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Results for "

Cyclophilin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cyclophilin (25) Adrenergic Receptor (2) AMPK (1) Antibiotic (7) Apoptosis (9) Arrestin (2) Bacterial (20) Biochemical Assay Reagents (6) Calcineurin (5) Caspase (1) Complement System (3) CXCR (2) Deubiquitinase (1) EGFR (1) Endogenous Metabolite (1) Endothelin Receptor (2) Enterovirus (1) ERK (3) Estrogen Receptor/ERR (1) Fungal (3) GHSR (1) HBV (1) HCV (8) HIF/HIF Prolyl-Hydroxylase (4) HIV (1) IFNAR (1) Integrin (11) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (1) MMP (2) Molecular Glues (5) Neurokinin Receptor (1) NF-κB (2) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (2) Oxytocin Receptor (1) Parasite (1) PARP (1) PD-1/PD-L1 (1) Phosphatase (1) PI3K (1) Proteasome (2) Radionuclide-Drug Conjugates (RDCs) (1) Raf (3) Ras (6) Reactive Oxygen Species (1) Ribosomal S6 Kinase (RSK) (1) Sirtuin (4) Somatostatin Receptor (5) STAT (1) Tyrosinase (1) Vasopressin Receptor (1) VEGFR (2)
By Research Areas:	Cancer (58) Cardiovascular Disease (6) Endocrinology (4) Infection (31) Inflammation/Immunology (22) Metabolic Disease (11) Neurological Disease (10)
Oligonucleotides:	Aptamers (1)

112

Inhibitors & Agonists

Fluorescent Dye

124

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Cyclophilin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138294

RAS/RAS-RAF-IN-1 1 Publications Verification	Ras Raf	Cancer
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a K_D of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity .

HY-153346

RMC-6291	Ras ERK Apoptosis	Cancer
RMC-6291 is an orally active and covalent inhibitor of KRAS ^G12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRAS ^G12C(ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRAS ^G12C(ON) from signaling via steric blockade of RAS effector binding. RMC-6291 inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. RMC-6291 also inhibits the proliferation of KRAS ^G12C mutant cells with a median IC₅₀ of 0.11 nM .

HY-N1511

Ganoderic acid D 1 Publications Verification	Sirtuin Apoptosis	Cancer
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-112712

Cyclophilin inhibitor 1	Cyclophilin HCV	Infection
Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a K_d of 5 nM, shows effective anti-HCV activity, with an EC₅₀ of 98 nM for HCV 2a .

HY-146648

Cyclophilin inhibitor 3	Cyclophilin HCV	Infection
Cyclophilin inhibitor 3 (compound 7c) is a potent cyclophilin A (CypA) inhibitor with an potent anti-HCV activity (EC₅₀ of 4.2 μM) .

HY-125182

SMCypI C31	Cyclophilin HCV	Infection
SMCypI C31 is a non-peptidic *cyclophilin* inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC₅₀ of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC₅₀s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction .

HY-116095

CypD-IN-5	Sirtuin	Neurological Disease Metabolic Disease
CypD-IN-5 (compound C-9) is a potent cyclophilin D (CypD) inhibitor. CypD-IN-5 can be used in the study of Alzheimer's disease .

HY-157088

C105SR	Caspase Apoptosis Cyclophilin	Others
C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC ₅₀ of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model .

HY-151487

CypD-IN-3	Cyclophilin	Neurological Disease Metabolic Disease Cancer
CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC₅₀ value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes .

HY-151488

CypD-IN-4	Cyclophilin	Neurological Disease Metabolic Disease Cancer
CypD-IN-4 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-4 has CypD affinity with an IC₅₀ value of 0.057 μM. CypD-IN-4 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes .

HY-N1511R

Ganoderic acid D (Standard)	Sirtuin Apoptosis	Cancer
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-P3351

ASP5286	Cyclophilin HCV	Infection
ASP5286 is a novel non-immunosuppressive *cyclophilin* inhibitor for the research of HCV.

HY-151489

CypE-IN-1	Cyclophilin	Neurological Disease Metabolic Disease Cancer
CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC₅₀ and K_i values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes .

HY-12559

Alisporivir 10+ Cited Publications Debio-025; DEB-025	Cyclophilin HCV	Infection
Alisporivir (Debio-025) is a *cyclophilin* inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.

HY-125640

NVP018 BC556	Cyclophilin HCV HBV HIV	Infection
NVP018 (BC556) is an orally active inhibitor for cyclophilin A with IC₅₀ of 0.3 and 0.1 nM for cyclophilin A and NS5A- cyclophilin A complex. NVP018 inhibits Bilirubin (HY-N0323) transporter OATP1B1 and OATP1B3 with IC₅₀ of 4.31 and 1.75 μM. NVP018 inhibits the replication of HBV (in HepG2), HCV (in Huh-7) and HIV-1 (in HeLa), with IC₅₀ in nanomolar levels. NVP018 exhibits anti-fibrotic effect by inhibiting the mRNA expression of COL1A1 and LOX .

HY-P1354

Cyclosporin A-Derivative 2	Calcineurin Cyclophilin	Others
Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-107635

TMN355 1 Publications Verification	Cyclophilin	Cardiovascular Disease
TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis .

HY-100731

Cyclosporin	Cyclophilin	Inflammation/Immunology
Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes .

HY-P1355

Cyclosporin A-Derivative 1	Calcineurin Cyclophilin	Inflammation/Immunology
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-W039943

Acetyl-cyclosporin A aldehyde	Molecular Glues	Cancer
Acetyl-cyclosporin A aldehyde is an acetylated Cyclosporin A (HY-B0579) derivative with a reducing aldehyde group. Cyclosporin A is a potent calmodulin inhibitor and cyclophilin binder that can target the nuclear translocation of NF-AT and cause mitochondrial damage.

HY-155172

ZX-J-19j	Cyclophilin	Cancer
ZX-J-19j (Compound ZX-J-19j) is a cyclophilin J inhibitor. ZX-J-19j showes potent antitumor activity .

HY-164186

M9-5 sodium	Cyclophilin	Others
M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.

HY-P1355A

Cyclosporin A-Derivative 1 Free base	Calcineurin Cyclophilin	Others
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-162536

Pan-RAS-IN-5	Molecular Glues Cyclophilin Ras	Cancer
Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects .

HY-P0025

NIM811 10+ Cited Publications (Melle-4)cyclosporin; SDZ NIM811	Cyclophilin Mitochondrial Metabolism HCV	Infection Inflammation/Immunology
NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and *cyclophilin* dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) .

HY-B0579S

Cyclosporin A-d4 Cyclosporine A-d₄; Ciclosporin A-d₄; CsA-d₄	Antibiotic Complement System Phosphatase	Inflammation/Immunology Cancer
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-135644

Rencofilstat CRV431	Cyclophilin Sirtuin	Cancer
Rencofilstat (CRV431) is a pan-cyclophilin inhibitor with IC₅₀ values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease .

HY-136804

CypD-IN-29	Others	Neurological Disease
CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP).

HY-B0579

Cyclosporin A Maximum Cited Publications 111 Publications Verification Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Complement System Antibiotic Cyclophilin	Inflammation/Immunology Cancer
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-128382

Brilliant Black BN E 151	Enterovirus	Infection
Brilliant black BN (E151) is an azo dye and a food colorant . Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease .

HY-B0579R

Cyclosporin A (Standard)	Molecular Glues Complement System Antibiotic Cyclophilin	Inflammation/Immunology Cancer
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-158409

Pan-RAS-IN-2	Molecular Glues Ras Cyclophilin	Cancer
Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects .

HY-B0579S2

Cyclosporin A acetate-d4 Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄; CsA acetate-d₄	Isotope-Labeled Compounds Cyclophilin Calcineurin	Inflammation/Immunology
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S3

Cyclosporin A-13C2,d4 Cyclosporine A-¹³C₂,d₄; Ciclosporin A-¹³C₂,d₄; CsA-¹³C₂,d₄	Isotope-Labeled Compounds Cyclophilin Calcineurin	Inflammation/Immunology
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-156498

RMC-7977	Ras ERK Raf Ribosomal S6 Kinase (RSK) AMPK Apoptosis PARP	Cancer
RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (K_d = 195 nM) and KRAS (G12V) (K_d = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS ^G12C cancer models, and demonstrates good tolerability across various RAS cancer models .

HY-P10221A

Cyclo(CKLIIF) TFA	HIF/HIF Prolyl-Hydroxylase	Cancer
Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains K_D of 2.6 and 2.2 μM, respectively .

HY-P3119

Desotamide Desotamide A	Bacterial	Infection
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).

HY-P1934A

Cyclo(L-Phe-L-Pro)	Fungal IFNAR Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-P5314

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .

HY-P0031

Cyclo(RADfK) 1 Publications Verification	Integrin	Others
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-P0023

Cyclo(-RGDfK) 10+ Cited Publications	Integrin	Cancer
Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-P0231

AZP-531 2 Publications Verification	GHSR	Metabolic Disease Endocrinology
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P1934

Cyclo(Phe-Pro) 4 Publications Verification Cyclo(phenylalanylprolyl); A-64863	HCV	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses .

HY-126810A

NP213 TFA	Fungal	Infection
NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .

HY-P0023A

Cyclo(-RGDfK) TFA 10+ Cited Publications	Integrin	Cancer
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-126810

NP213	Fungal	Infection
NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections .

HY-107245

Segetalin B 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease
Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity .

HY-P2300

Cyclo(Arg-Gly-Asp-D-Phe-Cys) Cyclo(RGDfC)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .

HY-P1938

Cyclo(L-Pro-L-Val)	Bacterial	Infection
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .

Cat. No.	Product Name	Type

HY-128382

Brilliant Black BN E 151	Dyes
Brilliant black BN (E151) is an azo dye and a food colorant . Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1511

Ganoderic acid D 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer	Sirtuin Apoptosis
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-100731

Cyclosporin	Structural Classification Natural Products Microorganisms Source classification	Cyclophilin
Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes .

HY-B0579

Cyclosporin A Maximum Cited Publications 111 Publications Verification Cyclosporine A; Ciclosporin A; CsA	Structural Classification Natural Products Microorganisms Classification of Application Fields Anti-aging Source classification Inflammation/Immunology Disease Research Fields Cancer	Molecular Glues Complement System Antibiotic Cyclophilin
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-P1934A

Cyclo(L-Phe-L-Pro)	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Cancer	Fungal IFNAR Reactive Oxygen Species
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-107245

Segetalin B 1 Publications Verification	Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Cyclopeptides Source classification Metabolic Disease Plants Disease Research Fields Caryophyllaceae	Estrogen Receptor/ERR
Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity .

HY-P1938

Cyclo(L-Pro-L-Val)	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .

HY-N1511R

Ganoderic acid D (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	Sirtuin Apoptosis
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-B0579R

Cyclosporin A (Standard)	Structural Classification Natural Products Microorganisms Source classification	Molecular Glues Complement System Antibiotic Cyclophilin
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	Structural Classification Natural Products Source classification Endogenous metabolite	NF-κB Endogenous Metabolite
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-P1935

Cyclo(Ala-Pro)	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Biochemical Assay Reagents
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-P5698

Cyclopetide 1	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL .

HY-P5699

Cyclopetide 2	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .

HY-P6293

Heterophyllin A	Structural Classification Natural Products Pseudostellaria heterophylla (Miq.) Pax Source classification Plants Caryophyllaceae	Others
Heterophyllin A can be isolated from the aboveground parts of Elaeagnus angustifolia.

HY-N13127

Segetalin C	Structural Classification Natural Products Source classification Plants Vaccaria hispanica Caryophyllaceae	Others
Segetalin C is a cyclic peptide that increases uterine weight in ovariectomized rats (2.5 mg/kg).

HY-P6294

Pseudostellarin G	Structural Classification Natural Products Pseudostellaria heterophylla (Miq.) Pax Source classification Plants Caryophyllaceae	Tyrosinase
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-P1680

Astin C Asterin	Structural Classification Natural Products Source classification Plants Compositae Erythrina latissima E. Mey.	Others
Astin C (Asterin) is a cyclic pentapeptide with anticancer and anti-inflammatory properties .

HY-P2040

Nodularin	Structural Classification other families Cyclopeptides Ketones, Aldehydes, Acids Marine natural products Source classification Plants	Others
Nodularin is a potent hepatotoxin, tumor promoter, and protein phosphatase inhibitor .

HY-W019721

Cyclosporin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Nuclear Factor of activated T Cells (NFAT)
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-P2005

Malformin C	Structural Classification Natural Products Microorganisms Source classification	Others
Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content .

HY-P5957

Omphalotin A	Structural Classification Microorganisms Cyclopeptides Source classification	Parasite
Omphalotin A is a cyclic peptide, and shows nematicidal activity .

Species:	Human (11) Mouse (3) E.coli (1)
Tag:	His (11) SUMO (1) Tag Free (4) Trx (1)
Source:	HEK293 (4) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P70007

	Cyclophilin A Protein, Mouse rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free. The total length of Cyclophilin A Protein, Mouse is 164 a.a., with molecular weight of ~17.0 kDa.

HY-P71225

	PPIE Protein, Human (His) Peptidyl-Prolyl Cis-Trans Isomerase E; PPIase E; Cyclophilin E; Cyclophilin-33; Rotamase E; PPIE; CYP33	Human	E. coli
	The PPIE protein is a key spliceosome component that complexly regulates pre-mRNA splicing through RNA binding and PPIase activity. It prefers single-stranded RNA with polyA and polyU stretches, indicating an affinity for the poly(A) region of the 3'-UTR. PPIE Protein, Human (His) is the recombinant human-derived PPIE protein, expressed by E. coli , with N-6*His labeled tag. The total length of PPIE Protein, Human (His) is 301 a.a., with molecular weight of ~34.0 kDa.

HY-P70007A

	Cyclophilin A Protein, Mouse (tag free) 1 Publications Verification rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse (tag free) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free. The total length of Cyclophilin A Protein, Mouse (tag free) is 164 a.a., with molecular weight of approximately 18.07 kDa.

HY-P71224

	PPID Protein, Human (His) 1 Publications Verification Peptidyl-Prolyl Cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-Prolyl Cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD	Human	E. coli
	PPID protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and contributes to protein folding. It serves as a co-chaperone in the HSP90 complex, contributing to dynamic regulation and may favor the estrogen receptor complex. PPID Protein, Human (His) is the recombinant human-derived PPID protein, expressed by E. coli , with N-6His, C-6His labeled tag. The total length of PPID Protein, Human (His) is 370 a.a., with molecular weight of ~43.85 kDa.

HY-P74211A

	Cyclophilin F/PPIF Protein, Human (HEK293, His) Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF	Human	HEK293
	Cyclophilin F/PPIF Protein, a peptidyl-prolyl cis-trans isomerase (PPIase), catalyzes proline imidic peptide bond isomerization, potentially aiding in protein folding. It crucially regulates the mitochondrial permeability transition pore (mPTP), influencing apoptosis or necrosis. Collaborating with mitochondrial p53/TP53, it activates oxidative stress-induced necrosis and modulates mitochondrial membrane F(1)F(0) ATP synthase activity. Cyclophilin F/PPIF, with BCL2, inhibits cytochrome c-dependent apoptosis independently of the mPTP, highlighting its diverse roles in mitochondrial function and cell survival mechanisms. Cyclophilin F/PPIF Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293, with C-6*His labeled tag. The total length of Cyclophilin F/PPIF Protein, Human (HEK293, His) is 178 a.a., with molecular weight of ~24-34 kDa.

HY-P74211

	Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF	Human	HEK293
	Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-His labeled tag. The total length of Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is 178 a.a., with molecular weight of ~20.3 kDa.

HY-P74212

	Cyclophilin A Protein, Mouse (His) Peptidyl-prolyl cis-trans isomerase A; PPIase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A (PPIA) protein, with integrin binding and peptidyl-prolyl cis-trans isomerase activity, influences platelet aggregation and neuron differentiation. It is found in the extracellular space and myelin sheath, showing ubiquitous expression in various tissues, including the liver and central nervous system. PPIA is associated with cholangiocarcinoma and HIV disease, suggesting its role in fundamental cellular processes. Cyclophilin A Protein, Mouse (His) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with C-His labeled tag.

HY-P71223

	PPIC Protein, Human (Trx-His) Peptidyl-Prolyl Cis-Trans Isomerase C; PPIase C; Cyclophilin C; Rotamase C; PPIC; CYPC	Human	E. coli
	PPIC protein is a peptidyl-prolyl cis-trans isomerase (PPIase) that actively catalyzes the cis-trans isomerization of prolyl imide peptide bonds, which is a key step in protein folding. Its role in promoting conformational changes ensures correct folding and maturation of proteins, contributing to cellular proteostasis. PPIC Protein, Human (Trx-His) is the recombinant human-derived PPIC protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of PPIC Protein, Human (Trx-His) is 152 a.a., with molecular weight of ~34.0 kDa.

HY-P70011

	Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) rHuPeptidyl-prolyl cis-trans isomerase B/PPIB, His; CYP-S1; CYPB; HEL-S-39; OI9; SCYLP	Human	HEK293
	Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is 179 a.a., with molecular weight of ~21.0 kDa.

HY-P71224A

	PPID Protein, Human (C-His;N-His) Peptidyl-Prolyl Cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-Prolyl Cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD	Human	E. coli
	PPID protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and contributes to protein folding. It serves as a co-chaperone in the HSP90 complex, contributing to dynamic regulation and may favor the estrogen receptor complex. PPID Protein, Human (His) is the recombinant human-derived PPID protein, expressed by E. coli , with N-6His, C-6His labeled tag.

HY-P71501

	PPIase A Protein, E.coli (His-SUMO) ppiA; Z4724; ECs4214; Peptidyl-prolyl cis-trans isomerase A; PPIase A; EC 5.2.1.8; Cyclophilin A; Rotamase A	E.coli	E. coli
	The PPIase A protein plays a central role in complex protein folding, utilizing its peptidyl-prolyl cis-trans isomerase (PPIase) activity to accelerate dynamic conformational changes that are critical for proper protein maturation. PPIase A specifically catalyzes the cis-trans isomerization of proline imide peptide bonds, effectively promoting protein folding. PPIase A Protein, E.coli (His-SUMO) is the recombinant E. coli-derived PPIase A protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P70047

	Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Human	E. coli
	CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.

HY-P70047A

	Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human (Tag Free) rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Human	E. coli
	CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.

HY-P70011A

	Cyclophilin B/PPIB Protein, Human (HEK293, His) Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4	Human	HEK293
	Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, His) is 179 a.a., with molecular weight of ~19 kDa.

HY-P71029

	PPIH Protein, Human (His) Peptidyl-Prolyl Cis-Trans Isomerase H; PPIase H; Rotamase H; Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H; CypH; U-snRNP-Associated Cyclophilin SnuCyp-20; USA-CYP; PPIH; CYP20; CYPH	Human	E. coli
	The PPIH protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and may contribute to protein folding. It plays a crucial role in pre-mRNA splicing and contributes to the formation of the U4/U5/U6 tri-snRNP complex in spliceosome assembly. PPIH Protein, Human (His) is the recombinant human-derived PPIH protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0579S

Cyclosporin A-d4
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-B0579S2

Cyclosporin A acetate-d4
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B0579S3

Cyclosporin A-13C2,d4
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80101

	Cyclophilin A Antibody	WB, IHC-P	Human, Mouse
	Cyclophilin A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to Cyclophilin A. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P82354

	Cyclophilin 40 Antibody (YA2099) Cyclophilin40; CyclophilinD; CYP40; CYPD; PPIase; PPIase D; Ppid; Rotamase; Rotamase D	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cyclophilin 40 Antibody (YA2099) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2099), targeting Cyclophilin 40, with a predicted molecular weight of 41 kDa (observed band size: 41 kDa). Cyclophilin 40 Antibody (YA2099) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P80638

	Cyclophilin B Antibody (YA787) PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-Cyclophilin; SCYLP	WB, IHC-P	Human, Rat, Mouse
	Cyclophilin B Antibody (YA787) is a non-conjugated and Mouse origined monoclonal antibody about 24 kDa, targeting to Cyclophilin B (5F10). It can be used for WB,IHC-P assays with tag free, in the background of Human, Rat, Mouse.

HY-P82857

	Cyclophilin F Antibody (YA2602) PPIF; CYP3; Peptidyl-prolyl cis-trans isomerase F; mitochondrial; PPIase F; Cyclophilin F; Rotamase F	WB, IHC-P	Human, Mouse, Rat
	Cyclophilin F Antibody (YA2602) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2602), targeting Cyclophilin F, with a predicted molecular weight of 22 kDa (observed band size: 18 kDa). Cyclophilin F Antibody (YA2602) can be used for WB, IHC-P experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-164186

M9-5 sodium		Aptamers
M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.

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