1. Search Result
Search Result
Results for "

Sn

" in MedChemExpress (MCE) Product Catalog:

592

Inhibitors & Agonists

8

Fluorescent Dye

156

Biochemical Assay Reagents

9

Peptides

43

Natural
Products

3

Recombinant Proteins

94

Isotope-Labeled Compounds

3

Antibodies

6

Click Chemistry

161

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145009

    STING Others
    SN-008, a less active SN-011 analog, can be used as a negative control .
    SN-008
  • HY-145010
    SN-011
    5 Publications Verification

    STING Inflammation/Immunology
    SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .
    SN-011
  • HY-153013

    Drug-Linker Conjugates for ADC Cancer
    SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis .
    SN38-COOH
  • HY-P3229
    SN52
    2 Publications Verification

    NF-κB Cancer
    SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .
    SN52
  • HY-W140974
    SN-001
    1 Publications Verification

    STING Cancer
    SN-001 is a STING inhibitor with an IC50 of 3.82 μM .
    SN-001
  • HY-16696
    SN 2
    3 Publications Verification

    Flavivirus Dengue Virus TRP Channel Infection
    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM . SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) .
    SN 2
  • HY-13704R

    Drug Metabolite Topoisomerase ADC Cytotoxin Autophagy Cancer
    SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .
    SN-38 (Standard)
  • HY-158230

    Topoisomerase Cancer
    SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .
    SN-398
  • HY-14871

    Sn2310

    Topoisomerase Cancer
    Tenifatecan (SN2310) is an injectable emulsion composed of vitamin E, a succinate derivative, as well as 7-ethyl-10-hydroxycamptothecin (SN-38, the active metabolite of irinotecan). Tenifatecan (SN2310) possesses anticancer activity .
    Tenifatecan
  • HY-157797

    Others Cancer
    SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells .
    SN-38-CM2
  • HY-113128

    Endogenous Metabolite Metabolic Disease
    sn-Glycerol 3-phosphate is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate for lipid metabolism .
    sn-Glycerol 3-phosphate
  • HY-120313

    Drug Derivative Cancer
    SN23862 is a cancer prodrug with anti-cancer activity, and an analogue of CB-1954 (HY-13543). SN23862 can be used for cancer research .
    SN23862
  • HY-W653919

    Isotope-Labeled Compounds Drug Metabolite Cancer
    SN-38 glucuronide-d3 is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
    SN-38 glucuronide-d3
  • HY-103375

    CRFR Neurological Disease
    SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat .
    SN003
  • HY-13704
    SN-38
    Maximum Cited Publications
    47 Publications Verification

    7-Ethyl-10-hydroxycamptothecin

    Drug Metabolite Topoisomerase ADC Cytotoxin Autophagy Cancer
    SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .
    SN-38
  • HY-126373S1

    Sn-38G-13C6

    Isotope-Labeled Compounds Others
    SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
    SN-38 glucuronide-13C6
  • HY-P2670

    NF-κB Others
    SN50M, a mutant peptide of SN50 (HY-P0151), is a cell membrane-permeable inactive control peptide .
    SN50M
  • HY-113128A

    Endogenous Metabolite Metabolic Disease
    sn-Glycerol 3-phosphate lithium is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate lithium from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate lithium for lipid metabolism .
    sn-Glycerol 3-phosphate lithium
  • HY-113128B

    Endogenous Metabolite Metabolic Disease
    sn-Glycerol 3-phosphate biscyclohexylammonium salt is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate biscyclohexylammonium salt from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate biscyclohexylammonium salt for lipid metabolism .
    sn-Glycerol 3-phosphate biscyclohexylammonium salt
  • HY-126373

    Sn-38G

    Drug Metabolite Cancer
    SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
    SN-38 glucuronide
  • HY-167885

    iGluR Neurological Disease
    SN-35210 free base, an ester analogue, is designed for rapid offset via esterase-mediated hydrolysis .
    SN-35210 free base
  • HY-116170

    Aldose Reductase Cancer
    SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression .
    SN34037
  • HY-P0151
    SN50
    35+ Cited Publications

    NF-κB Inflammation/Immunology
    SN50 is a cell permeable inhibitor of NF-κB translocation.
    SN50
  • HY-123849

    PI3K mTOR Cancer
    SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC50s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. SN32976 shows high selectivity among other 442 kinases. SN32976 shows anticancer effects .
    SN32976
  • HY-145767A

    Drug Intermediate Others
    SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035 .
    SN-38-CO-DMEDA TFA
  • HY-13704S

    NK012-d3

    Topoisomerase ADC Cytotoxin Autophagy Cancer
    SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].
    SN-38-d3
  • HY-146241B

    EAAT ASCT Others
    SN40 hydrochloride is a potent amino acid transport (AAT) inhibitor with Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 hydrochloride can be used for researching anticancer .
    SN40 hydrochloride
  • HY-146241

    EAAT ASCT Cancer
    SN40 is a potent amino acid transport (AAT) inhibitor with Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer .
    SN40
  • HY-107658
    SN 6
    5+ Cited Publications

    Na+/Ca2+ Exchanger Cardiovascular Disease
    SN 6 is a selective Na +/Ca 2+ exchanger (NCX) inhibitor, and inhibits 45Ca 2+ uptake by NCX1, NCX2, and NCX3, with IC50s of 2.9, 16, and 8.6 μM, respectively.
    SN 6
  • HY-146242

    EAAT ASCT Cancer
    SN05 is a potent amino acid transport (AAT) inhibitor with Kis of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN05 can be used for researching anticancer .
    SN05
  • HY-113128S

    Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    sn-Glycerol 3-phosphate- 13C3 disodium is the 13C-labeled sn-Glycerol 3-phosphate disodium. sn-Glycerol 3-phosphate disodium is produced by cytosolic glycerol 3-phosphate dehydrogenase pathway through the reduction of dihydroxyacetone phosphate using NADH formed during glycolysis .
    sn-Glycerol 3-phosphate-13C3 disodium
  • HY-B0002
    Ondansetron hydrochloride
    5+ Cited Publications

    GR 38032 hydrochloride; Sn 307 hydrochloride

    5-HT Receptor Neurological Disease
    Ondansetron hydrochloride (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
    Ondansetron hydrochloride
  • HY-153962

    Drug-Linker Conjugates for ADC Cancer
    SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a Drug-Linker Conjugate for ADC. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 consists of the anti-cancer agent SN38 (HY-13704) and a linker Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 (HY-131157). SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 can be used for synthesis of ADCs . SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3
  • HY-167538

    Biochemical Assay Reagents Others
    sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct is a biochemical reagent.
    sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct
  • HY-17552R

    Choline Alfoscerate (Standard); Alpha-GPC (Standard); L-α-GPC (Standard)

    Cholinesterase (ChE) Endogenous Metabolite Neurological Disease
    sn-Glycero-3-phosphocholine (Standard) is the analytical standard of sn-Glycero-3-phosphocholine. This product is intended for research and analytical applications. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].
    sn-Glycero-3-phosphocholine (Standard)
  • HY-14572

    Sn 27858

    DNA Alkylator/Crosslinker Drug Metabolite Cancer
    PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .
    PR-104A
  • HY-W127817

    Biochemical Assay Reagents Others
    Sn(IV) meso-Tetra (4-Pyridyl) Porphine Dichloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Sn(IV) meso-tetra (4-pyridyl) porphine dichloride
  • HY-B0002B
    Ondansetron
    5+ Cited Publications

    GR 38032; Sn 307

    5-HT Receptor Neurological Disease Cancer
    Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity .
    Ondansetron
  • HY-17552
    sn-Glycero-3-phosphocholine
    1 Publications Verification

    Choline Alfoscerate; Alpha-GPC; L-α-GPC

    Cholinesterase (ChE) Endogenous Metabolite Neurological Disease
    sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia .
    sn-Glycero-3-phosphocholine
  • HY-B0002BS1

    GR 38032-d3; Sn 307-d3

    5-HT Receptor Neurological Disease
    Ondansetron-d3 is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].
    Ondansetron-d3
  • HY-17552S

    Choline Alfoscerate-d9; Alpha-GPC-d9; L-α-GPC-d9

    Isotope-Labeled Compounds Cholinesterase (ChE) Endogenous Metabolite Neurological Disease
    sn-Glycero-3-phosphocholine-d9 is the deuterium labeled sn-Glycero-3-phosphocholine. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].
    sn-Glycero-3-phosphocholine-d9
  • HY-B0002BS

    GR 38032-d5; Sn 307-d5

    5-HT Receptor Neurological Disease
    Ondansetron-d5 is the deuterium labeled Ondansetron. Ondansetron (GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
    Ondansetron-d5
  • HY-141572

    Sn-1,2-Dioleoylglycerol

    Biochemical Assay Reagents Others
    ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.
    1,2-Dioleoyl-sn-glycerol
  • HY-138815S

    Isotope-Labeled Compounds Glycosidase Metabolic Disease
    (S)-N-(1H-Indole-3-acetyl)tryptophan-d4 is deuterium labeled (S)-N-(1H-Indole-3-acetyl)tryptophan. (S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .
    (S)-N-(1H-Indole-3-acetyl)tryptophan-d4
  • HY-164982

    Histone Methyltransferase Cancer
    S-N6-Methyladenosylhomocysteine (Chart 1-1) is a potent inhibitor of histone methyltransferase DOT1L, with the IC50 of 0.29 μM. S-N6-Methyladenosylhomocysteine plays an important role in cancer research .
    S-N6-Methyladenosylhomocysteine
  • HY-13735A
    Quinacrine dihydrochloride
    5 Publications Verification

    Mepacrine dihydrochloride; Sn-390 dihydrochloride

    Parasite Apoptosis Autophagy Mitophagy Infection Cancer
    Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis .
    Quinacrine dihydrochloride
  • HY-13735B
    Quinacrine hydrochloride hydrate
    5 Publications Verification

    Mepacrine hydrochloride hydrate; Sn-390 hydrochloride hydrate

    Parasite Apoptosis Autophagy Mitophagy Infection Cancer
    Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis .
    Quinacrine hydrochloride hydrate
  • HY-B0002A

    GR 38032 hydrochloride dihydrate; Sn 307 hydrochloride dihydrate

    5-HT Receptor Neurological Disease Cancer
    Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery .
    Ondansetron hydrochloride dihydrate
  • HY-W128037

    Amino Acid Derivatives Others
    (S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride is an arginine derivative .
    (S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride
  • HY-13735E

    Mepacrine methanesulfonate; Sn-390 methanesulfonate

    Parasite Apoptosis Autophagy Mitophagy Infection Cancer
    Quinacrine (Mepacrine) methanesulfonate is a potent, orally active antimalarial agent with antitumor effects in vitro and in vivo. Quinacrine dihydrochloride inhibits NF-κB and activates p53 signaling, inducing apoptosis in tumor cells .
    Quinacrine methanesulfonate

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

 

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

 

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: