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Results for "

PAR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Protease Activated Receptor (PAR) (101) 5-HT Receptor (1) Adrenergic Receptor (3) Antibiotic (1) Apoptosis (12) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) CDK (1) DNA/RNA Synthesis (3) Dopamine Receptor (1) Endogenous Metabolite (1) ERK (1) Factor Xa (1) Fluorescent Dye (1) Isotope-Labeled Compounds (1) JAK (3) Kallikrein (1) NF-κB (1) P-selectin (1) p38 MAPK (1) PARP (5) PIN1 (2) Poly(ADP-ribose) Glycohydrolase (PARG) (2) Reactive Oxygen Species (1) Ser/Thr Protease (4) Small Interfering RNA (siRNA) (1) Syk (1) Thrombin (1) α-synuclein (2)
By Research Areas:	Cancer (20) Cardiovascular Disease (40) Endocrinology (3) Infection (4) Inflammation/Immunology (55) Metabolic Disease (4) Neurological Disease (8)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

130

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Protease Activated Receptor (PAR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W115738

*PAR*	Biochemical Assay Reagents	Others
PAR is an azo dye widely used as a colorimetric reagent for metal ions. PAR forms stable chelates with different metal ions. PAR can also complex with heavy metal ions in polar organic solvent like ethanol .

HY-P1309

PAR-4 Agonist Peptide, amide 2 Publications Verification PAR-4-AP; AY-NH2	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

HY-P1309A

PAR-4 Agonist Peptide, amide TFA 2 Publications Verification PAR-4-AP TFA; AY-NH2 TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist .

HY-P4803

PAR-2 (1-6) (human) 1 Publications Verification	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a *PAR-2* agonist .

HY-138558

PAR-2-IN-1	Protease Activated Receptor (PAR)	Inflammation/Immunology Cancer
PAR-2-IN-1 is a protease-activated receptor-2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anticancer effects .

HY-163341

PAR4 antagonist 1	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 1 (Compound 48) is a protease activated receptor 4 (PAR4) antagonist with an IC₅₀ of 1.8 nM. PAR4 antagonist 1 has an IC₅₀ of 2 nM against γ-thrombin-activated PAR4 in platelet-rich plasma (PRP). PAR4 antagonist 1 can be used in antithrombotic research .

HY-P1313

PAR 4 (1-6) (human) GYPGQV	Protease Activated Receptor (PAR)	Others
PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist .

HY-P1313A

PAR 4 (1-6) (TFA) GYPGQV TFA	Protease Activated Receptor (PAR)	Others
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist .

HY-169817

PAR-2-IN-2	Protease Activated Receptor (PAR) Ser/Thr Protease	Inflammation/Immunology
PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC₅₀ of 10.79 μM for SLIGKV and an IC₅₀ of greater than 200 μM for Trypsin .

HY-161401

PAR4 antagonist 2	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 2 (Compound 31) is a protease activated receptor 4 (PAR4) antagonist, with IC₅₀ values of 95 nM and 367 nM for human PAR4 and mouse PAR4. PAR4 antagonist 2 is active against PAR4 activation by the native protease thrombin cleavage but not the synthetic PAR4 agonist peptide AYPGKF .

HY-P4004

PAR-4 (1-6) amide (human)	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 (1-6) amide human is an N-terminal fragment of protease-activated receptor 4 (PAR4). PAR-4 (1-6) amide human induce platelet aggregation .

HY-159895

PAR4 antagonist 7	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 7 (Compound 20f) is selective *PAR4* antagonist (IC₅₀: 1.72 nM). PAR4 antagonist 7 inhibits PAR4 agonist-induced platelet aggregation. PAR4 antagonist 7 has good metabolic stability. PAR4 antagonist 7 does not show a bleeding tendency in mice .

HY-162762

PAR-2 antagonist 1	Protease Activated Receptor (PAR)	Cancer
PAR-2 antagonist 1 (Compound 9a) is a protease-activated receptor 2 (PAR2) antagonist with an IC₅₀ value of 0.9 μM. PAR-2 antagonist 1 can effectively inhibit the proliferation and migration of breast cancer cells .

HY-P2380

PAR3 (1-6) (human) TFRGAP	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.

HY-159896

PAR4 antagonist 8	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 8 (Compound 20f) is an effective, orally active, and selective *PAR4* antagonist with an IC₅₀ value of 15.32 nM. PAR4 antagonist 8 exhibits favorable pharmacokinetic properties. PAR4 antagonist 8 not only effectively inhibits human platelet aggregation induced by PAR4 agonists (IC₅₀ = 6.39 nM) but also inhibits mouse platelet aggregation. PAR4 antagonist 8 can be used in antithrombotic research .

HY-162409

PAR4 antagonist 4	Protease Activated Receptor (PAR)	Others
PAR4 antagonist 4 (Compound 37) is a selective antagonist for protease activated receptor 4 (PAR4). PAR4 antagonist 3 exhibits antiplatelet efficacy with IC₅₀ of 14.2 nM. PAR4 antagonist 3 improves metabolic stablility in human liver microsomes with T_1/2 of 42.5 min .

HY-162408

PAR4 antagonist 3	Protease Activated Receptor (PAR)	Others
PAR4 antagonist 3 (Compound 36) is a selective antagonist for protease activated receptor 4 (PAR4). PAR4 antagonist 3 exhibits antiplatelet efficacy with IC₅₀ of 26.1 nM. PAR4 antagonist 3 improves metabolic stablility in human liver microsomes with T_1/2 of 97.6 min .

HY-163504

PAR4 antagonist 5	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 5 (compound 1) is a *PAR4* antagonist with an IC₅₀ less than 20 μM and potent anti-platelet aggregation activity. PAR4 antagonist 5 can be used for research of thrombosis disease .

HY-159632

PAR4 antagonist 6	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR4 antagonist 6 (Compound 12) is a *PAR4* antagonist, with IC₅₀ values of 134 and 401 nM for hPAR4 (PAC1) and mPAR4 (PAC1), respectively .

HY-P0078

TRAP-6 4 Publications Verification PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4 .

HY-P1261

Parstatin(mouse)	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1262

Parstatin(human)	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(human), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1262A

Parstatin(human) TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1261A

Parstatin(mouse) TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(mouse) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .

HY-RS10073

PARS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PARS2 Human Pre-designed siRNA Set A contains three designed siRNAs for PARS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PARS2 Human Pre-designed siRNA Set A PARS2 Human Pre-designed siRNA Set A

HY-17580

Fidaxomicin 5+ Cited Publications OPT-80; PAR-101	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic	Infection
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-13965

Parmodulin 2 2 Publications Verification ML161	Protease Activated Receptor (PAR)	Cardiovascular Disease
Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC₅₀ of 0.26 μM . Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo .

HY-P2518

*Protease-Activated Receptor-1, PAR-1 Agonist*	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 *(PAR-1)* agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .

HY-P2518A

*Protease-Activated Receptor-1, PAR-1 Agonist TFA*	Protease Activated Receptor (PAR)	Cancer
Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 *(PAR-1)* agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .

HY-P2519

*Protease-Activated Receptor-3 (PAR-3) (1-6), human*	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide .

HY-P2519A

*Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA*	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide .

HY-P4451

TRAP-5 amide	Protease Activated Receptor (PAR)	Others
TRAP-5 amide is a protease-activated receptor 1 (PAR 1) agonist peptide .

HY-146248

TFMU-ADPr	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

HY-146248A

TFMU-ADPr triethylamine	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
TFMU-ADPr triethylamine is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr triethylamine can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr triethylamine has excellent reactivity, generality, stability, and usability. TFMU-ADPr triethylamine is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

HY-116218C

Amelparib hydrochloride JPI-289 hydrochloride	PARP	Cardiovascular Disease Neurological Disease
Amelparib (JPI-289) hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib hydrochloride inhibits PARP-1 activity (IC₅₀ = 18.5 nM) and cellular PAR formation (IC₅₀ = 10.7 nM). Amelparib hydrochloride is a potential neuroprotective agent. Amelparib hydrochloride has the potential for the research of acute ischaemic stroke .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

HY-116218

Amelparib JPI-289 free base	PARP	Cardiovascular Disease Neurological Disease
Amelparib (JPI-289 free base) is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC₅₀=18.5 nM) and cellular PAR formation (IC₅₀=10.7 nM) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke .

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Others
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

HY-P1312

LRGILS-NH2	Protease Activated Receptor (PAR)	Others
LRGILS-NH2 is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide .

HY-P1312A

LRGILS-NH2 TFA	Protease Activated Receptor (PAR)	Others
LRGILS-NH2 TFA is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide .

HY-108556

RWJ-56110	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
RWJ-56110 is a potent, selective, peptide-mimetic inhibitor of *PAR-1* activation and internalization (binding IC₅₀=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 inhibits the aggregation of human platelets induced by?both?SFLLRN-NH2?(IC₅₀=0.16 μM) and thrombin (IC₅₀=0.34 μM), quite selective?relative to U46619 (HY-108566). RWJ-56110 inhibits angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 induces cell apoptosis .

HY-108556A

RWJ-56110 dihydrochloride	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of *PAR-1* activation and internalization (binding IC₅₀=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by?both?SFLLRN-NH2?(IC₅₀=0.16 μM) and thrombin (IC₅₀=0.34 μM), quite selective?relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis .

HY-129746

Arylquin 1	Apoptosis	Cancer
Arylquin 1, a prostate-apoptosis-response-4 *(Par-4)* secretagogue, targets vimentin to induce Par-4 secretion. Arylquin 1 induces non-apoptotic cell death in cancer cells through the induction of lysosomal membrane permeabilization (LMP) .

HY-P5359

FLLRN TRAP-6 (2-6)	Protease Activated Receptor (PAR)	Others
FLLRN is a biological active peptide. (PAR1-specific antagonist peptide)

HY-P5360

TFLLRN-NH2	Protease Activated Receptor (PAR)	Others
TFLLRN-NH2 is a biological active peptide. (PAR-1 Agonist)

HY-P2321

TRAP-6 amide	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide .

HY-108554

Q94 hydrochloride	Protease Activated Receptor (PAR)	Others
Q94 hydrochloride, a selective *PAR₁* antagonist (IC₅₀=916 nM), can selectively block *PAR₁/Gαq interaction and signalling. Q94 hydrochloride blocks PAR₁*-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation .

HY-P2321A

TRAP-6 amide TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide .

HY-P5371

TFLLRNPNDK-NH2	Thrombin	Others
TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)

HY-114164C

Thrombin, Pig blood	Protease Activated Receptor (PAR)	Inflammation/Immunology
Thrombin, Pig blood is a key enzyme in the coagulation cascade, responsible for converting fibrinogen into fibrin. Thrombin, Pig blood activates platelet activation, endothelial cell function, and inflammatory responses by binding to *PAR-1* and *PAR-4*, which triggers G protein-coupled signaling pathways. Thrombin, Pig blood holds promise for research in coagulation and inflammation fields .

Cat. No.	Product Name

HY-L085

Anti-Parkinson's Disease Compound Library

1,665 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1,665 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Cat. No.	Product Name	Type

HY-146248

TFMU-ADPr

Chromogenic Substrates

TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17580

Fidaxomicin 5+ Cited Publications OPT-80; PAR-101	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Polyphenols Antibacterial Disease Research Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-N6599

3-Feruloylquinic acid 3-O-Feruloylquinic acid	Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Phenols Phenylpropanoids Plants Disease Research Fields	Others
3-Feruloylquinic acid, a derivative of quinic acid-bound phenolic acid, shows antioxidant activity. 3-Feruloylquinic acid markedly enhances by high photosynthetically active radiation (PAR) and UV irradiances .

HY-N13008

4-Hydroxy-sterigmatocystin	Structural Classification Monophenols Microorganisms Source classification Phenols	Bacterial
4-Hydroxy-sterigmatocystin (compd 1) is a ParB inhibitor with antibacterial activity. 4-Hydroxy-sterigmatocystin can bind to purified ParB in a ParS-modulated manner and inhibits its ParS-dependent CTPase activity .

HY-W017158R

Melilotic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
Vorapaxar (sulfate) (Standard) is the analytical standard of Vorapaxar (sulfate). This product is intended for research and analytical applications. Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

Species:	Human (13) Mouse (4) Rat (1) E.coli (1) Cynomolgus (1)
Tag:	His (17) SUMO (1) Tag Free (2) Avi (5) GST (1) Flag (1) Fc (1)
Source:	HEK293 (13) Sf9 insect cells (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P71481

	Outer membrane porin C/OmpC Protein, E.coli (His-SUMO) ompC; meoA; PAR; b2215; JW2203; Outer membrane porin C; Outer membrane protein 1B; Outer membrane protein C; Porin OmpC	E.coli	E. coli
	Outer membrane porin C (OmpC) functions as a channel, creating pores that facilitate passive diffusion of small molecules across the bacterial outer membrane. In the context of microbial infection, OmpC plays a role in supporting the entry of colicin E5 even in the absence of its primary receptor OmpF. Outer membrane porin C/OmpC Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Outer membrane porin C/OmpC protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P73612

	*Thrombin Receptor/PAR1 Protein, Human (HEK293, His)* Cf2r; CF2RHTR; F2R; HTR; PAR1; Protease-Activated Receptor 1	Human	HEK293
	The thrombin receptor/PAR1 protein is a high-affinity receptor for activated thrombin that is coupled to G proteins to stimulate phosphoinositide hydrolysis. This signaling mechanism suggests its involvement in platelet activation, which is critical for hemostasis and thrombosis. Thrombin Receptor/PAR1 Protein, Human (HEK293, His) is the recombinant human-derived Thrombin Receptor/PAR1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P703125

	PAR2 Protein, Human (Sf9, Flag, His) GPR11; PAR2	Human	Sf9 insect cells
	PAR2 Protein, Human (Sf9, Flag, His) is the recombinant human-derived PAR2, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

HY-P701806

	MARK1 Protein, Human MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; PAR-1c; PAR1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human is the recombinant human-derived MARK1 protein, expressed by E. coli , with tag free.

HY-P701807

	MARK1 Protein, Human (His) MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; PAR-1c; PAR1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human (His) is the recombinant human-derived MARK1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MARK1 Protein, Human (His) is 751 a.a., .

HY-P700897

	uPAR Protein, Cynomolgus (HEK293, His) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Cynomolgus	HEK293
	uPAR protein is the receptor of urokinase plasminogen activator and plays an important role in localizing and promoting the formation of plasmin. It mediates proteolysis-independent signal transduction through U-PA and is regulated through negative feedback. uPAR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived uPAR protein, expressed by HEK293 , with C-His labeled tag. The total length of uPAR Protein, Cynomolgus (HEK293, His) is 283 a.a., with molecular weight of 60-70 kDa.

HY-P700844

	uPAR Protein, Human (HEK293, His-Avi) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Human	HEK293
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (HEK293, His-Avi) is the recombinant human-derived uPAR protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of uPAR Protein, Human (HEK293, His-Avi) is 283 a.a., with molecular weight of 50-60 kDa.

HY-P700849

	uPAR Protein, Mouse (HEK293, His-Avi) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Mouse	HEK293
	The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation. It interacts with SRPX2 and forms a monomer. uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization. Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1. uPAR Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of uPAR Protein, Mouse (HEK293, His-Avi) is 275 a.a., with molecular weight of 50-65 kDa.

HY-P702769

	uPAR Protein, Human (GST) Urokinase plasminogen activator surface receptor; U-PAR; CD87; PLAUR; MO3	Human	E. coli
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (GST) is the recombinant human-derived uPAR protein, expressed by E. coli , with N-GST labeled tag.

HY-P703682

	uPAR/PLAUR Protein, Rat (HEK293, His, Avi) Urokinase plasminogen activator surface receptor; Plaur; U-PAR	Rat	HEK293

HY-P700843

	uPAR Protein, Human (Biotinylated, HEK293, His-Avi) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Human	HEK293
	uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of uPAR Protein, Human (Biotinylated, HEK293, His-Avi) is 283 a.a., with molecular weight of 50-65 kDa.

HY-P700846

	uPAR Protein, Human (Domain 1, HEK293, His) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Human	HEK293
	uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 1, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 1, HEK293, His) is 92 a.a., with molecular weight of 17-25 kDa.

HY-P700847

	uPAR Protein, Human (Domain 3, HEK293, His) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Human	HEK293
	uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 3, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 3, HEK293, His) is 92 a.a., with molecular weight of 25-35 kDa.

HY-P700848

	uPAR Protein, Mouse (Biotinylated, HEK293, His-Avi) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Mouse	HEK293
	The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation. It interacts with SRPX2 and forms a monomer. uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization. Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1. uPAR Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of uPAR Protein, Mouse (Biotinylated, HEK293, His-Avi) is 275 a.a., with molecular weight of 50-70 kDa.

HY-P72433

	uPAR Protein, Human (HEK293, His) Urokinase plasminogen activator surface receptor; U-PAR; CD87; PLAUR; MO3	Human	HEK293
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77276

	uPAR Protein, Mouse (HEK293, His) Urokinase plasminogen activator surface receptor; U-PAR; CD87; PLAUR; MO3	Mouse	HEK293
	The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation.It interacts with SRPX2 and forms a monomer.uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization.Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1.uPAR Protein, Mouse (HEK293, His) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-His labeled tag.

HY-P77275

	uPAR Protein, Mouse (HEK293, His-Fc) Urokinase plasminogen activator surface receptor; U-PAR; CD87; PLAUR; MO3	Mouse	HEK293
	uPAR (urokinase plasminogen activator receptor) possesses enzyme, protein, and receptor binding activities.It regulates apoptotic signaling, epidermal growth factor signaling, and cytochrome c release.uPAR is widely expressed in structures like decidua and spleen.Its human ortholog, PLAUR, is linked to rheumatoid arthritis.Investigating uPAR can reveal its role in cellular processes and shed light on diseases like rheumatoid arthritis.uPAR Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P700845

	uPAR Protein, Human (Domain 2&3 , HEK293, His) U-PAR; uPAR; CD87; PLAUR; MO3; UPAR	Human	HEK293
	uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 2&3, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 2&3, HEK293, His) is 191 a.a., with molecular weight of 33-45 kDa.

HY-P701396

	PXR Protein, Human NR1I2; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human is the recombinant human-derived PXR protein, expressed by E. coli , with tag free. The total length of PXR Protein, Human is 305 a.a., .

HY-P701397

	PXR Protein, Human (His) NR1I2; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human (His) is the recombinant human-derived PXR protein, expressed by E. coli , with N-6*His labeled tag. The total length of PXR Protein, Human (His) is 305 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-10119S

Vorapaxar-d5
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82710

	PAR2 Antibody (YA2455) F2RL1; GPR11; PAR 2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PAR2 Antibody (YA2455) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2455), targeting PAR2, with a predicted molecular weight of 44 kDa (observed band size: 55 kDa). PAR2 Antibody (YA2455) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P81512A

	uPAR Antibody U-PAR; Monocyte activation antigen Mo3; CD87	WB, IHC-P	Human

HY-P81791

	PAR6 Antibody (YA1536) PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha	WB, IP	Human, Mouse, Rat
	PAR6 Antibody (YA1536) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1536), targeting PAR6, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). PAR6 Antibody (YA1536) can be used for WB, IP experiment in human, mouse, rat background.

HY-P82858

	PAR4 Antibody (YA2603) PAWR; PAR4; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; PAR-4	WB	Human, Mouse, Rat
	PAR4 Antibody (YA2603) is a non-conjugated IgG antibody, targeting PAR4, with a predicted molecular weight of 37 kDa (observed band size: 40 kDa). PAR4 Antibody (YA2603) can be used for WB experiment in human, mouse, rat background.

HY-P81896

	PIN4 Antibody (YA1641) EPVH; PAR14; PAR17	WB, IP	Human, Rat, Hamster
	PIN4 Antibody (YA1641) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1641), targeting PIN4, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). PIN4 Antibody (YA1641) can be used for WB, IP experiment in human, rat, hamster background.

HY-P82359

	MARK2 Antibody (YA2104) ELKL motif kinase 1 antibody; ELKL motif kinase antibody; EMK-1 antibody; EMK1 antibody; MAP/microtubule affinity regulating kinase 2 antibody; MAP/microtubule affinity-regulating kinase 2 antibody; Mark2 antibody; MARK2_HUMAN antibody; MGC99619 antibody; PAR 1 antibody; PAR 1b antibody; PAR1 homolog antibody; PAR1b antibody; Ser/Thr protein kinase PAR 1B antibody; Serine/threonine protein kinase EMK antibody; Serine/threonine protein kinase MARK2 antibody; Serine/threonine-protein kinase MARK2 antibody;	WB, FC	Human, Mouse, Rat
	MARK2 Antibody (YA2104) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2104), targeting MARK2, with a predicted molecular weight of 88 kDa (observed band size: 78, 82 kDa). MARK2 Antibody (YA2104) can be used for WB, FC experiment in human, mouse, rat background.

HY-P81512

	uPAR Antibody (YA1257) U-PAR; Monocyte activation antigen Mo3; CD87	IHC-P	Human
	uPAR Antibody (YA1257) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1257), targeting uPAR. uPAR Antibody (YA1257) can be used for IHC-P experiment in human background.

HY-P82405

	MARK3 Antibody (YA2150) C-TAK1 antibody; Cdc25C associated protein kinase 1 antibody; Cdc25C-associated protein kinase 1 antibody; cTAK1 antibody; ELKL motif kinase 2 antibody; EMK-2 antibody; Emk2 antibody; ETK 1 antibody; KIAA4230 antibody; KP78 antibody; MAP microtubule affinity regulating kinase 3 antibody; MAP/microtubule affinity-regulating kinase 3 antibody; Mark3 antibody; MARK3_HUMAN antibody; PAR 1a antibody; PAR1A antibody; Protein kinase STK10 antibody; Ser/Thr protein kinase PAR-1 antibody; Serine threonine protein kinase p78 antibody; Serine/threonine-protein kinase p78 antibody; SerThr protein kinase PAR 1 antibody;	WB, ICC/IF, IP, FC	Mouse, Human
	MARK3 Antibody (YA2150) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2150), targeting MARK3, with a predicted molecular weight of 84 kDa (observed band size: 84 kDa). MARK3 Antibody (YA2150) can be used for WB, ICC/IF, IP, FC experiment in mouse, human background.