E3 ligase ligand-linker Conjugates 30 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-107440

Thalidomide-O-amido-PEG3-C2-NH2 Cereblon ligand-linker Conjugates 3 ; E3 Ligase ligand-linker Conjugates 14	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-128716A

Pomalidomide-PEG3-C2-NH2 TFA Cereblon ligand-linker Conjugates 5 TFA; E3 ligase ligand-linker Conjugates 30 TFA	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs .

HY-103612

Thalidomide-O-amido-C3-COOH Cereblon ligand-linker Conjugates 7; E3 ligase ligand-linker Conjugates 15	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-128846A

Pomalidomide-C2-NH2 hydrochloride Cereblon ligand-linker Conjugates 15 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-128846

Pomalidomide-C2-NH2 Cereblon ligand-linker Conjugates 15	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.

HY-115560

Thalidomide-O-amido-C3-NH2 Cereblon ligand-linker Conjugates 16; E3 Ligase ligand-linker Conjugates 52	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-115560A

Thalidomide-O-amido-C3-NH2 TFA Cereblon ligand-linker Conjugates 16 TFA; E3 Ligase ligand-linker Conjugates 52 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-21930

Pomalidomide-PEG4-C-COOH Cereblon ligand -linker Conjugates 1; E3 Ligase ligand-linker Conjugates 1	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-41549

Pomalidomide-PEG4-Ph-NH2 Cereblon ligand-linker Conjugates 9; E3 Ligase ligand-linker Conjugates 2	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-125884

Pomalidomide-amido-C4-amido-C6-NH-Boc Cereblon ligand-linker Conjugates 21; E3 Ligase ligand-linker Conjugates 54	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-C4-amido-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-128716

Pomalidomide-PEG3-C2-NH2 Cereblon ligand-linker Conjugates 5; E3 ligase ligand-linker Conjugates 30	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-112599

Pomalidomide-PEG4-C2-NH2 Cereblon ligand-linker Conjugates 8; E3 Ligase ligand-linker Conjugates 22	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-112617A

Thalidomide-O-amido-PEG2-C2-NH2 TFA Cereblon ligand-linker Conjugates 10 TFA; E3 Ligase ligand-linker Conjugates 24 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Inflammation/Immunology Cancer
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

HY-103611

Thalidomide-O-amido-PEG3-C2-NH2 TFA Cereblon ligand-linker Conjugates 3 TFA; E3 ligase ligand-linker Conjugates 14 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-125883

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc Cereblon ligand-linker Conjugates 20; E3 Ligase ligand-linker Conjugates 53	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

HY-128848

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Cereblon ligand-linker Conjugates 14; E3 ligase ligand-linker Conjugates 49	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-112600

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 Cereblon ligand-linker Conjugates 12; E3 Ligase ligand-linker Conjugates 23	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-112600A

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA Cereblon ligand-linker Conjugates 12 TFA; E3 Ligase ligand-linker Conjugates 23 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon ligand-linker Conjugates 4; E3 ligase ligand-linker Conjugates 18	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon ligand-linker Conjugates 13; E3 ligase ligand-linker Conjugates 50	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-169357

Acepromazine-1-Piperazinepropanamine	E3 Ligase Ligand-Linker Conjugates	Cancer
Acepromazine-1-Piperazinepropanamine (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a cereblon ligand and a linker. Acepromazine-1-Piperazinepropanamine can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) .

HY-133484B

Thalidomide-PEG2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology .

HY-168911

E3 Ligase Ligand-linker Conjugate 168	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 168 is a conjugate composed of E3 ligase Cereblon ligand (HY-W249500) and a linker. E3 Ligase Ligand-linker Conjugate 168 can be used for synthesis of PROTAC c-Met degrader-3 (HY-168910) .

HY-157756

E3 Ligase Ligand-linker Conjugate 104	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 104 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 104 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162197

E3 ligase Ligand-Linker Conjugate 41	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 41 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 41 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157600

E3 ligase Ligand-Linker Conjugate 66	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 66 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 66 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157747

E3 Ligase Ligand-linker Conjugate 99	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 99 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157748

E3 Ligase Ligand-linker Conjugate 100	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 100 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162180

E3 Ligase Ligand-linker Conjugate 2	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 2 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162203

E3 Ligase Ligand-linker Conjugate 51	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 51 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 51 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162190

E3 Ligase Ligand-linker Conjugate 17	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 17 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 17 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162192

E3 Ligase Ligand-linker Conjugate 20	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 20 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 20 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162206

E3 Ligase Ligand-linker Conjugate 58	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 58 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 58 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162184

E3 ligase Ligand-Linker Conjugate 11	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 11 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 11 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157761

E3 Ligase Ligand-linker Conjugate 106	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 106 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 106 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157588

(S)-Thalidomide-Piperazine-CH2-Pyrrolidine-C2-OH	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 30 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 30 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162200

E3 Ligase Ligand-linker Conjugate 47	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 47 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 47 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162198

E3 ligase Ligand-Linker Conjugate 43	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 43 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 43 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162185

E3 Ligase Ligand-linker Conjugate 12	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 12 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 12 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162183

E3 Ligase Ligand-linker Conjugate 9	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 9 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 9 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162204

E3 Ligase Ligand-linker Conjugate 54	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 54 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 54 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

Cat. No.	Product Name		Classification

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon ligand-linker Conjugates 4; E3 ligase ligand-linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon ligand-linker Conjugates 13; E3 ligase ligand-linker Conjugates 50		PROTAC Synthesis Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase ligand-linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		PROTAC Synthesis Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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